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Journal Articles

Single-cell genomics details the maturation block in BCP-ALL and identifies therapeutic vulnerabilities in DUX4 -r cases

Hanna Thorsson, Rasmus Henningsson, Noelia Puente-Moncada, Pablo Peña-Martínez, Ludvig Sjöström, Helena Ågerstam, Carl Sandén, Marianne Rissler, Anders Castor, Hanne Marquart, Signe Modvig, Kajsa Paulsson, Cornelis Jan Pronk, Kjeld Schmiegelow, Axel Hyrenius-Wittsten, Christina Orsmark-Pietras, Henrik Lilljebjörn, Thoas Fioretos

Blood (2024) 144 (13): 1399–1411.

https://doi.org/10.1182/blood.2023021705

Published: 2024

Includes: Supplemental data

Journal Articles

Single-Cell Genomics Details the Maturation Block in BCP-ALL and Identifies Therapeutic Vulnerabilities in DUX4 -Rearranged Cases

Hanna Thorsson, Rasmus Henningsson, Noelia Puente-Moncada, Ludvig Sjöström, Helena Ågerstam, Pablo Enrique Peña-Martínez, Carl Sandén, Marianne Rissler, Anders Castor, Hanne Vibeke Marquart, Signe Modvig, Kajsa Paulsson, Cornelis Pronk, Kjeld Schmiegelow, Axel Hyrenius Wittsten, Christina Orsmark-Pietras, Henrik PhD Lilljebjörn, Thoas Fioretos

Blood (2023) 142 (Supplement 1): 842.

https://doi.org/10.1182/blood-2023-173350

Published: 2023

Journal Articles

Single Cell Multi-Omic Profiling of Acute Lymphoblastic Leukemia Identifies Altered Cellular Pathways and Highlights Heterogeneity in the Maturation Block of DUX4 -Rearranged ALL

Hanna Thorsson, Rasmus Henningsson, Noelia Puente-Moncada, Carl Sandén, Signe Modvig, Marianne Rissler, Kajsa Paulsson, Anders Castor, Cornelis Jan Pronk, Hanne Vibeke Marquart, Kjeld Schmiegelow, Christina Orsmark-Pietras, Henrik Lilljebjörn, Thoas Fioretos

Blood (2022) 140 (Supplement 1): 3467–3468.

https://doi.org/10.1182/blood-2022-163031

Published: 2022

Journal Articles

AML Xenografts Undergo Extensive Clonal Competition and Unmask Rare Clones in Patient Samples

Carl Sandén, PhD, Henrik Lilljebjörn, PhD, Christina Orsmark-Pietras, PhD, Karim Saba, MSc, Carl Högberg, PhD, Marianne Rissler, MSc, Vladimir Lazarevic, MD PhD, Gunnar Juliusson, MD PhD, Helena Ågerstam, PhD, Thoas Fioretos, MD PhD

Blood (2018) 132 (Supplement 1): 2621.

https://doi.org/10.1182/blood-2018-99-110497

Published: 2018

Journal Articles

Isolated myelosarcoma is characterized by recurrent NFE2 mutations and concurrent preleukemic clones in the bone marrow

Vladimir Lazarevic, Christina Orsmark-Pietras, Henrik Lilljebjörn, Louise Pettersson, Marianne Rissler, Anna Lübking, Mats Ehinger, Gunnar Juliusson, Thoas Fioretos

Blood (2018) 131 (5): 577–581.

https://doi.org/10.1182/blood-2017-07-793620

Published: 2018

Includes: Supplemental data

Journal Articles

IL1RAP antibodies block IL-1–induced expansion of candidate CML stem cells and mediate cell killing in xenograft models

Helena Ågerstam, Nils Hansen, Sofia von Palffy, Carl Sandén, Kristian Reckzeh, Christine Karlsson, Henrik Lilljebjörn, Niklas Landberg, Maria Askmyr, Carl Högberg, Marianne Rissler, Kimmo Porkka, Hans Wadenvik, Satu Mustjoki, Johan Richter, Marcus Järås, Thoas Fioretos

Blood (2016) 128 (23): 2683–2693.

https://doi.org/10.1182/blood-2015-11-679985

Published: 2016

Includes: Supplemental data

Journal Articles

Monitoring Minimal Residual Disease in AML By Patient Specific Mutational Fingerprint Using Multiplex PCR and Deep Sequencing

Christina Orsmark Pietras, Henrik Lilljebjörn, Vladimir Lazarevic, MD, Marianne Rissler, Mats Ehinger, Gunnar Juliusson, MD PhD, Thoas Fioretos

Blood (2016) 128 (22): 1715.

https://doi.org/10.1182/blood.V128.22.1715.1715

Published: 2016

Journal Articles

Mutational and Clonal Dynamics in Patient-Derived Xenografts of Acute Myeloid Leukemia

Carl Sandén, Karim Saba, Christina Orsmark-Pietras, Henrik Lilljebjörn, Carl Högberg, Marianne Rissler, Vladimir Lazarevic, Gunnar Juliusson, Helena Ågerstam, Thoas Fioretos

Blood (2016) 128 (22): 1154.

https://doi.org/10.1182/blood.V128.22.1154.1154

Published: 2016

Journal Articles

IL1RAP Antibodies Block IL1-Induced Expansion of Primitive CML Cells and Display Therapeutic Effects in Xenograft Models

Helena Ågerstam, Nils Hansen, Sofia Von Palffy, Carl Sandén, Kristian Reckzeh, Christine Karlsson, Henrik Lilljebjörn, Niklas Landberg, Maria Askmyr, Carl Högberg, Marianne Rissler, Kimmo Porkka, Hans Wadenvik, Satu Mustjoki, Johan Richter, MD, Marcus Järås, Thoas Fioretos

Blood (2016) 128 (22): 1118.

https://doi.org/10.1182/blood.V128.22.1118.1118

Published: 2016

Journal Articles

Comprehensive Prospective Next Generation Sequencing of Acute Myeloid Leukemia

Christina Orsmark-Pietras, Henrik Lilljebjörn, Marianne Rissler, Vladimir Lazarevic, Alexandros Arvanitakis, Mats Ehinger, Gunnar Juliusson, MD PhD, Thoas Fioretos

Blood (2015) 126 (23): 3830.

https://doi.org/10.1182/blood.V126.23.3830.3830

Published: 2015

Journal Articles

Modeling Chronic Myeloid Leukemia in Immunodeficient Mice Reveals an Inflammatory State with Expansion of Aberrant Mast Cells and Accumulation of Pre B Cells

Maria Askmyr, PhD, Helena Agerstam, PhD, Henrik Lilljebjörn, PhD, Nils Hansen, PhD, Christine Karlsson, PhD, Niklas Landberg, Carl Hogberg, PhD, Carin Lassen, Msc, Marianne Rissler, Johan Richter, MD PhD, Mats Ehinger, MD PhD, Marcus Jaras, PhD, Thoas Fioretos, MD PhD

Blood (2014) 124 (21): 3132.

https://doi.org/10.1182/blood.V124.21.3132.3132

Published: 2014

Journal Articles

Upregulation Of IL1RAP On Human Progenitor/Stem Cells Induces Features Of a Myeloproliferative Disorder In Mice

Nils Hansen, Kristian Reckzeh, PhD, Helena Agerstam, PhD, Maria Askmyr, PhD, Sandra Gordon, Marianne Rissler, Carl Högberg, PhD, Johan Richter, MD, PhD, Marcus Järås, PhD, Thoas Fioretos, MD, PhD

Blood (2013) 122 (21): 1650.

https://doi.org/10.1182/blood.V122.21.1650.1650

Published: 2013

Journal Articles

Strong Therapeutic Effect Of Anti-IL1RAP Immunotherapy In a Xenograft Model Of Acute Myeloid Leukemia

Helena Agerstam, PhD, Maria Askmyr, PhD, Nils Hansen, Marianne Rissler, Gunnar Juliusson, MD, PhD, Johan Richter, MD, PhD, Mark Wunderlich, MS, Marcus Järås, PhD, James C. Mulloy, PhD, Thoas Fioretos, MD PhD

Blood (2013) 122 (21): 3954.

https://doi.org/10.1182/blood.V122.21.3954.3954

Published: 2013

Journal Articles

Selective killing of candidate AML stem cells by antibody targeting of IL1RAP

Maria Askmyr, Helena Ågerstam, Nils Hansen, Sandra Gordon, Alexandros Arvanitakis, Marianne Rissler, Gunnar Juliusson, Johan Richter, Marcus Järås, Thoas Fioretos

Blood (2013) 121 (18): 3709–3713.

https://doi.org/10.1182/blood-2012-09-458935

Published: 2013

Includes: Supplemental data

Journal Articles

Smad4 binds Hoxa9 in the cytoplasm and protects primitive hematopoietic cells against nuclear activation by Hoxa9 and leukemia transformation

Ronan Quéré, Göran Karlsson, Falk Hertwig, Marianne Rissler, Beata Lindqvist, Thoas Fioretos, Peter Vandenberghe, Marilyn L. Slovak, Jörg Cammenga, Stefan Karlsson

Blood (2011) 117 (22): 5918–5930.

https://doi.org/10.1182/blood-2010-08-301879

Published: 2011

Includes: Supplemental data

Journal Articles

SMAD4 Sequestrates HOXA9 to Protect Hematopoietic Stem Cells Against Leukemia Transformation

Ronan Quere, PhD, Göran Karlsson, PhD, Falk Hertwig, Marianne Rissler, Beata Lindqvist, Thoas Fioretos, MD, PhD, Peter Vandenberghe, MD, PhD, Marilyn L. Slovak, PhD, Kristian Reckzeh, Jörg Cammenga, MD, PhD, Stefan Karlsson, MD, PhD

Blood (2010) 116 (21): 3153.

https://doi.org/10.1182/blood.V116.21.3153.3153

Published: 2010

Journal Articles

Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice

Helena Ågerstam, Marcus Järås, Anna Andersson, Petra Johnels, Nils Hansen, Carin Lassen, Marianne Rissler, David Gisselsson, Tor Olofsson, Johan Richter, Xiaolong Fan, Mats Ehinger, Thoas Fioretos

Blood (2010) 116 (12): 2103–2111.

https://doi.org/10.1182/blood-2009-05-217182

Published: 2010

Includes: Supplemental data

Journal Articles

Smad4 as a Therapeutic Target in Nup98-HoxA9-Induced Leukemia.

Ronan Quere, Ph.D., Goran Karlsson, Ph.D., Silja Andradottir, Marianne Rissler, Karin Olsson, Falk Hertwig, Kristian Reckzeh, MSc, Jorg Cammenga, MD, Ph.D., Stefan Karlsson, MD, Ph.D.

Blood (2008) 112 (11): 1799.

https://doi.org/10.1182/blood.V112.11.1799.1799

Published: 2008

NARROW

Single-cell genomics details the maturation block in BCP-ALL and identifies therapeutic vulnerabilities in DUX4 -r cases

Single-Cell Genomics Details the Maturation Block in BCP-ALL and Identifies Therapeutic Vulnerabilities in DUX4 -Rearranged Cases

Single Cell Multi-Omic Profiling of Acute Lymphoblastic Leukemia Identifies Altered Cellular Pathways and Highlights Heterogeneity in the Maturation Block of DUX4 -Rearranged ALL

AML Xenografts Undergo Extensive Clonal Competition and Unmask Rare Clones in Patient Samples

Isolated myelosarcoma is characterized by recurrent NFE2 mutations and concurrent preleukemic clones in the bone marrow

IL1RAP antibodies block IL-1–induced expansion of candidate CML stem cells and mediate cell killing in xenograft models

Monitoring Minimal Residual Disease in AML By Patient Specific Mutational Fingerprint Using Multiplex PCR and Deep Sequencing

Mutational and Clonal Dynamics in Patient-Derived Xenografts of Acute Myeloid Leukemia

IL1RAP Antibodies Block IL1-Induced Expansion of Primitive CML Cells and Display Therapeutic Effects in Xenograft Models

Comprehensive Prospective Next Generation Sequencing of Acute Myeloid Leukemia

Modeling Chronic Myeloid Leukemia in Immunodeficient Mice Reveals an Inflammatory State with Expansion of Aberrant Mast Cells and Accumulation of Pre B Cells

Upregulation Of IL1RAP On Human Progenitor/Stem Cells Induces Features Of a Myeloproliferative Disorder In Mice

Strong Therapeutic Effect Of Anti-IL1RAP Immunotherapy In a Xenograft Model Of Acute Myeloid Leukemia

Selective killing of candidate AML stem cells by antibody targeting of IL1RAP

Smad4 binds Hoxa9 in the cytoplasm and protects primitive hematopoietic cells against nuclear activation by Hoxa9 and leukemia transformation

SMAD4 Sequestrates HOXA9 to Protect Hematopoietic Stem Cells Against Leukemia Transformation

Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice

Smad4 as a Therapeutic Target in Nup98-HoxA9-Induced Leukemia.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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