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Volume 90, Issue 2

July 15 1997

In this Issue

CORRESPONDENCE
REVIEW ARTICLES
RAPID COMMUNICATIONS
CLINICAL INTERVENTION AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
RED CELLS
TRANSPLANTATION

CORRESPONDENCE

The Effectiveness of Deferiprone in Thalassemia

Paul Dogherty,Tom Einarson,Gideon Koren,Graham Sher

View Articletitled, The Effectiveness of Deferiprone in Thalassemia

Downregulation of Increased CD95 (APO-1/Fas) Ligand in T Cells From Human Immunodeficiency Virus-Type 1–Infected Children After Antiretroviral Therapy

Thomas Böhler,Ingrid Herr,Klaus-Michael Debatin,Magdalena Geiss,Jürgen Haas

View Articletitled, Downregulation of Increased CD95 (APO-1/Fas) Ligand in T Cells From Human Immunodeficiency Virus-Type 1–Infected Children After Antiretroviral Therapy

Severe Proximal Deep Vein Thrombosis in a Glanzmann Thrombasthenia Variant Successfully Treated With a Low Molecular Weight Heparin

Yves Gruel,Gérard Pacouret,Sylvia Bellucci,Jacques Caen

View Articletitled, Severe Proximal Deep Vein Thrombosis in a Glanzmann Thrombasthenia Variant Successfully Treated With a Low Molecular Weight Heparin

Are Activated Cytoxic T Cells in Hodgkin's Disease Biopsies a Poor Prognostic Marker?

Anas Younes

View Articletitled, Are Activated Cytoxic T Cells in Hodgkin's Disease Biopsies a Poor Prognostic Marker?

Valproic Acid and Augmentation of Fetal Hemoglobin in Individuals With and Without Sickle Cell Disease

Rita Selby,Eric Nisbet-Brown,Raveen K. Basran,Lebe Chang,Nancy F. Olivieri

View Articletitled, Valproic Acid and Augmentation of Fetal Hemoglobin in Individuals With and Without Sickle Cell Disease

Elevated Serum Level of Fas Ligand Correlates With the Asymptomatic Stage of Human Immunodeficiency Virus Infection

George M. Bahr,Andre Capron,Joelle Dewulf,Shigekazu Nagata,Masato Tanaka,Jean-Michel Bourez,Yves Mouton

View Articletitled, Elevated Serum Level of Fas Ligand Correlates With the Asymptomatic Stage of Human Immunodeficiency Virus Infection

REVIEW ARTICLES

Juvenile Myelomonocytic Leukemia

Maurizio Aricò,Andrea Biondi,Ching-Hon Pui

View Articletitled, Juvenile Myelomonocytic Leukemia

Transcription Factors, Normal Myeloid Development, and Leukemia

Daniel G. Tenen,Robert Hromas,Jonathan D. Licht,Dong-Er Zhang

View Articletitled, Transcription Factors, Normal Myeloid Development, and Leukemia

RAPID COMMUNICATIONS

Abnormal Expression of the B-Cell Homing Chemokine Receptor BLR1 During the Progression of Acquired Immunodeficiency Syndrome

Reinhold Förster,Georgina Schweigard,Sabine Johann,Thomas Emrich,Elisabeth Kremmer,Christoph Nerl,Martin Lipp

View Articletitled, Abnormal Expression of the B-Cell Homing Chemokine Receptor BLR1 During the Progression of Acquired Immunodeficiency Syndrome

The Ig Heavy Chain Gene Is Frequently Involved in Chromosomal Translocations in Multiple Myeloma and Plasma Cell Leukemia as Detected by In Situ Hybridization

Kazuhiro Nishida,Akiko Tamura,Naozo Nakazawa,Yutaka Ueda,Tatsuo Abe,Fumihiko Matsuda,Kei Kashima,Masafumi Taniwaki

View Articletitled, The Ig Heavy Chain Gene Is Frequently Involved in Chromosomal Translocations in Multiple Myeloma and Plasma Cell Leukemia as Detected by In Situ Hybridization

All Patients With the T(11; 16)(q23; p13.3) That Involves MLL and CBP Have Treatment-Related Hematologic Disorders

Janet D. Rowley,Shalini Reshmi,Olatoyosi Sobulo,Tarannum Musvee,John Anastasi,Susana Raimondi,Nancy R. Schneider,Julio C. Barredo,Eduardo S. Cantu,Brigitte Schlegelberger,Frederick Behm,Norman A. Doggett,Julian Borrow,Nancy Zeleznik-Le

View Articletitled, All Patients With the T(11; 16)(q23; p13.3) That Involves MLL and CBP Have Treatment-Related Hematologic Disorders

A Metalloproteinase Inhibitor Prevents Lethal Acute Graft-Versus-Host Disease in Mice

Koichi Hattori,Takao Hirano,Chifuyu Ushiyama,Hiroaki Miyajima,Norifumi Yamakawa,Tomohiko Ebata,Yukihisa Wada,Shoji Ikeda,Kohichiro Yoshino,Masatoshi Tateno,Kazuo Oshimi,Nobuhiko Kayagaki,Hideo Yagita,Ko Okumura

View Articletitled, A Metalloproteinase Inhibitor Prevents Lethal Acute Graft-Versus-Host Disease in Mice

Ex Vivo Generation of Human Anti–Pre-B Leukemia-Specific Autologous Cytolytic T Cells

Angelo A. Cardoso,Mark J. Seamon,Hernani M. Afonso,Paolo Ghia,Vassiliki A. Boussiotis,Gordon J. Freeman,John G. Gribben,Stephen E. Sallan,Lee M. Nadler

View Articletitled, Ex Vivo Generation of Human Anti–Pre-B Leukemia-Specific Autologous Cytolytic T Cells

Comparative Activity of Melarsoprol and Arsenic Trioxide in Chronic B-Cell Leukemia Lines

Andrea König,Laura Wrazel,Raymond P. Warrell, Jr,Roberta Rivi,Pier Paolo Pandolfi,Ann Jakubowski,Janice L. Gabrilove

View Articletitled, Comparative Activity of Melarsoprol and Arsenic Trioxide in Chronic B-Cell Leukemia Lines

CLINICAL INTERVENTION AND THERAPEUTIC TRIALS

Incidence and Clinical Relevance of TEL/AML1 Fusion Genes in Children With Acute Lymphoblastic Leukemia Enrolled in the German and Italian Multicenter Therapy Trials

Arndt Borkhardt,Giovanni Cazzaniga,Susanne Viehmann,Maria Grazia Valsecchi,Wolf Dieter Ludwig,Linda Burci,Silvia Mangioni,Martin Schrappe,Hansjörg Riehm,Fritz Lampert,Giuseppe Basso,Giuseppe Masera,Jochen Harbott,Andrea Biondi,for the “Associazione Italiana Ematologia Oncologia Pediatrica” and the “Berlin-Frankfurt-Münster” Study Group

View Articletitled, Incidence and Clinical Relevance of TEL/AML1 Fusion Genes in Children With Acute Lymphoblastic Leukemia Enrolled in the German and Italian Multicenter Therapy Trials

Increased Frequency of Expression of Elevated Dihydrofolate Reductase in T-Cell Versus B-Precursor Acute Lymphoblastic Leukemia in Children

Larry H. Matherly,Jeffrey W. Taub,So C. Wong,Pippa M. Simpson,Rachenii Ekizian,Steve Buck,Michael Williamson,Michael Amylon,Jeannette Pullen,Bruce Camitta,Y. Ravindranath

View Articletitled, Increased Frequency of Expression of Elevated Dihydrofolate Reductase in T-Cell Versus B-Precursor Acute Lymphoblastic Leukemia in Children

Granulocyte Colony-Stimulating Factor as an Adjunct to Induction Chemotherapy for Adult Acute Lymphoblastic Leukemia — A Randomized Phase-III Study

Klaus Geissler,Elisabeth Koller,Eva Hubmann,Dietger Niederwieser,Wolfgang Hinterberger,Dietmar Geissler,Paul Kyrle,Paul Knöbl,Ingrid Pabinger,Renate Thalhammer,Ilse Schwarzinger,Christine Mannhalter,Ulrich Jaeger,Renate Heinz,Werner Linkesch,Klaus Lechner

View Articletitled, Granulocyte Colony-Stimulating Factor as an Adjunct to Induction Chemotherapy for Adult Acute Lymphoblastic Leukemia — A Randomized Phase-III Study

HEMATOPOIESIS

Jak1 Plays an Essential Role for Receptor Phosphorylation and Stat Activation in Response to Granulocyte Colony-Stimulating Factor

Kazuya Shimoda,Jian Feng,Hiroshi Murakami,Shigekazu Nagata,Diane Watling,Neil C. Rogers,George R. Stark,Ian M. Kerr,James N. Ihle

View Articletitled, Jak1 Plays an Essential Role for Receptor Phosphorylation and Stat Activation in Response to Granulocyte Colony-Stimulating Factor

Inhibition of Immature Erythroid Progenitor Cell Proliferation by Macrophage Inflammatory Protein-1α by Interacting Mainly With a C-C Chemokine Receptor, CCR1

Shao-bo Su,Naofumi Mukaida,Jian-bin Wang,Yi Zhang,Akiyoshi Takami,Sinji Nakao,Kouji Matsushima

View Articletitled, Inhibition of Immature Erythroid Progenitor Cell Proliferation by Macrophage Inflammatory Protein-1α by Interacting Mainly With a C-C Chemokine Receptor, CCR1

Thrombopoietin in Patients With Congenital Thrombocytopenia and Absent Radii: Elevated Serum Levels, Normal Receptor Expression, But Defective Reactivity to Thrombopoietin

Matthias Ballmaier,Harald Schulze,Gabriele Strauβ,Klara Cherkaoui,Nicole Wittner,Stefanie Lynen,Susanne Wolters,Jakob Bogenberger,Karl Welte

View Articletitled, Thrombopoietin in Patients With Congenital Thrombocytopenia and Absent Radii: Elevated Serum Levels, Normal Receptor Expression, But Defective Reactivity to Thrombopoietin

In Vivo Effects of Flt3/Flk2 Ligand on Mobilization of Hematopoietic Progenitors in Primates and Potent Synergistic Enhancement With Granulocyte Colony-Stimulating Factor

Thalia Papayannopoulou,Betty Nakamoto,Robert G. Andrews,Stewart D. Lyman,Minako Y. Lee

View Articletitled, In Vivo Effects of Flt3/Flk2 Ligand on Mobilization of Hematopoietic Progenitors in Primates and Potent Synergistic Enhancement With Granulocyte Colony-Stimulating Factor

The Roles of Bcl-X_L and Apopain in the Control of Erythropoiesis by Erythropoietin

Paul A. Gregoli,Maurice C. Bondurant

View Articletitled, The Roles of Bcl-XL and Apopain in the Control of Erythropoiesis by Erythropoietin

Differential Maintenance of Primitive Human SCID-Repopulating Cells, Clonogenic Progenitors, and Long-Term Culture-Initiating Cells After Incubation on Human Bone Marrow Stromal Cells

Olga I. Gan,Barbara Murdoch,Andre Larochelle,John E. Dick

View Articletitled, Differential Maintenance of Primitive Human SCID-Repopulating Cells, Clonogenic Progenitors, and Long-Term Culture-Initiating Cells After Incubation on Human Bone Marrow Stromal Cells

Identification of Increased Protein Tyrosine Phosphatase Activity in Polycythemia Vera Erythroid Progenitor Cells

Xingwei Sui,Sanford B. Krantz,Zhizhuang Zhao

View Articletitled, Identification of Increased Protein Tyrosine Phosphatase Activity in Polycythemia Vera Erythroid Progenitor Cells

Orderly Process of Sequential Cytokine Stimulation Is Required for Activation and Maximal Proliferation of Primitive Human Bone Marrow CD34⁺ Hematopoietic Progenitor Cells Residing in G₀

Amy C. Ladd,Robert Pyatt,Andre Gothot,Susan Rice,Jon McMahel,Christie M. Traycoff,Edward F. Srour

View Articletitled, Orderly Process of Sequential Cytokine Stimulation Is Required for Activation and Maximal Proliferation of Primitive Human Bone Marrow CD34+ Hematopoietic Progenitor Cells Residing in G0

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

A Three Amino Acid Deletion in Glycoprotein IIIa Is Responsible for Type I Glanzmann's Thrombasthenia: Importance of Residues Ile³²⁵Pro³²⁶Gly³²⁷ for β3 Integrin Subunit Association

Marie-Christine Morel-Kopp,Cécile Kaplan,Valérie Proulle,Vincent Jallu,Chantal Melchior,Olivier Peyruchaud,Marie-Hélène Aurousseau,Nelly Kieffer

View Articletitled, A Three Amino Acid Deletion in Glycoprotein IIIa Is Responsible for Type I Glanzmann's Thrombasthenia: Importance of Residues Ile325Pro326Gly327 for β3 Integrin Subunit Association

Binding of Phosphorylated Sp1 Protein to Tandem Sp1 Binding Sites Regulates α₂ Integrin Gene Core Promoter Activity

Mary M. Zutter,Ellen E. Ryan,Audrey D. Painter

View Articletitled, Binding of Phosphorylated Sp1 Protein to Tandem Sp1 Binding Sites Regulates α2 Integrin Gene Core Promoter Activity

High Molecular Weight Kininogen Peptides Inhibit the Formation of Kallikrein on Endothelial Cell Surfaces and Subsequent Urokinase-Dependent Plasmin Formation

Yingzhang Lin,Robert B. Harris,Wuyi Yan,Keith R. McCrae,Hong Zhang,Robert W. Colman

View Articletitled, High Molecular Weight Kininogen Peptides Inhibit the Formation of Kallikrein on Endothelial Cell Surfaces and Subsequent Urokinase-Dependent Plasmin Formation

Expression and Functional Characterization of an Abnormal Platelet Membrane Glycoprotein Ibα (Met²³⁹ → Val) Reported in Patients With Platelet-Type von Willebrand Disease

Takanori Moriki,Mitsuru Murata,Tetsuya Kitaguchi,Hironobu Anbo,Makoto Handa,Kiyoaki Watanabe,Hoyu Takahashi,Yasuo Ikeda

View Articletitled, Expression and Functional Characterization of an Abnormal Platelet Membrane Glycoprotein Ibα (Met239 → Val) Reported in Patients With Platelet-Type von Willebrand Disease

Regulation of Tie Receptor Expression on Human Endothelial Cells by Protein Kinase C-Mediated Release of Soluble Tie

Rachel Yabkowitz,Susanne Meyer,Donna Yanagihara,David Brankow,Tabitha Staley,Gary Elliott,Sylvia Hu,Barry Ratzkin

View Articletitled, Regulation of Tie Receptor Expression on Human Endothelial Cells by Protein Kinase C-Mediated Release of Soluble Tie

IMMUNOBIOLOGY

Signaling Pathways Regulating CD44-Dependent Cytolysis in Natural Killer Cells

Giuseppe Sconocchia,Julie A. Titus,David M. Segal

View Articletitled, Signaling Pathways Regulating CD44-Dependent Cytolysis in Natural Killer Cells

Antibodies to HLA Class I α1 Domain Trigger Apoptosis of CD40-Activated Human B Lymphocytes

Laurent Genestier,Geneviève Meffre,Pierre Garrone,Jean-Jacques Pin,Yong-Jun Liu,Jacques Banchereau,Jean-Pierre Revillard

View Articletitled, Antibodies to HLA Class I α1 Domain Trigger Apoptosis of CD40-Activated Human B Lymphocytes

Ig D_H Gene Segment Transcription and Rearrangement Before Surface Expression of the Pan-B–Cell Marker CD19 in Normal Human Bone Marrow

F.E. Bertrand, III,L.G. Billips,P.D. Burrows,G.L. Gartland,H. Kubagawa,H.W. Schroeder, Jr

View Articletitled, Ig DH Gene Segment Transcription and Rearrangement Before Surface Expression of the Pan-B–Cell Marker CD19 in Normal Human Bone Marrow

Modulation of Bcl-2 Protein by CD4 Cross-Linking: A Possible Mechanism for Lymphocyte Apoptosis in Human Immunodeficiency Virus Infection and for Rescue of Apoptosis by Interleukin-2

Futoshi Hashimoto,Naoki Oyaizu,Vaniambadi S. Kalyanaraman,Savita Pahwa

View Articletitled, Modulation of Bcl-2 Protein by CD4 Cross-Linking: A Possible Mechanism for Lymphocyte Apoptosis in Human Immunodeficiency Virus Infection and for Rescue of Apoptosis by Interleukin-2

NEOPLASIA

The Development of a Model for the Homing of Multiple Myeloma Cells to Human Bone Marrow

Mitsuyoshi Urashima,Benjamin P. Chen,Shirley Chen,Geraldine S. Pinkus,Roderick T. Bronson,Douglas A. Dedera,Yasutaka Hoshi,Gerrard Teoh,Atsushi Ogata,Steve P. Treon,Dharminder Chauhan,Kenneth C. Anderson

View Articletitled, The Development of a Model for the Homing of Multiple Myeloma Cells to Human Bone Marrow

Lymphomas in Patients With Sjögren's Syndrome Are Marginal Zone B-Cell Neoplasms, Arise in Diverse Extranodal and Nodal Sites, and Are Not Associated With Viruses

Bruno Royer,Dominique Cazals-Hatem,Jean Sibilia,Felix Agbalika,Jean-Michel Cayuela,Thierry Soussi,Frédéric Maloisel,Jean-Pierre Clauvel,Jean-Claude Brouet,Xavier Mariette

View Articletitled, Lymphomas in Patients With Sjögren's Syndrome Are Marginal Zone B-Cell Neoplasms, Arise in Diverse Extranodal and Nodal Sites, and Are Not Associated With Viruses

Characterization of Overt B-Cell Lymphomas in Patients With Hepatitis C Virus Infection

Salvatore De Vita,Cosimo Sacco,Domenico Sansonno,Annunziata Gloghini,Franco Dammacco,Marina Crovatto,Gianfranco Santini,Riccardo Dolcetti,Mauro Boiocchi,Antonino Carbone,Vittorina Zagonel

View Articletitled, Characterization of Overt B-Cell Lymphomas in Patients With Hepatitis C Virus Infection

Cytokine Expression and Tumorigenicity of Large Granular Lymphocytic Leukemia Cells From Mice Transgenic for the tax Gene of Human T-Cell Leukemia Virus Type I

William J. Grossman,Lee Ratner

View Articletitled, Cytokine Expression and Tumorigenicity of Large Granular Lymphocytic Leukemia Cells From Mice Transgenic for the tax Gene of Human T-Cell Leukemia Virus Type I

A Specific Stimulator of Granulocyte Colony-Stimulating Factor Accelerates Recovery From Cyclophosphamide-Induced Neutropenia in the Mouse

Jay S. Fine,Xiao-Yan Cai,Luminita Justice,Carl P. Gommoll, Jr,Linda D. Hamilton,Tracey A. Waters,Satwant K. Narula,Loretta A. Bober,Michael J. Grace

View Articletitled, A Specific Stimulator of Granulocyte Colony-Stimulating Factor Accelerates Recovery From Cyclophosphamide-Induced Neutropenia in the Mouse

Neutrophil Secondary-Granule Deficiency as a Hallmark of All-Trans Retinoic Acid–Induced Differentiation of Acute Promyelocytic Leukemia Cells

Jun Miyauchi,Kazuma Ohyashiki,Yuka Inatomi,Keisuke Toyama

View Articletitled, Neutrophil Secondary-Granule Deficiency as a Hallmark of All-Trans Retinoic Acid–Induced Differentiation of Acute Promyelocytic Leukemia Cells

RED CELLS

Hereditary Hyperferritinemia-Cataract Syndrome: Relationship Between Phenotypes and Specific Mutations in the Iron-Responsive Element of Ferritin Light-Chain mRNA

Mario Cazzola,Gaetano Bergamaschi,Laura Tonon,Eloisa Arbustini,Maurizia Grasso,Elena Vercesi,Giovanni Barosi,Paolo Emilio Bianchi,Gaetano Cairo,Paolo Arosio

View Articletitled, Hereditary Hyperferritinemia-Cataract Syndrome: Relationship Between Phenotypes and Specific Mutations in the Iron-Responsive Element of Ferritin Light-Chain mRNA

Pyridoxine Refractory X-Linked Sideroblastic Anemia Caused by a Point Mutation in the Erythroid 5-Aminolevulinate Synthase Gene

Kazumichi Furuyama,Hiroyoshi Fujita,Tadashi Nagai,Kentaro Yomogida,Hiroshi Munakata,Masao Kondo,Akiro Kimura,Atsushi Kuramoto,Norio Hayashi,Masayuki Yamamoto

View Articletitled, Pyridoxine Refractory X-Linked Sideroblastic Anemia Caused by a Point Mutation in the Erythroid 5-Aminolevulinate Synthase Gene

Utilization of Intracellular Ferritin Iron for Hemoglobin Synthesis in Developing Human Erythroid Precursors

Boris Vaisman,Eitan Fibach,Abraham M. Konijn

View Articletitled, Utilization of Intracellular Ferritin Iron for Hemoglobin Synthesis in Developing Human Erythroid Precursors

Wide Variety of Point Mutations in the H Gene of Bombay and Para-Bombay Individuals That Inactivate H Enzyme

Mika Kaneko,Shoko Nishihara,Naoko Shinya,Takashi Kudo,Hiroko Iwasaki,Taiko Seno,Yasuto Okubo,Hisashi Narimatsu

View Articletitled, Wide Variety of Point Mutations in the H Gene of Bombay and Para-Bombay Individuals That Inactivate H Enzyme

TRANSPLANTATION

Essential Role of the Thymus to Reconstitute Naive (CD45RA⁺) T-Helper Cells After Human Allogeneic Bone Marrow Transplantation

Andreas Heitger,Nikolaus Neu,Hannelore Kern,Eva-Renate Panzer-Grümayer,Hildegard Greinix,David Nachbaur,Dietger Niederwieser,Franz Martin Fink

View Articletitled, Essential Role of the Thymus to Reconstitute Naive (CD45RA+) T-Helper Cells After Human Allogeneic Bone Marrow Transplantation

Bone Marrow Transplantation for Severe Aplastic Anemia: Has Outcome Improved?

Jakob R. Passweg,Gérard Socié,Wolfgang Hinterberger,Andrea Bacigalupo,James C. Biggs,Bruce M. Camitta,Richard E. Champlin,Robert Peter Gale,Eliane Gluckman,Edward C. Gordon-Smith,Jill M. Hows,John P. Klein,Melodee L. Nugent,Ricardo Pasquini,Philip A. Rowlings,Bruno Speck,André Tichelli,Mei-Jie Zhang,Mary M. Horowitz,Mortimer M. Bortin

View Articletitled, Bone Marrow Transplantation for Severe Aplastic Anemia: Has Outcome Improved?

Cytokine-Facilitated Transduction Leads to Low-Level Engraftment in Nonablated Hosts

Ellen L.W. Kittler,Stefan O. Peters,Rowena B. Crittenden,Michelle E. Debatis,Hayley S. Ramshaw,F. Marc Stewart,Peter J. Quesenberry

View Articletitled, Cytokine-Facilitated Transduction Leads to Low-Level Engraftment in Nonablated Hosts

Constitutive Expression of a CD44 Variant Isoform on T Cells Facilitates Regaining of Immunocompetence in Allogeneic Bone Marrow Transplantation

Margot Zöller,Annette Schmidt,Angela Denzel,Jürgen Moll

View Articletitled, Constitutive Expression of a CD44 Variant Isoform on T Cells Facilitates Regaining of Immunocompetence in Allogeneic Bone Marrow Transplantation

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