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Acute promyelocytic leukemia blasts with t(X;17)(p11;q12), resulting in BCOR-RARA fusion transcript, exhibit unique cytoplasmic inclusion bodies. The patient's bone marrow cells were positively stained with Sudan black B. The blasts typically show round inclusions as indicated at the upper right corner and rectangular cytoplasmic bodies. A complex of rectangular inclusions, reminiscent of the Chinese character meaning “six,” was observed at the middle left panel. See the article by Yamamoto et al on page 4274.
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Cardiac complete response in AL amyloidosis has similar survival to matched general population

Randomized Bendamustine-Rituximab(R) + Bortezomib Induction and R + Lenalidomide Maintenance for Mantle Cell Lymphoma

Heme induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice

Interleukin-1 mediated hyperinflammation in XIAP-deficiency is associated with defective autophagy.

NOVEL THERAPEUTIC APPROACHES IN THALASSEMIAS, SICKLE CELL DISEASE AND OTHER RED CELL DISORDERS

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Review Article

How I Treat

Clinical Trials and Observations

Rationale and efficacy of interleukin-1 targeting in Erdheim–Chester disease Clinical Trials & Observations

Gene therapy

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19 Brief Report

Hematopoiesis and Stem Cells

Vitamin D receptor deletion leads to increased hematopoietic stem and progenitor cells residing in the spleen Brief Report

Immunobiology

Lymphoid Neoplasia

DNA methylation signatures define molecular subtypes of diffuse large B-cell lymphoma e-blood

InterLymph hierarchical classification of lymphoid neoplasms for epidemiologic research based on the WHO classification (2008): update and future directions e-blood

Myeloid Neoplasia

Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: a randomized, placebo-controlled trial of the Eastern Cooperative Oncology Group 3999 Clinical Trials & Observations

Distinct clinical and biological features of de novo acute myeloid leukemia with additional sex comb-like 1 (ASXL1) mutations Clinical Trials & Observations

Recurrent expression signatures of cytokines and chemokines are present and are independently prognostic in acute myelogenous leukemia and myelodysplasia Clinical Trials & Observations

Phagocytes, Granulocytes, and Myelopoiesis

Improvement in hematological, visceral, and skeletal manifestations of Gaucher disease type 1 with oral eliglustat tartrate (Genz-112638) treatment: 2-year results of a phase 2 study Brief Report

Platelets and Thrombopoiesis

Red Cells, Iron, and Erythropoiesis

Fetal globin expression is regulated by Friend of Prmt1 Brief Report

Thrombosis and Hemostasis

Transplantation

Adoptive transfer of pp65-specific T cells for the treatment of chemorefractory cytomegalovirus disease or reactivation after haploidentical and matched unrelated stem cell transplantation Clinical Trials & Observations

Allogeneic stem cell transplantation for adult Philadelphia chromosome–negative acute lymphocytic leukemia: comparable survival rates but different risk factors between related and unrelated transplantation in first complete remission Clinical Trials & Observations

Vascular Biology

Treatment with the Bcl-xL inhibitor ABT-737 in combination with interferon α specifically targets JAK2V617F-positive polycythemia vera hematopoietic progenitor cells Brief Report

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Rationale and efficacy of interleukin-1 targeting in Erdheim–Chester disease
Clinical Trials & Observations

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19
Brief Report

Vitamin D receptor deletion leads to increased hematopoietic stem and progenitor cells residing in the spleen
Brief Report

DNA methylation signatures define molecular subtypes of diffuse large B-cell lymphoma
e-blood

InterLymph hierarchical classification of lymphoid neoplasms for epidemiologic research based on the WHO classification (2008): update and future directions
e-blood

Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: a randomized, placebo-controlled trial of the Eastern Cooperative Oncology Group 3999
Clinical Trials & Observations

Distinct clinical and biological features of de novo acute myeloid leukemia with additional sex comb-like 1 (ASXL1) mutations
Clinical Trials & Observations

Recurrent expression signatures of cytokines and chemokines are present and are independently prognostic in acute myelogenous leukemia and myelodysplasia
Clinical Trials & Observations

Improvement in hematological, visceral, and skeletal manifestations of Gaucher disease type 1 with oral eliglustat tartrate (Genz-112638) treatment: 2-year results of a phase 2 study
Brief Report

Fetal globin expression is regulated by Friend of Prmt1
Brief Report

Adoptive transfer of pp65-specific T cells for the treatment of chemorefractory cytomegalovirus disease or reactivation after haploidentical and matched unrelated stem cell transplantation
Clinical Trials & Observations

Allogeneic stem cell transplantation for adult Philadelphia chromosome–negative acute lymphocytic leukemia: comparable survival rates but different risk factors between related and unrelated transplantation in first complete remission
Clinical Trials & Observations

Treatment with the Bcl-xL inhibitor ABT-737 in combination with interferon α specifically targets JAK2V617F-positive polycythemia vera hematopoietic progenitor cells
Brief Report