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Human platelets producing new cell bodies are shown in this composite picture, containing images obtained by various methods including by scanning electron microscopy (middle), transmission electron microscopy (top and lower right images), and confocal microscopy (background of purple cells). The freshly isolated platelet in the top right is discoid and packed with granular constituents. When placed in suspension culture, platelets form new cell bodies that are connected by thin shafts (middle and bottom cells). The platelets in the background are stained with sialic acids (purple) and represent the morphologies observed in a typical suspension culture. See the article by Schwertz et al on page 3801. This composite cover figure was prepared by Diana Lim.