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Journal Articles

A Blood Dendritic Cell Vaccine for Acute Myeloid Leukemia

Jennifer Hsu, PhD, Christian Bryant, Phillip Fromm, PhD, Michael Papadimitrious, Daniel Orellana, Hayley Suen, Shihong Yang, Claire Weatherburn, Robin Gasiorowski, Harry J Iland, MBBS FRACP FRCPA, Ross D Brown, Douglas E Joshua, Phoebe Joy Ho, MBBS, DPhil, John Gibson, Georgina Clark, Derek NJ Hart

Blood (2016) 128 (22): 5221.

https://doi.org/10.1182/blood.V128.22.5221.5221

Published: 2016

Journal Articles

Phospho-Flow Cytometry Quantitation of STAT Signalling Checkpoints in Malignant and Non-Malignant Cells Identifies Patients Suitable for pSTAT3 and 5 Targeted Inhibitors

Ross D Brown, P Joy Ho, Douglas E Joshua, Shihong Yang, Christian Bryant, Hayley Suen, Claire Weatherburn, Stephen Larsen, Derek NJ Hart, John Gibson

Blood (2015) 126 (23): 5356.

https://doi.org/10.1182/blood.V126.23.5356.5356

Published: 2015

Journal Articles

Protective Cytotoxic Clonal T-Cells in Myeloma Have the Characteristics of Telomere-Independent Senescence Rather Than an Exhausted or Anergic Phenotype: Implications for Immunotherapy

Hayley Suen, BSc (Hons), Douglas E Joshua, MBBS DPhil, Ross D Brown, PhD, Shihong Yang, MSc, Pasquale Mario Barbaro, MBBS, P Joy Ho, MBBS DPhil, John Gibson, MBBS PhD

Blood (2014) 124 (21): 3367.

https://doi.org/10.1182/blood.V124.21.3367.3367

Published: 2014

Journal Articles

Ten Year Survival in Patients with Myeloma Is Characterized by the Persistence of Immunological Control Which Is Detected by Immunological Biomarkers

Ross D Brown, PhD, Hayley Suen, BSc (Hons), Christian E Bryant, MBBS, Shihong Yang, MSc, James Favaloro, BSc, John Gibson, MBBS PhD, P Joy Ho, MBBS, DPhil, Phillip Fromm, PhD, Derek NJ Hart, MBCHB, DPhil, Douglas E Joshua, MBBS, DPhil

Blood (2012) 120 (21): 1818.

https://doi.org/10.1182/blood.V120.21.1818.1818

Published: 2012

Journal Articles

Blockade of the Hedgehog Signaling Pathway by the Novel Agent NVP-LDE225 Induces Differentiation, Prevents De-Differentiation and Inhibits Proliferation of Multiple Myeloma Stem Cells in Vitro

Shihong Yang, MSc, Ross D Brown, PhD, Yen S Loh, PhD, Hayley Suen, BSc (Hons), James Favaloro, BSc, John Gibson, MBBS, PhD, Phoebe Joy Ho, MBBS, DPhil, Douglas E Joshua, MBBS, DPhil

Blood (2012) 120 (21): 3950.

https://doi.org/10.1182/blood.V120.21.3950.3950

Published: 2012

Journal Articles

Ten Year Survivors of Multiple Myeloma Demonstrate a Differential Expression of Immunological Biomarkers Including a High Incidence of Cytotoxic T-Cell Clones Which Have Not Acquired Myeloma-Associated Anergy,

Christian E Bryant, MBBS, Ross D Brown, DPhil, Shihong Yang, BSc, Hayley Suen, BSc, Esther Aklilu, BSc, James Favaloro, BSc, Derek NJ Hart, MBCHB, DPhil, Phillip Fromm, DPhil, Narelle Woodland, MSc, Najah Nassif, DPhil, Harry Iland, MBBS FRACP FRCPA MHGSA, John Gibson, MBBS FRACP FRCPA DPhil, P Joy Ho, MBBS, DPhil, Douglas E Joshua, MBBS, DPhil

Blood (2011) 118 (21): 3924.

https://doi.org/10.1182/blood.V118.21.3924.3924

Published: 2011

Journal Articles

HLA-G and CD86 Expression on Malignant Plasma Cells Convey a Poor Prognosis and Immunoregulate T Cells In Patients with Myeloma

Ross D. Brown, PhD, Karieshma Kabani, Shihong Yang, Esther Aklilu, Phoebe Joy Ho, MBBS, John Gibson, MBBS, Douglas E. Joshua, MBBS, DPhil

Blood (2010) 116 (21): 983.

https://doi.org/10.1182/blood.V116.21.983.983

Published: 2010

Journal Articles

Clonal expansions of cytotoxic T cells exist in the blood of patients with Waldenström macroglobulinemia but exhibit anergic properties and are eliminated by nucleoside analogue therapy

Jia Li, Daniel M.-Y. Sze, Ross D. Brown, Mark J. Cowley, Warren Kaplan, Sui-Lin Mo, Shihong Yang, Esther Aklilu, Karieshma Kabani, Yen S. Loh, Tetsuo Yamagishi, Yuling Chen, P. Joy Ho, Douglas E. Joshua

Blood (2010) 115 (17): 3580–3588.

https://doi.org/10.1182/blood-2009-10-246991

Published: 2010

Includes: Supplemental data

Journal Articles

Clonal Expansions of Cytotoxic T Cells in the Blood of Patients with Waldenstrom's Macroglobulinaemia Are Anergic and Disappear After Nucleoside Analogue Therapy.

Ross D Brown, Jia Li, Daniel Sze, Mark Cowley, Warren Kaplan, Shihong Yang, Esther Aklilu, Karieshma Kabani, Phoebe Joy Ho, Yen S Loh, Tetsuo Yamagishi, Suilin Mo, Yuling Chen, Douglas Joshua

Blood (2009) 114 (22): 1820.

https://doi.org/10.1182/blood.V114.22.1820.1820

Published: 2009

Journal Articles

The Investigation of Mechanisms Underlying Hoechst 33342 Efflux in Myeloma ‘Side Population' Cells.

Yen Siew Loh, PhD, John D Allen, PhD, Ammira Al-shabeeb, PhD, Ross D. Brown, PhD, MBA, Jia Li, Joshua Douglas, Professor, Daniel Sze, A/Professor

Blood (2009) 114 (22): 2759.

https://doi.org/10.1182/blood.V114.22.2759.2759

Published: 2009

Journal Articles

Trogocytosis in Multiple Myeloma.

Ross D. Brown, PhD, MBA, Karieshma Kabani, BSc, Shihong Yang, MSc, Aklilu Esther, BSc, Phoebe Joy Ho, MBBS, DPhil, John Gibson, MBBS, PhD, Douglas E. Joshua, MBBS, DPhil

Blood (2008) 112 (11): 1681.

https://doi.org/10.1182/blood.V112.11.1681.1681

Published: 2008

Journal Articles

Differentiation of Multiple Myeloma and MGUS by Cross Validated Differential Proteomic Analysis.

Ross D. Brown, PhD, Larissa Belov, PhD, Cris dos Remedios, PhD, Daniel Sze, PhD, Simon Cooper, Mila Dolotin, John Gibson, MD, Douglas E. Joshua, MD

Blood (2006) 108 (11): 3524.

https://doi.org/10.1182/blood.V108.11.3524.3524

Published: 2006

Journal Articles

Gene Expression Profiling of the Clinical Significant CD57 + CD8 + Cytotoxic T Cell Expansions in Patients with Waldenstrom’s Macroglobulinemia.

Daniel Sze, PhD, Tetsuo Yamagishi, BSc, Warren Kaplan, PhD, Ross D. Brown, PhD, Phoebe Joy Ho, MD, John Gibson, MD, Douglas E. Joshua, MD

Blood (2006) 108 (11): 3395.

https://doi.org/10.1182/blood.V108.11.3395.3395

Published: 2006

Journal Articles

Identification and Characterization of Cancer Stem Cells in Multiple Myeloma.

Daniel Sze, PhD, Yen S. Loh, BSc, Suilin Mo, MSc, Warren Kaplan, PhD, Ross D. Brown, PhD, Phoebe Joy Ho, MD, John Gibson, MD, Douglas E. Joshua, MD

Blood (2006) 108 (11): 512.

https://doi.org/10.1182/blood.V108.11.512.512

Published: 2006

Journal Articles

Gene Expression Profiles of the Clinically Significant "Late" Stage Expanded Cytotoxic T Cells in Myeloma.

Tetsuo Yamagishi, BSc, Warren Kaplan, PhD, Devanshi Seth, PhD, Shihong Yang, MMed, Xin An, PhD, Ross D. Brown, PhD, Joy Ho, MBBS, John Gibson, MBBS, Douglas E. Joshua, MBBS, Daniel M. Sze, PhD

Blood (2005) 106 (11): 3418.

https://doi.org/10.1182/blood.V106.11.3418.3418

Published: 2005

Journal Articles

Development of Retargeted CD38-Specific NK-92 Cell Line for Potential Anti-Myeloma Immunotherapy.

Shihong Yang, MMed, Xin An, PhD, Ross D. Brown, PhD, Joy Ho, PhD, John Gibson, PhD, Douglas E. Joshua, PhD, Winfried Wels, PhD, Daniel M. Sze, PhD

Blood (2005) 106 (11): 5104.

https://doi.org/10.1182/blood.V106.11.5104.5104

Published: 2005

Journal Articles

The Immunomodulatory Action of Thalidomide in Patients with Multiple Myeloma Involves a Clonal Expansion of Late-Differentiated Cytotoxic Effector Cells.

Ross D. Brown, PhD, Allan Murray, Daniel M. Sze, PhD, Andrew Spencer, MD, Phoebe Joy Ho, MD, John Gibson, MD, Douglas E. Joshua, MD

Blood (2005) 106 (11): 5108.

https://doi.org/10.1182/blood.V106.11.5108.5108

Published: 2005

Journal Articles

Dendritic cells from patients with myeloma are numerically normal but functionally defective as they fail to up-regulate CD80 (B7-1) expression after huCD40LT stimulation because of inhibition by transforming growth factor-β 1 and interleukin-10

Ross D. Brown, Belinda Pope, Allan Murray, Warren Esdale, Daniel M. Sze, John Gibson, P. Joy Ho, Derek Hart, Doug Joshua

Blood (2001) 98 (10): 2992–2998.

https://doi.org/10.1182/blood.V98.10.2992

Published: 2001

Journal Articles

Clonal cytotoxic T cells are expanded in myeloma and reside in the CD8 + CD57 + CD28 − compartment

Daniel M.-Y. Sze, Gillian Giesajtis, Ross D. Brown, Maria Raitakari, John Gibson, Joy Ho, Alan G. Baxter, Barbara Fazekas de St Groth, Antony Basten, Douglas E. Joshua

Blood (2001) 98 (9): 2817–2827.

https://doi.org/10.1182/blood.V98.9.2817

Published: 2001

Journal Articles

Illegitimate switch recombinations are present in approximately half of primary myeloma tumors, but do not relate to known prognostic indicators or survival

P. Joy Ho, Ross D. Brown, Gregory J. Pelka, Antony Basten, John Gibson, Douglas E. Joshua

Blood (2001) 97 (2): 490–495.

https://doi.org/10.1182/blood.V97.2.490

Published: 2001

NARROW

A Blood Dendritic Cell Vaccine for Acute Myeloid Leukemia

Phospho-Flow Cytometry Quantitation of STAT Signalling Checkpoints in Malignant and Non-Malignant Cells Identifies Patients Suitable for pSTAT3 and 5 Targeted Inhibitors

Protective Cytotoxic Clonal T-Cells in Myeloma Have the Characteristics of Telomere-Independent Senescence Rather Than an Exhausted or Anergic Phenotype: Implications for Immunotherapy

Ten Year Survival in Patients with Myeloma Is Characterized by the Persistence of Immunological Control Which Is Detected by Immunological Biomarkers

Blockade of the Hedgehog Signaling Pathway by the Novel Agent NVP-LDE225 Induces Differentiation, Prevents De-Differentiation and Inhibits Proliferation of Multiple Myeloma Stem Cells in Vitro

Ten Year Survivors of Multiple Myeloma Demonstrate a Differential Expression of Immunological Biomarkers Including a High Incidence of Cytotoxic T-Cell Clones Which Have Not Acquired Myeloma-Associated Anergy,

HLA-G and CD86 Expression on Malignant Plasma Cells Convey a Poor Prognosis and Immunoregulate T Cells In Patients with Myeloma

Clonal expansions of cytotoxic T cells exist in the blood of patients with Waldenström macroglobulinemia but exhibit anergic properties and are eliminated by nucleoside analogue therapy

Clonal Expansions of Cytotoxic T Cells in the Blood of Patients with Waldenstrom's Macroglobulinaemia Are Anergic and Disappear After Nucleoside Analogue Therapy.

The Investigation of Mechanisms Underlying Hoechst 33342 Efflux in Myeloma ‘Side Population' Cells.

Trogocytosis in Multiple Myeloma.

Differentiation of Multiple Myeloma and MGUS by Cross Validated Differential Proteomic Analysis.

Gene Expression Profiling of the Clinical Significant CD57 + CD8 + Cytotoxic T Cell Expansions in Patients with Waldenstrom’s Macroglobulinemia.

Identification and Characterization of Cancer Stem Cells in Multiple Myeloma.

Gene Expression Profiles of the Clinically Significant "Late" Stage Expanded Cytotoxic T Cells in Myeloma.

Development of Retargeted CD38-Specific NK-92 Cell Line for Potential Anti-Myeloma Immunotherapy.

The Immunomodulatory Action of Thalidomide in Patients with Multiple Myeloma Involves a Clonal Expansion of Late-Differentiated Cytotoxic Effector Cells.

Dendritic cells from patients with myeloma are numerically normal but functionally defective as they fail to up-regulate CD80 (B7-1) expression after huCD40LT stimulation because of inhibition by transforming growth factor-β 1 and interleukin-10

Clonal cytotoxic T cells are expanded in myeloma and reside in the CD8 + CD57 + CD28 − compartment

Illegitimate switch recombinations are present in approximately half of primary myeloma tumors, but do not relate to known prognostic indicators or survival

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American Society of Hematology

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ASH Publications

American Society of Hematology

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