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Volume 91, Issue 3

February 1 1998

In this Issue

REVIEW ARTICLES
RAPID COMMUNICATIONS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
CORRESPONDENCE
ERRATA

REVIEW ARTICLES

Role of Calcium in Glucocorticosteroid-Induced Apoptosis of Thymocytes and Lymphoma Cells: Resurrection of Old Theories by New Findings

Clark W. Distelhorst,George Dubyak

View Articletitled, Role of Calcium in Glucocorticosteroid-Induced Apoptosis of Thymocytes and Lymphoma Cells: Resurrection of Old Theories by New Findings

Biology and Treatment of Childhood T-Lineage Acute Lymphoblastic Leukemia

Fatih M. Uckun,Martha G. Sensel,Lei Sun,Peter G. Steinherz,Michael E. Trigg,Nyla A. Heerema,Harland N. Sather,Gregory H. Reaman,Paul S. Gaynon

View Articletitled, Biology and Treatment of Childhood T-Lineage Acute Lymphoblastic Leukemia

RAPID COMMUNICATIONS

Differential Expression of BCL-6, CD138/Syndecan-1, and Epstein-Barr Virus–Encoded Latent Membrane Protein-1 Identifies Distinct Histogenetic Subsets of Acquired Immunodeficiency Syndrome–Related Non-Hodgkin's Lymphomas

Antonino Carbone,Gianluca Gaidano,Annunziata Gloghini,Luigi M. Larocca,Daniela Capello,Vincenzo Canzonieri,Andrea Antinori,Umberto Tirelli,Brunangelo Falini,Riccardo Dalla-Favera

View Articletitled, Differential Expression of BCL-6, CD138/Syndecan-1, and Epstein-Barr Virus–Encoded Latent Membrane Protein-1 Identifies Distinct Histogenetic Subsets of Acquired Immunodeficiency Syndrome–Related Non-Hodgkin's Lymphomas

Nonmyeloablative Stem Cell Transplantation and Cell Therapy as an Alternative to Conventional Bone Marrow Transplantation With Lethal Cytoreduction for the Treatment of Malignant and Nonmalignant Hematologic Diseases

Shimon Slavin,Arnon Nagler,Ella Naparstek,Yossi Kapelushnik,Memet Aker,Gabriel Cividalli,Gabor Varadi,Mark Kirschbaum,Aliza Ackerstein,Simcha Samuel,Avraham Amar,Chaim Brautbar,Ofira Ben-Tal,Amiram Eldor,Reuven Or

View Articletitled, Nonmyeloablative Stem Cell Transplantation and Cell Therapy as an Alternative to Conventional Bone Marrow Transplantation With Lethal Cytoreduction for the Treatment of Malignant and Nonmalignant Hematologic Diseases

Expression of the Wilms' Tumor Suppressor Gene, WT1, Is Upregulated by Leukemia Inhibitory Factor and Induces Monocytic Differentiation in M1 Leukemic Cells

Shirley I. Smith,Dominique Weil,Gregory R. Johnson,Andrew W. Boyd,Chung L. Li

View Articletitled, Expression of the Wilms' Tumor Suppressor Gene, WT1, Is Upregulated by Leukemia Inhibitory Factor and Induces Monocytic Differentiation in M1 Leukemic Cells

The Incidence and Natural Course of Transfusion-Associated GB Virus C/Hepatitis G Virus Infection in a Cohort of Thalassemic Patients

Daniele Prati,Alberto Zanella,Patrizia Bosoni,Paolo Rebulla,Elena Farma,Claudia De Mattei,Carmen Capelli,Fulvio Mozzi,Domenico Gallisai,Carmelo Magnano,Caterina Melevendi,Girolamo Sirchia for th e Cooleycare Cooperative Group

View Articletitled, The Incidence and Natural Course of Transfusion-Associated GB Virus C/Hepatitis G Virus Infection in a Cohort of Thalassemic Patients

HEMATOPOIESIS

Deficient Heme and Globin Synthesis in Embryonic Stem Cells Lacking the Erythroid-Specific δ-Aminolevulinate Synthase Gene

Hideo Harigae,Naruyoshi Suwabe,Peter H. Weinstock,Mayumi Nagai,Hiroyoshi Fujita,Masayuki Yamamoto,Shigeru Sassa

View Articletitled, Deficient Heme and Globin Synthesis in Embryonic Stem Cells Lacking the Erythroid-Specific δ-Aminolevulinate Synthase Gene

Elevated Serum Concentrations of Hepatocyte Growth Factor in Patients With Multiple Myeloma

Carina Seidel,Magne Børset,Ingemar Turesson,Niels Abildgaard,Anders Sundan,Anders Waage for th e Nordic Myeloma Study Group

View Articletitled, Elevated Serum Concentrations of Hepatocyte Growth Factor in Patients With Multiple Myeloma

Protein Kinase C Mediates the Mitogenic Action of Thrombopoietin in c-Mpl–Expressing UT-7 Cells

Ying Hong,Dominique Dumènil,Bernd van der Loo,Frédérique Goncalves,William Vainchenker,Jorge D. Erusalimsky

View Articletitled, Protein Kinase C Mediates the Mitogenic Action of Thrombopoietin in c-Mpl–Expressing UT-7 Cells

Overexpression of Protein Kinase C Isoform  but not δ in Human Interleukin-3–Dependent Cells Suppresses Apoptosis and Induces bcl-2 Expression

E. Gubina,M.S. Rinaudo,Z. Szallasi,P.M. Blumberg,R.A. Mufson

View Articletitled, Overexpression of Protein Kinase C Isoform  but not δ in Human Interleukin-3–Dependent Cells Suppresses Apoptosis and Induces bcl-2 Expression

Effects of Cytokines on Platelet Production From Blood and Marrow CD34⁺ Cells

Françoise Norol,Natacha Vitrat,Elisabeth Cramer,Josette Guichard,Samuel A. Burstein,William Vainchenker,Najet Debili

View Articletitled, Effects of Cytokines on Platelet Production From Blood and Marrow CD34+ Cells

Cloning and Characterization of the Human Homolog of Mouse Jak2

Ilan Dalal,Enrico Arpaia,Harjit Dadi,Shaila Kulkarni,Jerami Squire,Chaim M. Roifman

View Articletitled, Cloning and Characterization of the Human Homolog of Mouse Jak2

Oligodeoxyribonucleotide Uptake in Primary Human Hematopoietic Cells Is Enhanced by Cationic Lipids and Depends on the Hematopoietic Cell Subset

Ralf Kronenwett,Ulrich Steidl,Michael Kirsch,Georg Sczakiel,Rainer Haas

View Articletitled, Oligodeoxyribonucleotide Uptake in Primary Human Hematopoietic Cells Is Enhanced by Cationic Lipids and Depends on the Hematopoietic Cell Subset

Essential Roles for Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and G-CSF in the Sustained Hematopoietic Response ofListeria monocytogenes–Infected Mice

Yifan Zhan,Graham J. Lieschke,Dianne Grail,Ashley R. Dunn,Christina Cheers

View Articletitled, Essential Roles for Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and G-CSF in the Sustained Hematopoietic Response ofListeria monocytogenes–Infected Mice

Redundant and Selective Roles for Erythropoietin Receptor Tyrosines in Erythropoiesis In Vivo

Gregory D. Longmore,Yun You,Jaime Molden,Kathleen D. Liu,Aki Mikami,Stephen Y. Lai,Pamela Pharr,Mark A. Goldsmith

View Articletitled, Redundant and Selective Roles for Erythropoietin Receptor Tyrosines in Erythropoiesis In Vivo

Signaling Through the Interaction of Membrane-Restricted Stem Cell Factor and c-kit Receptor Tyrosine Kinase: Genetic Evidence for a Differential Role in Erythropoiesis

Reuben Kapur,Manus Majumdar,Xiangli Xiao,Monica McAndrews-Hill,Karen Schindler,David A. Williams

View Articletitled, Signaling Through the Interaction of Membrane-Restricted Stem Cell Factor and c-kit Receptor Tyrosine Kinase: Genetic Evidence for a Differential Role in Erythropoiesis

Stimulating Cell Proliferation Through the Pharmacologic Activation of c-kit

Liqing Jin,Haruhiko Asano,C. Anthony Blau

View Articletitled, Stimulating Cell Proliferation Through the Pharmacologic Activation of c-kit

Analysis of c-kit Receptor Dimerization by Fluorescence Resonance Energy Transfer

Virginia C. Broudy,Nancy L. Lin,Hans-Jörg Bühring,Norio Komatsu,Terrance J. Kavanagh

View Articletitled, Analysis of c-kit Receptor Dimerization by Fluorescence Resonance Energy Transfer

Neither Human Immunodeficiency Virus-1 (HIV-1) nor HIV-2 Infects Most-Primitive Human Hematopoietic Stem Cells as Assessed in Long-Term Bone Marrow Cultures

Frank F. Weichold,Davide Zella,Oxana Barabitskaja,Jaroslaw P. Maciejewski,Daniel E. Dunn,Elaine M. Sloand,Neal S. Young

View Articletitled, Neither Human Immunodeficiency Virus-1 (HIV-1) nor HIV-2 Infects Most-Primitive Human Hematopoietic Stem Cells as Assessed in Long-Term Bone Marrow Cultures

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Antibodies From Patients With Heparin-Induced Thrombocytopenia/Thrombosis Recognize Different Epitopes on Heparin: Platelet Factor 4

Jang-Soo Suh,Richard H. Aster,Gian P. Visentin

View Articletitled, Antibodies From Patients With Heparin-Induced Thrombocytopenia/Thrombosis Recognize Different Epitopes on Heparin: Platelet Factor 4

Thrombopoietin and Its Receptor, c-mpl, Are Constitutively Expressed by Mouse Liver Endothelial Cells: Evidence of Thrombopoietin as a Growth Factor for Liver Endothelial Cells

José E. Cardier,Jack Dempsey

View Articletitled, Thrombopoietin and Its Receptor, c-mpl, Are Constitutively Expressed by Mouse Liver Endothelial Cells: Evidence of Thrombopoietin as a Growth Factor for Liver Endothelial Cells

The p85 and p110 Subunits of Phosphatidylinositol 3-Kinase-α Are Substrates, In Vitro, for a Constitutively Associated Protein Tyrosine Kinase in Platelets

Norman R. Geltz,James A. Augustine

View Articletitled, The p85 and p110 Subunits of Phosphatidylinositol 3-Kinase-α Are Substrates, In Vitro, for a Constitutively Associated Protein Tyrosine Kinase in Platelets

IMMUNOBIOLOGY

Expression and Activation of the Nonreceptor Tyrosine Kinase Tec in Human B Cells

Akira Kitanaka,Hiroyuki Mano,Mary Ellen Conley,Dario Campana

View Articletitled, Expression and Activation of the Nonreceptor Tyrosine Kinase Tec in Human B Cells

Development of Autologous, Oligoclonal, Poorly Functioning T Lymphocytes in a Patient With Autosomal Recessive Severe Combined Immunodeficiency Caused by Defects of the Jak3 Tyrosine Kinase

Duilio Brugnoni,Luigi D. Notarangelo,Alessandra Sottini,Paolo Airò,Marta Pennacchio,Evelina Mazzolari,Simona Signorini,Fabio Candotti,Anna Villa,Patrizia Mella,Paolo Vezzoni,Roberto Cattaneo,Alberto G. Ugazio,Luisa Imberti

View Articletitled, Development of Autologous, Oligoclonal, Poorly Functioning T Lymphocytes in a Patient With Autosomal Recessive Severe Combined Immunodeficiency Caused by Defects of the Jak3 Tyrosine Kinase

γ-Interferon Produced by CD8⁺ T Cells Infiltrating Kaposi's Sarcoma Induces Spindle Cells With Angiogenic Phenotype and Synergy With Human Immunodeficiency Virus-1 Tat Protein: An Immune Response to Human Herpesvirus-8 Infection?

Valeria Fiorelli,Rita Gendelman,Maria Caterina Sirianni,Hsiao-Kuey Chang,Sandra Colombini,Phillip D. Markham,Paolo Monini,Joseph Sonnabend,Aldo Pintus,Robert C. Gallo,Barbara Ensoli

View Articletitled, γ-Interferon Produced by CD8+ T Cells Infiltrating Kaposi's Sarcoma Induces Spindle Cells With Angiogenic Phenotype and Synergy With Human Immunodeficiency Virus-1 Tat Protein: An Immune Response to Human Herpesvirus-8 Infection?

γ-Interferon Production in Peripheral Blood Mononuclear Cells and Tumor Infiltrating Lymphocytes From Kaposi's Sarcoma Patients: Correlation With the Presence of Human Herpesvirus-8 in Peripheral Blood Mononuclear Cells and Lesional Macrophages

Maria Caterina Sirianni,Laura Vincenzi,Valeria Fiorelli,Simone Topino,Enrico Scala,Stefania Uccini,Antonio Angeloni,Alberto Faggioni,Decio Cerimele,Francesca Cottoni,Fernando Aiuti,Barbara Ensoli

View Articletitled, γ-Interferon Production in Peripheral Blood Mononuclear Cells and Tumor Infiltrating Lymphocytes From Kaposi's Sarcoma Patients: Correlation With the Presence of Human Herpesvirus-8 in Peripheral Blood Mononuclear Cells and Lesional Macrophages

Dendritic Cells Stimulate the Expansion of bcr-abl Specific CD8⁺ T Cells With Cytotoxic Activity Against Leukemic Cells From Patients With Chronic Myeloid Leukemia

Mie Nieda,Andrew Nicol,Akiko Kikuchi,Koichi Kashiwase,Kerry Taylor,Kenji Suzuki,Kenji Tadokoro,Takeo Juji

View Articletitled, Dendritic Cells Stimulate the Expansion of bcr-abl Specific CD8+ T Cells With Cytotoxic Activity Against Leukemic Cells From Patients With Chronic Myeloid Leukemia

NEOPLASIA

Application of Interphase Fluorescence In Situ Hybridization for the Detection of the Burkitt Translocation t(8;14)(q24;q32) in B-Cell Lymphomas

Reiner Siebert,Peter Matthiesen,Svetlana Harder,Yanming Zhang,Annekathrin Borowski,Reina Zühlke-Jenisch,Simone Metzke,Stefan Joos,Klaus Weber-Matthiesen,Werner Grote,Brigitte Schlegelberger

View Articletitled, Application of Interphase Fluorescence In Situ Hybridization for the Detection of the Burkitt Translocation t(8;14)(q24;q32) in B-Cell Lymphomas

Elevated Expression of the Apoptotic Regulator Mcl-1 at the Time of Leukemic Relapse

Scott H. Kaufmann,Judith E. Karp,Phyllis A. Svingen,Stan Krajewski,Philip J. Burke,Steven D. Gore,John C. Reed

View Articletitled, Elevated Expression of the Apoptotic Regulator Mcl-1 at the Time of Leukemic Relapse

Cyclosporin A Induces Apoptosis in Childhood Acute Lymphoblastic Leukemia Cells

Chikako Ito,Raul C. Ribeiro,Frederick G. Behm,Susana C. Raimondi,Ching-Hon Pui,Dario Campana

View Articletitled, Cyclosporin A Induces Apoptosis in Childhood Acute Lymphoblastic Leukemia Cells

17p Deletion in Acute Myeloid Leukemia and Myelodysplastic Syndrome. Analysis of Breakpoints and Deleted Segments by Fluorescence In Situ

Valérie Soenen,Claude Preudhomme,Christophe Roumier,Agnès Daudignon,Jean Luc Laı̈,Pierre Fenaux

View Articletitled, 17p Deletion in Acute Myeloid Leukemia and Myelodysplastic Syndrome. Analysis of Breakpoints and Deleted Segments by Fluorescence In Situ

Genomic Alterations of the p19^ARF Encoding Exons in T-Cell Acute Lymphoblastic Leukemia

Betty Gardie,Jean-Michel Cayuela,Sophie Martini,François Sigaux

View Articletitled, Genomic Alterations of the p19ARF Encoding Exons in T-Cell Acute Lymphoblastic Leukemia

E2A-PBX1 Chimeric Transcript Status at End of Consolidation Is Not Predictive of Treatment Outcome in Childhood Acute Lymphoblastic Leukemias With a t(1;19)(q23;p13): A Pediatric Oncology Group Study

Stephen P. Hunger,Majilinde Z. Fall,Bruce M. Camitta,Andrew J. Carroll,Michael P. Link,Stephen J. Lauer,Donald H. Mahoney,D. Jeanette Pullen,Jonathan J. Shuster,C. Philip Steuber,Michael L. Cleary

View Articletitled, E2A-PBX1 Chimeric Transcript Status at End of Consolidation Is Not Predictive of Treatment Outcome in Childhood Acute Lymphoblastic Leukemias With a t(1;19)(q23;p13): A Pediatric Oncology Group Study

Lung-Resistance–Related Protein Expression Is a Negative Predictive Factor for Response to Conventional Low but not to Intensified Dose Alkylating Chemotherapy in Multiple Myeloma

H.G.P. Raaijmakers,M.A.I. Izquierdo,H.M. Lokhorst,C. de Leeuw,J.A.M. Belien,A.C. Bloem,A.W. Dekker,R.J. Scheper,P. Sonneveld

View Articletitled, Lung-Resistance–Related Protein Expression Is a Negative Predictive Factor for Response to Conventional Low but not to Intensified Dose Alkylating Chemotherapy in Multiple Myeloma

Expression of Granulocyte-Macrophage Colony-Stimulating Factor Receptors in Human Prostate Cancer

Coralia I. Rivas,Juan Carlos Vera,Fernando Delgado-López,Mark L. Heaney,Victor H. Guaiquil,Rong H. Zhang,Howard I. Scher,Ilona I. Concha,Francisco Nualart,Carlos Cordon-Cardo,David W. Golde

View Articletitled, Expression of Granulocyte-Macrophage Colony-Stimulating Factor Receptors in Human Prostate Cancer

PHAGOCYTES

Azurophilic Granules of Human Neutrophilic Leukocytes Are Deficient in Lysosome-Associated Membrane Proteins but Retain the Mannose 6-Phosphate Recognition Marker

A.-M. Cieutat,P. Lobel,J.T. August,L. Kjeldsen,H. Sengeløv,N. Borregaard,D.F. Bainton

View Articletitled, Azurophilic Granules of Human Neutrophilic Leukocytes Are Deficient in Lysosome-Associated Membrane Proteins but Retain the Mannose 6-Phosphate Recognition Marker

Nitric Oxide–Mediated Induction of Ferritin Synthesis in J774 Macrophages by Inflammatory Cytokines: Role of Selective Iron Regulatory Protein-2 Downregulation

Stefania Recalcati,Donatella Taramelli,Dario Conte,Gaetano Cairo

View Articletitled, Nitric Oxide–Mediated Induction of Ferritin Synthesis in J774 Macrophages by Inflammatory Cytokines: Role of Selective Iron Regulatory Protein-2 Downregulation

Functional Characterization of L-Selectin Ligands on Human Neutrophils and Leukemia Cell Lines: Evidence for Mucinlike Ligand Activity Distinct From P-Selectin Glycoprotein Ligand-1

Carroll L. Ramos,McRae J. Smith,Karen R. Snapp,Geoffrey S. Kansas,George W. Stickney,Klaus Ley,Michael B. Lawrence

View Articletitled, Functional Characterization of L-Selectin Ligands on Human Neutrophils and Leukemia Cell Lines: Evidence for Mucinlike Ligand Activity Distinct From P-Selectin Glycoprotein Ligand-1

RED CELLS

Evidence of Genetic Transmission in African Iron Overload

Victor M. Moyo,Eberhard Mandishona,Sandra J. Hasstedt,Innocent T. Gangaidzo,Zvenyika A.R. Gomo,Hlosukwazi Khumalo,Thokozile Saungweme,Clement F. Kiire,Alan C. Paterson,Peter Bloom,A. Patrick MacPhail,Tracey Rouault,Victor R. Gordeuk

View Articletitled, Evidence of Genetic Transmission in African Iron Overload

TRANSPLANTATION

T-Cell–Depleted Allogeneic Bone Marrow Transplantation as Postremission Therapy for Acute Myelogenous Leukemia: Freedom From Relapse in the Absence of Graft-Versus-Host Disease

Esperanza B. Papadopoulos,Matthew H. Carabasi,Hugo Castro-Malaspina,Barrett H. Childs,Stephen Mackinnon,Farid Boulad,Alfred P. Gillio,Nancy A. Kernan,Trudy N. Small,Paul Szabolcs,Joanne Taylor,Joachim Yahalom,Nancy H. Collins,Sharon A. Bleau,Patricia M. Black,Glenn Heller,Richard J. O' Reilly,James W. Young

View Articletitled, T-Cell–Depleted Allogeneic Bone Marrow Transplantation as Postremission Therapy for Acute Myelogenous Leukemia: Freedom From Relapse in the Absence of Graft-Versus-Host Disease

CORRESPONDENCE

Busulfan Alone as Cytoreduction Before Autografting for Chronic Myelogenous Leukemia

Stephen G. O' Brien,John M. Goldman

View Articletitled, Busulfan Alone as Cytoreduction Before Autografting for Chronic Myelogenous Leukemia

The Prothrombin Gene 3′-Untranslated Region Mutation Is Frequently Associated With Factor V Leiden in Thrombophilic Patients and Shows Ethnic-Specific Variation in Allele Frequency

Tom E. Howard,Mira Marusa,Jody Boisza,Andrew Young,Judy Sequeira,Cindy Channell,Cindy Guy,Elizabeth Benson,Alexander Duncan

View Articletitled, The Prothrombin Gene 3′-Untranslated Region Mutation Is Frequently Associated With Factor V Leiden in Thrombophilic Patients and Shows Ethnic-Specific Variation in Allele Frequency

UGT1 Promoter Polymorphism Accounts for Increased Neonatal Appearance of Hereditary Spherocytosis

A. Iolascon,M.F. Faienza,A. Moretti,S. Perrotta,E. Miraglia del Giudice

View Articletitled, UGT1 Promoter Polymorphism Accounts for Increased Neonatal Appearance of Hereditary Spherocytosis

Increase of Red Blood Cells Can Shorten the Bleeding Time in Patients With Iron Deficiency Anemia

Chao Hung Ho

View Articletitled, Increase of Red Blood Cells Can Shorten the Bleeding Time in Patients With Iron Deficiency Anemia

Disappearance of Cytogenetic Abnormalities Induced by Cyclosporine Therapy in a Case of Aplastic Anemia

Minoru Takeshima,Yasuhiro Mochizuki,Takashi Yoshida,Hideyuki Takamatsu,Hirokazu Okumura

View Articletitled, Disappearance of Cytogenetic Abnormalities Induced by Cyclosporine Therapy in a Case of Aplastic Anemia

In Vivo Adenoviral-Mediated Gene Transfer of Interleukin-2 in Cutaneous Plasmacytoma

A. Keith Stewart,Aaron D. Schimmer,Dennis J. Bailey,Ian D. Dubé,Darrin Cappe,Robert C. Moen,Jack Gauldie,Frank L. Graham

View Articletitled, In Vivo Adenoviral-Mediated Gene Transfer of Interleukin-2 in Cutaneous Plasmacytoma

ERRATA

ERRATUM

View Articletitled, ERRATUM

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