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Journal Articles

CD19 Redirected CAR NK Cells Are Equally Effective but Less Toxic Than CAR T Cells

Concetta Quintarelli, PhD, Simona Sivori, PhD, Simona Caruso, PhD, Simona Carlomagno, PhD, Iolanda Boffa, PhDstudent, Domenico Orlando, PhDstudent, Marika Guercio, Biancamaria Cembrola, PhD, Angela Pitisci, Stefano Di Cecca, PhD, Giuseppina Li Pira, PhD, Luciana Vinti, MD, Biagio De Angelis, PhD, Lorenzo Moretta, MD PhD, Franco Locatelli

Blood (2018) 132 (Supplement 1): 3491.

https://doi.org/10.1182/blood-2018-99-118005

Published: 2018

Journal Articles

Alpha/Beta T-Cell and B-Cell Depletion HLA-Haploidentical Hematopoietic Stem Cell Transplantation Is an Effective Treatment for Children/Young Adults with Acute Leukemia

Pietro Merli, MD, Mattia Algeri, MD, Giuseppina Li Pira, PhD, Michela Falco, PhD, Daniela Pende, PhD, Valentina Bertaina, Daria Pagliara, MD PhD, Federica Galaverna, MD, Annalisa Ruggeri, MD PhD, Concetta Quintarelli, PhD, Lorenzo Moretta, MD PhD, Alice Bertaina, MD PhD, Franco Locatelli

Blood (2018) 132 (Supplement 1): 2169.

https://doi.org/10.1182/blood-2018-99-117136

Published: 2018

Journal Articles

Outcome of children with acute leukemia given HLA-haploidentical HSCT after αβ T-cell and B-cell depletion

Blood (2017) 130 (5): 677–685.

https://doi.org/10.1182/blood-2017-04-779769

Published: 2017

Includes: Supplemental data

Journal Articles

Zoledronic Acid Boosts γδ T-Cell Activity in Children Receiving αβ + T and CD19 + CELL-Depleted Grafts from a Haplo-Identical DONOR

Giulia Barbarito, Irma Airoldi, PhD, Alessia Zorzoli, Alice Bertaina, MDPhD, Andrea Petretto, Elvira Inglese, Chiara Lavarello, Letizia Pomponia Brescia, MD, Biagio De Angelis, PhD, Gino Tripodi, Pietro Merli, MD, Lorenzo Moretta, MD, Franco Locatelli, MD

Blood (2016) 128 (22): 5771.

https://doi.org/10.1182/blood.V128.22.5771.5771

Published: 2016

Journal Articles

T-Cell Depleted HLA-Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation (haplo-HSCT) Followed By Donor Lymphocyte Infusion with T Cells Transduced with the Inducible Caspase 9 (iC9) Suicide Gene in Children with Hematological Malignancies

Barbarella Lucarelli, MD, Alice Bertaina, MD PhD, Pietro Merli, MD, Concetta Quintarelli, PhD, Daniela Pende, MD, Michela Falco, PhD, Maria Giuseppina Cefalo, MD, Giuseppina Li Pira, PhD, Ignazio Caruana, PhD, Letizia Pomponia Brescia, MD, Luisa Strocchio, MD, Giuseppe Maria Milano, MD, Valentina Bertaina, PhD, Matilde Sinibaldi, PhD, Mattia Algeri, MD, Lorenzo Moretta, MD, Joanna Stanson, Annemarie Moseley, MD PhD, Franco Locatelli, MD

Blood (2016) 128 (22): 4683.

https://doi.org/10.1182/blood.V128.22.4683.4683

Published: 2016

Journal Articles

Children with Acute Leukemia Given Hematopoietic Stem Cell Transplantation (HSCT) from an HLA-Compatible Sibling, or an Unrelated Donor (UD) or an HLA-Haploidentical Relative after Alpha/Beta T-Cell Depletion Have a Comparable Outcome

Alice Bertaina, MDPhD, Barbarella Lucarelli, MD, Riccardo Masetti, MD, Pietro Merli, MD, Roberto Rondelli, MD, Giuseppina Li Pira, PhD, Marco Andreani, PhD, Lavinia Grapulin, MD, Daniela Pende, MD, Michela Falco, PhD, Maria Rita Pinto, MD, Valentina Bertaina, PhD, Maria Teresa Romano, MD, Stefano Ceccarelli, MD, Letizia Pomponia Brescia, MD, Daria Pagliara, MD, Alessandro Moretta, MD, Lorenzo Moretta, MD, Franco Locatelli, Prof, MD PhD

Blood (2015) 126 (23): 195.

https://doi.org/10.1182/blood.V126.23.195.195

Published: 2015

Journal Articles

Clinical Outcome after Adoptive Infusion of BPX-501 Cells (donor T cells transduced with iC9 suicide gene) in Children Given Alpha/Beta T-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (haplo-HSCT): Preliminary Results of a Phase I-II Trial

Franco Locatelli, Prof, MD PhD, Pietro Merli, MD, Giuseppina Li Pira, PhD, Valentina Bertaina, PhD, Barbarella Lucarelli, MD, Letizia Pomponia Brescia, MD, Mauro Montanari, MD, Daniela Pende, MD, Michela Falco, PhD, Daria Pagliara, MD, Maria Giuseppina Cefalo, MD, Alessandro Moretta, MD, Concetta Quintarelli, PhD, Brigitte Strahm, MD, Waseem Qasim, MBBS PhD, Mary Slatter, Lorenzo Moretta, MD, Annemarie Moseley, MDPhD, Alice Bertaina, MDPhD

Blood (2015) 126 (23): 1931.

https://doi.org/10.1182/blood.V126.23.1931.1931

Published: 2015

Journal Articles

Immune Reconstitution after Adoptive Infusion of BPX501 Cells (donor T cells transduced with iC9 suicide gene) in Children Given Alpha/Beta T-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (haplo-HSCT): Preliminary Phenotypic and Functional Results of a Phase I-II Trial

Pietro Merli, MD, Giuseppina Li Pira, PhD, Valentina Bertaina, PhD, Matilde Sinibaldi, PhD, Barbarella Lucarelli, MD, Letizia Pomponia Brescia, MD, Giuseppe Palumbo, MD, Giuseppe Maria Milano, MD, Maria Teresa Romano, MD, Valentina Cirillo, PhD, Luisa Strocchio, MD, Irma Airoldi, PhD, Luciana Vinti, MD, Concetta Quintarelli, PhD, Lorenzo Moretta, MD, Annemarie Moseley, MDPhD, Alice Bertaina, MDPhD, Franco Locatelli, Prof, MD PhD

Blood (2015) 126 (23): 3093.

https://doi.org/10.1182/blood.V126.23.3093.3093

Published: 2015

Journal Articles

γδ T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-αβ + /CD19 + lymphocytes

Irma Airoldi, Alice Bertaina, Ignazia Prigione, Alessia Zorzoli, Daria Pagliara, Claudia Cocco, Raffaella Meazza, Fabrizio Loiacono, Barbarella Lucarelli, Maria Ester Bernardo, Giulia Barbarito, Daniela Pende, Alessandro Moretta, Vito Pistoia, Lorenzo Moretta, Franco Locatelli

Blood (2015) 125 (15): 2349–2358.

https://doi.org/10.1182/blood-2014-09-599423

Published: 2015

Includes: Supplemental data

Journal Articles

KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with ALL

Lena Oevermann, Sebastian U. Michaelis, Markus Mezger, Peter Lang, Jacek Toporski, Alice Bertaina, Marco Zecca, Lorenzo Moretta, Franco Locatelli, Rupert Handgretinger

Blood (2014) 124 (17): 2744–2747.

https://doi.org/10.1182/blood-2014-03-565069

Published: 2014

Journal Articles

HLA-haploidentical stem cell transplantation after removal of αβ + T and B cells in children with nonmalignant disorders

Blood (2014) 124 (5): 822–826.

https://doi.org/10.1182/blood-2014-03-563817

Published: 2014

Journal Articles

Recovery Of Gamma/Delta+ T Cells After Transplantation With Alpha-Beta+/CD19+ Lymphocyte Depleted Hematopoietic Stem Cells From HLA-Haploidentical Donors

Irma Airoldi, PhD, Ignazia Prigione, PhD, Alice Bertaina, MD, Claudia Cocco, PhD, Daria Pagliara, MD, Alessia Zorzoli, Dr., Sergio Rutella, MD, Rita M Pinto, MD, Vito Pistoia, MD, Riccardo Masetti, MD, Mariateresa Romano, MD, Francesca Di Florio, Dr, Francesca Del Bufalo, MD, Lorenzo Moretta, MD, Franco Locatelli

Blood (2013) 122 (21): 3245.

https://doi.org/10.1182/blood.V122.21.3245.3245

Published: 2013

Journal Articles

Removal Of Alpha/Beta+ T Cells and Of CD19+ B Cells From The Graft Translates Into Rapid Engraftment, Absence Of Visceral Graft-Versus-Host Disease and Low Transplant-Related Mortality In Children With Acute Leukemia Given HLA-Haploidentical Hematopoietic Stem Cell Transplantation

Blood (2013) 122 (21): 157.

https://doi.org/10.1182/blood.V122.21.157.157

Published: 2013

Journal Articles

KIR2DS1-dependent acquisition of CCR7 and migratory properties by human NK cells interacting with allogeneic HLA-C2 + DCs or T-cell blasts

Emanuela Marcenaro, Silvia Pesce, Simona Sivori, Simona Carlomagno, Lorenzo Moretta, Alessandro Moretta

Blood (2013) 121 (17): 3396–3401.

https://doi.org/10.1182/blood-2012-09-458752

Published: 2013

Journal Articles

HLA Haploidentical Stem Cell Transplantation After Removal of αβ + T Lymphocytes and B Lymphocytes Is an Effective Treatment for Children with Life-Threatening, Non-Malignant Disorders

Alice Bertaina, MD, Mariateresa Romano, MD, Sergio Rutella, MD PhD, Giuseppe Palumbo, MD, Daria Pagliara, MD, Stefano Ceccarelli, MD, Letizia P Brescia, MD, Giuseppina Li Pira, BSc, Francesca Cocca, MD, Maria Ester Bernardo, MD, Giuseppe M Milano, MD, Daniela Pende, PhD, Michela Falco, BSc, Lorenzo Moretta, MD, Franco Locatelli, MD, PhD

Blood (2012) 120 (21): 2018.

https://doi.org/10.1182/blood.V120.21.2018.2018

Published: 2012

Journal Articles

Human NK cells at early stages of differentiation produce CXCL8 and express CD161 molecule that functions as an activating receptor

Elisa Montaldo, Chiara Vitale, Francesca Cottalasso, Romana Conte, Timor Glatzer, Paolo Ambrosini, Lorenzo Moretta, Maria Cristina Mingari

Blood (2012) 119 (17): 3987–3996.

https://doi.org/10.1182/blood-2011-09-379693

Published: 2012

Includes: Supplemental data

Journal Articles

A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes

Blood (2012) 119 (12): 2754–2763.

https://doi.org/10.1182/blood-2011-08-374199

Published: 2012

Includes: Supplemental data

Journal Articles

Phenotypic and functional heterogeneity of human NK cells developing after umbilical cord blood transplantation: a role for human cytomegalovirus?

Mariella Della Chiesa, Michela Falco, Marina Podestà, Franco Locatelli, Lorenzo Moretta, Francesco Frassoni, Alessandro Moretta

Blood (2012) 119 (2): 399–410.

https://doi.org/10.1182/blood-2011-08-372003

Published: 2012

Includes: Supplemental data

Journal Articles

Transplantation of TcRαβ/CD19 Depleted Stem Cells From Haploidentical Donors: Robust Engraftment and Rapid Immune Reconstitution In Children with High Risk Leukemia

Rupert Handgretinger, MD, Peter Lang, MD, Tobias F. Feuchtinger, MD, Michael Schumm, DVM, Heiko-Manuel Teltschik, MD, Ansgar S Schulz, MD, PhD, Volker Huppert, PhD, Lorenzo Moretta, MD, Alesandro Moretta, MD, Maria Ester Bernardo, MD, Maurizio Caniglia, MD, Alice Bertaina, MD, Francesco Zinno, MD, Franco Locatelli, MD

Blood (2011) 118 (21): 1005.

https://doi.org/10.1182/blood.V118.21.1005.1005

Published: 2011

Journal Articles

Dual-functional capability of CD3 + CD56 + CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity

Alice Pievani, Gianmaria Borleri, Daniela Pende, Lorenzo Moretta, Alessandro Rambaldi, Josée Golay, Martino Introna

Blood (2011) 118 (12): 3301–3310.

https://doi.org/10.1182/blood-2011-02-336321

Published: 2011

Includes: Supplemental data

NARROW

CD19 Redirected CAR NK Cells Are Equally Effective but Less Toxic Than CAR T Cells

Alpha/Beta T-Cell and B-Cell Depletion HLA-Haploidentical Hematopoietic Stem Cell Transplantation Is an Effective Treatment for Children/Young Adults with Acute Leukemia

Outcome of children with acute leukemia given HLA-haploidentical HSCT after αβ T-cell and B-cell depletion

Zoledronic Acid Boosts γδ T-Cell Activity in Children Receiving αβ + T and CD19 + CELL-Depleted Grafts from a Haplo-Identical DONOR

T-Cell Depleted HLA-Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation (haplo-HSCT) Followed By Donor Lymphocyte Infusion with T Cells Transduced with the Inducible Caspase 9 (iC9) Suicide Gene in Children with Hematological Malignancies

Children with Acute Leukemia Given Hematopoietic Stem Cell Transplantation (HSCT) from an HLA-Compatible Sibling, or an Unrelated Donor (UD) or an HLA-Haploidentical Relative after Alpha/Beta T-Cell Depletion Have a Comparable Outcome

Clinical Outcome after Adoptive Infusion of BPX-501 Cells (donor T cells transduced with iC9 suicide gene) in Children Given Alpha/Beta T-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (haplo-HSCT): Preliminary Results of a Phase I-II Trial

Immune Reconstitution after Adoptive Infusion of BPX501 Cells (donor T cells transduced with iC9 suicide gene) in Children Given Alpha/Beta T-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell Transplantation (haplo-HSCT): Preliminary Phenotypic and Functional Results of a Phase I-II Trial

γδ T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-αβ + /CD19 + lymphocytes

KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with ALL

HLA-haploidentical stem cell transplantation after removal of αβ + T and B cells in children with nonmalignant disorders

Recovery Of Gamma/Delta+ T Cells After Transplantation With Alpha-Beta+/CD19+ Lymphocyte Depleted Hematopoietic Stem Cells From HLA-Haploidentical Donors

Removal Of Alpha/Beta+ T Cells and Of CD19+ B Cells From The Graft Translates Into Rapid Engraftment, Absence Of Visceral Graft-Versus-Host Disease and Low Transplant-Related Mortality In Children With Acute Leukemia Given HLA-Haploidentical Hematopoietic Stem Cell Transplantation

KIR2DS1-dependent acquisition of CCR7 and migratory properties by human NK cells interacting with allogeneic HLA-C2 + DCs or T-cell blasts

HLA Haploidentical Stem Cell Transplantation After Removal of αβ + T Lymphocytes and B Lymphocytes Is an Effective Treatment for Children with Life-Threatening, Non-Malignant Disorders

Human NK cells at early stages of differentiation produce CXCL8 and express CD161 molecule that functions as an activating receptor

A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes

Phenotypic and functional heterogeneity of human NK cells developing after umbilical cord blood transplantation: a role for human cytomegalovirus?

Transplantation of TcRαβ/CD19 Depleted Stem Cells From Haploidentical Donors: Robust Engraftment and Rapid Immune Reconstitution In Children with High Risk Leukemia

Dual-functional capability of CD3 + CD56 + CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity

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American Society of Hematology

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American Society of Hematology

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