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Journal Articles

How unique structural adaptations support and coordinate the complex function of von Willebrand factor

Peter J. Lenting, Cécile V. Denis, Olivier D. Christophe

Blood (2024) 144 (21): 2174–2184.

https://doi.org/10.1182/blood.2023023277

Published: 2024

Journal Articles

Fitusiran reduces bleeding in factor X–deficient mice

Sebastien Verhenne, Geneviève McCluskey, Hortense Maynadié, Frédéric Adam, Caterina Casari, Laurence Panicot-Dubois, Lydie Crescence, Christophe Dubois, Cécile V. Denis, Peter J. Lenting, Olivier D. Christophe

Blood (2024) 144 (2): 227–236.

https://doi.org/10.1182/blood.2023023404

Published: 2024

Includes: Multimedia, Supplemental data

Journal Articles

Plasmin-cleaved von Willebrand factor as a biomarker for microvascular thrombosis

Hinde El Otmani, Rowan Frunt, Simone Smits, Arjan D. Barendrecht, Steven de Maat, Rob Fijnheer, Peter J. Lenting, Claudia Tersteeg

Blood (2024) 143 (20): 2089–2098.

https://doi.org/10.1182/blood.2023021265

Published: 2024

Includes: Supplemental data

Journal Articles

Plasmin-Cleaved Von Willebrand Factor As a Biomarker for Microvascular Thrombosis

Hinde El Otmani, Rowan Frunt, Simone Smits, Steven De Maat, Rob Fijnheer, Arjan Barendrecht, Peter J Lenting, Claudia Tersteeg

Blood (2023) 142 (Supplement 1): 5391.

https://doi.org/10.1182/blood-2023-188515

Published: 2023

Journal Articles

Efficacy of platelet-inspired hemostatic nanoparticles on bleeding in von Willebrand disease murine models

Stéphanie Roullet, Norman Luc, Julie Rayes, Jean Solarz, Dante Disharoon, Andrew Ditto, Emily Gahagan, Christa Pawlowski, Thibaud Sefiane, Frédéric Adam, Caterina Casari, Olivier D. Christophe, Michael Bruckman, Peter J. Lenting, Anirban Sen Gupta, Cécile V. Denis

Blood (2023) 141 (23): 2891–2900.

https://doi.org/10.1182/blood.2022018956

Published: 2023

Includes: Multimedia, Supplemental data

Journal Articles

A nanobody against the VWF A3 domain detects ADAMTS13-induced proteolysis in congenital and acquired VWD

Blood (2023) 141 (12): 1457–1468.

https://doi.org/10.1182/blood.2022017569

Published: 2023

Includes: Supplemental data

Journal Articles

A FVIII-Mimetic Bispecific Antibody with an Embedded Self-Regulation Mechanism Reduces the Risk of Prothrombotic Events for the Treatment of Haemophilia a

Vincent Muczynski, Angel Smith, Thibaud Sefiane, Olivier D. Christophe, Peter J. Lenting, David Granger, Kerry Chester, Amit C. Nathwani

Blood (2022) 140 (Supplement 1): 677–678.

https://doi.org/10.1182/blood-2022-169482

Published: 2022

Journal Articles

Microlyse: a thrombolytic agent that targets VWF for clearance of microvascular thrombosis

Steven de Maat, Chantal C. Clark, Arjan D. Barendrecht, Simone Smits, Nadine D. van Kleef, Hinde El Otmani, Manon Waning, Marc van Moorsel, Michael Szardenings, Nicolas Delaroque, Kristof Vercruysse, Rolf T. Urbanus, Silvie Sebastian, Peter J. Lenting, Christoph Hagemeyer, Thomas Renné, Karen Vanhoorelbeke, Claudia Tersteeg, Coen Maas

Blood (2022) 139 (4): 597–607.

https://doi.org/10.1182/blood.2021011776

Published: 2022

Includes: Supplemental data

Journal Articles

von Willebrand disease: what does the future hold?

Cécile V. Denis, Sophie Susen, Peter J. Lenting

Blood (2021) 137 (17): 2299–2306.

https://doi.org/10.1182/blood.2020008501

Published: 2021

Journal Articles

Impaired adhesion of neutrophils expressing Slc44a2/HNA-3b to VWF protects against NETosis under venous shear rates

Gaïa Zirka, Philippe Robert, Julia Tilburg, Victoria Tishkova, Chrissta X. Maracle, Paulette Legendre, Bart J. M. van Vlijmen, Marie-Christine Alessi, Peter J. Lenting, Pierre-Emmanuel Morange, Grace M. Thomas

Blood (2021) 137 (16): 2256–2266.

https://doi.org/10.1182/blood.2020008345

Published: 2021

Includes: Multimedia, Supplemental data

Journal Articles

A hemophilia A mouse model for the in vivo assessment of emicizumab function

Stephen Ferrière, Ivan Peyron, Olivier D. Christophe, Charlotte Kawecki, Caterina Casari, Vincent Muczynski, Amit Nathwani, Alexandre Kauskot, Peter J. Lenting, Cécile V. Denis

Blood (2020) 136 (6): 740–748.

https://doi.org/10.1182/blood.2019004334

Published: 2020

Includes: Supplemental data

Journal Articles

Cofactor and Cofactor Mimetics

Peter J. Lenting, PhD

Blood (2019) 134 (Supplement_1): SCI-17.

https://doi.org/10.1182/blood-2019-121059

Published: 2019

Journal Articles

Targeting protease nexin-1, a natural anticoagulant serpin, to control bleeding and improve hemostasis in hemophilia

Karen Aymonnier, Charlotte Kawecki, Laurence Venisse, Yacine Boulaftali, Olivier D. Christophe, Peter J. Lenting, Véronique Arocas, Emmanuelle de Raucourt, Cécile V. Denis, Marie-Christine Bouton

Blood (2019) 134 (19): 1632–1644.

https://doi.org/10.1182/blood.2019000281

Published: 2019

Includes: Supplemental data

Journal Articles

Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor

Emma-Ruoqi Xu, Sören von Bülow, Po-Chia Chen, Peter J. Lenting, Katra Kolšek, Camilo Aponte-Santamaría, Bernd Simon, Jaelle Foot, Tobias Obser, Reinhard Schneppenheim, Frauke Gräter, Cécile V. Denis, Matthias Wilmanns, Janosch Hennig

Blood (2019) 133 (4): 366–376.

https://doi.org/10.1182/blood-2018-04-843615

Published: 2019

Includes: Supplemental data

Journal Articles

A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation

Vincent Muczynski, Caterina Casari, François Moreau, Gabriel Aymé, Charlotte Kawecki, Paulette Legendre, Valerie Proulle, Olivier D. Christophe, Cécile V. Denis, Peter J. Lenting

Blood (2018) 132 (11): 1193–1197.

https://doi.org/10.1182/blood-2018-01-829523

Published: 2018

Includes: Supplemental data

Journal Articles

VWF clearance: it’s glycomplicated

Cécile V. Denis, Peter J. Lenting

Blood (2018) 131 (8): 842–843.

https://doi.org/10.1182/blood-2018-01-824904

Published: 2018

Journal Articles

Emicizumab, a bispecific antibody recognizing coagulation factors IX and X: how does it actually compare to factor VIII?

Peter J. Lenting, Cécile V. Denis, Olivier D. Christophe

Blood (2017) 130 (23): 2463–2468.

https://doi.org/10.1182/blood-2017-08-801662

Published: 2017

Journal Articles

Platelet Desialylation Is a Novel Mechanism of Thrombocytopenia during Mechanical Circulatory Assistance

Hugues Spillemaeker, Annabelle Dupont, PhD PharmD, Alexandre Kauskot, PhD, Antoine Rauch, MD PhD, Flavien Vincent, MD, Delphine Borgel, PharmD, PhD, Alexandre Ung, Mouhamed Moussa, MD, Natacha Rousse, MD, Christophe Nix, MD, Bart Staels, PharmD, PhD, André Vincentelli, MD PhD, Cecile V. Denis, PhD, Peter J Lenting, PhD, Eric van Belle, MD PhD, Sophie Susen, MD PhD

Blood (2017) 130 (Supplement 1): 2330.

https://doi.org/10.1182/blood.V130.Suppl_1.2330.2330

Published: 2017

Journal Articles

Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions

Vincent Muczynski, Gabriel Aymé, Véronique Regnault, Marc Vasse, Delphine Borgel, Paulette Legendre, Amine Bazaa, Amélie Harel, Cécile Loubière, Peter J. Lenting, Cécile V. Denis, Olivier D. Christophe

Blood (2017) 129 (17): 2443–2454.

https://doi.org/10.1182/blood-2016-06-724351

Published: 2017

Includes: Supplemental data

Journal Articles

Von Willebrand Factor Interaction with FVIII: Development of Long Acting FVIII Therapies

Peter J Lenting, PhD, Vincent Muczynski, PhD, Gabriel Aymé, PhD, Cecile V. Denis, PhD, Olivier D. Christophe, PhD

Blood (2016) 128 (22): SCI-8.

https://doi.org/10.1182/blood.V128.22.SCI-8.SCI-8

Published: 2016

NARROW

How unique structural adaptations support and coordinate the complex function of von Willebrand factor

Fitusiran reduces bleeding in factor X–deficient mice

Plasmin-cleaved von Willebrand factor as a biomarker for microvascular thrombosis

Plasmin-Cleaved Von Willebrand Factor As a Biomarker for Microvascular Thrombosis

Efficacy of platelet-inspired hemostatic nanoparticles on bleeding in von Willebrand disease murine models

A nanobody against the VWF A3 domain detects ADAMTS13-induced proteolysis in congenital and acquired VWD

A FVIII-Mimetic Bispecific Antibody with an Embedded Self-Regulation Mechanism Reduces the Risk of Prothrombotic Events for the Treatment of Haemophilia a

Microlyse: a thrombolytic agent that targets VWF for clearance of microvascular thrombosis

von Willebrand disease: what does the future hold?

Impaired adhesion of neutrophils expressing Slc44a2/HNA-3b to VWF protects against NETosis under venous shear rates

A hemophilia A mouse model for the in vivo assessment of emicizumab function

Cofactor and Cofactor Mimetics

Targeting protease nexin-1, a natural anticoagulant serpin, to control bleeding and improve hemostasis in hemophilia

Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor

A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation

VWF clearance: it’s glycomplicated

Emicizumab, a bispecific antibody recognizing coagulation factors IX and X: how does it actually compare to factor VIII?

Platelet Desialylation Is a Novel Mechanism of Thrombocytopenia during Mechanical Circulatory Assistance

Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions

Von Willebrand Factor Interaction with FVIII: Development of Long Acting FVIII Therapies

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American Society of Hematology

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American Society of Hematology

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