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Issue Archive

Volume 124, Issue 7
August 14 2014
Blood Cover Image for Volume 124, Issue 7

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Novel insights related to CF neutrophils
Silvia M. Uriarte
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INSIDE BLOOD COMMENTARY
Oral therapy for multiple myeloma: ixazomib arriving soon
Clinical Trials & Observations
Philippe Moreau
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INSIDE BLOOD COMMENTARY
First do no harm: infectious deaths in pediatric ALL
Clinical Trials & Observations
Karen R. Rabin
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INSIDE BLOOD COMMENTARY
Old and new news in CLL: “It’s the pathway, stupid!”
Alexander Egle
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INSIDE BLOOD COMMENTARY
A common progenitor cell in LCH and ECD
Gayane Badalian-Very
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INSIDE BLOOD COMMENTARY
Is JAK2V617F finally off the hook?
Ingeborg Hers,Alastair W. Poole
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INSIDE BLOOD COMMENTARY
A step forward back to (induced) fetal
Nancy S. Green
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INSIDE BLOOD COMMENTARY
Less (bacterial diversity) is more (deaths)
John E. Levine
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BLOOD WORK

Nodular sclerosis Hodgkin lymphoma with classic Reed-Sternberg cells
Selina Jing Li,Suzanne Maria Vercauteren
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Auer rods in dysplastic granulocyte
Anila Rashid
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PLENARY PAPER

A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy
Kerstin Pohl,Elaine Hayes,Joanne Keenan,Michael Henry,Paula Meleady,Kevin Molloy,Bakr Jundi,David A. Bergin,Cormac McCarthy,Oliver J. McElvaney,Michelle M. White,Martin Clynes,Emer P. Reeves,Noel G. McElvaney
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PERSPECTIVES

Mouse models in the study of chronic lymphocytic leukemia pathogenesis and therapy
Giorgia Simonetti,Maria Teresa Sabrina Bertilaccio,Paolo Ghia,Ulf Klein
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REVIEW ARTICLE

Evolving use of new oral anticoagulants for treatment of venous thromboembolism
Clinical Trials & Observations
Calvin H. Yeh,Peter L. Gross,Jeffrey I. Weitz
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Extracellular nucleotide and nucleoside signaling in vascular and blood disease
Marco Idzko,Davide Ferrari,Ann-Kathrin Riegel,Holger K. Eltzschig
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CLINICAL TRIALS AND OBSERVATIONS

Phase 1 study of twice-weekly ixazomib, an oral proteasome inhibitor, in relapsed/refractory multiple myeloma patients
Clinical Trials & Observations
Paul G. Richardson,Rachid Baz,Michael Wang,Andrzej J. Jakubowiak,Jacob P. Laubach,R. Donald Harvey,Moshe Talpaz,Deborah Berg,Guohui Liu,Jiang Yu,Neeraj Gupta,Alessandra Di Bacco,Ai-Min Hui,Sagar Lonial
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Supplemental data
Phase 1 study of weekly dosing with the investigational oral proteasome inhibitor ixazomib in relapsed/refractory multiple myeloma
Clinical Trials & Observations
Shaji K. Kumar,William I. Bensinger,Todd M. Zimmerman,Craig B. Reeder,James R. Berenson,Deborah Berg,Ai-Min Hui,Neeraj Gupta,Alessandra Di Bacco,Jiang Yu,Yaping Shou,Ruben Niesvizky
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Infection-related mortality in children with acute lymphoblastic leukemia: an analysis of infectious deaths on UKALL2003
Clinical Trials & Observations
David O’Connor,Jessica Bate,Rachel Wade,Rachel Clack,Sunita Dhir,Rachael Hough,Ajay Vora,Nick Goulden,Sujith Samarasinghe
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Clinical effect of driver mutations of JAK2, CALR, or MPL in primary myelofibrosis
Clinical Trials & Observations
Elisa Rumi,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Daniela Pietra,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Cristiana Pascutto,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Paola Guglielmelli,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Alejandra Martínez-Trillos,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Ilaria Casetti,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Dolors Colomer,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Lisa Pieri,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Marta Pratcorona,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Giada Rotunno,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Emanuela Sant’Antonio,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Marta Bellini,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Chiara Cavalloni,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Carmela Mannarelli,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Chiara Milanesi,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Emanuela Boveri,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Virginia Ferretti,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Cesare Astori,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Vittorio Rosti,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Francisco Cervantes,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Giovanni Barosi,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Alessandro M. Vannucchi,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators,Mario Cazzola,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators
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GENE THERAPY

ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells
Sonia Guedan,Xi Chen,Aviv Madar,Carmine Carpenito,Shannon E. McGettigan,Matthew J. Frigault,Jihyun Lee,Avery D. Posey, Jr,John Scholler,Nathalie Scholler,Richard Bonneau,Carl H. June
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IMMUNOBIOLOGY

Autonomous growth and increased cytotoxicity of natural killer cells expressing membrane-bound interleukin-15
Masaru Imamura,David Shook,Takahiro Kamiya,Noriko Shimasaki,Sally M. H. Chai,Elaine Coustan-Smith,Chihaya Imai,Dario Campana
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LYMPHOID NEOPLASIA

Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL
Lili Wang,Alex K. Shalek,Mike Lawrence,Ruihua Ding,Jellert T. Gaublomme,Nathalie Pochet,Petar Stojanov,Carrie Sougnez,Sachet A. Shukla,Kristen E. Stevenson,Wandi Zhang,Jessica Wong,Quinlan L. Sievers,Bryan T. MacDonald,Alexander R. Vartanov,Natalie R. Goldstein,Donna Neuberg,Xi He,Eric Lander,Nir Hacohen,Aviv Regev,Gad Getz,Jennifer R. Brown,Hongkun Park,Catherine J. Wu
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Plasmacytomagenesis in Eμ-v-abl transgenic mice is accelerated when apoptosis is restrained
Cassandra J. Vandenberg,Paul Waring,Andreas Strasser,Suzanne Cory
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MYELOID NEOPLASIA

Characterization of acute myeloid leukemia based on levels of global hydroxymethylation
Leonie I. Kroeze,on behalf of the EORTC Leukemia Group and GIMEMA,Mariam G. Aslanyan,on behalf of the EORTC Leukemia Group and GIMEMA,Arno van Rooij,on behalf of the EORTC Leukemia Group and GIMEMA,Theresia N. Koorenhof-Scheele,on behalf of the EORTC Leukemia Group and GIMEMA,Marion Massop,on behalf of the EORTC Leukemia Group and GIMEMA,Thomas Carell,on behalf of the EORTC Leukemia Group and GIMEMA,Jan B. Boezeman,on behalf of the EORTC Leukemia Group and GIMEMA,Jean-Pierre Marie,on behalf of the EORTC Leukemia Group and GIMEMA,Constantijn J. M. Halkes,on behalf of the EORTC Leukemia Group and GIMEMA,Theo de Witte,on behalf of the EORTC Leukemia Group and GIMEMA,Gerwin Huls,on behalf of the EORTC Leukemia Group and GIMEMA,Stefan Suciu,on behalf of the EORTC Leukemia Group and GIMEMA,Ron A. Wevers,on behalf of the EORTC Leukemia Group and GIMEMA,Bert A. van der Reijden,on behalf of the EORTC Leukemia Group and GIMEMA,Joop H. Jansen,on behalf of the EORTC Leukemia Group and GIMEMA
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Association of both Langerhans cell histiocytosis and Erdheim-Chester disease linked to the BRAFV600E mutation
Baptiste Hervier,on behalf of the French Histiocytoses Study Group,Julien Haroche,on behalf of the French Histiocytoses Study Group,Laurent Arnaud,on behalf of the French Histiocytoses Study Group,Frédéric Charlotte,on behalf of the French Histiocytoses Study Group,Jean Donadieu,on behalf of the French Histiocytoses Study Group,Antoine Néel,on behalf of the French Histiocytoses Study Group,François Lifermann,on behalf of the French Histiocytoses Study Group,Carles Villabona,on behalf of the French Histiocytoses Study Group,Bruno Graffin,on behalf of the French Histiocytoses Study Group,Olivier Hermine,on behalf of the French Histiocytoses Study Group,Aude Rigolet,on behalf of the French Histiocytoses Study Group,Camille Roubille,on behalf of the French Histiocytoses Study Group,Eric Hachulla,on behalf of the French Histiocytoses Study Group,Thierry Carmoi,on behalf of the French Histiocytoses Study Group,Maud Bézier,on behalf of the French Histiocytoses Study Group,Véronique Meignin,on behalf of the French Histiocytoses Study Group,Marie Conrad,on behalf of the French Histiocytoses Study Group,Laurence Marie,on behalf of the French Histiocytoses Study Group,Elise Kostrzewa,on behalf of the French Histiocytoses Study Group,Jean-Marie Michot,on behalf of the French Histiocytoses Study Group,Stéphane Barete,on behalf of the French Histiocytoses Study Group,Valerie Taly,on behalf of the French Histiocytoses Study Group,Karine Cury,on behalf of the French Histiocytoses Study Group,Jean-François Emile,on behalf of the French Histiocytoses Study Group,Zahir Amoura,on behalf of the French Histiocytoses Study Group
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Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells
Yin Wang,Yan Liu,Fei Tang,Kelsie M. Bernot,Reuven Schore,Guido Marcucci,Michael A. Caligiuri,Pan Zheng,Yang Liu
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PLATELETS AND THROMBOPOIESIS

Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm
Lamia Lamrani,Catherine Lacout,Véronique Ollivier,Cécile V. Denis,Elizabeth Gardiner,Benoit Ho Tin Noe,William Vainchenker,Jean-Luc Villeval,Martine Jandrot-Perrus
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RED CELLS, IRON, AND ERYTHROPOIESIS

Hydroxyurea-inducible SAR1 gene acts through the Giα/JNK/Jun pathway to regulate γ-globin expression
Jianqiong Zhu,Kyung Chin,Wulin Aerbajinai,Chutima Kumkhaek,Hongzhen Li,Griffin P. Rodgers
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THROMBOSIS AND HEMOSTASIS

The endothelial protein C receptor enhances hemostasis of FVIIa administration in hemophilic mice in vivo
Giulia Pavani,Lacramioara Ivanciu,Armida Faella,Oscar A. Marcos-Contreras,Paris Margaritis
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Postthrombotic syndrome following upper extremity deep vein thrombosis in children
Maria L. Avila,Lucy Duan,Amanda Cipolla,Ashley Kim,Walter H. A. Kahr,Suzan Williams,Leonardo R. Brandão
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TRANSPLANTATION

The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation
Ying Taur,Robert R. Jenq,Miguel-Angel Perales,Eric R. Littmann,Sejal Morjaria,Lilan Ling,Daniel No,Asia Gobourne,Agnes Viale,Parastoo B. Dahi,Doris M. Ponce,Juliet N. Barker,Sergio Giralt,Marcel van den Brink,Eric G. Pamer
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MPD-RC 101 prospective study of reduced-intensity allogeneic hematopoietic stem cell transplantation in patients with myelofibrosis
Damiano Rondelli,Judith D. Goldberg,Luis Isola,Leah S. Price,Tsiporah B. Shore,Michael Boyer,Andrea Bacigalupo,Alessandro Rambaldi,Marco Scarano,Rebecca B. Klisovic,Vikas Gupta,Bjorn Andreasson,John Mascarenhas,Meir Wetzler,Alessandro M. Vannucchi,Josef T. Prchal,Vesna Najfeld,Attilio Orazi,Rona S. Weinberg,Crystal Miller,Giovanni Barosi,Lewis R. Silverman,Giuseppe Prosperini,Roberto Marchioli,Ronald Hoffman
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CORRESPONDENCE

Blood collection methods affect cellular protein integrity: implications for clinical trial biomarkers and ZAP-70 in CLL
Lisa S. Chen,Michael J. Keating,Varsha Gandhi
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Activation of TRKB receptor in murine hematopoietic stem/progenitor cells induced mastocytosis
Min Yang,Kezhi Huang,Guntram Büsche,Arnold Ganser,Zhixiong Li
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Supplemental data
Engraftment of donor cells with germ-line integration of HHV6 mimics HHV6 reactivation following cord blood/haplo transplantation
Enkhtsetseg Purev,Thomas Winkler,Robert L. Danner,Gary A. Fahle,Linda Cook,Danielle M. Zerr,Keith R. Jerome,Richard W. Childs
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ERRATA

Wolyniec K, Shortt J, de Stanchina E, et al. E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis. Blood. 2012;120(4):822-832.
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Eriguchi Y, Takashima S, Oka H, et al. Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins. Blood. 2012;120(1):223-231.
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Rothe A, Sasse S, Goergen H, et al. Brentuximab vedotin for relapsed or refractory CD30+ hematologic malignancies: the German Hodgkin Study Group experience. Blood. 2012;120(7):1470-1472.
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San-Miguel J, Bladé J, Shpilberg O, et al. Phase 2 randomized study of bortezomib-melphalan-prednisone with or without siltuximab (anti–IL-6) in multiple myeloma. Blood. 2014;123(26):4136-4142.
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