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Volume 121, Issue 18
May 2 2013
Issue Cover

Table of Contents

Inside Blood

CLINICAL TRIALS & OBSERVATIONS
EBV DNA: a Hodgkin lymphoma biomarker?
Clinical Trials & Observations
Ralph M. Meyer
View Articletitled, EBV DNA: a Hodgkin lymphoma biomarker?
THROMBOSIS & HEMOSTASIS
Blocking direct inhibitor bleeding
Carolyn M. Millar,David A. Lane
View Articletitled, Blocking direct inhibitor bleeding
TRANSPLANTATION
Pharmacotherapy versus T lymphocytes for CMV
Helen E. Heslop
View Articletitled, Pharmacotherapy versus T lymphocytes for CMV

Blood Work

Neutrophil alphabet
Adam S. Morgan,David T. Yang
View Articletitled, Neutrophil alphabet

Plenary Paper

Plasma Epstein-Barr virus DNA predicts outcome in advanced Hodgkin lymphoma: correlative analysis from a large North American cooperative group trial
Jennifer A. Kanakry,Hailun Li,Lan L. Gellert,M. Victor Lemas,Wen-son Hsieh,Fangxin Hong,King L. Tan,Randy D. Gascoyne,Leo I. Gordon,Richard I. Fisher,Nancy L. Bartlett,Patrick Stiff,Bruce D. Cheson,Ranjana Advani,Thomas P. Miller,Brad S. Kahl,Sandra J. Horning,Richard F. Ambinder
View Articletitled, Plasma Epstein-Barr virus DNA predicts outcome in advanced Hodgkin lymphoma: correlative analysis from a large North American cooperative group trial
Supplemental data

Plenary Paper

A specific antidote for dabigatran: functional and structural characterization
Felix Schiele,Joanne van Ryn,Keith Canada,Corey Newsome,Eliud Sepulveda,John Park,Herbert Nar,Tobias Litzenburger
View Articletitled, A specific antidote for dabigatran: functional and structural characterization
Supplemental data

Review Series

Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia
Omar Abdel-Wahab,Ross L. Levine
View Articletitled, Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia

Clinical Trials and Observations

Effectiveness of supportive care measures to reduce infections in pediatric AML: a report from the Children’s Oncology Group
Clinical Trials & Observations
Lillian Sung,Richard Aplenc,Todd A. Alonzo,Robert B. Gerbing,Thomas Lehrnbecher,Alan S. Gamis
View Articletitled, Effectiveness of supportive care measures to reduce infections in pediatric AML: a report from the Children’s Oncology Group
Supplemental data

Hematopoiesis and Stem Cells

Interferon-γ impairs proliferation of hematopoietic stem cells in mice
Alexander M. de Bruin,Özlem Demirel,Berend Hooibrink,Christian H. Brandts,Martijn A. Nolte
View Articletitled, Interferon-γ impairs proliferation of hematopoietic stem cells in mice
Supplemental data
A homozygous telomerase T-motif variant resulting in markedly reduced repeat addition processivity in siblings with Hoyeraal Hreidarsson syndrome
Maria M. Gramatges,Xiaodong Qi,Ghadir S. Sasa,Julian J.-L. Chen,Alison A. Bertuch
View Articletitled, A homozygous telomerase T-motif variant resulting in markedly reduced repeat addition processivity in siblings with Hoyeraal Hreidarsson syndrome
Supplemental data
Erk1 and Erk2 are required for maintenance of hematopoietic stem cells and adult hematopoiesis
Brief Report
Gordon Chan,Shengqing Gu,Benjamin G. Neel
View Articletitled, <em>Erk1</em> and <em>Erk2</em> are required for maintenance of hematopoietic stem cells and adult hematopoiesis
Supplemental data

Immunobiology

NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)
Rizwan Romee,Bree Foley,Todd Lenvik,Yue Wang,Bin Zhang,Dave Ankarlo,Xianghua Luo,Sarah Cooley,Mike Verneris,Bruce Walcheck,Jeffrey Miller
View Articletitled, NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)
Supplemental data
FcγRIII (CD16) equips immature 6-sulfo LacNAc–expressing dendritic cells (slanDCs) with a unique capacity to handle IgG-complexed antigens
Thomas Döbel,Anja Kunze,Jana Babatz,Katja Tränkner,Andreas Ludwig,Marc Schmitz,Alexander Enk,Knut Schäkel
View Articletitled, FcγRIII (CD16) equips immature 6-sulfo LacNAc–expressing dendritic cells (slanDCs) with a unique capacity to handle IgG-complexed antigens
Supplemental data
Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction
Brian R. Rosborough,Dàlia Raïch-Regué,Benjamin M. Matta,Keunwook Lee,Boyi Gan,Ronald A. DePinho,Holger Hackstein,Mark Boothby,Hēth R. Turnquist,Angus W. Thomson
View Articletitled, Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction
Supplemental data
Foxp3+ T-regulatory cells require DNA methyltransferase 1 expression to prevent development of lethal autoimmunity
Liqing Wang,Yujie Liu,Ulf H. Beier,Rongxiang Han,Tricia R. Bhatti,Tatiana Akimova,Wayne W. Hancock
View Articletitled, Foxp3+ T-regulatory cells require DNA methyltransferase 1 expression to prevent development of lethal autoimmunity
Supplemental data

Lymphoid Neoplasia

SOX4 is a direct target gene of FRA-2 and induces expression of HDAC8 in adult T-cell leukemia/lymphoma
Tomonori Higuchi,Takashi Nakayama,Tokuzo Arao,Kazuto Nishio,Osamu Yoshie
View Articletitled, <em>SOX4</em> is a direct target gene of <em>FRA-2</em> and induces expression of <em>HDAC8</em> in adult T-cell leukemia/lymphoma
Supplemental data
Inactivation of TP53 correlates with disease progression and low miR-34a expression in previously treated chronic lymphocytic leukemia patients
Annika Dufour,Giuseppe Palermo,Evelyn Zellmeier,Gudrun Mellert,Guillemette Duchateau-Nguyen,Stephanie Schneider,Tobias Benthaus,Purvi M. Kakadia,Karsten Spiekermann,Wolfgang Hiddemann,Jan Braess,Sim Truong,Nancy Patten,Lin Wu,Sabine Lohmann,David Dornan,Debraj GuhaThakurta,Ru-Fang Yeh,Galina Salogub,Philippe Solal-Celigny,Anna Dmoszynska,Tadeusz Robak,Marco Montillo,John Catalano,Christian H. Geisler,Martin Weisser,Stefan K. Bohlander
View Articletitled, Inactivation of TP53 correlates with disease progression and low miR-34a expression in previously treated chronic lymphocytic leukemia patients
Supplemental data
Soluble ligands for NK cell receptors promote evasion of chronic lymphocytic leukemia cells from NK cell anti-tumor activity
Katrin S. Reiners,Daniela Topolar,Alexander Henke,Venkateswara R. Simhadri,Jörg Kessler,Maike Sauer,Martina Bessler,Hinrich P. Hansen,Samir Tawadros,Marco Herling,Martin Krönke,Michael Hallek,Elke Pogge von Strandmann
View Articletitled, Soluble ligands for NK cell receptors promote evasion of chronic lymphocytic leukemia cells from NK cell anti-tumor activity
Supplemental data
Analysis of FOXO1 mutations in diffuse large B-cell lymphoma
Diane L. Trinh,David W. Scott,Ryan D. Morin,Maria Mendez-Lago,Jianghong An,Steven J. M. Jones,Andrew J. Mungall,Yongjun Zhao,Jacqueline Schein,Christian Steidl,Joseph M. Connors,Randy D. Gascoyne,Marco A. Marra
View Articletitled, Analysis of <em>FOXO1</em> mutations in diffuse large B-cell lymphoma
Supplemental data

Myeloid Neoplasia

Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors
Jessica K. Altman,Amy Szilard,Bruce W. Konicek,Philip W. Iversen,Barbara Kroczynska,Heather Glaser,Antonella Sassano,Eliza Vakana,Jeremy R. Graff,Leonidas C. Platanias
View Articletitled, Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors
Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in AML cells
Yan Chen,Hui Hui,Hao Yang,Kai Zhao,Yansu Qin,Cong Gu,Xiaotang Wang,Na Lu,Qinglong Guo
View Articletitled, Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in AML cells
Supplemental data
Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera
Ann Mullally,Claudia Bruedigam,Luke Poveromo,Florian H. Heidel,Amy Purdon,Therese Vu,Rebecca Austin,Dirk Heckl,Lawrence J. Breyfogle,Catherine Paine Kuhn,Demetrios Kalaitzidis,Scott A. Armstrong,David A. Williams,Geoff R. Hill,Benjamin L. Ebert,Steven W. Lane
View Articletitled, Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera
Supplemental data
Nilotinib is associated with a reduced incidence of BCR-ABL mutations vs imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase
Andreas Hochhaus,Giuseppe Saglio,Richard A. Larson,Dong-Wook Kim,Gabriel Etienne,Gianantonio Rosti,Carmino De Souza,Mineo Kurokawa,Matt E. Kalaycio,Albert Hoenekopp,Xiaolin Fan,Yaping Shou,Hagop M. Kantarjian,Timothy P. Hughes
View Articletitled, Nilotinib is associated with a reduced incidence of BCR-ABL mutations vs imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase
Selective killing of candidate AML stem cells by antibody targeting of IL1RAP
Brief Report
Maria Askmyr,Helena Ågerstam,Nils Hansen,Sandra Gordon,Alexandros Arvanitakis,Marianne Rissler,Gunnar Juliusson,Johan Richter,Marcus Järås,Thoas Fioretos
View Articletitled, Selective killing of candidate AML stem cells by antibody targeting of IL1RAP
Supplemental data
Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential
Brief Report
Russell C. DeKelver,Ming Yan,Eun-Young Ahn,Wei-Jong Shia,Nancy A. Speck,Dong-Er Zhang
View Articletitled, Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential
Supplemental data

Platelets and Thrombopoiesis

PDK1 regulates platelet activation and arterial thrombosis
Xue Chen,Yue Zhang,Yanhua Wang,Ding Li,Lin Zhang,Kemin Wang,Xinping Luo,Zhongzhou Yang,Yi Wu,Junling Liu
View Articletitled, PDK1 regulates platelet activation and arterial thrombosis
Novel diagnostic assays for heparin-induced thrombocytopenia
Adam Cuker,Ann H. Rux,Jillian L. Hinds,May Dela Cruz,Serge V. Yarovoi,Isola A. M. Brown,Wei Yang,Barbara A. Konkle,Gowthami M. Arepally,Stephen P. Watson,Douglas B. Cines,Bruce S. Sachais
View Articletitled, Novel diagnostic assays for heparin-induced thrombocytopenia

Thrombosis and Hemostasis

Red blood cells mediate the onset of thrombosis in the ferric chloride murine model
Justin D. Barr,Anil K. Chauhan,Gilbert V. Schaeffer,Jessica K. Hansen,David G. Motto
View Articletitled, Red blood cells mediate the onset of thrombosis in the ferric chloride murine model
Supplemental data
No increase in bleeding identified in type 1 VWD subjects with D1472H sequence variation
Brief Report
Veronica H. Flood,Kenneth D. Friedman,Joan Cox Gill,Sandra L. Haberichter,Pamela A. Christopherson,Brian R. Branchford,Raymond G. Hoffmann,Thomas C. Abshire,Amy L. Dunn,Jorge A. Di Paola,W. Keith Hoots,Deborah L. Brown,Cindy Leissinger,Jeanne M. Lusher,Margaret V. Ragni,Amy D. Shapiro,Robert R. Montgomery
View Articletitled, No increase in bleeding identified in type 1 VWD subjects with D1472H sequence variation

Transplantation

Donor-derived CMV-specific T cells reduce the requirement for CMV-directed pharmacotherapy after allogeneic stem cell transplantation
Emily Blyth,Leighton Clancy,Renee Simms,Chun K. K. Ma,Jane Burgess,Shivashni Deo,Karen Byth,Ming-Celine Dubosq,Peter J. Shaw,Kenneth P. Micklethwaite,David J. Gottlieb
View Articletitled, Donor-derived CMV-specific T cells reduce the requirement for CMV-directed pharmacotherapy after allogeneic stem cell transplantation
Anti-CD45 radioimmunotherapy using 211At with bone marrow transplantation prolongs survival in a disseminated murine leukemia model
Johnnie J. Orozco,Tom Bäck,Aimee Kenoyer,Ethan R. Balkin,Donald K. Hamlin,D. Scott Wilbur,Darrell R. Fisher,Shani L. Frayo,Mark D. Hylarides,Damian J. Green,Ajay K. Gopal,Oliver W. Press,John M. Pagel
View Articletitled, Anti-CD45 radioimmunotherapy using <sup>211</sup>At with bone marrow transplantation prolongs survival in a disseminated murine leukemia model

Vascular Biology

An analysis of the function and expression of D6 on lymphatic endothelial cells
Clive S. McKimmie,Mark D. Singh,Kay Hewit,Oscar Lopez-Franco,Michelle Le Brocq,Stefan Rose-John,Kit Ming Lee,Andrew H. Baker,Rachel Wheat,David J. Blackbourn,Robert J. B. Nibbs,Gerard J. Graham
View Articletitled, An analysis of the function and expression of D6 on lymphatic endothelial cells

Expression of Concern

Pandey MK, Sung B, Ahn KS, Kunnumakkara AB, Chaturvedi MM, Aggarwal BB. Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-κB signaling pathway. Blood. 2007;110(10):3517-3525.
View Articletitled, Pandey MK, Sung B, Ahn KS, Kunnumakkara AB, Chaturvedi MM, Aggarwal BB. Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-κB signaling pathway. <em>Blood</em>. 2007;110(10):<span class="related-article">3517-3525</span>.
Harikumar KB, Kunnumakkara AB, Ahn KS, Anand P, Krishnan S, Guha S, Aggarwal BB. Modification of the cysteine residues in IκBα kinase and NF-κB (p65) by xanthohumol leads to suppression of NF-κB–regulated gene products and potentiation of apoptosis in leukemia cells. Blood. 2009;113(9):2003-2013.
View Articletitled, Harikumar KB, Kunnumakkara AB, Ahn KS, Anand P, Krishnan S, Guha S, Aggarwal BB. Modification of the cysteine residues in IκBα kinase and NF-κB (p65) by xanthohumol leads to suppression of NF-κB–regulated gene products and potentiation of apoptosis in leukemia cells. <em>Blood</em>. 2009;113(9):<span class="related-article">2003-2013</span>.
  • Cover Image

    Cover Image

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    Red blood cell (RBC) adhesion to the mouse carotid artery endothelial surface following initiation of thrombosis with ferric chloride (scanning electron microscopy). The smooth-appearing spherical structures are RBC fragments, and the rough-appearing material observed throughout also is derived from RBCs. Numerous platelets are visible, but are observed to be adherent to the RBC-derived structures rather than to the endothelial surface itself. See the article by Barr et al on page 3733.

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