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Journal Articles

Genetic identification of patients with AML older than 60 years achieving long-term survival with intensive chemotherapy

CME Clinical Trials & Observations
Raphael Itzykson, Elise Fournier, Céline Berthon, Christoph Röllig, Thorsten Braun, Alice Marceau-Renaut, Cécile Pautas, Olivier Nibourel, Emilie Lemasle, Jean-Baptiste Micol, Lionel Adès, Delphine Lebon, Jean-Valère Malfuson, Lauris Gastaud, Laure Goursaud, Emmanuel Raffoux, Kevin-James Wattebled, Philippe Rousselot, Xavier Thomas, Sylvain Chantepie, Thomas Cluzeau, Hubert Serve, Nicolas Boissel, Christine Terré, Karine Celli-Lebras, Claude Preudhomme, Christian Thiede, Hervé Dombret, Claude Gardin, Nicolas Duployez
Journal: Blood
Blood (2021) 138 (7): 507–519.
https://doi.org/10.1182/blood.2021011103
Published: 2021
Includes: Supplemental data
Journal Articles

Prognostic significance of concurrent gene mutations in intensively treated patients with IDH -mutated AML: an ALFA study

CME Clinical Trials & Observations
Matthieu Duchmann, Jean-Baptiste Micol, Nicolas Duployez, Emmanuel Raffoux, Xavier Thomas, Jean-Pierre Marolleau, Thorsten Braun, Lionel Adès, Sylvain Chantepie, Emilie Lemasle, Céline Berthon, Jean-Valère Malfuson, Cécile Pautas, Juliette Lambert, Nicolas Boissel, Karine Celli-Lebras, Denis Caillot, Pascal Turlure, Norbert Vey, Arnaud Pigneux, Christian Recher, Christine Terré, Claude Gardin, Raphaël Itzykson, Claude Preudhomme, Hervé Dombret, Stéphane de Botton
Journal: Blood
Blood (2021) 137 (20): 2827–2837.
https://doi.org/10.1182/blood.2020010165
Published: 2021
Includes: Supplemental data
Journal Articles

What can Heraclitus tell us about AML?

Arnold Ganser
Journal: Blood
Blood (2021) 137 (20): 2719–2720.
https://doi.org/10.1182/blood.2021011264
Published: 2021
Journal Articles

How I diagnose and treat NPM1 -mutated AML

Brunangelo Falini, Lorenzo Brunetti, Maria Paola Martelli
Journal: Blood
Blood (2021) 137 (5): 589–599.
https://doi.org/10.1182/blood.2020008211
Published: 2021
Journal Articles

Acute myeloid leukemia with NPM1 and FLT3 ITD mimicking acute promyelocytic leukemia

Michael Pepper, Brent Tan
Journal: Blood
Blood (2020) 136 (12): 1467.
https://doi.org/10.1182/blood.2020007198
Published: 2020
Journal Articles

Co-occurrence of DNMT3A , NPM1 , FLT3 mutations identifies a subset of acute myeloid leukemia with adverse prognosis

Clinical Trials & Observations
Matheus F. Bezerra, Aleide S. Lima, Maria-Riera Piqué-Borràs, Douglas R. Silveira, Juan L. Coelho-Silva, Diego A. Pereira-Martins, Isabel Weinhäuser, Pedro L. Franca-Neto, Lynn Quek, Anna Corby, Mayara M. Oliveira, Marinus M. Lima, Reijane A. de Assis, Paula de Melo Campos, Bruno K. Duarte, Israel Bendit, Vanderson Rocha, Eduardo M. Rego, Fabiola Traina, Sara T. Saad, Eduardo I. Beltrão, Marcos A. Bezerra, Antonio R. Lucena-Araujo
Journal: Blood
Blood (2020) 135 (11): 870–875.
https://doi.org/10.1182/blood.2019003339
Published: 2020
Includes: Supplemental data
Journal Articles

Molecular MRD status and outcome after transplantation in NPM1 -mutated AML

Clinical Trials & Observations
Richard Dillon, Robert Hills, Sylvie Freeman, Nicola Potter, Jelena Jovanovic, Adam Ivey, Anju Shankar Kanda, Manohursingh Runglall, Nicola Foot, Mikel Valganon, Asim Khwaja, Jamie Cavenagh, Matthew Smith, Hans Beier Ommen, Ulrik Malthe Overgaard, Mike Dennis, Steven Knapper, Harpreet Kaur, David Taussig, Priyanka Mehta, Kavita Raj, Igor Novitzky-Basso, Emmanouil Nikolousis, Robert Danby, Pramila Krishnamurthy, Kate Hill, Damian Finnegan, Samah Alimam, Erin Hurst, Peter Johnson, Anjum Khan, Rahuman Salim, Charles Craddock, Ruth Spearing, Amanda Gilkes, Rosemary Gale, Alan Burnett, Nigel H. Russell, David Grimwade
Journal: Blood
Blood (2020) 135 (9): 680–688.
https://doi.org/10.1182/blood.2019002959
Published: 2020
Includes: Supplemental data
Journal Articles

Impact of NPM1 / FLT3 -ITD genotypes defined by the 2017 European LeukemiaNet in patients with acute myeloid leukemia

Clinical Trials & Observations
Konstanze Döhner, Christian Thiede, Nikolaus Jahn, Ekaterina Panina, Agnes Gambietz, Richard A. Larson, Thomas W. Prior, Guido Marcucci, Dan Jones, Jürgen Krauter, Michael Heuser, Maria Teresa Voso, Tiziana Ottone, Josep F. Nomdedeu, Sumithra J. Mandrekar, Rebecca B. Klisovic, Andrew H. Wei, Jorge Sierra, Miguel A. Sanz, Joseph M. Brandwein, Theo de Witte, Joop H. Jansen, Dietger Niederwieser, Frederick R. Appelbaum, Bruno C. Medeiros, Martin S. Tallman, Richard F. Schlenk, Arnold Ganser, Hubert Serve, Gerhard Ehninger, Sergio Amadori, Insa Gathmann, Axel Benner, Celine Pallaud, Richard M. Stone, Hartmut Döhner, Clara D. Bloomfield
Journal: Blood
Blood (2020) 135 (5): 371–380.
https://doi.org/10.1182/blood.2019002697
Published: 2020
Includes: Supplemental data
Journal Articles

Molecular roulette: nucleophosmin mutations in AML are orchestrated through N-nucleotide addition by TdT

Julian Borrow, Sara A. Dyer, Susanna Akiki, Michael J. Griffiths
Journal: Blood
Blood (2019) 134 (25): 2291–2303.
https://doi.org/10.1182/blood.2019001240
Published: 2019
Includes: Supplemental data
Journal Articles

DNMT3A wt NPM1-Mutation Defines a Subgroup of MDS with Special Favorable Outcomes Towards Decitabine Therapy

Lingyun Wu, MD PhD, Xiao Li, MD, Feng Xu, He Qi, Zheng Zhang, Dong Wu, Luxi Song, MD, Liyu Zhou, Chao Xiao, Jiying Su, Juan Guo, Chunkang Chang
Journal: Blood
Blood (2019) 134 (Supplement_1): 1724.
https://doi.org/10.1182/blood-2019-124008
Published: 2019
Journal Articles

The Disease-Risk Stratification Scheme (DRSS), a Contemporary Risk-Stratification System for Allogeneic Stem Cell Transplantation

Roni Shouval, Joshua A Fein, MD, Myriam Labopin, MD, Ali Bazarbachi, MD PhD, Frédéric Baron, MD PhD, Gesine Bug, Fabio Ciceri, MD, Selim Corbacioglu, MD, Sebastian Giebel, MD PhD, Maria H Gilleece, MD FRCPath, MB, BSc, FRCP, Silvia Montoto, MD, Zinaida Peric, MD PhD, Emmanuelle Polge, M.Sc, Annalisa Ruggeri, MD, Jaime Sanz, MDPhD, Bipin N. Savani, MD, Christoph Schmid, MD, Alexandros Spyridonidis, MD PhD, Jurjen Versluis, MD PhD, Ibrahim Yakoub-Agha, MD PhD, Mohamad Mohty, MD PhD, Arnon Nagler, MD MSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 43.
https://doi.org/10.1182/blood-2019-123310
Published: 2019
Journal Articles

A Personalized Prediction Model to Risk Stratify Patients with Acute Myeloid Leukemia (AML) Using Artificial Intelligence

Jacob Shreve, MD MS, Manja Meggendorfer, PhD, Hassan Awada, MD, Sudipto Mukherjee, MD PhD MPH, Wencke Walter, PhD, Stephan Hutter, PhD, Ahed Makhoul, MD, Cameron Beau Hilton, BA, Nathan Radakovich, BA, Yasunobu Nagata, MD PhD, Yazan Rouphail, Vera Adema, PhD, Cassandra M Kerr, MS, Bhumika J. Patel, MD, Teodora Kuzmanovic, Jaroslaw P. Maciejewski, MD PhD, Claudia Haferlach, MD, Mikkael A. Sekeres, MD MS, Torsten Haferlach, MD, Aziz Nazha, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2091.
https://doi.org/10.1182/blood-2019-128066
Published: 2019
Journal Articles

Challenging Blast Counts By Machine Learning Techniques and Genome Sequencing for Discriminating AML and MDS

Manja Meggendorfer, PhD, Wencke Walter, PhD, Claudia Haferlach, MD, Wolfgang Kern, MD, Torsten Haferlach, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4663.
https://doi.org/10.1182/blood-2019-126449
Published: 2019
Journal Articles

Preclinical Evaluation of Gilteritinib on NPM1-ALK Driven Anaplastic Large Cell Lymphoma Cells

Sudhakiranmayi Kuravi, M.S., Janice Cheng, MD, Kishore Polireddy, PhD, Gabrielle Fangman, B.S., Roy A Jensen, MD, Tara L. Lin, MD, Siddhartha Ganguly, MD, Joseph P. McGuirk, DO, Ramesh Balusu, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2865.
https://doi.org/10.1182/blood-2019-130633
Published: 2019
Journal Articles

Molecular Characterization of Leukemia Evolving from Paroxysmal Nocturnal Hemoglobinuria

Hassan Awada, MD, Shafia Rahman, MBBS, Cassandra M Kerr, MS, Jibran Durrani, Vera Adema, PhD, Ashwin Kishtagari, MBBS, Sunisa Kongkiatkamon, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski, MD PhD, Valeria Visconte, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2499.
https://doi.org/10.1182/blood-2019-131918
Published: 2019
Journal Articles

NPM1 Quantitative Monitoring of Minimal Residual Disease in Acute Myeloid Leukemia Allows More Precise Selection of Patients for Allogeneic Stem Cell Transplantation without Affecting Their Survival

Yishai Ofran, MD, Ronit Leiba, Dina Rosenberg, Israel Henig, MD, Dana Yehudai-Ofir, MD, Nuhad Haddad, MD, Riva Fineman, MD, Avraham Frisch, MD, Doaa Okasha, MD, Yariv Carasso, MD, Tsila Zuckerman, MD, Nurit Horesh, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2603.
https://doi.org/10.1182/blood-2019-126553
Published: 2019
Journal Articles

Combinatorial Genetics Uncovers Novel Targets for the Treatment of Npm1/Cohesin Mutated AML

Alison E Meyer, PhD, Cary Stelloh, Joseph B Fisher, PhD, Kirthi Pulakanti, George S. Vassiliou, FRCPath, MRCP, PhD, Aaron D Viny, MDMS, Ross L. Levine, MD, Sridhar Rao, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2515.
https://doi.org/10.1182/blood-2019-126042
Published: 2019
Journal Articles

Improved Anti-Leukemic Pre-Clinical Efficacy of a Protac Based MDM2 Degrader in a Large AML Cohort

Malathi Kandarpa, PhD, Luke F. Peterson, PhD, Harish Potu, PhD, Megha Ramappan, Yihong Liu, Avery Polk, Shaomeng Wang, PhD, Moshe Talpaz, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2670.
https://doi.org/10.1182/blood-2019-131949
Published: 2019
Journal Articles

Genetic Vulnerabilities of DNMT3A R882H in Myeloid Malignancies

Malgorzata Gozdecka, PhD, Monika Dudek, MSc, Konstantinos Tzelepis, Aristi Damaskou, MSc, Vijay Baskar, PhD, Penny Wright, Graham Duddy, Eshwar Meduri, PhD, Milena Mazan, PhD, Kosuke Yusa, PhD, Brian J. P. Huntly, PhD MRCP, MB, FRCPath, George S. Vassiliou, FRCPath, MRCP, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 111.
https://doi.org/10.1182/blood-2019-126505
Published: 2019
Journal Articles

Fludarabine, High Dose Cytarabine and Idarubicin-Based Induction Is Highly Effective in Young AML Patients with Concomitant NPM1 and FLT3-ITD Mutation Irrespectively of FLT3-ITD Allelic Burden

Paola Minetto, MD, Anna Candoni, MD, Fabio Guolo, MD, Marino Clavio, MD, Maria Elena Zannier, MD, Maurizio Miglino, PhD, Maria Vittoria Dubbini, MD, Enrico Carminati, Anna Sicuranza, PhD, Sara Ciofini, Elisabetta Tedone, Nicoletta Colombo, PhD, Girolamo Pugliese, Riccardo Marcolin, MD, Filippo Ballerini, MD, Michele Cea, Marco Gobbi, MD, Monica Bocchia, Renato Fanin, MD, Roberto Massimo Lemoli, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3828.
https://doi.org/10.1182/blood-2019-131303
Published: 2019