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John Kulman
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Journal Articles

BIVV001, a new class of factor VIII replacement for hemophilia A that is independent of von Willebrand factor in primates and mice

Ekta Seth Chhabra, Tongyao Liu, John Kulman, Susannah Patarroyo-White, Buyue Yang, Qi Lu, Douglas Drager, Nancy Moore, Jiayun Liu, Amy M. Holthaus, Jurg M. Sommer, Ayman Ismail, Deana Rabinovich, Zhan Liu, Arjan van der Flier, Allison Goodman, Chris Furcht, Mark Tie, Tyler Carlage, Randy Mauldin, Terrence M. Dobrowsky, Zhiqian Liu, Oblaise Mercury, Lily Zhu, Baisong Mei, Volker Schellenberger, Haiyan Jiang, Glenn F. Pierce, Joe Salas, Robert Peters
Journal: Blood
Blood (2020) 135 (17): 1484–1496.
https://doi.org/10.1182/blood.2019001292
Published: 2020
Includes: Supplemental data
Journal Articles

Recombinant FIX/X-Bp from the Japanese Habu Snake Is a Universal Ligand for Purification of Highly Carboxylated Factor IX Variants and Factor X

Oblaise Mercury, BS, Lucy Liu, PhD, Ayman Ismail, PhD, Ming Zhang, PhD, Qi Lu, PhD, Tom O Cameron, PhD, Allison Goodman, BS, Liz Culyba, PhD, Rahul Ravindran Nair, BS, MS, Amy M Holthaus, BS, MS, John Kulman, PhD, Robert Peters, PhD
Journal: Blood
Blood (2015) 126 (23): 1081.
https://doi.org/10.1182/blood.V126.23.1081.1081
Published: 2015
Journal Articles

Evaluation of Enhanced in Vitro Plasma Stability of a Novel Long Acting Recombinant FVIIIFc-VWF-XTEN Fusion Protein

Ekta Seth Chhabra, PhD, Nancy Moore, Chris Furcht, Amy M Holthaus, BS, MS, Jiayun Liu, MS, Tongyao Liu, Volker Schellenberger, PhD, John Kulman, PhD, Joe Salas, PhD, Robert Peters, PhD
Journal: Blood
Blood (2015) 126 (23): 2279.
https://doi.org/10.1182/blood.V126.23.2279.2279
Published: 2015
Journal Articles

Identification of Active Coagulation Factor IX Variants with Insertion or Fusion of Unstructured Polypeptide Xten

Zhiqian Lucy Liu, PhD, Arjan van der Flier, PhD, Sara Bardan, Sheng Ding, Volker Schellenberger, PhD, John Kulman, PhD, Robert Peters, PhD
Journal: Blood
Blood (2015) 126 (23): 2280.
https://doi.org/10.1182/blood.V126.23.2280.2280
Published: 2015
Journal Articles

Recombinant FVIIIFc-VWF-XTEN Demonstrates Significant Bioavailability Following Subcutaneous Administration in Hemophilia A Mice

Douglas Drager, Sue Patarroyo-White, Hoson Chao, Ayman Ismail, PhD, Jiayun Liu, Amy M Holthaus, BS, MS, Ekta Chhabra, John Kulman, PhD, Volker Schellenberger, PhD, Tongyao Liu, Robert Peters, PhD
Journal: Blood
Blood (2015) 126 (23): 3492.
https://doi.org/10.1182/blood.V126.23.3492.3492
Published: 2015
Journal Articles

Prolonged Half-Life and Improved Recovery of Recombinant Factor IX-XTEN Fusion Proteins in Hemophilia B Mouse Model

Arjan van der Flier, PhD, Zhiqian Lucy Liu, PhD, Zhan Liu, MSc, Oblaise Mercury, BS, Ayman Ismail, PhD, Ekta Seth-Chhabra, PhD, John Kulman, PhD, Volker Schellenberger, PhD, David R. Light, PhD, Robert Peters, PhD
Journal: Blood
Blood (2015) 126 (23): 2271.
https://doi.org/10.1182/blood.V126.23.2271.2271
Published: 2015
Journal Articles

Assessing Structure-Activity Relationships in FVIII By Integration of Structural, Biophysical, and Biochemical Data Obtained with Anti-FVIII Antibodies

Zhiqian Lucy Liu, PhD, George Bou-Assaf, PhD, Ming Zhang, PhD, Allison Goodman, Po-lin Chiu, PhD, Melissa Chambers, Thomas Walz, PhD, Robert Peters, PhD, John Kulman, PhD
Journal: Blood
Blood (2014) 124 (21): 4223.
https://doi.org/10.1182/blood.V124.21.4223.4223
Published: 2014
Journal Articles

Evidence For Flexible Tethering Of Fc To FVIII In Recombinant FVIII-Fc Fusion Protein rFVIIIFc

Nina Leksa, Ph.D., Lucy Liu, Ph.D., Allison Goodman, Po-lin Chiu, Ph.D., Thomas Walz, Ph.D., Robert Peters, Ph.D., John Kulman, Ph.D.
Journal: Blood
Blood (2013) 122 (21): 1102.
https://doi.org/10.1182/blood.V122.21.1102.1102
Published: 2013
Journal Articles

Structural Comparability Between Recombinant FVIII-Fc and Its Isolated FVIII and Fc Constituents

John Kulman, Ph.D., Susan Tsutakawa, PhD, George Bou-Assaf, PhD, Steven Berkowitz, PhD, David R. Light, PhD, Adam Mezo, PhD, Deping Wang, PhD, Marc Whitlow, PhD, Liz Culyba, PhD, John Tainer, PhD, Robert Peters, PhD
Journal: Blood
Blood (2012) 120 (21): 1135.
https://doi.org/10.1182/blood.V120.21.1135.1135
Published: 2012
Journal Articles

Calcium-Independent Detection and Isolation of Phosphatidylserine-Exposing Cells and Microparticles Using Recombinant Del-1

Pavel Davizon, MD, John Kulman, PhD, José A. López, MD
Journal: Blood
Blood (2010) 116 (21): 4224.
https://doi.org/10.1182/blood.V116.21.4224.4224
Published: 2010
Journal Articles

Regulation of Von Willebrand Factor A1 Domain by Mechanical Force and Neighboring Domains

Wendy E Thomas, PhD, Rebecca A Penkala, Elaine Hillenmeyer, Matthew Whitfield, An-yue Tu, Adam D Munday, Peter J Lenting, John Kulman, PhD, José A. López, MD
Journal: Blood
Blood (2010) 116 (21): 2117.
https://doi.org/10.1182/blood.V116.21.2117.2117
Published: 2010
Journal Articles

Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13

Junmei Chen, Xiaoyun Fu, Yi Wang, Minhua Ling, Brad McMullen, John Kulman, Dominic W. Chung, José A. López
Journal: Blood
Blood (2010) 115 (3): 706–712.
https://doi.org/10.1182/blood-2009-03-213967
Published: 2010
Journal Articles

Oxidative Modification of Von Willebrand Factor Inhibits Its Cleavage by ADAMTS13

Junmei Chen, PhD, Xiaoyun Fu, Ph.D, Minhua Ling, PhD, Brad McMullen, John Kulman, PhD, Dominic Chung, PhD, Jose A Lopez, MD
Journal: Blood
Blood (2008) 112 (11): 3921.
https://doi.org/10.1182/blood.V112.11.3921.3921
Published: 2008