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Issue Archive

Volume 115, Issue 17
April 29 2010
Issue Cover

Table of Contents

INSIDE BLOOD

IMMUNOBIOLOGY
When T cells cannot help
Eva Severinson
View Articletitled, When T cells cannot help
CLINICAL TRIALS
Haploidentical transplantation in children
Kirk R. Schultz
View Articletitled, Haploidentical transplantation in children
HEMATOPOIESIS & STEM CELLS
Fanconi anemia strikes early in utero
Johnson M. Liu
View Articletitled, Fanconi anemia strikes early in utero
INSIDE BLOOD
Positioning NK-κB in multiple myeloma
Bernard Klein
View Articletitled, Positioning NK-κB in multiple myeloma
INSIDE BLOOD
Genetic relicts from the origin of ALL
Markus Müschen
View Articletitled, Genetic relicts from the origin of ALL
RED CELLS & IRON
2 out of 3 isn't bad
James P. Kushner
View Articletitled, 2 out of 3 isn't bad

REVIEW ARTICLES

Deadly allies: the fatal interplay between platelets and metastasizing cancer cells
Luise Erpenbeck,Michael P. Schön
View Articletitled, Deadly allies: the fatal interplay between platelets and metastasizing cancer cells

CLINICAL TRIALS AND OBSERVATIONS

Results and factors influencing outcome after fully haploidentical hematopoietic stem cell transplantation in children with very high-risk acute lymphoblastic leukemia: impact of center size: an analysis on behalf of the Acute Leukemia and Pediatric Disease Working Parties of the European Blood and Marrow Transplant group
Clinical Trials & Observations
Thomas Klingebiel,Jacqueline Cornish,Myriam Labopin,Franco Locatelli,Philippe Darbyshire,Rupert Handgretinger,Adriana Balduzzi,Joanna Owoc-Lempach,Franca Fagioli,Reuven Or,Christina Peters,Franco Aversa,Emmanuelle Polge,Giorgio Dini,Vanderson Rocha,on behalf of the Pediatric Diseases and Acute Leukemia Working Parties of the European Group for Blood and Marrow Transplantation (EBMT)
View Articletitled, Results and factors influencing outcome after fully haploidentical hematopoietic stem cell transplantation in children with very high-risk acute lymphoblastic leukemia: impact of center size: an analysis on behalf of the Acute Leukemia and Pediatric Disease Working Parties of the European Blood and Marrow Transplant group
Improved survival of children and adolescents with sickle cell disease
Clinical Trials & Observations
Charles T. Quinn,Zora R. Rogers,Timothy L. McCavit,George R. Buchanan
View Articletitled, Improved survival of children and adolescents with sickle cell disease

HEMATOPOIESIS AND STEM CELLS

Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage
Asmin Tulpule,M. William Lensch,Justine D. Miller,Karyn Austin,Alan D'Andrea,Thorsten M. Schlaeger,Akiko Shimamura,George Q. Daley
View Articletitled, Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage
Supplemental data
Lineage-specific combinatorial action of enhancers regulates mouse erythroid Gata1 expression
Roy Drissen,Boris Guyot,Lin Zhang,Ann Atzberger,Jackie Sloane-Stanley,Bill Wood,Catherine Porcher,Paresh Vyas
View Articletitled, Lineage-specific combinatorial action of enhancers regulates mouse erythroid <em>Gata1</em> expression
Supplemental data
Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose γ-irradiation
Hui Yu,Hongmei Shen,Youzhong Yuan,Richard XuFeng,Xiaoxia Hu,Sean P. Garrison,Lin Zhang,Jian Yu,Gerard P. Zambetti,Tao Cheng
View Articletitled, Deletion of <em>Puma</em> protects hematopoietic stem cells and confers long-term survival in response to high-dose γ-irradiation
Supplemental data
Haploinsufficiency of Apc leads to ineffective hematopoiesis
Jianghong Wang,Anthony A. Fernald,John Anastasi,Michelle M. Le Beau,Zhijian Qian
View Articletitled, Haploinsufficiency of <em>Apc</em> leads to ineffective hematopoiesis
Supplemental data
The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS
Steven W. Lane,Stephen M. Sykes,Fatima Al-Shahrour,Sebastian Shterental,Mahnaz Paktinat,Cristina Lo Celso,Jonathan L. Jesneck,Benjamin L. Ebert,David A. Williams,D. Gary Gilliland
View Articletitled, The <em>Apc<sup>min</sup></em> mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS
Supplemental data

IMMUNOBIOLOGY

Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function
Vanessa Morales-Tirado,Dorothy K. Sojka,Shoshana D. Katzman,Christopher A. Lazarski,Fred D. Finkelman,Joseph F. Urban,Deborah J. Fowell
View Articletitled, Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function
Supplemental data
IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell–mediated rejection of systemic lymphoma in immunodeficient mice
John C. Markley,Michel Sadelain
View Articletitled, IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell–mediated rejection of systemic lymphoma in immunodeficient mice
Supplemental data
Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity
Xiangdong Liu,Niu Shin,Holly K. Koblish,Gengjie Yang,Qian Wang,Kathy Wang,Lynn Leffet,Michael J. Hansbury,Beth Thomas,Mark Rupar,Paul Waeltz,Kevin J. Bowman,Padmaja Polam,Richard B. Sparks,Eddy W. Yue,Yanlong Li,Richard Wynn,Jordan S. Fridman,Timothy C. Burn,Andrew P. Combs,Robert C. Newton,Peggy A. Scherle
View Articletitled, Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity
Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells
Andreas Weigert,Sarah Cremer,Martina Victoria Schmidt,Andreas von Knethen,Carlo Angioni,Gerd Geisslinger,Bernhard Brüne
View Articletitled, Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells
Supplemental data

LYMPHOID NEOPLASIA

Classical and/or alternative NF-κB pathway activation in multiple myeloma
Yulia N. Demchenko,Oleg K. Glebov,Adriana Zingone,Jonathan J. Keats,P. Leif Bergsagel,W. Michael Kuehl
View Articletitled, Classical and/or alternative NF-κB pathway activation in multiple myeloma
Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia
Caroline M. Bateman,Susan M. Colman,Tracy Chaplin,Bryan D. Young,Tim O. Eden,Manoo Bhakta,Eric J. Gratias,Elisabeth R. van Wering,Giovanni Cazzaniga,Christine J. Harrison,Richard Hain,Philip Ancliff,Anthony M. Ford,Lyndal Kearney,Mel Greaves
View Articletitled, Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia
Supplemental data
Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma
Gaofeng Fan,Matthew J. Simmons,Sheng Ge,Jui Dutta-Simmons,Jérôme Kucharczak,Yacov Ron,David Weissmann,Chiann-Chyi Chen,Chandreyee Mukherjee,Eileen White,Céline Gélinas
View Articletitled, Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma
Supplemental data
The AF4·MLL fusion protein is capable of inducing ALL in mice without requirement of MLL·AF4
Adelheid Bursen,Karen Schwabe,Brigitte Rüster,Reinhard Henschler,Martin Ruthardt,Theo Dingermann,Rolf Marschalek
View Articletitled, The AF4·MLL fusion protein is capable of inducing ALL in mice without requirement of MLL·AF4
Supplemental data
Clonal expansions of cytotoxic T cells exist in the blood of patients with Waldenström macroglobulinemia but exhibit anergic properties and are eliminated by nucleoside analogue therapy
Jia Li,Daniel M.-Y. Sze,Ross D. Brown,Mark J. Cowley,Warren Kaplan,Sui-Lin Mo,Shihong Yang,Esther Aklilu,Karieshma Kabani,Yen S. Loh,Tetsuo Yamagishi,Yuling Chen,P. Joy Ho,Douglas E. Joshua
View Articletitled, Clonal expansions of cytotoxic T cells exist in the blood of patients with Waldenström macroglobulinemia but exhibit anergic properties and are eliminated by nucleoside analogue therapy
Supplemental data

MYELOID NEOPLASIA

Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera–like disease
Hajime Akada,Dongqing Yan,Haiying Zou,Steven Fiering,Robert E. Hutchison,M. Golam Mohi
View Articletitled, Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera–like disease
Supplemental data
Palmitoylation of oncogenic NRAS is essential for leukemogenesis
Benjamin Cuiffo,Ruibao Ren
View Articletitled, Palmitoylation of oncogenic NRAS is essential for leukemogenesis

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

MyD88-dependent TLR4 signaling is selectively impaired in alveolar macrophages from asymptomatic HIV+ persons
Souvenir D. Tachado,Xin Li,Medhavi Bole,Katharine Swan,Asha Anandaiah,Naimish R. Patel,Henry Koziel
View Articletitled, MyD88-dependent TLR4 signaling is selectively impaired in alveolar macrophages from asymptomatic HIV<sup>+</sup> persons

RED CELLS, IRON, AND ERYTHROPOIESIS

Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia
Barbra J. Sasu,Keegan S. Cooke,Tara L. Arvedson,Cherylene Plewa,Aaron R. Ellison,Jackie Sheng,Aaron Winters,Todd Juan,Hongyan Li,C. Glenn Begley,Graham Molineux
View Articletitled, Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia

TRANSPLANTATION

Insufficient evidence for association of NOD2/CARD15 or other inflammatory bowel disease–associated markers on GVHD incidence or other adverse outcomes in T-replete, unrelated donor transplantation
Yume Nguyen,Abed Al-Lehibi,Elizabeth Gorbe,Ellen Li,Michael Haagenson,Tao Wang,Stephen Spellman,Stephanie J. Lee,Nicholas O. Davidson
View Articletitled, Insufficient evidence for association of <em>NOD2/CARD15</em> or other inflammatory bowel disease–associated markers on GVHD incidence or other adverse outcomes in T-replete, unrelated donor transplantation

VASCULAR BIOLOGY

Platelet interleukin-1α drives cerebrovascular inflammation
Peter Thornton,Barry W. McColl,Andrew Greenhalgh,Adam Denes,Stuart M. Allan,Nancy J. Rothwell
View Articletitled, Platelet interleukin-1α drives cerebrovascular inflammation
Supplemental data

CORRESPONDENCE

The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas is a CpG-type translocation, but the t(11;18)(q21;q21)/API2-MALT1 translocation in MALT lymphomas is not
Albert G. Tsai,Zhengfei Lu,Michael R. Lieber
View Articletitled, The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas is a CpG-type translocation, but the t(11;18)(q21;q21)/API2-MALT1 translocation in MALT lymphomas is not
Response: The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas is a CpG-type translocation, but the t(11;18)(q21;q21)/API2-MALT1 translocation in MALT lymphomas is not
Eva Maria Murga Penas,Judith Dierlamm
View Articletitled, Response: The t(14;18)(q32;q21)/<em>IGH-MALT1</em> translocation in MALT lymphomas is a CpG-type translocation, but the t(11;18)(q21;q21)/<em>API2-MALT1</em> translocation in MALT lymphomas is not
Meis1 maintains stemness signature in MLL-AF9 leukemia
Ashish R. Kumar,Aaron L. Sarver,Baolin Wu,John H. Kersey
View Articletitled, Meis1 maintains stemness signature in MLL-AF9 leukemia
Bone marrow as a site for pancreatic islet transplantation
Anastasio Salazar-Bañuelos,Luis Benitez-Bribiesca,David L. Sigalet,Greg Korbutt,James R. Wright, Jr
View Articletitled, Bone marrow as a site for pancreatic islet transplantation
No influence of gene polymorphism of LCT (C13910T) on transplantation outcomes in acute myeloid leukemia patients who received transplantations from HLA-identical sibling donors
Ahmet H. Elmaagacli,Nina Steckel,Markus Ditschkowski,Yael Hegerfeldt,Hellmut Ottinger,Rudolf Trenschel,Dietrich W. Beelen
View Articletitled, No influence of gene polymorphism of LCT (C13910T) on transplantation outcomes in acute myeloid leukemia patients who received transplantations from HLA-identical sibling donors
Response: Significant influence of LCT-13910C>T on transplantation outcomes in acute myeloid leukemia patients receiving transplantations from HLA-identical sibling donors
Hanns Hauser,Otto Zach,Otto Krieger,Hedwig Kasparu,Josef Koenig,Michael Girschikofsky,Dieter Lutz
View Articletitled, Response: Significant influence of LCT-13910C&gt;T on transplantation outcomes in acute myeloid leukemia patients receiving transplantations from HLA-identical sibling donors
All Issues

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The elusive endothelial iron transporter
AAV delivers as a lingering guest, not an invader
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