Skip to Main Content

Advertisement intended for health care professionals

American Society of Hematology Logo Open Menu
Cart
header search
Search
Skip Nav Destination

Issue Archive

Volume 115, Issue 3
January 21 2010
Blood Cover Image for Volume 115, Issue 3

Table of Contents

INSIDE BLOOD

CLINICAL TRIALS
Improving FCR immunochemotherapy in CLL
Tadeusz Robak
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
HEMATOPOIESIS & STEM CELLS
Every cloud has a silver lining
Cristina Lo Celso
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
THROMBOSIS & HEMOSTASIS
Oxidative stress on VWF proteolysis
Jing-fei Dong
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
THROMBOSIS & HEMOSTASIS
Opposites attract
Andreas Greinacher
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

PLENARY PAPERS

In vivo cellular imaging pinpoints the role of reactive oxygen species in the early steps of adult hematopoietic reconstitution
Daniel Lewandowski,Vilma Barroca,Frédéric Ducongé,Jan Bayer,Jeanne Tran Van Nhieu,Carine Pestourie,Pierre Fouchet,Bertrand Tavitian,Paul-Henri Roméo
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data

REVIEW ARTICLES

Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet
Hartmut Döhner,Elihu H. Estey,Sergio Amadori,Frederick R. Appelbaum,Thomas Büchner,Alan K. Burnett,Hervé Dombret,Pierre Fenaux,David Grimwade,Richard A. Larson,Francesco Lo-Coco,Tomoki Naoe,Dietger Niederwieser,Gert J. Ossenkoppele,Miguel A. Sanz,Jorge Sierra,Martin S. Tallman,Bob Löwenberg,Clara D. Bloomfield
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

CLINICAL TRIALS AND OBSERVATIONS

Results of a phase 2 study of bortezomib in patients with relapsed or refractory indolent lymphoma
Clinical Trials & Observations
Nicholas Di Bella,Raymond Taetle,Kathryn Kolibaba,Thomas Boyd,Robert Raju,David Barrera,Ernest W. Cochran, Jr,Philip Y. Dien,Roger Lyons,Peter J. Schlegel,Svetislava J. Vukelja,Julie Boston,Kristi A. Boehm,Yunfei Wang,Lina Asmar
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Usefulness of repeated D-dimer testing after stopping anticoagulation for a first episode of unprovoked venous thromboembolism: the PROLONG II prospective study
Clinical Trials & Observations
Benilde Cosmi,Cristina Legnani,Alberto Tosetto,Vittorio Pengo,Angelo Ghirarduzzi,Sophie Testa,Domenico Prisco,Daniela Poli,Armando Tripodi,Francesco Marongiu,Gualtiero Palareti,for the PROLONG Investigators (on behalf of Italian Federation of Anticoagulation Clinics)
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Phase 1/2 study of lumiliximab combined with fludarabine, cyclophosphamide, and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia
Clinical Trials & Observations
John C. Byrd,Thomas J. Kipps,Ian W. Flinn,Januaro Castro,Thomas S. Lin,William Wierda,Nyla Heerema,James Woodworth,Steve Hughes,Shabnam Tangri,Sarah Harris,Dee Wynne,Arturo Molina,Bryan Leigh,Susan O'Brien
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
International Prognostic Scoring System–independent cytogenetic risk categorization in primary myelofibrosis
Brief Report
Kebede Hussein,Animesh D. Pardanani,Daniel L. Van Dyke,Curtis A. Hanson,Ayalew Tefferi
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data

GENE THERAPY

Induction of immune tolerance to FIX by intramuscular AAV gene transfer is independent of the activation status of dendritic cells
Arpita S. Bharadwaj,Meagan Kelly,Dongsoo Kim,Hengjun Chao
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

HEMATOPOIESIS AND STEM CELLS

Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development
Xiaoming Feng,Gregory C. Ippolito,Lifeng Tian,Karla Wiehagen,Soyoung Oh,Arivazhagan Sambandam,Jessica Willen,Ralph M. Bunte,Shanna D. Maika,June V. Harriss,Andrew J. Caton,Avinash Bhandoola,Philip W. Tucker,Hui Hu
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data

IMMUNOBIOLOGY

Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells
Santi Suryani,David A. Fulcher,Brigitte Santner-Nanan,Ralph Nanan,Melanie Wong,Peter J. Shaw,John Gibson,Andrew Williams,Stuart G. Tangye
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data
Regulating human Th17 cells via differential expression of IL-1 receptor
Won-Woo Lee,Seong Wook Kang,Jihoon Choi,Seung-Hyun Lee,Kamini Shah,Elizabeth E. Eynon,Richard A. Flavell,Insoo Kang
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data
The role of the Th1 transcription factor T-bet in a mouse model of immune-mediated bone-marrow failure
Yong Tang,Marie J. Desierto,Jichun Chen,Neal S. Young
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Annexin A2 tetramer activates human and murine macrophages through TLR4
Jennifer F. A. Swisher,Nicholas Burton,Silvia M. Bacot,Stefanie N. Vogel,Gerald M. Feldman
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

LYMPHOID NEOPLASIA

Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia
Aldo M. Roccaro,Antonio Sacco,Emanuel N. Husu,Costas Pitsillides,Steven Vesole,Abdel Kareem Azab,Feda Azab,Molly Melhem,Hai T. Ngo,Phong Quang,Patricia Maiso,Judith Runnels,Mei-Chih Liang,Kwok-Kin Wong,Charles Lin,Irene M. Ghobrial
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data
Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas
Kristopher A. Sarosiek,Raquel Malumbres,Hovav Nechushtan,Andrew J. Gentles,Eli Avisar,Izidore S. Lossos
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data
Gastric MALT lymphoma B cells express polyreactive, somatically mutated immunoglobulins
Vanessa J. Craig,Isabelle Arnold,Christiane Gerke,Minh Q. Huynh,Thomas Wündisch,Andreas Neubauer,Christoph Renner,Stanley Falkow,Anne Müller
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data
A recombinant adenovirus type 35 fiber knob protein sensitizes lymphoma cells to rituximab therapy
Hongjie Wang,Ying Liu,Zong-Yi Li,Xiaolong Fan,Akseli Hemminki,André Lieber
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data
Targeting EXT1 reveals a crucial role for heparan sulfate in the growth of multiple myeloma
Brief Report
Rogier M. Reijmers,Richard W. J. Groen,Henk Rozemuller,Annemieke Kuil,Anneke de Haan-Kramer,Tamás Csikós,Anton C. M. Martens,Marcel Spaargaren,Steven T. Pals
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data

MYELOID NEOPLASIA

Immunomodulatory derivatives induce PU.1 down-regulation, myeloid maturation arrest, and neutropenia
Rekha Pal,Sara A. Monaghan,Andrea Cortese Hassett,Markus Y. Mapara,Peter Schafer,G. David Roodman,Margaret V. Ragni,Lynn Moscinski,Alan List,Suzanne Lentzsch
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data
SETBP1 overexpression is a novel leukemogenic mechanism that predicts adverse outcome in elderly patients with acute myeloid leukemia
Ion Cristóbal,Francisco J. Blanco,Laura Garcia-Orti,Nerea Marcotegui,Carmen Vicente,José Rifon,Francisco J. Novo,Eva Bandres,María J. Calasanz,Carmelo Bernabeu,María D. Odero
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data
PTEN is a tumor suppressor in CML stem cells and BCR-ABL–induced leukemias in mice
Cong Peng,Yaoyu Chen,Zhongfa Yang,Haojian Zhang,Lori Osterby,Alan G. Rosmarin,Shaoguang Li
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data
Quantitative DNA methylation predicts survival in adult acute myeloid leukemia
Lars Bullinger,Mathias Ehrich,Konstanze Döhner,Richard F. Schlenk,Hartmut Döhner,Matthew R. Nelson,Dirk van den Boom
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data
Leukemic transformation by the APL fusion protein PRKAR1A-RARα critically depends on recruitment of RXRα
Jihui J. Qiu,Xiaoxi Lu,Bernd B. Zeisig,Zhigui Ma,Xun Cai,Saijuan Chen,Hinrich Gronemeyer,David J. Tweardy,Chi Wai Eric So,Shuo Dong
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data
DNA vaccination with all-trans retinoic acid treatment induces long-term survival and elicits specific immune responses requiring CD4+ and CD8+ T-cell activation in an acute promyelocytic leukemia mouse model
Brief Report
Kouichi Furugaki,Katerina Pokorna,Carole Le Pogam,Masayuki Aoki,Murielle Reboul,Véronique Bajzik,Patricia Krief,Anne Janin,Marie-Elena Noguera,Robert West,Dominique Charron,Christine Chomienne,Marika Pla,Hélène Moins-Teisserenc,Rose Ann Padua
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Orai1 regulates intracellular calcium, arrest, and shape polarization during neutrophil recruitment in shear flow
Ulrich Y. Schaff,Neha Dixit,Emily Procyk,Itsukyo Yamayoshi,Tiffany Tse,Scott I. Simon
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data
Comparison of gene expression profiles between human and mouse monocyte subsets
e-blood
Molly A. Ingersoll,Rainer Spanbroek,Claudio Lottaz,Emmanuel L. Gautier,Marion Frankenberger,Reinhard Hoffmann,Roland Lang,Muzlifah Haniffa,Matthew Collin,Frank Tacke,Andreas J. R. Habenicht,Loems Ziegler-Heitbrock,Gwendalyn J. Randolph
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data

PLATELETS AND THROMBOPOIESIS

Src tyrosine kinase preactivation is associated with platelet hypersensitivity in essential thrombocythemia and polycythemia vera
Maria Luigia Randi,Anna Maria Brunati,Margherita Scapin,Martina Frasson,Renzo Deana,Elisa Magrin,Fabrizio Fabris,Arianna Donella-Deana
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation
Hozumi Motohashi,Momoko Kimura,Rie Fujita,Ai Inoue,Xiaoqing Pan,Mariko Takayama,Fumiki Katsuoka,Hiroyuki Aburatani,Emery H. Bresnick,Masayuki Yamamoto
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

High-mobility group protein HMGB2 regulates human erythroid differentiation through trans-activation of GFI1B transcription
Benoît Laurent,Voahangy Randrianarison-Huetz,Vincent Maréchal,Patrick Mayeux,Isabella Dusanter-Fourt,Dominique Duménil
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data
Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages
Céline Barrès,Lionel Blanc,Pascale Bette-Bobillo,Sabine André,Robert Mamoun,Hans-Joachim Gabius,Michel Vidal
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data

THROMBOSIS AND HEMOSTASIS

Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13
Junmei Chen,Xiaoyun Fu,Yi Wang,Minhua Ling,Brad McMullen,John Kulman,Dominic W. Chung,José A. López
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
β2 Glycoprotein I (β2GPI) binds platelet factor 4 (PF4): implications for the pathogenesis of antiphospholipid syndrome
Marina P. Sikara,John G. Routsias,Martina Samiotaki,George Panayotou,Haralampos M. Moutsopoulos,Panayiotis G. Vlachoyiannopoulos
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text

TRANSPLANTATION

Immunization with host-type CD8α+ dendritic cells reduces experimental acute GVHD in an IL-10–dependent manner
Tomomi Toubai,Chelsea Malter,Isao Tawara,Chen Liu,Evelyn Nieves,Kathleen P. Lowler,Yaping Sun,Pavan Reddy
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data

VASCULAR BIOLOGY

In vivo biotinylation of the vasculature in B-cell lymphoma identifies BST-2 as a target for antibody-based therapy
Christoph Schliemann,Christoph Roesli,Haruhiko Kamada,Beatrice Borgia,Tim Fugmann,Wolfram Klapper,Dario Neri
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Supplemental data

CORRESPONDENCE

Comparison of prognostic scoring systems in primary myelofibrosis
Pierre Morel,Alain Duhamel
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Response: Capturing variables with prognostic relevance in development of a new scoring system for primary myelofibrosis
Francisco Cervantes,Arturo Pereira,Ayalew Tefferi
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Chemokine receptors as therapeutic tools in Hodgkin lymphoma: CCR4 and beyond
Donatella Aldinucci,Antonio Pinto,Annunziata Gloghini,Antonino Carbone
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Response: To force the expression of CCR4 and/or of CCR5 chemokine receptor in T cells for immunotherapy of Hodgkin lymphoma: that is the question
Gianpietro Dotti,Barbara Savoldo
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
WHO classification of myeloid neoplasms and leukemia
Hannes Wandt,Torsten Haferlach,Christian Thiede,Gerhard Ehninger
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
Response: Factors considered in the 2008 WHO classification of myeloid neoplasms and acute leukemias
James Vardiman,Jürgen Thiele,Daniel A. Arber,Richard Brunning,Michael J. Borowitz,Anna Porwit,Nancy Lee Harris,Michelle M. Le Beau,Eva Hellström-Lindberg,Ayalew Tefferi,Clara D. Bloomfield
View Articletitled, SCM.SharedControls.Infrastructure.TitleDisplayModel?.Text
  • Cover Image

    Cover Image

    issue cover

    This figure depicts a plausible model for the mode of autoantibody binding to β2GPI antigen. Platelet factor 4 tetramer binds to β2GPI, promoting the natural dimerization of the latter. Upon dimerization of β2GPI, the epitopes—that thrombosis-associated antibodies recognize on domain I—are arranged in a geometry that precisely fits to the 2 antigen-binding sites of an antibody, allowing their bivalent recognition by low-affinity autoantibodies. On the opposite site of the β2GPI-PF4 complex, positively charged patches in domain V of β2GPI are involved in interaction with negatively charged membranes. See article by Sikara et al on page 713.

  • PDF Icon Front MatterFront Matter
  • PDF Icon Table of ContentsTable of Contents
  • PDF Icon Back MatterBack Matter
  • PDF Icon AdvertisingAdvertising
  • PDF Icon Editorial BoardEditorial Board
All Issues

Advertisement intended for health care professionals

Integrin αvβ8-mediated TGF-β1 activation regulates sustained response in immune thrombocytopenia after TPO-RA withdrawal
CPX-351 versus daunorubicin, cytarabine plus gemtuzumab ozogamicin in older adults with non-adverse risk AML: NCRI AML18
Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation
Highly discriminative globin gene activation by the non-canonical BAF chromatin remodeling complex
Hijack the HiJAKer: rethinking therapy for JAK2-mutant MPN

Advertisement intended for health care professionals

Advertisement intended for health care professionals

  • American Society of Hematology
  • 2021 L Street NW, Suite 900
  • Washington, DC 20036
  • TEL +1 202-776-0544
  • FAX +1 202-776-0545

ASH Publications

American Society of Hematology

Copyright 2025 by American Society of Hematology
 
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal

Advertisement intended for health care professionals