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Issue Archive

Volume 114, Issue 3
July 16 2009
Issue Cover

Table of Contents

INSIDE BLOOD

VASCULAR BIOLOGY
Platelet MPs obscure some EPC definitions
Mervin C. Yoder
View Articletitled, Platelet MPs obscure some EPC definitions
CLINICAL TRIALS
Risky business in myeloma
Sagar Lonial
View Articletitled, Risky business in myeloma
IMMUNOBIOLOGY
Ablative RT protects immune responses
Anatoly Dritschilo
View Articletitled, Ablative RT protects immune responses
INSIDE BLOOD
Unfolding a CLL mystery
Emili Montserrat
View Articletitled, Unfolding a CLL mystery
TRANSPLANTATION
Magic bullet, part III?
Georgia B. Vogelsang
View Articletitled, Magic bullet, part III?
VASCULAR BIOLOGY
“Home sweet home” for lymphocytes
Steven D. Rosen,Hanayo Arata-Kawai
View Articletitled, “Home sweet home” for lymphocytes

REVIEW ARTICLES

Extranodal marginal zone lymphoma of the ocular adnexa
Alexandra Stefanovic,Izidore S. Lossos
View Articletitled, Extranodal marginal zone lymphoma of the ocular adnexa

CLINICAL TRIALS AND OBSERVATIONS

Etanercept, mycophenolate, denileukin, or pentostatin plus corticosteroids for acute graft-versus-host disease: a randomized phase 2 trial from the Blood and Marrow Transplant Clinical Trials Network
Clinical Trials & Observations
Amin M. Alousi,Daniel J. Weisdorf,Brent R. Logan,Javier Bolaños-Meade,Shelly Carter,Nancy DiFronzo,Marcelo Pasquini,Steven C. Goldstein,Vincent T. Ho,Brandon Hayes-Lattin,John R. Wingard,Mary M. Horowitz,John E. Levine,on behalf of the Blood and Marrow Transplant Clinical Trials Network
View Articletitled, Etanercept, mycophenolate, denileukin, or pentostatin plus corticosteroids for acute graft-versus-host disease: a randomized phase 2 trial from the Blood and Marrow Transplant Clinical Trials Network
Impact of risk stratification on outcome among patients with multiple myeloma receiving initial therapy with lenalidomide and dexamethasone
Brief Report
Prashant Kapoor,Shaji Kumar,Rafael Fonseca,Martha Q. Lacy,Thomas E. Witzig,Suzanne R. Hayman,Angela Dispenzieri,Francis Buadi,P. Leif Bergsagel,Morie A. Gertz,Robert J. Dalton,Joseph R. Mikhael,David Dingli,Craig B. Reeder,John A. Lust,Stephen J. Russell,Vivek Roy,Steven R. Zeldenrust,A. Keith Stewart,Robert A. Kyle,Philip R. Greipp,S. Vincent Rajkumar
View Articletitled, Impact of risk stratification on outcome among patients with multiple myeloma receiving initial therapy with lenalidomide and dexamethasone
Influence of cytogenetics in patients with relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone: adverse effect of deletion 17p13
Brief Report
Donna Reece,Kevin W. Song,Tommy Fu,Birgitte Roland,Hong Chang,Douglas E. Horsman,Adnan Mansoor,Christine Chen,Esther Masih-Khan,Young Trieu,Helene Bruyere,Douglas A. Stewart,Nizar J. Bahlis
View Articletitled, Influence of cytogenetics in patients with relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone: adverse effect of deletion 17p13

GENE THERAPY

Correction of murine hemophilia A following nonmyeloablative transplantation of hematopoietic stem cells engineered to encode an enhanced human factor VIII variant using a safety-augmented retroviral vector
Ali Ramezani,Robert G. Hawley
View Articletitled, Correction of murine hemophilia A following nonmyeloablative transplantation of hematopoietic stem cells engineered to encode an enhanced human factor VIII variant using a safety-augmented retroviral vector
Supplemental data
Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen
Laura A. Johnson,Richard A. Morgan,Mark E. Dudley,Lydie Cassard,James C. Yang,Marybeth S. Hughes,Udai S. Kammula,Richard E. Royal,Richard M. Sherry,John R. Wunderlich,Chyi-Chia R. Lee,Nicholas P. Restifo,Susan L. Schwarz,Alexandria P. Cogdill,Rachel J. Bishop,Hung Kim,Carmen C. Brewer,Susan F. Rudy,Carter VanWaes,Jeremy L. Davis,Aarti Mathur,Robert T. Ripley,Debbie A. Nathan,Carolyn M. Laurencot,Steven A. Rosenberg
View Articletitled, Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

IMMUNOBIOLOGY

AID constrains germinal center size by rendering B cells susceptible to apoptosis
Ahmad Zaheen,Bryant Boulianne,Jahan-Yar Parsa,Shaliny Ramachandran,Jennifer L. Gommerman,Alberto Martin
View Articletitled, AID constrains germinal center size by rendering B cells susceptible to apoptosis
Supplemental data
Indoleamine 2,3-dioxygenase–expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells
David J. Chung,Marco Rossi,Emanuela Romano,Jennifer Ghith,Jianda Yuan,David H. Munn,James W. Young
View Articletitled, Indoleamine 2,3-dioxygenase–expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells
Supplemental data
Enhanced development of CD4+ γδ T cells in the absence of Itk results in elevated IgE production
Qian Qi,Mingcan Xia,Jianfang Hu,Elizabeth Hicks,Archana Iyer,Na Xiong,Avery August
View Articletitled, Enhanced development of CD4<sup>+</sup> γδ T cells in the absence of Itk results in elevated IgE production
Supplemental data
A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein
Nana Ueffing,Kusum K. Singh,Andrea Christians,Christoph Thorns,Alfred C. Feller,Florian Nagl,Falko Fend,Sebastian Heikaus,Alexander Marx,Rainer B. Zotz,Joachim Brade,Wolfgang A. Schulz,Klaus Schulze-Osthoff,Ingo Schmitz,Christian Schwerk
View Articletitled, A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein
Supplemental data
CCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathway
Kathrin Gollmer,François Asperti-Boursin,Yoshihiko Tanaka,Klaus Okkenhaug,Bart Vanhaesebroeck,Jeffrey R. Peterson,Yoshinori Fukui,Emmanuel Donnadieu,Jens V. Stein
View Articletitled, CCL21 mediates CD4<sup>+</sup> T-cell costimulation via a DOCK2/Rac-dependent pathway
Supplemental data
Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment
Youjin Lee,Sogyong L. Auh,Yugang Wang,Byron Burnette,Yang Wang,Yuru Meng,Michael Beckett,Rohit Sharma,Robert Chin,Tony Tu,Ralph R. Weichselbaum,Yang-Xin Fu
View Articletitled, Therapeutic effects of ablative radiation on local tumor require CD8<sup>+</sup> T cells: changing strategies for cancer treatment
Type 17 CD8+ T cells display enhanced antitumor immunity
Brief Report
Christian S. Hinrichs,Andrew Kaiser,Chrystal M. Paulos,Lydie Cassard,Luis Sanchez-Perez,Bianca Heemskerk,Claudia Wrzesinski,Zachary A. Borman,Pawel Muranski,Nicholas P. Restifo
View Articletitled, Type 17 CD8<sup>+</sup> T cells display enhanced antitumor immunity

LYMPHOID NEOPLASIA

RARα2 expression is associated with disease progression and plays a crucial role in efficacy of ATRA treatment in myeloma
Siqing Wang,Guido Tricot,Lei Shi,Wei Xiong,Zhaoyang Zeng,Hongwei Xu,Maurizio Zangari,Bart Barlogie,John D. Shaughnessy, Jr,Fenghuang Zhan
View Articletitled, RARα2 expression is associated with disease progression and plays a crucial role in efficacy of ATRA treatment in myeloma
Supplemental data
Activation of cAMP signaling inhibits DNA damage–induced apoptosis in BCP-ALL cells through abrogation of p53 accumulation
Elin Hallan Naderi,Harry W. Findley,Ellen Ruud,Heidi Kiil Blomhoff,Soheil Naderi
View Articletitled, Activation of cAMP signaling inhibits DNA damage–induced apoptosis in BCP-ALL cells through abrogation of p53 accumulation
RhoA and Rac1 GTPases play major and differential roles in stromal cell–derived factor-1–induced cell adhesion and chemotaxis in multiple myeloma
Abdel Kareem Azab,Feda Azab,Simona Blotta,Costas M. Pitsillides,Brian Thompson,Judith M. Runnels,Aldo M. Roccaro,Hai T. Ngo,Molly R. Melhem,Antonio Sacco,Xiaoying Jia,Kenneth C. Anderson,Charles P. Lin,Barrett J. Rollins,Irene M. Ghobrial
View Articletitled, RhoA and Rac1 GTPases play major and differential roles in stromal cell–derived factor-1–induced cell adhesion and chemotaxis in multiple myeloma
Supplemental data
Immunosuppression and other risk factors for early and late non-Hodgkin lymphoma after kidney transplantation
Marina T. van Leeuwen,Andrew E. Grulich,Angela C. Webster,Margaret R.E. McCredie,John H. Stewart,Stephen P. McDonald,Janaki Amin,John M. Kaldor,Jeremy R. Chapman,Claire M. Vajdic
View Articletitled, Immunosuppression and other risk factors for early and late non-Hodgkin lymphoma after kidney transplantation
Spontaneous regression of chronic lymphocytic leukemia: clinical and biologic features of 9 cases
Ilaria Del Giudice,Sabina Chiaretti,Simona Tavolaro,Maria Stefania De Propris,Roberta Maggio,Francesca Mancini,Nadia Peragine,Simona Santangelo,Marilisa Marinelli,Francesca Romana Mauro,Anna Guarini,Robin Foà
View Articletitled, Spontaneous regression of chronic lymphocytic leukemia: clinical and biologic features of 9 cases
Supplemental data
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia
Brief Report
Alejandro Gutierrez,Takaomi Sanda,Ruta Grebliunaite,Arkaitz Carracedo,Leonardo Salmena,Yebin Ahn,Suzanne Dahlberg,Donna Neuberg,Lisa A. Moreau,Stuart S. Winter,Richard Larson,Jianhua Zhang,Alexei Protopopov,Lynda Chin,Pier Paolo Pandolfi,Lewis B. Silverman,Stephen P. Hunger,Stephen E. Sallan,A. Thomas Look
View Articletitled, High frequency of <em>PTEN, PI3K</em>, and <em>AKT</em> abnormalities in T-cell acute lymphoblastic leukemia
Supplemental data

MYELOID NEOPLASIA

Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10–positive leukemias
Yi-Hui Lin,Purvi M. Kakadia,Ying Chen,Ya-Qiang Li,Aniruddha J. Deshpande,Christian Buske,Kang-Ling Zhang,Yi Zhang,Guo-Liang Xu,Stefan K. Bohlander
View Articletitled, Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10–positive leukemias
Supplemental data
Polo-like kinase 1 is overexpressed in acute myeloid leukemia and its inhibition preferentially targets the proliferation of leukemic cells
Brief Report
Annelies G. Renner,Cédric Dos Santos,Christian Recher,Christian Bailly,Laurent Créancier,Anna Kruczynski,Bernard Payrastre,Stéphane Manenti
View Articletitled, Polo-like kinase 1 is overexpressed in acute myeloid leukemia and its inhibition preferentially targets the proliferation of leukemic cells
Supplemental data

PLATELETS AND THROMBOPOIESIS

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function
Brief Report
Simone M. Schoenwaelder,Yuping Yuan,Emma C. Josefsson,Michael J. White,Yu Yao,Kylie D. Mason,Lorraine A. O'Reilly,Katya J. Henley,Akiko Ono,Sarah Hsiao,Abbey Willcox,Andrew W. Roberts,David C. S. Huang,Hatem H. Salem,Benjamin T. Kile,Shaun P. Jackson
View Articletitled, Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-γ and CXCR3 chemokines
Kori L. Wallace,Melissa A. Marshall,Susan I. Ramos,Joanne A. Lannigan,Joshua J. Field,Robert M. Strieter,Joel Linden
View Articletitled, NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-γ and CXCR3 chemokines
Supplemental data

THROMBOSIS AND HEMOSTASIS

A murine model for induction of long-term immunologic tolerance to factor VIII does not require persistent detectable levels of plasma factor VIII and involves contributions from Foxp3+ T regulatory cells
Hideto Matsui,Masaru Shibata,Brian Brown,Andrea Labelle,Carol Hegadorn,Chandler Andrews,Marinee Chuah,Thierry VandenDriessche,Carol H. Miao,Christine Hough,David Lillicrap
View Articletitled, A murine model for induction of long-term immunologic tolerance to factor VIII does not require persistent detectable levels of plasma factor VIII and involves contributions from Foxp3<sup>+</sup> T regulatory cells
Venom factor V from the common brown snake escapes hemostatic regulation through procoagulant adaptations
Mettine H. A. Bos,Michael Boltz,Liam St. Pierre,Paul P. Masci,John de Jersey,Martin F. Lavin,Rodney M. Camire
View Articletitled, Venom factor V from the common brown snake escapes hemostatic regulation through procoagulant adaptations

TRANSPLANTATION

Multipotent adult progenitor cells can suppress graft-versus-host disease via prostaglandin E2 synthesis and only if localized to sites of allopriming
Steven L. Highfill,Ryan M. Kelly,Matthew J. O'Shaughnessy,Qing Zhou,Lily Xia,Angela Panoskaltsis-Mortari,Patricia A. Taylor,Jakub Tolar,Bruce R. Blazar
View Articletitled, Multipotent adult progenitor cells can suppress graft-versus-host disease via prostaglandin E<sub>2</sub> synthesis and only if localized to sites of allopriming
Supplemental data
Evaluation of NIH consensus criteria for classification of late acute and chronic GVHD
Afonso C. Vigorito,Paulo V. Campregher,Barry E. Storer,Paul A. Carpenter,Carina K. Moravec,Hans-Peter Kiem,Matthew L. Fero,Edus H. Warren,Stephanie J. Lee,Frederick R. Appelbaum,Paul J. Martin,Mary E. D. Flowers
View Articletitled, Evaluation of NIH consensus criteria for classification of late acute and chronic GVHD
Supplemental data
Imatinib for refractory chronic graft-versus-host disease with fibrotic features
Attilio Olivieri,Franco Locatelli,Marco Zecca,Adele Sanna,Michele Cimminiello,Roberto Raimondi,Guido Gini,Nicola Mordini,Adriana Balduzzi,Pietro Leoni,Armando Gabrielli,Andrea Bacigalupo
View Articletitled, Imatinib for refractory chronic graft-versus-host disease with fibrotic features
Supplemental data
Imatinib mesylate as salvage therapy for refractory sclerotic chronic graft-versus-host disease
Brief Report
Leonardo Magro,Mohamad Mohty,Benoit Catteau,Valérie Coiteux,Patrice Chevallier,Louis Terriou,Jean-Pierre Jouet,Ibrahim Yakoub-Agha
View Articletitled, Imatinib mesylate as salvage therapy for refractory sclerotic chronic graft-versus-host disease

VASCULAR BIOLOGY

Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures
Marianna Prokopi,Giordano Pula,Ursula Mayr,Cécile Devue,Joy Gallagher,Qingzhong Xiao,Chantal M. Boulanger,Nigel Westwood,Carmen Urbich,Johann Willeit,Marianne Steiner,Johannes Breuss,Qingbo Xu,Stefan Kiechl,Manuel Mayr
View Articletitled, Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures
Supplemental data
Glycoforms of human endothelial CD34 that bind L-selectin carry sulfated sialyl Lewis x capped O- and N-glycans
Gerard Hernandez Mir,Jari Helin,Kari-Pekka Skarp,Richard D. Cummings,Antti Mäkitie,Risto Renkonen,Anne Leppänen
View Articletitled, Glycoforms of human endothelial CD34 that bind L-selectin carry sulfated sialyl Lewis x capped O- and N-glycans
Supplemental data

CORRESPONDENCE

Glucose 6 phosphate dehydrogenase deficiency is not associated with cerebrovascular disease in children with sickle cell anemia
David C. Rees,Christopher Lambert,Elaine Cooper,Jack Bartram,David Goss,Colin Deane,Swee Lay Thein
View Articletitled, Glucose 6 phosphate dehydrogenase deficiency is not associated with cerebrovascular disease in children with sickle cell anemia
Response: G6PD deficiency and cerebrovascular disease in sickle cell anemia?
Françoise Bernaudin,Suzanne Verlhac,Martine Torres
View Articletitled, Response: G6PD deficiency and cerebrovascular disease in sickle cell anemia?
Proportions of immature CD19+CD21− B lymphocytes predict the response to extracorporeal photopheresis in patients with chronic graft-versus-host disease
Zoya Kuzmina,Hildegard T. Greinix,Robert Knobler,Nina Worel,Michal Kouba,Roman Weigl,Ulrike Körmöczi,Arno Rottal,David Pohlreich,Christoph Zielinski,Winfried F. Pickl
View Articletitled, Proportions of immature CD19<sup>+</sup>CD21<sup>−</sup> B lymphocytes predict the response to extracorporeal photopheresis in patients with chronic graft-versus-host disease
Activated human B cells: stimulatory or tolerogenic antigen-presenting cells?
Alexander Shimabukuro-Vornhagen,Eisei Kondo,Tanja Liebig,Michael von Bergwelt-Baildon
View Articletitled, Activated human B cells: stimulatory or tolerogenic antigen-presenting cells?
Response: Stimulatory or tolerogenic role of CD40-activated B cells depends on the strength of the activation to T cells
Wenwei Tu,Jian Zheng,Yinping Liu,Yu-Lung Lau
View Articletitled, Response: Stimulatory or tolerogenic role of CD40-activated B cells depends on the strength of the activation to T cells
  • Cover Image

    Cover Image

    issue cover

    The Australian Common Brown Snake (Pseudonaja textilis) has one of the most toxic venoms in the world, containing neurotoxic and procoagulant components. The latter consists of a factor V and a factor Xa-like enzyme. The factor V component has unique gain-of-function properties not present in mammalian factor V. See the article by Bos et al on page 686. Photo kindly provided by Professor Christopher Pollitt, University of Queensland School of Veterinary Science, Brisbane, Australia.

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