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Journal Articles

Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma

Simona Blotta, Jana Jakubikova, Teresa Calimeri, Aldo M. Roccaro, Nicola Amodio, Abdel Kareem Azab, Umberto Foresta, Constantine S. Mitsiades, Marco Rossi, Katia Todoerti, Stefano Molica, Fortunato Morabito, Antonino Neri, Piersandro Tagliaferri, Pierfrancesco Tassone, Kenneth C. Anderson, Nikhil C. Munshi

Blood (2012) 120 (25): 5002–5013.

https://doi.org/10.1182/blood-2011-07-368142

Published: 2012

Journal Articles

Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications

Jana Jakubikova, Sophia Adamia, Maria Kost-Alimova, Steffen Klippel, David Cervi, John F. Daley, Dana Cholujova, Sun-Young Kong, Merav Leiba, Simona Blotta, Melissa Ooi, Jake Delmore, Jacob Laubach, Paul G. Richardson, Jan Sedlak, Kenneth C. Anderson, Constantine S. Mitsiades

Blood (2011) 117 (17): 4409–4419.

https://doi.org/10.1182/blood-2010-02-267344

Published: 2011

Includes: Supplemental data

Journal Articles

Vaccination with dendritic cell/tumor fusion cells results in cellular and humoral antitumor immune responses in patients with multiple myeloma

Jacalyn Rosenblatt, Baldev Vasir, Lynne Uhl, Simona Blotta, Claire MacNamara, Poorvi Somaiya, Zekui Wu, Robin Joyce, James D. Levine, Dilani Dombagoda, Yan Emily Yuan, Karen Francoeur, Donna Fitzgerald, Paul Richardson, Edie Weller, Kenneth Anderson, Donald Kufe, Nikhil Munshi, David Avigan

Blood (2011) 117 (2): 393–402.

https://doi.org/10.1182/blood-2010-04-277137

Published: 2011

Journal Articles

Targeting the Clonogenic Side Population of Multiple Myeloma by Immunomodulatory Drugs (IMiDs) in the Context of Stromal Cell Microenvironment: Pathophysiologic and Clinical Implications.

Jana Jakubikova, David N. Cervi, John F. Daley, Danka Cholujova, Melissa G. Ooi, Steffen Klippel, Simona Blotta, Merav Leiba, Jake Delmore, Douglas McMillin, Efstathios Kastritis, Jacob Laubach, Paul Richardson, Jan Sedlak, Kenneth C. Anderson, Constantine S. Mitsiades, M.D., Ph.D

Blood (2009) 114 (22): 954.

https://doi.org/10.1182/blood.V114.22.954.954

Published: 2009

Journal Articles

Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significance

Simona Blotta, Pierfrancesco Tassone, Rao H. Prabhala, Piersandro Tagliaferri, David Cervi, Samir Amin, Jana Jakubikova, Yu-Tzu Tai, Klaus Podar, Constantine S. Mitsiades, Alessandro Zullo, Brunella Franco, Kenneth C. Anderson, Nikhil C. Munshi

Blood (2009) 114 (15): 3276–3284.

https://doi.org/10.1182/blood-2009-04-219436

Published: 2009

Journal Articles

RhoA and Rac1 GTPases play major and differential roles in stromal cell–derived factor-1–induced cell adhesion and chemotaxis in multiple myeloma

Abdel Kareem Azab, Feda Azab, Simona Blotta, Costas M. Pitsillides, Brian Thompson, Judith M. Runnels, Aldo M. Roccaro, Hai T. Ngo, Molly R. Melhem, Antonio Sacco, Xiaoying Jia, Kenneth C. Anderson, Charles P. Lin, Barrett J. Rollins, Irene M. Ghobrial

Blood (2009) 114 (3): 619–629.

https://doi.org/10.1182/blood-2009-01-199281

Published: 2009

Includes: Multimedia, Supplemental data

Journal Articles

The Novel, Orally Available Multi-Kinase Inhibitor BAY 73-4506 in Multiple Myeloma

Iris Breitkreutz, Marc S Raab, Olaf Christensen, Alexander Zimmerhackl, Jing Zhang, Simona Blotta, Teru Hideshima, Dharminder Chauhan, Scott Wilhelm, Kenneth C Anderson, MD, Klaus Podar, MD, MSc, PhD

Blood (2008) 112 (11): 2766.

https://doi.org/10.1182/blood.V112.11.2766.2766

Published: 2008

Journal Articles

A Novel Aurora-a Kinase Inhibitor MLN8237 Induces Cytotoxicity and Cell Cycle Arrest in Experimental Multiple Myeloma Models.

Gullu Gorgun, PhD, Elisabetta Calabrese, MD, Mala Mani, PhD, Teru Hideshima, M.D., Ph.D., Hiroshi Ikeda, MD, PhD, Giulia Perrone, MD, Loredana Santo, MD, Diana Cirstea, MD, Simona Blotta, Paul G. Richardson, MD, Jeffrey Ecsedy, Kenneth C. Anderson, MD

Blood (2008) 112 (11): 1719.

https://doi.org/10.1182/blood.V112.11.1719.1719

Published: 2008

Journal Articles

Canonical and Non Canonical Activation of Hedgehog Pathway in Multiple Myeloma

Simona Blotta, Klaus Podar, Yu-Tzu Tai, Aldo M. Roccaro, Gullu Gorgun, Brunella Franco, Constantine S. Mitsiades, Salvatore Venuta, Kenneth C. Anderson

Blood (2008) 112 (11): 2748.

https://doi.org/10.1182/blood.V112.11.2748.2748

Published: 2008

Journal Articles

Anti-DKK1 mAb (BHQ880) as a Potential Therapeutic for Multiple Myeloma.

Mariateresa Fulciniti, PhD, Pierfrancesco Tassone, MD, Teru Hideshima, MD, Sonia Vallet, MD, Seth Ettenberg, PhD, David Stover, PhD, Simona Blotta, MD, Zhenxin Shen, PhD, Maria Teresa Dimartino, PhD, Paola Neri, MD, Rao Prabhala, PhD, Raje Nopur, MD, Steven R. Goldring, MD, Kenneth C. Anderson, MD, Nikhil C. Munshi, MD

Blood (2007) 110 (11): 551.

https://doi.org/10.1182/blood.V110.11.551.551

Published: 2007

Journal Articles

T H 17 Pathway and Associated Pro-Inflammatory Cytokines Promote Immune Dysfunction in Myeloma.

Rao Prabhala, PhD, Dheeraj Pelluru, PhD, Paola Neri, MD, Mariateresa Fulciniti, PhD, James J. Driscoll, MD, PhD, Song Weihua, MD, Simona Blotta, MD, Yu-Tzu Tai, PhD, Hiren Patel, BS, Yvonne A. Efebera, MD, Teru Hideshima, MD, PhD, Dhaminder Chauhan, PhD, John F. Daley, PhD, Kenneth C. Anderson, MD, Nikhil C. Munshi, MD

Blood (2007) 110 (11): 3517.

https://doi.org/10.1182/blood.V110.11.3517.3517

Published: 2007

Journal Articles

The Novel, Orally Available Multi-Kinase Inhibitor BAY 73-4506 Targets Myeloma Cells and Their Bone Marrow Microenvironment.

Marc S. Raab, MD, Iris Breitkreutz, MD, Podar Klaus, MD, PhD, Jing Zhang, MSc, Simona Blotta, MD, Olaf Christensen, MD, Teru Hideshima, MD, Dharminder Chauhan, PhD, Scott Wilhelm, PhD, Kenneth C. Anderson, MD

Blood (2007) 110 (11): 2525.

https://doi.org/10.1182/blood.V110.11.2525.2525

Published: 2007

Journal Articles

OFD1-Mediated T Cell Responses in MGUS Patients: Implications for Immunotherapy.

Simona Blotta, MD, Rao Prabhala, PhD, Dheeraj Pelluru, PhD, Sasada Tetsuro, PhD, Brunella Franco, MD, PhD, Pierosandro Tagliaferri, MD, Pierfranceso Tassone, MD, Kenneth C. Anderson, MD, Nikhil C. Munshi, MD

Blood (2007) 110 (11): 1488.

https://doi.org/10.1182/blood.V110.11.1488.1488

Published: 2007

Journal Articles

Modulation of Gene Expression Profile and In Vivo Anti-Myeloma Activity Induced by Valproic Acid, a Histone Deacytylase Inhibitor.

Paola Neri, MD, Teresa Calimeri, MD, Mariateresa Di Martino, PhD, Marco Rossi, MD, Orietta Eramo, PhD, Mariagrazia Propato, MD, Gino Perri, MD, Antonella Pietragalla, MD, Monica Ventura, MD, Alessandra Bulotta, MD, Simona Blotta, MD, Pierosandro Tagliaferri, MD, Kenneth C. Anderson, MD, Nikhil C. Munshi, MD, Pierfrancesco Tassone, MD

Blood (2007) 110 (11): 4790.

https://doi.org/10.1182/blood.V110.11.4790.4790

Published: 2007

Journal Articles

Hedgehog Pathway as a Potential Therapeutic Target in Multiple Myeloma.

Simona Blotta, MD, Joeseph Negri, Purushothama Nanjappa, Anne-Sophie Moreau, MD, Rao Prabhala, PhD, Masood Shammas, PhD, Dheeraj Pelluru, PhD, Douglas McMillin, PhD, Yu-Tzu Tai, PhD, Pierfrancesco Tassone, MD, Kenneth C. Anderson, MD, Constantine Mitsiades, MD, PhD, Nikhil C. Munshi, MD

Blood (2007) 110 (11): 672.

https://doi.org/10.1182/blood.V110.11.672.672

Published: 2007

Journal Articles

Novel Murine Model To Study Modulation of Genes and Molecular Pathways Induced Following In Vivo Interaction between Multiple Myeloma Cells and Human BM Milieu.

Paola Neri, MD, Pierfrancesco Tassone, MD, Masood Shammas, PhD, Mariateresa Fulciniti, PhD, Yu-Tzu Tai, PhD, Simona Blotta, MD, Rao Prabhala, PhD, Mariateresa Di Martino, PhD, Laurence Catley, MD, Pierosandro Tagliaferri, MD, Salvatore Venuta, MD, Ruben Carrasco, MD, Kenneth C. Anderson, MD, Nikhil C. Munshi, MD

Blood (2006) 108 (11): 3409.

https://doi.org/10.1182/blood.V108.11.3409.3409

Published: 2006

Journal Articles

Defining a Murine Model To Study Bone Disease in Multiple Myeloma (MM).

Paola Neri, MD, Pierfrancesco Tassone, MD, Zhenxin Shen, PhD, Nipun Patel, PhD, Robert Fajardo, PhD, Mariateresa Fulciniti, PhD, Rao Prabhala, PhD, Masood Shammas, PhD, Simona Blotta, MD, Teru Hideshima, MD, Dharminder Chauhan, PhD, John Muller, PhD, Salvatore Venuta, MD, Brian D. Snyder, MD, Steven R. Goldring, MD, Kenneth C. Anderson, MD, Nikhil C. Munshi, MD

Blood (2006) 108 (11): 3518.

https://doi.org/10.1182/blood.V108.11.3518.3518

Published: 2006

Journal Articles

Biological Pathways and In Vivo Anti-Tumor Activity Induced by Atiprimod in Multiple Myeloma (MM).

Paola Neri, MD, Pierfrancesco Tassone, MD, Masood Shammas, PhD, Hiroshi Yasui, MD, Ernestina Schipani, MD, Ramesh B. Batchu, PhD, Simona Blotta, MD, Rao Prabhala, PhD, Laurence Catley, MD, Makoto Hamasaki, MD, Teru Hideshima, MD, Dharminder Chauhan, PhD, Gary S. Jacob, PhD, Donald Picker, PhD, Salvatore Venuta, MD, Kenneth C. Anderson, MD, Nikhil C. Munshi, MD

Blood (2006) 108 (11): 3455.

https://doi.org/10.1182/blood.V108.11.3455.3455

Published: 2006

Journal Articles

Identification of Novel Antigens with Induced Immune Response in MGUS.

Simona Blotta, MD, Hiroshi Yasui, MD, Pierfrancesco Tassone, MD, Roberto Bellucci, PhD, Yu-Tzu Tai, PhD, Rao Prabhala, PhD, Masood A. Shammas, PhD, Pierosandro Tagliaferri, MD, Klaus Podar, MD, PhD, Paola E. Neri, MD, Mariateresa Fulciniti, PhD, Vidit Munshi, Dharminder Chauhan, PhD, Teru Hideshima, MD, PhD, Salvatore Venuta, MD, PhD, Jerome Ritz, MD, Kenneth C. Anderson, MD, Nikhil C. Munshi, MD

Blood (2006) 108 (11): 655.

https://doi.org/10.1182/blood.V108.11.655.655

Published: 2006

Journal Articles

In Vivo Anti-Tumor Activity of Atiprimod on SCID Models of Multiple Myeloma.

Paola Neri, MD, Pierfrancesco Tassone, MD, Masood A. Shammas, PhD, Ramesh B. Batchu, PhD, Simona Blotta, MD, Sushma Samala, PhD, Laurence Catley, MD, Makoto Hamasaki, PhD, Teru Hideshima, MD, Gary S. Jacob, PhD, Donald H. Picker, PhD, Salvatore Venuta, MD, Kenneth C. Anderson, MD, Nikhil C. Munshi, MD

Blood (2005) 106 (11): 249.

https://doi.org/10.1182/blood.V106.11.249.249

Published: 2005

NARROW

Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma

Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications

Vaccination with dendritic cell/tumor fusion cells results in cellular and humoral antitumor immune responses in patients with multiple myeloma

Targeting the Clonogenic Side Population of Multiple Myeloma by Immunomodulatory Drugs (IMiDs) in the Context of Stromal Cell Microenvironment: Pathophysiologic and Clinical Implications.

Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significance

RhoA and Rac1 GTPases play major and differential roles in stromal cell–derived factor-1–induced cell adhesion and chemotaxis in multiple myeloma

The Novel, Orally Available Multi-Kinase Inhibitor BAY 73-4506 in Multiple Myeloma

A Novel Aurora-a Kinase Inhibitor MLN8237 Induces Cytotoxicity and Cell Cycle Arrest in Experimental Multiple Myeloma Models.

Canonical and Non Canonical Activation of Hedgehog Pathway in Multiple Myeloma

Anti-DKK1 mAb (BHQ880) as a Potential Therapeutic for Multiple Myeloma.

T H 17 Pathway and Associated Pro-Inflammatory Cytokines Promote Immune Dysfunction in Myeloma.

The Novel, Orally Available Multi-Kinase Inhibitor BAY 73-4506 Targets Myeloma Cells and Their Bone Marrow Microenvironment.

OFD1-Mediated T Cell Responses in MGUS Patients: Implications for Immunotherapy.

Modulation of Gene Expression Profile and In Vivo Anti-Myeloma Activity Induced by Valproic Acid, a Histone Deacytylase Inhibitor.

Hedgehog Pathway as a Potential Therapeutic Target in Multiple Myeloma.

Novel Murine Model To Study Modulation of Genes and Molecular Pathways Induced Following In Vivo Interaction between Multiple Myeloma Cells and Human BM Milieu.

Defining a Murine Model To Study Bone Disease in Multiple Myeloma (MM).

Biological Pathways and In Vivo Anti-Tumor Activity Induced by Atiprimod in Multiple Myeloma (MM).

Identification of Novel Antigens with Induced Immune Response in MGUS.

In Vivo Anti-Tumor Activity of Atiprimod on SCID Models of Multiple Myeloma.

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American Society of Hematology

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American Society of Hematology

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