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Volume 106, Issue 12

December 1 2005

In this Issue

INSIDE BLOOD
BLOOD WORK
PLENARY PAPERS
REVIEWS IN TRANSLATIONAL HEMATOLOGY
CHEMOKINES, CYTOKINES, AND INTERLEUKINS
CLINICAL TRIALS AND OBSERVATIONS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
STEM CELLS IN HEMATOLOGY
TRANSPLANTATION

INSIDE BLOOD

IMMUNOBIOLOGY

T cells bet on sugars to help

Linda G. Baum

View Articletitled, T cells bet on sugars to help

CLINICAL OBSERVATIONS

R-CHOP strikes again with survival benefit in follicular lymphoma

Wyndham H. Wilson

View Articletitled, R-CHOP strikes again with survival benefit in follicular lymphoma

HEMOSTASIS

Hemodynamic manipulation of eNOS in vivo

Peter F. Davies

View Articletitled, Hemodynamic manipulation of eNOS in vivo

HEMOSTASIS

Another fibrin αC scene unmasked

Dennis K. Galanakis

View Articletitled, Another fibrin αC scene unmasked

CLINICAL OBSERVATIONS

Dueling mutations in normal karyotype AML

Robert E. Gallagher

View Articletitled, Dueling mutations in normal karyotype AML

STEM CELLS IN HEMATOLOGY

The wizard of Hox

Curt I. Civin

View Articletitled, The wizard of Hox

HEMOSTASIS

VKORC1: the little big protein

Johannes Oldenburg

View Articletitled, VKORC1: the little big protein

HEMATOPOIESIS

A green light for the thrombopoietic program

Pudur Jagadeeswaran

View Articletitled, A green light for the thrombopoietic program

IMMUNOBIOLOGY

Cytokine receptor gene plays antioncogene

Giorgio Trinchieri

View Articletitled, Cytokine receptor gene plays antioncogene

TRANSPLANTATION

Antagonizing CXCR4 accelerates CD34⁺ cell mobilization

Steven M. Devine

View Articletitled, Antagonizing CXCR4 accelerates CD34+ cell mobilization

CLINICAL OBSERVATIONS

The immune paradox of fondaparinux

Gowthami M. Arepally

View Articletitled, The immune paradox of fondaparinux

CLINICAL OBSERVATIONS

To transplant or not to transplant?

Nikhil C. Munshi,Kenneth C. Anderson

View Articletitled, To transplant or not to transplant?

BLOOD WORK

Dysplastic polychromatic “snowmoblast”

View Articletitled, Dysplastic polychromatic “snowmoblast”

PLENARY PAPERS

Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique

Caroline Cheng,Rien van Haperen,Monique de Waard,Luc C. A. van Damme,Dennie Tempel,Laurens Hanemaaijer,Gert W. A. van Cappellen,Joop Bos,Cornelis J. Slager,Dirk J. Duncker,Anton F. W. van der Steen,Rini de Crom,Rob Krams

View Articletitled, Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique

REVIEWS IN TRANSLATIONAL HEMATOLOGY

Diagnosis and management of paroxysmal nocturnal hemoglobinuria

Charles Parker,Mitsuhiro Omine,Stephen Richards,Jun-ichi Nishimura,Monica Bessler,Russell Ware,Peter Hillmen,Lucio Luzzatto,Neal Young,Taroh Kinoshita,Wendell Rosse,Gerard Socié,for the International PNH Interest Group

View Articletitled, Diagnosis and management of paroxysmal nocturnal hemoglobinuria

Supplemental data

Understanding iron homeostasis through genetic analysis of hemochromatosis and related disorders
Clinical Trials & Observations

Clara Camaschella

View Articletitled, Understanding iron homeostasis through genetic analysis of hemochromatosis and related disorders

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

Human CD8⁺ T cells store CXCR1 in a distinct intracellular compartment and up-regulate it rapidly to the cell surface upon activation

Olivier Gasser,Anna Missiou,Ceylan Eken,Christoph Hess

View Articletitled, Human CD8+ T cells store CXCR1 in a distinct intracellular compartment and up-regulate it rapidly to the cell surface upon activation

CLINICAL TRIALS AND OBSERVATIONS

Frontline therapy with rituximab added to the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) significantly improves the outcome for patients with advanced-stage follicular lymphoma compared with therapy with CHOP alone: results of a prospective randomized study of the German Low-Grade Lymphoma Study Group
Clinical Trials & Observations

Wolfgang Hiddemann,Michael Kneba,Martin Dreyling,Norbert Schmitz,Eva Lengfelder,Rudolf Schmits,Marcel Reiser,Bernd Metzner,Harriet Harder,Susanna Hegewisch-Becker,Thomas Fischer,Martin Kropff,Hans-Edgar Reis,Mathias Freund,Bernhard Wörmann,Roland Fuchs,Manfred Planker,Jörg Schimke,Hartmut Eimermacher,Lorenz Trümper,Ali Aldaoud,Reza Parwaresch,Michael Unterhalt

View Articletitled, Frontline therapy with rituximab added to the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) significantly improves the outcome for patients with advanced-stage follicular lymphoma compared with therapy with CHOP alone: results of a prospective randomized study of the German Low-Grade Lymphoma Study Group

Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype
Clinical Trials & Observations

Susanne Schnittger,Claudia Schoch,Wolfgang Kern,Cristina Mecucci,Claudia Tschulik,Massimo F. Martelli,Torsten Haferlach,Wolfgang Hiddemann,Brunangelo Falini

View Articletitled, Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype

Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations
Clinical Trials & Observations

Konstanze Döhner,Richard F. Schlenk,Marianne Habdank,Claudia Scholl,Frank G. Rücker,Andrea Corbacioglu,Lars Bullinger,Stefan Fröhling,Hartmut Döhner,for the AML Study Group (AMLSG)

View Articletitled, Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations

Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance
Clinical Trials & Observations

Roel G. W. Verhaak,Chantal S. Goudswaard,Wim van Putten,Maarten A. Bijl,Mathijs A. Sanders,Wendy Hugens,André G. Uitterlinden,Claudia A. J. Erpelinck,Ruud Delwel,Bob Löwenberg,Peter J. M. Valk

View Articletitled, Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance

Supplemental data

High-dose therapy intensification compared with continued standard chemotherapy in multiple myeloma patients responding to the initial chemotherapy: long-term results from a prospective randomized trial from the Spanish cooperative group PETHEMA
Clinical Trials & Observations

Joan Bladé,Laura Rosiñol,Ana Sureda,Josep M. Ribera,Joaquín Díaz-Mediavilla,José García-Laraña,M. Victoria Mateos,Luis Palomera,Javier Fernández-Calvo,Josep M. Martí,Pilar Giraldo,Félix Carbonell,Manel Callís,Jesús Trujillo,Santiago Gardella,M. Jesús Moro,Abelardo Barez,Alfons Soler,Llorenç Font,Montserrat Fontanillas,Jesús San Miguel,for Programa para el Estudio de la Terapéutica en Hemopatía Maligna (PETHEMA)

View Articletitled, High-dose therapy intensification compared with continued standard chemotherapy in multiple myeloma patients responding to the initial chemotherapy: long-term results from a prospective randomized trial from the Spanish cooperative group PETHEMA

Induction therapy for adults with acute lymphoblastic leukemia: results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993
Clinical Trials & Observations

Jacob M. Rowe,Georgina Buck,Alan K. Burnett,Raj Chopra,Peter H. Wiernik,Susan M. Richards,Hillard M. Lazarus,Ian M. Franklin,Mark R. Litzow,Niculae Ciobanu,H. Grant Prentice,Jill Durrant,Martin S. Tallman,Anthony H. Goldstone,for ECOG and the MRC/NCRI Adult Leukemia Working Party

View Articletitled, Induction therapy for adults with acute lymphoblastic leukemia: results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993

Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia
Clinical Trials & Observations

Rosemary E. Gale,Robert Hills,Arnold R. Pizzey,Panagiotis D. Kottaridis,David Swirsky,Amanda F. Gilkes,Elizabeth Nugent,Kenneth I. Mills,Keith Wheatley,Ellen Solomon,Alan K. Burnett,David C. Linch,David Grimwade,for the NCRI Adult Leukaemia Working Party

View Articletitled, Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia

Supplemental data

Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma
Clinical Trials & Observations

Sagar Lonial,Edmund K. Waller,Paul G. Richardson,Sundar Jagannath,Robert Z. Orlowski,Cynthia R. Giver,David L. Jaye,Dixil Francis,Sara Giusti,Claire Torre,Bart Barlogie,James R. Berenson,Seema Singhal,David P. Schenkein,Dixie-Lee W. Esseltine,Jessica Anderson,Hugh Xiao,Leonard T. Heffner,Kenneth C. Anderson,for the SUMMIT/CREST Investigators

View Articletitled, Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma

Local tumor invasiveness is more predictive of survival than International Prognostic Index in stage I_E/II_E extranodal NK/T-cell lymphoma, nasal type
Clinical Trials & Observations

Tae Min Kim,Yeon Hee Park,Sang-Yoon Lee,Ji-Hoon Kim,Dong-Wan Kim,Seock-Ah Im,Tae-You Kim,Chul Woo Kim,Dae Seog Heo,Yung-Jue Bang,Kee-Hyun Chang,Noe Kyeong Kim

View Articletitled, Local tumor invasiveness is more predictive of survival than International Prognostic Index in stage IE/IIE extranodal NK/T-cell lymphoma, nasal type

Anti–platelet factor 4/heparin antibodies in orthopedic surgery patients receiving antithrombotic prophylaxis with fondaparinux or enoxaparin
Clinical Trials & Observations

Theodore E. Warkentin,Richard J. Cook,Victor J. Marder,Jo-Ann I. Sheppard,Jane C. Moore,Bengt I. Eriksson,Andreas Greinacher,John G. Kelton

View Articletitled, Anti–platelet factor 4/heparin antibodies in orthopedic surgery patients receiving antithrombotic prophylaxis with fondaparinux or enoxaparin

GENE THERAPY

Intrabodies targeting the Kaposi sarcoma–associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells

Sofia Corte-Real,Chris Collins,Frederico Aires da Silva,J. Pedro Simas,Carlos F. Barbas, III,Yuan Chang,Patrick Moore,Joao Goncalves

View Articletitled, Intrabodies targeting the Kaposi sarcoma–associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells

HEMATOPOIESIS

Analysis of thrombocyte development in CD41-GFP transgenic zebrafish

Hui-Feng Lin,David Traver,Hao Zhu,Kimberly Dooley,Barry H. Paw,Leonard I. Zon,Robert I. Handin

View Articletitled, Analysis of thrombocyte development in CD41-GFP transgenic zebrafish

Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Vitamin K epoxide reductase significantly improves carboxylation in a cell line overexpressing factor X

Yan-Mei Sun,Da-Yun Jin,Rodney M. Camire,Darrel W. Stafford

View Articletitled, Vitamin K epoxide reductase significantly improves carboxylation in a cell line overexpressing factor X

The Ig-ITIM superfamily member PECAM-1 regulates the “outside-in” signaling properties of integrin α_IIbβ₃ in platelets

Janet L. Wee,Denise E. Jackson

View Articletitled, The Ig-ITIM superfamily member PECAM-1 regulates the “outside-in” signaling properties of integrin αIIbβ3 in platelets

The αC domains of fibrinogen affect the structure of the fibrin clot, its physical properties, and its susceptibility to fibrinolysis

Jean-Philippe Collet,Jennifer L. Moen,Yuri I. Veklich,Oleg V. Gorkun,Susan T. Lord,Gilles Montalescot,John W. Weisel

View Articletitled, The αC domains of fibrinogen affect the structure of the fibrin clot, its physical properties, and its susceptibility to fibrinolysis

Inhibition of pathologic retinal neovascularization by α-defensins

Matina Economopoulou,Khalil Bdeir,Douglas B. Cines,Franz Fogt,Yasmina Bdeir,Jacek Lubkowski,Wuyuan Lu,Klaus T. Preissner,Hans-Peter Hammes,Triantafyllos Chavakis

View Articletitled, Inhibition of pathologic retinal neovascularization by α-defensins

IMMUNOBIOLOGY

Timely triggering of homeostatic mechanisms involved in the regulation of T-cell levels in SIVsm-infected sooty mangabeys

Alagarraju Muthukumar,Dejiang Zhou,Mirko Paiardini,Ashley P. Barry,Kelly S. Cole,Harold M. McClure,Silvija I. Staprans,Guido Silvestri,Donald L. Sodora

View Articletitled, Timely triggering of homeostatic mechanisms involved in the regulation of T-cell levels in SIVsm-infected sooty mangabeys

Lack of Il12rb2 signaling predisposes to spontaneous autoimmunity and malignancy

Irma Airoldi,Emma Di Carlo,Claudia Cocco,Carlo Sorrentino,Franco Fais,Michele Cilli,Tommaso D'Antuono,Mario Paolo Colombo,Vito Pistoia

View Articletitled, Lack of Il12rb2 signaling predisposes to spontaneous autoimmunity and malignancy

The extracellular matrix protein mindin serves as an integrin ligand and is critical for inflammatory cell recruitment

Wei Jia,Hong Li,You-Wen He

View Articletitled, The extracellular matrix protein mindin serves as an integrin ligand and is critical for inflammatory cell recruitment

Thrombospondin-1 and indoleamine 2,3-dioxygenase are major targets of extracellular ATP in human dendritic cells

Frédéric Marteau,Nathalie Suarez Gonzalez,David Communi,Michel Goldman,Jean-Marie Boeynaems,Didier Communi

View Articletitled, Thrombospondin-1 and indoleamine 2,3-dioxygenase are major targets of extracellular ATP in human dendritic cells

A crucial role for T-bet in selectin ligand expression in T helper 1 (Th1) cells

Greg H. Underhill,Dimitrios G. Zisoulis,K. Pallav Kolli,Lesley G. Ellies,Jamey D. Marth,Geoffrey S. Kansas

View Articletitled, A crucial role for T-bet in selectin ligand expression in T helper 1 (Th1) cells

Secretion of IFN-γ and not IL-2 by anergic human T cells correlates with assembly of an immature immune synapse

Leo M. Carlin,Kumiko Yanagi,Adrienne Verhoef,Esther N. M. Nolte-'t Hoen,John Yates,Leanne Gardner,Jonathan Lamb,Giovanna Lombardi,Margaret J. Dallman,Daniel M. Davis

View Articletitled, Secretion of IFN-γ and not IL-2 by anergic human T cells correlates with assembly of an immature immune synapse

Oxidized β₂-glycoprotein I induces human dendritic cell maturation and promotes a T helper type 1 response

Brigitta Buttari,Elisabetta Profumo,Vincenzo Mattei,Alessandra Siracusano,Elena Ortona,Paola Margutti,Bruno Salvati,Maurizio Sorice,Rachele Riganò

View Articletitled, Oxidized β2-glycoprotein I induces human dendritic cell maturation and promotes a T helper type 1 response

Supplemental data

PPAR-γ agonists inhibit toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-κB pathways

Silke Appel,Valdete Mirakaj,Anita Bringmann,Markus M. Weck,Frank Grünebach,Peter Brossart

View Articletitled, PPAR-γ agonists inhibit toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-κB pathways

Analysis of T-cell repertoire diversity in Wiskott-Aldrich syndrome
Brief Report

Taizo Wada,Shepherd H. Schurman,Elizabeth K. Garabedian,Akihiro Yachie,Fabio Candotti

View Articletitled, Analysis of T-cell repertoire diversity in Wiskott-Aldrich syndrome

NEOPLASIA

Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies

Patrick A. Zweidler-McKay,Yiping He,Lanwei Xu,Carlos G. Rodriguez,Fredrick G. Karnell,Andrea C. Carpenter,Jon C. Aster,David Allman,Warren S. Pear

View Articletitled, Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies

p130Cas mediates the transforming properties of the anaplastic lymphoma kinase

Chiara Ambrogio,Claudia Voena,Andrea D. Manazza,Roberto Piva,Ludovica Riera,Laura Barberis,Carlotta Costa,Guido Tarone,Paola Defilippi,Emilio Hirsch,Elisabetta Boeri Erba,Shabaz Mohammed,Ole N. Jensen,Giorgio Palestro,Giorgio Inghirami,Roberto Chiarle

View Articletitled, p130Cas mediates the transforming properties of the anaplastic lymphoma kinase

NF-κB and FLIP in arsenic trioxide (ATO)-induced apoptosis in myelodysplastic syndromes (MDSs)

Daniella M. B. Kerbauy,Vladimir Lesnikov,Nissa Abbasi,Sudeshna Seal,Bart Scott,H. Joachim Deeg

View Articletitled, NF-κB and FLIP in arsenic trioxide (ATO)-induced apoptosis in myelodysplastic syndromes (MDSs)

Phenotypic and functional analyses of dendritic cells in patients with lymphoproliferative disease of granular lymphocytes (LDGL)

Renato Zambello,Tamara Berno,Giovanna Cannas,Ilenia Baesso,Gianni Binotto,Emanuela Bonoldi,Pierantonio Bevilacqua,Marta Miorin,Monica Facco,Livio Trentin,Carlo Agostini,Gianpietro Semenzato

View Articletitled, Phenotypic and functional analyses of dendritic cells in patients with lymphoproliferative disease of granular lymphocytes (LDGL)

Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells

Yang Du,Nancy A. Jenkins,Neal G. Copeland

View Articletitled, Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells

Constitutive NF-κB and NFAT activation in aggressive B-cell lymphomas synergistically activates the CD154 gene and maintains lymphoma cell survival

Lan V. Pham,Archito T. Tamayo,Linda C. Yoshimura,Yen-Chiu Lin-Lee,Richard J. Ford

View Articletitled, Constitutive NF-κB and NFAT activation in aggressive B-cell lymphomas synergistically activates the CD154 gene and maintains lymphoma cell survival

NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia

Shinya Kimura,Haruna Naito,Hidekazu Segawa,Junya Kuroda,Takeshi Yuasa,Kiyoshi Sato,Asumi Yokota,Yuri Kamitsuji,Eri Kawata,Eishi Ashihara,Yohei Nakaya,Haruna Naruoka,Tatsushi Wakayama,Kimio Nasu,Tetsuo Asaki,Tomoko Niwa,Kazuko Hirabayashi,Taira Maekawa

View Articletitled, NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia

Up-regulated expression in nonhematopoietic tissues of the BCL2A1-derived minor histocompatibility antigens in response to inflammatory cytokines: relevance for allogeneic immunotherapy of leukemia
Brief Report

Freke M. Kloosterboer,Simone A. P. van Luxemburg-Heijs,Ronald A. van Soest,H. M. Esther van Egmond,Roel Willemze,J. H. Frederik Falkenburg

View Articletitled, Up-regulated expression in nonhematopoietic tissues of the BCL2A1-derived minor histocompatibility antigens in response to inflammatory cytokines: relevance for allogeneic immunotherapy of leukemia

Extracellular KIT receptor mutants, commonly found in core binding factor AML, are constitutively active and respond to imatinib mesylate
Brief Report

Jörg Cammenga,Stefan Horn,Ulla Bergholz,Gunhild Sommer,Peter Besmer,Walter Fiedler,Carol Stocking

View Articletitled, Extracellular KIT receptor mutants, commonly found in core binding factor AML, are constitutively active and respond to imatinib mesylate

PHAGOCYTES

p21-activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils

Kendra D. Martyn,Moon-Ju Kim,Mark T. Quinn,Mary C. Dinauer,Ulla G. Knaus

View Articletitled, p21-activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils

Mechanism and effect of thrombospondin-4 polymorphisms on neutrophil function

Elzbieta Pluskota,Olga I. Stenina,Irene Krukovets,Dorota Szpak,Eric J. Topol,Edward F. Plow

View Articletitled, Mechanism and effect of thrombospondin-4 polymorphisms on neutrophil function

Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin

Constance Delaby,Nathalie Pilard,Ana Sofia Gonçalves,Carole Beaumont,François Canonne-Hergaux

View Articletitled, Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin

RED CELLS

Functional consequences of the human DMT1 (SLC11A2) mutation on protein expression and iron uptake
Brief Report

Monika Priwitzerova,Guangjun Nie,Alex D. Sheftel,Dagmar Pospisilova,Vladimir Divoky,Prem Ponka

View Articletitled, Functional consequences of the human DMT1 (SLC11A2) mutation on protein expression and iron uptake

STEM CELLS IN HEMATOLOGY

Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells

H. Jeffrey Lawrence,Julie Christensen,Stephen Fong,Yu-Long Hu,Irving Weissman,Guy Sauvageau,R. Keith Humphries,Corey Largman

View Articletitled, Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells

Supplemental data

TRANSPLANTATION

Genetic variation in the IL-10 pathway modulates severity of acute graft-versus-host disease following hematopoietic cell transplantation: synergism between IL-10 genotype of patient and IL-10 receptor β genotype of donor

Ming-Tseh Lin,Barry Storer,Paul J. Martin,Li-Hui Tseng,Bryan Grogan,Pei-Jer Chen,Lue P. Zhao,John A. Hansen

View Articletitled, Genetic variation in the IL-10 pathway modulates severity of acute graft-versus-host disease following hematopoietic cell transplantation: synergism between IL-10 genotype of patient and IL-10 receptor β genotype of donor

Durable engraftment of AMD3100-mobilized autologous and allogeneic peripheral-blood mononuclear cells in a canine transplantation model

Lauri Burroughs,Marco Mielcarek,Marie-Térèse Little,Gary Bridger,Ron MacFarland,Simon Fricker,Jean Labrecque,Brenda M. Sandmaier,Rainer Storb

View Articletitled, Durable engraftment of AMD3100-mobilized autologous and allogeneic peripheral-blood mononuclear cells in a canine transplantation model

L-selectin and β₇ integrin on donor CD4 T cells are required for the early migration to host mesenteric lymph nodes and acute colitis of graft-versus-host disease

Suparna Dutt,Joerg Ermann,Diane Tseng,Yin Ping Liu,Tracy I. George,C. Garrison Fathman,Samuel Strober

View Articletitled, L-selectin and β7 integrin on donor CD4 T cells are required for the early migration to host mesenteric lymph nodes and acute colitis of graft-versus-host disease

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Asciminib is a novel inhibitor of ABL1 and ABL2 gene fusions in ALL but requires the ABL SH3 domain for efficacy

NGS-based stratification refines the risk stratification in T-ALL and identifies a Very High-Risk subgroup of patients

Foxo1 is an iron-responsive transcriptional factor regulating systemic iron homeostasis

How I Treat Low-risk Polycythemia Vera Patients who Require Cytoreduction

How I manage major hemorrhage

Issue Archive

Table of Contents

INSIDE BLOOD

BLOOD WORK

PLENARY PAPERS

REVIEWS IN TRANSLATIONAL HEMATOLOGY

Understanding iron homeostasis through genetic analysis of hemochromatosis and related disorders Clinical Trials & Observations

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

CLINICAL TRIALS AND OBSERVATIONS

Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype Clinical Trials & Observations

Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations Clinical Trials & Observations

Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance Clinical Trials & Observations

High-dose therapy intensification compared with continued standard chemotherapy in multiple myeloma patients responding to the initial chemotherapy: long-term results from a prospective randomized trial from the Spanish cooperative group PETHEMA Clinical Trials & Observations

Induction therapy for adults with acute lymphoblastic leukemia: results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993 Clinical Trials & Observations

Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia Clinical Trials & Observations

Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma Clinical Trials & Observations

Local tumor invasiveness is more predictive of survival than International Prognostic Index in stage IE/IIE extranodal NK/T-cell lymphoma, nasal type Clinical Trials & Observations

Anti–platelet factor 4/heparin antibodies in orthopedic surgery patients receiving antithrombotic prophylaxis with fondaparinux or enoxaparin Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

IMMUNOBIOLOGY

Analysis of T-cell repertoire diversity in Wiskott-Aldrich syndrome Brief Report

NEOPLASIA

Up-regulated expression in nonhematopoietic tissues of the BCL2A1-derived minor histocompatibility antigens in response to inflammatory cytokines: relevance for allogeneic immunotherapy of leukemia Brief Report

Extracellular KIT receptor mutants, commonly found in core binding factor AML, are constitutively active and respond to imatinib mesylate Brief Report

PHAGOCYTES

RED CELLS

Functional consequences of the human DMT1 (SLC11A2) mutation on protein expression and iron uptake Brief Report

STEM CELLS IN HEMATOLOGY

TRANSPLANTATION

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American Society of Hematology

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Understanding iron homeostasis through genetic analysis of hemochromatosis and related disorders
Clinical Trials & Observations

Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype
Clinical Trials & Observations

Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations
Clinical Trials & Observations

Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance
Clinical Trials & Observations

High-dose therapy intensification compared with continued standard chemotherapy in multiple myeloma patients responding to the initial chemotherapy: long-term results from a prospective randomized trial from the Spanish cooperative group PETHEMA
Clinical Trials & Observations

Induction therapy for adults with acute lymphoblastic leukemia: results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993
Clinical Trials & Observations

Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia
Clinical Trials & Observations

Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma
Clinical Trials & Observations

Local tumor invasiveness is more predictive of survival than International Prognostic Index in stage I_E/II_E extranodal NK/T-cell lymphoma, nasal type
Clinical Trials & Observations

Anti–platelet factor 4/heparin antibodies in orthopedic surgery patients receiving antithrombotic prophylaxis with fondaparinux or enoxaparin
Clinical Trials & Observations

Analysis of T-cell repertoire diversity in Wiskott-Aldrich syndrome
Brief Report

Up-regulated expression in nonhematopoietic tissues of the BCL2A1-derived minor histocompatibility antigens in response to inflammatory cytokines: relevance for allogeneic immunotherapy of leukemia
Brief Report

Extracellular KIT receptor mutants, commonly found in core binding factor AML, are constitutively active and respond to imatinib mesylate
Brief Report

Functional consequences of the human DMT1 (SLC11A2) mutation on protein expression and iron uptake
Brief Report