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Journal Articles

Activated Human iNKT Cells in Pediatric Sickle Cell Disease Patients and in Culture Upregulate Ectonucleotidase CD39 and Adenosine a 2A Receptor

Jennifer C. Yu, MD, Gene W. Lin, MD PhD, Jenny Kim, MD, Joel Linden, PhD

Blood (2014) 124 (21): 2734.

https://doi.org/10.1182/blood.V124.21.2734.2734

Published: 2014

Journal Articles

Antibody Mediated Depletion of iNKT Cells Protects Against Hypoxia-Induced Pulmonary Injury in a Murine Model of Sickle Cell Disease

Hong Pei, PhD, Robert Schaub, PhD, Felix Scheuplein, PhD, Robert Mashal, MD, Joel Linden, PhD

Blood (2014) 124 (21): 2697.

https://doi.org/10.1182/blood.V124.21.2697.2697

Published: 2014

Journal Articles

Contrast-Enhanced Ultrasound Detects Differences in Microvascular Blood Flow in Adults with Sickle Cell Disease Administered Regadenoson

Jonathan R. Lindner, MD, Michael Widlansky, MD, Melinda D. Wu, MD, Jillian Dargatz, RN, Leanne M. Harmann, RDCS, RDMS, RVT, Todd Belcik, BS, RCS, RDCS, Donna S. Neuberg, ScD, David G. Nathan, MD, Joel Linden, PhD, Joshua J. Field, MD MS

Blood (2014) 124 (21): 2705.

https://doi.org/10.1182/blood.V124.21.2705.2705

Published: 2014

Journal Articles

Intravital Imaging of Pulmonary Neutrophils in Sickle Cell Anemia

Natacha Ralainirina, PhD, Grzegorz Chodaczek, PhD, Joel Linden, PhD

Blood (2014) 124 (21): 1398.

https://doi.org/10.1182/blood.V124.21.1398.1398

Published: 2014

Journal Articles

Non-Invasive Contrast Ultrasound Imaging Of Abnormal Microvascular Perfusion and Reduced Functional Blood Volume In Sickle Cell Disease

Melinda D. Wu, MD, J. Todd Belcik, RCS, RDCS, Yue Qi, MD, Ted Foster, DO, MPH, Yan Zhao, MD, Joel Linden, PhD, Jonathan R. Lindner, MD

Blood (2013) 122 (21): 994.

https://doi.org/10.1182/blood.V122.21.994.994

Published: 2013

Journal Articles

The Role Of NF-κB In The Activation Of Human iNKT Cells In Sickle Cell Disease Patients and In Vitro

Jennifer C. Yu, MD, Gene Lin, MD, PhD, Ruey Ken, PhD, Joshua J. Field, MD, MS, Joel Linden, PhD

Blood (2013) 122 (21): 2291.

https://doi.org/10.1182/blood.V122.21.2291.2291

Published: 2013

Journal Articles

Human Sickle Cell Disease Increases Numbers and Activation Of Peripheral Blood Myeloid Dendritic Cells, Monocytes, and Neutrophils

Gene Lin, MD, PhD, Jennifer C. Yu, MD, Joshua J. Field, MD, MS, David G. Nathan, MD, Joel Linden, PhD

Blood (2013) 122 (21): 1033.

https://doi.org/10.1182/blood.V122.21.1033.1033

Published: 2013

Journal Articles

NF-κB Activation Mediates Induction Of Anti-Inflammatory Adenosine A2A Receptors In iNKT Cells Of Sickle Cell Patients During Vaso-Occlusive Episodes and Upon Activation Of Cultured Human iNKT Cells

Joel Linden, PhD, Gene Lin, MD, PhD, Jennifer C. Yu, MD, Donna S. Neuberg, ScD, David G. Nathan, MD, Joshua J. Field, MD, MS

Blood (2013) 122 (21): 975.

https://doi.org/10.1182/blood.V122.21.975.975

Published: 2013

Journal Articles

The Use Of Two Photon Microscopy To Image Vaso-Occulsion In Pulmonary Microvessels Of Living Mice With Sickle Cell Disease

Natacha Ralainirina, Ph.D., Ferron Lynn Sonderegger, PhD, Hong Pei, M.D., Ph.D., Grzegorz Chodaczek, Ph.D., Joel Linden, PhD

Blood (2013) 122 (21): 976.

https://doi.org/10.1182/blood.V122.21.976.976

Published: 2013

Journal Articles

Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A 2A receptor agonist regadenoson

Joshua J. Field, Gene Lin, Maureen M. Okam, Elaine Majerus, Jeffrey Keefer, Onyinye Onyekwere, Ainsley Ross, Federico Campigotto, Donna Neuberg, Joel Linden, David G. Nathan

Blood (2013) 121 (17): 3329–3334.

https://doi.org/10.1182/blood-2012-11-465963

Published: 2013

Includes: Supplemental data

Journal Articles

Regadenoson, An Adenosine 2A Receptor Agonist, Is Safe and Inhibits Invariant NKT Cells in Sickle Cell Disease

Joshua Field, MD, MS, Gene Lin, MD, PhD, Maureen Okam, MD, MPH, Elaine Majerus, MD, PhD, Onyinye Onyekwere, MD, MS, Ainsley Ross, BA, Donna Neuberg, ScD, Federico Campigotto, MS, David G. Nathan, MD, Joel Linden, PhD

Blood (2011) 118 (21): 849.

https://doi.org/10.1182/blood.V118.21.849.849

Published: 2011

Journal Articles

Adenosine A 2A receptors induced on iNKT and NK cells reduce pulmonary inflammation and injury in mice with sickle cell disease

Kori L. Wallace, Joel Linden

Blood (2010) 116 (23): 5010–5020.

https://doi.org/10.1182/blood-2010-06-290643

Published: 2010

Journal Articles

NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-γ and CXCR3 chemokines

Kori L. Wallace, Melissa A. Marshall, Susan I. Ramos, Joanne A. Lannigan, Joshua J. Field, Robert M. Strieter, Joel Linden

Blood (2009) 114 (3): 667–676.

https://doi.org/10.1182/blood-2009-02-205492

Published: 2009

Includes: Supplemental data

Journal Articles

A 2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells

Paul E. Zarek, Ching-Tai Huang, Eric R. Lutz, Jeanne Kowalski, Maureen R. Horton, Joel Linden, Charles G. Drake, Jonathan D. Powell

Blood (2008) 111 (1): 251–259.

https://doi.org/10.1182/blood-2007-03-081646

Published: 2008

Includes: Supplemental data

Journal Articles

Ups and downs of adenosine

Joel Linden

Blood (2006) 108 (5): 1430.

https://doi.org/10.1182/blood-2006-06-028480

Published: 2006

NARROW

Activated Human iNKT Cells in Pediatric Sickle Cell Disease Patients and in Culture Upregulate Ectonucleotidase CD39 and Adenosine a 2A Receptor

Antibody Mediated Depletion of iNKT Cells Protects Against Hypoxia-Induced Pulmonary Injury in a Murine Model of Sickle Cell Disease

Contrast-Enhanced Ultrasound Detects Differences in Microvascular Blood Flow in Adults with Sickle Cell Disease Administered Regadenoson

Intravital Imaging of Pulmonary Neutrophils in Sickle Cell Anemia

Non-Invasive Contrast Ultrasound Imaging Of Abnormal Microvascular Perfusion and Reduced Functional Blood Volume In Sickle Cell Disease

The Role Of NF-κB In The Activation Of Human iNKT Cells In Sickle Cell Disease Patients and In Vitro

Human Sickle Cell Disease Increases Numbers and Activation Of Peripheral Blood Myeloid Dendritic Cells, Monocytes, and Neutrophils

NF-κB Activation Mediates Induction Of Anti-Inflammatory Adenosine A2A Receptors In iNKT Cells Of Sickle Cell Patients During Vaso-Occlusive Episodes and Upon Activation Of Cultured Human iNKT Cells

The Use Of Two Photon Microscopy To Image Vaso-Occulsion In Pulmonary Microvessels Of Living Mice With Sickle Cell Disease

Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A 2A receptor agonist regadenoson

Regadenoson, An Adenosine 2A Receptor Agonist, Is Safe and Inhibits Invariant NKT Cells in Sickle Cell Disease

Adenosine A 2A receptors induced on iNKT and NK cells reduce pulmonary inflammation and injury in mice with sickle cell disease

NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-γ and CXCR3 chemokines

A 2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells

Ups and downs of adenosine

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American Society of Hematology

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American Society of Hematology

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