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Issue Archive

Volume 121, Issue 21
May 23 2013
Issue Cover

Table of Contents

Inside Blood

THROMBOSIS & HEMOSTASIS
Give me an intron: any intron
Jerry Ware
View Articletitled, Give me an intron: any intron
PHAGOCYTES, GRANULOCYTES, & MYELOPOIESIS
Learning to roll before you stop and drop
Joyce Marie Koenig,Mervin C. Yoder
View Articletitled, Learning to roll before you stop and drop
VASCULAR BIOLOGY
The “cord of life” serving antiangiogenic therapy
Massimiliano Mazzone
View Articletitled, The “cord of life” serving antiangiogenic therapy

Blood Work

A case of refractory anemia with ring sideroblasts and associated thrombocytosis
Samar Issa,Katrina Ingley
View Articletitled, A case of refractory anemia with ring sideroblasts and associated thrombocytosis

Plenary Paper

An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state
Martin Wahlestedt,Gudmundur L. Norddahl,Gerd Sten,Amol Ugale,Mary-Ann Micha Frisk,Ragnar Mattsson,Tomas Deierborg,Mikael Sigvardsson,David Bryder
View Articletitled, An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state
Supplemental data

Blood Spotlight

Tribbles in acute leukemia
Kai Ling Liang,Loveena Rishi,Karen Keeshan
View Articletitled, Tribbles in acute leukemia
Supplemental data

Review Series

Mechanisms of epigenetic deregulation in lymphoid neoplasms
Yanwen Jiang,Katerina Hatzi,Rita Shaknovich
View Articletitled, Mechanisms of epigenetic deregulation in lymphoid neoplasms

How I Treat

How we treat lower-risk myelodysplastic syndromes
Pierre Fenaux,Lionel Adès
View Articletitled, How we treat lower-risk myelodysplastic syndromes

Clinical Trials and Observations

Geriatric assessment predicts survival for older adults receiving induction chemotherapy for acute myelogenous leukemia
Clinical Trials & Observations
Heidi D. Klepin,Ann M. Geiger,Janet A. Tooze,Stephen B. Kritchevsky,Jeff D. Williamson,Timothy S. Pardee,Leslie R. Ellis,Bayard L. Powell
View Articletitled, Geriatric assessment predicts survival for older adults receiving induction chemotherapy for acute myelogenous leukemia

Immunobiology

The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor
Shaun-Paul Cordoba,Kaushik Choudhuri,Hao Zhang,Marcus Bridge,Alp Bugra Basat,Michael L. Dustin,P. Anton van der Merwe
View Articletitled, The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor
Supplemental data
Long-term prevention of chronic allograft rejection by regulatory T-cell immunotherapy involves host Foxp3-expressing T cells
Lise Pasquet,Jean-Yves Douet,Tim Sparwasser,Paola Romagnoli,Joost P. M. van Meerwijk
View Articletitled, Long-term prevention of chronic allograft rejection by regulatory T-cell immunotherapy involves host Foxp3-expressing T cells
Supplemental data
Downregulation of FOXP1 is required during germinal center B-cell function
Ainara Sagardoy,Jose I. Martinez-Ferrandis,Sergio Roa,Karen L. Bunting,María Angela Aznar,Olivier Elemento,Rita Shaknovich,Lorena Fontán,Vicente Fresquet,Ignacio Perez-Roger,Eloy F. Robles,Linde De Smedt,Xavier Sagaert,Ari Melnick,Jose A. Martinez-Climent
View Articletitled, Downregulation of FOXP1 is required during germinal center B-cell function
Supplemental data
Interleukin-7 promotes HIV persistence during antiretroviral therapy
Claire Vandergeeten,Rémi Fromentin,Sandrina DaFonseca,Mariam B. Lawani,Irini Sereti,Michael M. Lederman,Moti Ramgopal,Jean-Pierre Routy,Rafick-Pierre Sékaly,Nicolas Chomont
View Articletitled, Interleukin-7 promotes HIV persistence during antiretroviral therapy
Supplemental data
Correlates of T-cell–mediated viral control and phenotype of CD8+ T cells in HIV-2, a naturally contained human retroviral infection
Thushan I. de Silva,Yanchun Peng,Aleksandra Leligdowicz,Irfan Zaidi,Lucy Li,Harry Griffin,Marie-Eve Blais,Tim Vincent,Mavinga Saraiva,Louis-Marie Yindom,Carla van Tienen,Philippa Easterbrook,Assan Jaye,Hilton Whittle,Tao Dong,Sarah L. Rowland-Jones
View Articletitled, Correlates of T-cell–mediated viral control and phenotype of CD8<sup>+</sup> T cells in HIV-2, a naturally contained human retroviral infection
Supplemental data

Lymphoid Neoplasia

Preapoptotic protease calpain-2 is frequently suppressed in adult T-cell leukemia
Makoto Ishihara,Natsumi Araya,Tomoo Sato,Ayako Tatsuguchi,Naomi Saichi,Atae Utsunomiya,Yusuke Nakamura,Hidewaki Nakagawa,Yoshihisa Yamano,Koji Ueda
View Articletitled, Preapoptotic protease calpain-2 is frequently suppressed in adult T-cell leukemia
Supplemental data
Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia
Fatih M. Uckun,Sanjive Qazi,Ingrid Cely,Kazim Sahin,Anoush Shahidzadeh,Ibrahim Ozercan,Qian Yin,Paul Gaynon,Amanda Termuhlen,Jianjun Cheng,Seang Yiv
View Articletitled, Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia
Supplemental data
A Sleeping Beauty screen reveals NF-kB activation in CLL mouse model
Brief Report
Nicola Zanesi,Veronica Balatti,Jesse Riordan,Aaron Burch,Lara Rizzotto,Alexey Palamarchuk,Luciano Cascione,Alessandro Lagana,Adam J. Dupuy,Carlo M. Croce,Yuri Pekarsky
View Articletitled, A Sleeping Beauty screen reveals NF-kB activation in CLL mouse model
Supplemental data

Myeloid Neoplasia

PARP1 is required for chromosomal translocations
Justin Wray,Elizabeth A. Williamson,Sudha B. Singh,Yuehan Wu,Christopher R. Cogle,David M. Weinstock,Yu Zhang,Suk-Hee Lee,Daohong Zhou,Lijian Shao,Martin Hauer-Jensen,Rupak Pathak,Virginia Klimek,Jac A. Nickoloff,Robert Hromas
View Articletitled, PARP1 is required for chromosomal translocations
Comprehensive genetic analysis of cytarabine sensitivity in a cell-based model identifies polymorphisms associated with outcome in AML patients
Eric R. Gamazon,Jatinder K. Lamba,Stanley Pounds,Amy L. Stark,Heather E. Wheeler,Xueyuan Cao,Hae K. Im,Amit K. Mitra,Jeffrey E. Rubnitz,Raul C. Ribeiro,Susana Raimondi,Dario Campana,Kristine R. Crews,Shan S. Wong,Marleen Welsh,Imge Hulur,Lidija Gorsic,Christine M. Hartford,Wei Zhang,Nancy J. Cox,M. Eileen Dolan
View Articletitled, Comprehensive genetic analysis of cytarabine sensitivity in a cell-based model identifies polymorphisms associated with outcome in AML patients
Supplemental data
Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome
Satoshi Saida,Ken-ichiro Watanabe,Aiko Sato-Otsubo,Kiminori Terui,Kenichi Yoshida,Yusuke Okuno,Tsutomu Toki,RuNan Wang,Yuichi Shiraishi,Satoru Miyano,Itaru Kato,Tatsuya Morishima,Hisanori Fujino,Katsutsugu Umeda,Hidefumi Hiramatsu,Souichi Adachi,Etsuro Ito,Seishi Ogawa,Mamoru Ito,Tatsutoshi Nakahata,Toshio Heike
View Articletitled, Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome
Supplemental data
Acquired copy-neutral loss of heterozygosity of chromosome 1p as a molecular event associated with marrow fibrosis in MPL-mutated myeloproliferative neoplasms
Elisa Rumi,Daniela Pietra,Paola Guglielmelli,Roberta Bordoni,Ilaria Casetti,Chiara Milanesi,Emanuela Sant’Antonio,Virginia Ferretti,Alessandro Pancrazzi,Giada Rotunno,Marco Severgnini,Alessandro Pietrelli,Cesare Astori,Elena Fugazza,Cristiana Pascutto,Emanuela Boveri,Francesco Passamonti,Gianluca De Bellis,Alessandro Vannucchi,Mario Cazzola,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative,on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative
View Articletitled, Acquired copy-neutral loss of heterozygosity of chromosome 1p as a molecular event associated with marrow fibrosis in <em>MPL</em>-mutated myeloproliferative neoplasms
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Ontogenetic regulation of leukocyte recruitment in mouse yolk sac vessels
e-blood
Markus Sperandio,Elizabeth J. Quackenbush,Natalia Sushkova,Johannes Altstätter,Claudia Nussbaum,Stephan Schmid,Monika Pruenster,Angela Kurz,Andreas Margraf,Alina Steppner,Natalie Schweiger,Lubor Borsig,Ildiko Boros,Nele Krajewski,Orsolya Genzel-Boroviczeny,Udo Jeschke,David Frommhold,Ulrich H. von Andrian
View Articletitled, Ontogenetic regulation of leukocyte recruitment in mouse yolk sac vessels
Supplemental data

Thrombosis and Hemostasis

Minimal modification in the factor VIII B-domain sequence ameliorates the murine hemophilia A phenotype
Joshua I. Siner,Nicholas P. Iacobelli,Denise E. Sabatino,Lacramiora Ivanciu,Shangzhen Zhou,Mortimer Poncz,Rodney M. Camire,Valder R. Arruda
View Articletitled, Minimal modification in the factor VIII B-domain sequence ameliorates the murine hemophilia A phenotype
Role of RNA splicing in mediating lineage-specific expression of the von Willebrand factor gene in the endothelium
Lei Yuan,Lauren Janes,David Beeler,Katherine C. Spokes,Joshua Smith,Dan Li,Shou-Ching Jaminet,Peter Oettgen,William C. Aird
View Articletitled, Role of RNA splicing in mediating lineage-specific expression of the von Willebrand factor gene in the endothelium
Supplemental data
Acute and severe coagulopathy in adult mice following silencing of hepatic antithrombin and protein C production
Brief Report
Huma Safdar,Ka Lei Cheung,Daniela Salvatori,Henri H. Versteeg,El Houari Laghmani,Gerry T. M. Wagenaar,Pieter H. Reitsma,Bart J. M. van Vlijmen
View Articletitled, Acute and severe coagulopathy in adult mice following silencing of hepatic antithrombin and protein C production
Supplemental data

Vascular Biology

Platelet factor 4 mediates vascular smooth muscle cell injury responses
Guanfang Shi,David J. Field,Xiaochun Long,Deanne Mickelsen,Kyung-ae Ko,Sara Ture,Vyacheslav A. Korshunov,Joseph M. Miano,Craig N. Morrell
View Articletitled, Platelet factor 4 mediates vascular smooth muscle cell injury responses
Supplemental data
Modeling human tumor angiogenesis in a three-dimensional culture system
e-blood
Giorgio Seano,Giulia Chiaverina,Paolo Armando Gagliardi,Laura di Blasio,Roberto Sessa,Federico Bussolino,Luca Primo
View Articletitled, Modeling human tumor angiogenesis in a three-dimensional culture system
Supplemental data

Correspondence

Initial experience with l-leucine therapy in myelodysplastic syndromes with associated chromosome 5q deletion
David P. Steensma,Benjamin L. Ebert
View Articletitled, Initial experience with <span class="small-caps">l</span>-leucine therapy in myelodysplastic syndromes with associated chromosome 5q deletion
Transient proliferation of donor-derived ATL cell–like lymphocytes early after allogeneic stem cell transplantation in an adult T-cell leukemia/lymphoma patient
Masataka Taguchi,Yoshitaka Imaizumi,Jun Taguchi,Daisuke Imanishi,Daisuke Sasaki,Hiroo Hasegawa,Hideki Tsushima,Tomoko Hata,Yasushi Miyazaki
View Articletitled, Transient proliferation of donor-derived ATL cell–like lymphocytes early after allogeneic stem cell transplantation in an adult T-cell leukemia/lymphoma patient

Errata

Chen DY, Balamurugan A, Ng HL, Cumberland WG, Yang OO. Epitope targeting and viral inoculum are determinants of Nef-mediated immune evasion of HIV-1 from cytotoxic T lymphocytes. Blood. 2012;120(1):100-111.
View Articletitled, Chen DY, Balamurugan A, Ng HL, Cumberland WG, Yang OO. Epitope targeting and viral inoculum are determinants of Nef-mediated immune evasion of HIV-1 from cytotoxic T lymphocytes. <em>Blood.</em> 2012;120(1):<span class="related-article">100-111</span>.
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