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Results of a phase 2 trial of the single-agent histone deacetylase inhibitor panobinostat in patients with relapsed/refractory Waldenström macroglobulinemia
Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia
Circulating CD34+ progenitor cell frequency is associated with clinical and genetic factors
Issue Archive
February 21 2013
In this Issue
Table of Contents
Inside Blood
Blood Work
Plenary Paper
Hematopoiesis and Stem Cells
In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells
Giovanni Amabile,Robert S. Welner,Cesar Nombela-Arrieta,Anna Morena D'Alise,Annalisa Di Ruscio,Alexander K. Ebralidze,Yevgenya Kraytsberg,Min Ye,Olivier Kocher,Donna S. Neuberg,Konstantin Khrapko,Leslie E. Silberstein,Daniel G. Tenen
Plenary Paper
IMMUNOBIOLOGY
A novel function for FOXP3 in humans: intrinsic regulation of conventional T cells
Alicia N. McMurchy,Jana Gillies,Maria Concetta Gizzi,Michela Riba,Jose Manuel Garcia-Manteiga,Davide Cittaro,Dejan Lazarevic,Sara Di Nunzio,Ignazio S. Piras,Alessandro Bulfone,Maria Grazia Roncarolo,Elia Stupka,Rosa Bacchetta,Megan K. Levings
Perspectives
Review Article
Clinical Trials and Observations
Results of a phase 2 trial of the single-agent histone deacetylase inhibitor panobinostat in patients with relapsed/refractory Waldenström macroglobulinemia
Clinical Trials & Observations
Irene M. Ghobrial,Federico Campigotto,Timothy J. Murphy,Erica N. Boswell,Ranjit Banwait,Feda Azab,Stacey Chuma,Janet Kunsman,Amanda Donovan,Farzana Masood,Diane Warren,Scott Rodig,Kenneth C. Anderson,Paul G. Richardson,Edie Weller,Jeffrey Matous
Gene Therapy
TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo
Qifang Zhang,Dewan Md Sakib Hossain,Sergey Nechaev,Anna Kozlowska,Wang Zhang,Yong Liu,Claudia M. Kowolik,Piotr Swiderski,John J. Rossi,Stephen Forman,Sumanta Pal,Ravi Bhatia,Andrew Raubitschek,Hua Yu,Marcin Kortylewski
Hematopoiesis and Stem Cells
Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment
Takuji Yamauchi,Katsuto Takenaka,Shingo Urata,Takahiro Shima,Yoshikane Kikushige,Takahito Tokuyama,Chika Iwamoto,Mariko Nishihara,Hiromi Iwasaki,Toshihiro Miyamoto,Nakayuki Honma,Miki Nakao,Takashi Matozaki,Koichi Akashi
Immunobiology
Comparison of primary human cytotoxic T-cell and natural killer cell responses reveal similar molecular requirements for lytic granule exocytosis but differences in cytokine production
Samuel C. C. Chiang,Jakob Theorell,Miriam Entesarian,Marie Meeths,Monika Mastafa,Waleed Al-Herz,Per Frisk,Kimberly C. Gilmour,Marianne Ifversen,Cecilia Langenskiöld,Maciej Machaczka,Ahmed Naqvi,Jeanette Payne,Antonio Perez-Martinez,Magnus Sabel,Ekrem Unal,Sule Unal,Jacek Winiarski,Magnus Nordenskjöld,Hans-Gustaf Ljunggren,Jan-Inge Henter,Yenan T. Bryceson
Anti–IFN-γ autoantibodies in adults with disseminated nontuberculous mycobacterial infections are associated with HLA-DRB1*16:02 and HLA-DQB1*05:02 and the reactivation of latent varicella-zoster virus infection
Chih-Yu Chi,Chen-Chung Chu,Jing-Pei Liu,Chia-Hao Lin,Mao-Wang Ho,Wen-Jyi Lo,Po-Chang Lin,Hung-Jen Chen,Chia-Huei Chou,Jia-Yih Feng,Chang-Phone Fung,Yuh-Pyng Sher,Chi-Yuan Li,Jen-Hsien Wang,Cheng-Lung Ku
Lymphoid Neoplasia
High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells
June H. Myklebust,Jonathan M. Irish,Joshua Brody,Debra K. Czerwinski,Roch Houot,Holbrook E. Kohrt,John Timmerman,Jonathan Said,Michael R. Green,Jan Delabie,Arne Kolstad,Ash A. Alizadeh,Ronald Levy
CCND2 rearrangements are the most frequent genetic events in cyclin D1− mantle cell lymphoma
Itziar Salaverria,Cristina Royo,Alejandra Carvajal-Cuenca,Guillem Clot,Alba Navarro,Alejandra Valera,Joo Y. Song,Renata Woroniecka,Grzegorz Rymkiewicz,Wolfram Klapper,Elena M. Hartmann,Pierre Sujobert,Iwona Wlodarska,Judith A. Ferry,Philippe Gaulard,German Ott,Andreas Rosenwald,Armando Lopez-Guillermo,Leticia Quintanilla-Martinez,Nancy L. Harris,Elaine S. Jaffe,Reiner Siebert,Elias Campo,Sílvia Beà
Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia
CME
Davide Rossi,Silvia Rasi,Valeria Spina,Alessio Bruscaggin,Sara Monti,Carmela Ciardullo,Clara Deambrogi,Hossein Khiabanian,Roberto Serra,Francesco Bertoni,Francesco Forconi,Luca Laurenti,Roberto Marasca,Michele Dal-Bo,Francesca Maria Rossi,Pietro Bulian,Josep Nomdedeu,Giovanni Del Poeta,Valter Gattei,Laura Pasqualucci,Raul Rabadan,Robin Foà,Riccardo Dalla-Favera,Gianluca Gaidano
Myeloid Neoplasia
PBX3 is an important cofactor of HOXA9 in leukemogenesis
Zejuan Li,Zhiyu Zhang,Yuanyuan Li,Stephen Arnovitz,Ping Chen,Hao Huang,Xi Jiang,Gia-Ming Hong,Rejani B. Kunjamma,Haomin Ren,Chunjiang He,Chong-Zhi Wang,Abdel G. Elkahloun,Peter J. M. Valk,Konstanze Döhner,Mary Beth Neilly,Lars Bullinger,Ruud Delwel,Bob Löwenberg,Paul P. Liu,Richard Morgan,Janet D. Rowley,Chun-Su Yuan,Jianjun Chen
Red Cells, Iron, and Erythropoiesis
HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α–induced excessive erythropoiesis
Kristin Franke,Joanna Kalucka,Soulafa Mamlouk,Rashim Pal Singh,Antje Muschter,Alexander Weidemann,Vasuprada Iyengar,Steffen Jahn,Kathrin Wieczorek,Kathrin Geiger,Michael Muders,Alex M. Sykes,David M. Poitz,Tatsiana Ripich,Teresa Otto,Sybille Bergmann,Georg Breier,Gustavo Baretton,Guo-Hua Fong,David R. Greaves,Stefan Bornstein,Triantafyllos Chavakis,Joachim Fandrey,Max Gassmann,Ben Wielockx
Thrombosis and Hemostasis
The polygenic nature of inhibitors in hemophilia A: results from the Hemophilia Inhibitor Genetics Study (HIGS) Combined Cohort
Jan Astermark,Sharyne M. Donfield,Edward D. Gomperts,John Schwarz,Erika D. Menius,Anna Pavlova,Johannes Oldenburg,Bailey Kessing,Donna M. DiMichele,Amy D. Shapiro,Cheryl A. Winkler,Erik Berntorp,on behalf of the Hemophilia Inhibitor Genetics Study (HIGS) Combined Cohort
Transfusion Medicine
Transplantation
Circulating CD34+ progenitor cell frequency is associated with clinical and genetic factors
e-blood
Kenneth S. Cohen,Susan Cheng,Martin G. Larson,L. Adrienne Cupples,Elizabeth L. McCabe,Ying A. Wang,Julius S. Ngwa,Roderick P. Martin,Rachael J. Klein,Basma Hashmi,Yin Ge,Christopher J. O'Donnell,Ramachandran S. Vasan,Stanley Y. Shaw,Thomas J. Wang
Correspondence
Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263)
Jianlin Qiao,Simone M. Schoenwaelder,Kylie D. Mason,Huy Tran,Amanda K. Davis,Zane S. Kaplan,Shaun P. Jackson,Benjamin T. Kile,Robert K. Andrews,Andrew W. Roberts,Elizabeth E. Gardiner
Continuing Medical Education (CME) Questions
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Cover Image
Cover Image
![issue cover]()
The cover shows a computer-generated model of Forssman synthase (green) superimposed on the x-ray crystal structure of ABO glycosyltransferase (orange). Donor and acceptor substrates are indicated, as is the manganese ion critical for enzyme activity. The authors describe how Forssman synthase, normally inactive in humans, can be activated to make Forssman glycosphingolipid by a polymorphism in the ABO-like GBGT1 gene. This constitutes the basis of a novel blood group system, designated FORS. Cover art by René Jørgensen. See the article by Svensson et al on page 1459.
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