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Issue Archive

Volume 118, Issue 12
September 22 2011
Issue Cover

Table of Contents

Inside Blood

CLINICAL TRIALS
Ironing out fatigue
Annette von Drygalski,John W. Adamson
View Articletitled, Ironing out fatigue
INSIDE BLOOD
Fox and Blimp in NK-cell lymphoma
Lubomir Sokol
View Articletitled, Fox and Blimp in NK-cell lymphoma
TRANSPLANTATION
Type I-IFNs interfere with GVH responses
Pavan Reddy
View Articletitled, Type I-IFNs interfere with GVH responses

Plenary Paper

PLENARY PAPER
Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses
Kennosuke Karube,Masao Nakagawa,Shinobu Tsuzuki,Ichiro Takeuchi,Keiichiro Honma,Yasuhiro Nakashima,Norio Shimizu,Young-Hyeh Ko,Yasuo Morishima,Koichi Ohshima,Shigeo Nakamura,Masao Seto
View Articletitled, Identification of <em>FOXO3</em> and <em>PRDM1</em> as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses
Supplemental data

Perspectives

Approach to the treatment of multiple myeloma: a clash of philosophies
Clinical Trials & Observations
S. Vincent Rajkumar,Gösta Gahrton,P. Leif Bergsagel
View Articletitled, Approach to the treatment of multiple myeloma: a clash of philosophies

Review Article

Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor
James T. B. Crawley,Rens de Groot,Yaozu Xiang,Brenda M. Luken,David A. Lane
View Articletitled, Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor

Hematopoiesis and Stem Cells

IGF binding protein 2 supports the survival and cycling of hematopoietic stem cells
HoangDinh Huynh,Junke Zheng,Masato Umikawa,Chaozheng Zhang,Robert Silvany,Satoru Iizuka,Martin Holzenberger,Wei Zhang,Cheng Cheng Zhang
View Articletitled, IGF binding protein 2 supports the survival and cycling of hematopoietic stem cells
Supplemental data
Human mesenchymal stem cells derived from induced pluripotent stem cells down-regulate NK-cell cytolytic machinery
Massimo Giuliani,Noufissa Oudrhiri,Zaeem M. Noman,Amelia Vernochet,Salem Chouaib,Bruno Azzarone,Antoine Durrbach,Annelise Bennaceur-Griscelli
View Articletitled, Human mesenchymal stem cells derived from induced pluripotent stem cells down-regulate NK-cell cytolytic machinery
Supplemental data

Immunobiology

Decreases in IL-7 levels during antiretroviral treatment of HIV infection suggest a primary mechanism of receptor-mediated clearance
Jessica N. Hodge,Sharat Srinivasula,Zonghui Hu,Sarah W. Read,Brian O. Porter,Insook Kim,JoAnn M. Mican,Chang Paik,Paula DeGrange,Michele Di Mascio,Irini Sereti
View Articletitled, Decreases in IL-7 levels during antiretroviral treatment of HIV infection suggest a primary mechanism of receptor-mediated clearance
Supplemental data
Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy–treated immunologic nonresponders
Clinical Trials & Observations
Stefania Piconi,Serena Parisotto,Giuliano Rizzardini,Simone Passerini,Roberta Terzi,Barbara Argenteri,Paola Meraviglia,Amedeo Capetti,Mara Biasin,Daria Trabattoni,Mario Clerici
View Articletitled, Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy–treated immunologic nonresponders
Lack of the T cell–specific alternative p38 activation pathway reduces autoimmunity and inflammation
Ludmila Jirmanova,Maria Letizia Giardino Torchia,Nandakumara D. Sarma,Paul R. Mittelstadt,Jonathan D. Ashwell
View Articletitled, Lack of the T cell–specific alternative p38 activation pathway reduces autoimmunity and inflammation
Supplemental data
Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis
Rajkumar Noubade,Dimitry N. Krementsov,Roxana del Rio,Tina Thornton,Viswas Nagaleekar,Naresha Saligrama,Anthony Spitzack,Karen Spach,Guadalupe Sabio,Roger J. Davis,Mercedes Rincon,Cory Teuscher
View Articletitled, Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis
Supplemental data
Dual-functional capability of CD3+CD56+ CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity
Alice Pievani,Gianmaria Borleri,Daniela Pende,Lorenzo Moretta,Alessandro Rambaldi,Josée Golay,Martino Introna
View Articletitled, Dual-functional capability of CD3<sup>+</sup>CD56<sup>+</sup> CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity
Supplemental data
Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and promote cytotoxic potential in NKp44+ mucosal NK cells during SIV infection
R. Keith Reeves,Premeela A. Rajakumar,Tristan I. Evans,Michelle Connole,Jacqueline Gillis,Fay E. Wong,Yury V. Kuzmichev,Angela Carville,R. Paul Johnson
View Articletitled, Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and promote cytotoxic potential in NKp44<sup>+</sup> mucosal NK cells during SIV infection
Supplemental data

Lymphoid Neoplasia

Splenic marginal zone lymphoma with VH1-02 gene rearrangement expresses poly- and self-reactive antibodies with similar reactivity
Abdirashid A. Warsame,Hans-Christian Aasheim,Kjell Nustad,Gunhild Trøen,Anne Tierens,Vivian Wang,Ulla Randen,Hiep P. Dong,Sverre Heim,Andreas Brech,Jan Delabie
View Articletitled, Splenic marginal zone lymphoma with <em>VH1-02</em> gene rearrangement expresses poly- and self-reactive antibodies with similar reactivity
Supplemental data
Hyperphosphorylation of autoantigenic targets of paraproteins is due to inactivation of PP2A
Klaus-Dieter Preuss,Michael Pfreundschuh,Natalie Fadle,Evi Regitz,Sybille Raudies,Niels Murwaski,Manfred Ahlgrimm,Joerg Bittenbring,Markus Klotz,Karl-Herbert Schäfer,Gerhard Held,Frank Neumann,Sandra Grass
View Articletitled, Hyperphosphorylation of autoantigenic targets of paraproteins is due to inactivation of PP2A
Rituximab infusion induces NK activation in lymphoma patients with the high-affinity CD16 polymorphism
Brief Report
Suresh Veeramani,Siao-Yi Wang,Christopher Dahle,Sue Blackwell,Laura Jacobus,Tina Knutson,Anna Button,Brian K. Link,George J. Weiner
View Articletitled, Rituximab infusion induces NK activation in lymphoma patients with the high-affinity CD16 polymorphism
Supplemental data

Myeloid Neoplasia

Combination of pegylated IFN-α2b with imatinib increases molecular response rates in patients with low- or intermediate-risk chronic myeloid leukemia
Clinical Trials & Observations
Bengt Simonsson,Tobias Gedde-Dahl,Berit Markevärn,Kari Remes,Jesper Stentoft,Anders Almqvist,Mats Björeman,Max Flogegård,Perttu Koskenvesa,Anders Lindblom,Claes Malm,Satu Mustjoki,Kristina Myhr-Eriksson,Lotta Ohm,Anu Räsänen,Marjatta Sinisalo,Anders Själander,Ulla Strömberg,Ole Weiss Bjerrum,Hans Ehrencrona,Franz Gruber,Veli Kairisto,Karin Olsson,Fredrik Sandin,Arnon Nagler,Johan Lanng Nielsen,Henrik Hjorth-Hansen,Kimmo Porkka,for the Nordic CML Study Group
View Articletitled, Combination of pegylated IFN-α2b with imatinib increases molecular response rates in patients with low- or intermediate-risk chronic myeloid leukemia
Successful transfer of alloreactive haploidentical KIR ligand-mismatched natural killer cells after infusion in elderly high risk acute myeloid leukemia patients
Antonio Curti,Loredana Ruggeri,Alessandra D'Addio,Andrea Bontadini,Elisa Dan,Maria Rosa Motta,Sara Trabanelli,Valeria Giudice,Elena Urbani,Giovanni Martinelli,Stefania Paolini,Fiorenza Fruet,Alessandro Isidori,Sarah Parisi,Giuseppe Bandini,Michele Baccarani,Andrea Velardi,Roberto M. Lemoli
View Articletitled, Successful transfer of alloreactive haploidentical KIR ligand-mismatched natural killer cells after infusion in elderly high risk acute myeloid leukemia patients
Supplemental data
Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells
Florian Kuchenbauer,Sarah M. Mah,Michael Heuser,Andrew McPherson,Jens Rüschmann,Arefeh Rouhi,Tobias Berg,Lars Bullinger,Bob Argiropoulos,Ryan D. Morin,David Lai,Daniel T. Starczynowski,Aly Karsan,Connie J. Eaves,Akira Watahiki,Yuzhuo Wang,Samuel A. Aparicio,Arnold Ganser,Jürgen Krauter,Hartmut Döhner,Konstanze Döhner,Marco A. Marra,Fernando D. Camargo,Lars Palmqvist,Christian Buske,R. Keith Humphries
View Articletitled, Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

TH1, TH2, and TH17 cells instruct monocytes to differentiate into specialized dendritic cell subsets
Michael N. Alonso,Michael T. Wong,Angela L. Zhang,Daniel Winer,Megan M. Suhoski,Lorna L. Tolentino,Juliana Gaitan,Matthew G. Davidson,Tiffany H. Kung,David M. Galel,Kari C. Nadeau,Jinah Kim,Paul J. Utz,Kalle Söderström,Edgar G. Engleman
View Articletitled, T<sub>H</sub>1, T<sub>H</sub>2, and T<sub>H</sub>17 cells instruct monocytes to differentiate into specialized dendritic cell subsets
Supplemental data
SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset
e-blood
Adam M. Zawada,Kyrill S. Rogacev,Björn Rotter,Peter Winter,Rolf-R. Marell,Danilo Fliser,Gunnar H. Heine
View Articletitled, SuperSAGE evidence for CD14<sup>++</sup>CD16<sup>+</sup> monocytes as a third monocyte subset
Supplemental data

Platelets and Thrombopoiesis

Clearance of circulating activated platelets in polycythemia vera and essential thrombocythemia
Norma Maugeri,Simona Malato,Eti A. Femia,Mariateresa Pugliano,Lara Campana,Francesca Lunghi,Patrizia Rovere-Querini,Federico Lussana,GianMarco Podda,Marco Cattaneo,Fabio Ciceri,Angelo A. Manfredi
View Articletitled, Clearance of circulating activated platelets in polycythemia vera and essential thrombocythemia
Supplemental data
Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression
Nauder Faraday,Lisa R. Yanek,Xiao Ping Yang,Rasika Mathias,J. Enrique Herrera-Galeano,Bhoom Suktitipat,Rehan Qayyum,Andrew D. Johnson,Ming-Huei Chen,Geoffrey H. Tofler,Ingo Ruczinski,Alan D. Friedman,Arnaldur Gylfason,Unnur Thorsteinsdottir,Paul F. Bray,Christopher J. O'Donnell,Diane M. Becker,Lewis C. Becker
View Articletitled, Identification of a specific intronic <em>PEAR1</em> gene variant associated with greater platelet aggregability and protein expression
Supplemental data

Red Cells, Iron, and Erythropoiesis

Intravenous iron for the treatment of fatigue in nonanemic, premenopausal women with low serum ferritin concentration
CME
Pierre-Alexandre Krayenbuehl,Edouard Battegay,Christian Breymann,Joerg Furrer,Georg Schulthess
View Articletitled, Intravenous iron for the treatment of fatigue in nonanemic, premenopausal women with low serum ferritin concentration
Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease
Cheryl A. Hillery,Patrick C. Kerstein,Daniel Vilceanu,Marie E. Barabas,Dawn Retherford,Amanda M. Brandow,Nancy J. Wandersee,Cheryl L. Stucky
View Articletitled, Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease
Supplemental data

Thrombosis and Hemostasis

Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin
Bin Zhang,Chunlei Zheng,Min Zhu,Jiayi Tao,Matthew P. Vasievich,Andrea Baines,Jinoh Kim,Randy Schekman,Randal J. Kaufman,David Ginsburg
View Articletitled, Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin
Supplemental data

Transplantation

Type I-IFNs control GVHD and GVL responses after transplantation
Renee J. Robb,Ellen Kreijveld,Rachel D. Kuns,Yana A. Wilson,Stuart D. Olver,Alistair L. J. Don,Neil C. Raffelt,Nicole A. De Weerd,Katie E. Lineburg,Antiopi Varelias,Kate A. Markey,Motoko Koyama,Andrew D. Clouston,Paul J. Hertzog,Kelli P. A. MacDonald,Geoffrey R. Hill
View Articletitled, Type I-IFNs control GVHD and GVL responses after transplantation
Mouse embryonic stem cell-derived thymic epithelial cell progenitors enhance T-cell reconstitution after allogeneic bone marrow transplantation
Laijun Lai,Cheng Cui,Jingjun Jin,Zhifang Hao,Qiuhong Zheng,Mingang Ying,Richard Boyd,Yong Zhao
View Articletitled, Mouse embryonic stem cell-derived thymic epithelial cell progenitors enhance T-cell reconstitution after allogeneic bone marrow transplantation
Supplemental data
BeEAM (bendamustine, etoposide, cytarabine, melphalan) before autologous stem cell transplantation is safe and effective for resistant/relapsed lymphoma patients
Clinical Trials & Observations
Giuseppe Visani,Lara Malerba,Pietro Maria Stefani,Saveria Capria,Piero Galieni,Francesco Gaudio,Giorgina Specchia,Giovanna Meloni,Filippo Gherlinzoni,Claudio Giardini,Sadia Falcioni,Francesca Cuberli,Marco Gobbi,Barbara Sarina,Armando Santoro,Felicetto Ferrara,Marco Rocchi,Enrique M. Ocio,Maria Dolores Caballero,Alessandro Isidori
View Articletitled, BeEAM (bendamustine, etoposide, cytarabine, melphalan) before autologous stem cell transplantation is safe and effective for resistant/relapsed lymphoma patients

Vascular Biology

Shiga toxin (Stx)1B and Stx2B induce von Willebrand factor secretion from human umbilical vein endothelial cells through different signaling pathways
Fang Liu,Jing Huang,J. Evan Sadler
View Articletitled, Shiga toxin (Stx)1B and Stx2B induce von Willebrand factor secretion from human umbilical vein endothelial cells through different signaling pathways
G-CSF supplementation with chemotherapy can promote revascularization and subsequent tumor regrowth: prevention by a CXCR4 antagonist
Tali Voloshin,Svetlana Gingis-Velitski,Rotem Bril,Liat Benayoun,Michal Munster,Chloe Milsom,Shan Man,Robert S. Kerbel,Yuval Shaked
View Articletitled, G-CSF supplementation with chemotherapy can promote revascularization and subsequent tumor regrowth: prevention by a CXCR4 antagonist
Supplemental data
Notch1 controls macrophage recruitment and Notch signaling is activated at sites of endothelial cell anastomosis during retinal angiogenesis in mice
Brief Report
Hasina H. Outtz,Ian W. Tattersall,Natalie M. Kofler,Nicole Steinbach,Jan Kitajewski
View Articletitled, Notch1 controls macrophage recruitment and Notch signaling is activated at sites of endothelial cell anastomosis during retinal angiogenesis in mice

Correspondence

The VH1-69–expressing marginal zone B cells expanded in HCV-associated mixed cryoglobulinemia display proliferative anergy irrespective of CD21low phenotype
Marcella Visentini,Maria Cagliuso,Valentina Conti,Maurizio Carbonari,Milvia Casato,Massimo Fiorilli
View Articletitled, The V<sub>H</sub>1-69–expressing marginal zone B cells expanded in HCV-associated mixed cryoglobulinemia display proliferative anergy irrespective of CD21<sup>low</sup> phenotype
Response: proliferative versus functional anergy
Edgar D. Charles,Lynn B. Dustin
View Articletitled, Response: proliferative versus functional anergy
A unique case of follicular lymphoma provides insights to the clonal evolution from follicular lymphoma in situ to manifest follicular lymphoma
Irina Bonzheim,Itziar Salaverria,Andrea Haake,Günther Gastl,Patrick Adam,Reiner Siebert,Falko Fend,Leticia Quintanilla-Martinez
View Articletitled, A unique case of follicular lymphoma provides insights to the clonal evolution from follicular lymphoma in situ to manifest follicular lymphoma
Concomitant occurrence of BCR-ABL and JAK2V617F mutation
Lisa Pieri,Ambra Spolverini,Barbara Scappini,Umberto Occhini,Silvia Birtolo,Alberto Bosi,Francesco Albano,Carmen Fava,Alessandro M. Vannucchi
View Articletitled, Concomitant occurrence of BCR-ABL and <em>JAK2</em>V617F mutation
Complete abolishment of coagulant activity in monomeric disulfide-deficient tissue factor
Lisa G. van den Hengel,Begüm Kocatürk,Pieter H. Reitsma,Wolfram Ruf,Henri H. Versteeg
View Articletitled, Complete abolishment of coagulant activity in monomeric disulfide-deficient tissue factor
Haploidentical hematopoietic stem cell transplantation for graft-versus-host disease after liver transplantation
Michael Kriss,Josephine Feliciano,Jonathan Fryer,Jayesh Mehta,Josh Levitsky
View Articletitled, Haploidentical hematopoietic stem cell transplantation for graft-versus-host disease after liver transplantation

Other Departments

Continuing Medical Education (CME) questions: intravenous iron for the treatment of fatigue
CME
View Articletitled, Continuing Medical Education (CME) questions: intravenous iron for the treatment of fatigue
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