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Journal Articles

Cbl Q367P Cooperates with Loss of Tet2 to Drive a Cnl-like Disease Via the NF-Kb Pathway

Takuma Ohashi, Hiroyoshi Kunimoto, Akiko Adachi, Ayaka Miura, Takayuki Sakuma, Junji Ikeda, Yoko Ino, Jotaro Harada, Yuko Shimosato, Keita Yamamoto, Yayoi Kimura, Susumu Goyama, Satoshi Fujii, Tomohiko Tamura, Hiroaki Honda, Sheng F. Cai, Hideaki Nakajima
Journal: Blood
Blood (2024) 144 (Supplement 1): 4515.
https://doi.org/10.1182/blood-2024-206175
Published: 2024
Journal Articles

PRC2-Mediated Apoptosis Evasion Is a Therapeutic Target of MDS/AML Harboring Inv(3)/t(3;3) and -7

Hiroyoshi Kunimoto, Ayaka Miura, Maiko Sagisaka, Mieko Ito, Daisuke Honma, Shinji Tsutsumi, Takayuki Sakuma, Takuma Ohashi, Hiroshi Teranaka, Junji Ikeda, Takashi Toya, Yuka Harada, Noriko Doki, Sheng F. Cai, Akihide Yoshimi, Hiroaki Goto, Ross L Levine, Hideaki Nakajima
Journal: Blood
Blood (2023) 142 (Supplement 1): 2803.
https://doi.org/10.1182/blood-2023-178436
Published: 2023
Journal Articles

Deconvoluting Clonal and Cellular Architecture in IDH -Mutant Acute Myeloid Leukemia

Maria Sirenko, Soobeom Lee, Zhengxi Sun, Ronan Chaligne, Georgios Asimomitis, Charlotte K Brierley, Elsa Bernard, Sheng F. Cai, Robert M Myers, Bettina Nadorp, Max F Levine, Dylan Domenico, Juan E Arango Ossa, Juan Santiago Medina Martinez, Kamal Menghrajani, Audrey Lasry, Alice Mims, Helee Desai, Andrea Laganson, Christopher Famulare, Minal Patel, Gerard Lozanski, Sanam Loghavi, Kelly L. Bolton, Aaron D. Viny, Mikhail Roshal, Ross L Levine, Eytan M. Stein, Dan A. Landau, Ann-Kathrin Eisfeld, Iannis Aifantis, Elli Papaemmanuil
Journal: Blood
Blood (2023) 142 (Supplement 1): 1591.
https://doi.org/10.1182/blood-2023-186322
Published: 2023
Journal Articles

A Risk-Adapted Study to Assess the Efficacy of Enasidenib and Subsequent Response-Driven Addition of Azacitidine for Newly Diagnosed IDH2 -Mutant AML Patients: 3-Year Follow-up

Eytan Stein, Sheng F Cai, Ying Huang, Andrew Dunbar, Maria R. Baer, Wendy Stock, Tibor Kovacsovics, William G. Blum, Gary J. Schiller, Rebecca L. Olin, James M. Foran, Mark R. Litzow, Tara L. Lin, Prapti A. Patel, Matthew C. Foster, Michael M. Boyiadzis, Robert H. Collins, Jordan Chervin, Abigail B. Shoben, Jo-Anne Vergilio, Nyla A. Heerema, Leonard Rosenberg, Timothy Chen, Ashley O. Yocum, Franchesca Druggan, Sonja Marcus, Mona Stefanos, Molly Martycz, Brian J. Druker, Alice S. Mims, Uma Borate, Amy Burd, John C. Byrd, Ross L. Levine
Journal: Blood
Blood (2022) 140 (Supplement 1): 2016–2019.
https://doi.org/10.1182/blood-2022-166850
Published: 2022
Journal Articles

Jak2 V617F Reversible Activation Shows an Essential Requirement for Jak2 V617F in Myeloproliferative Neoplasms (MPNs)

Andrew Dunbar, Robert L. Bowman, Young Park, Franco Izzo, Robert M. Myers, Abdul Karzai, Won Jun Kim, Inés Fernández Maestre, Michael R. Waarts, Abbas Nazir, Wenbin Xiao, Max Brodsky, Mirko Farina, Louise Cai, Sheng F Cai, Benjamin Wang, Wenbin An, Julie Yang, Shoron Mowla, Shira E. Eisman, Tanmay Mishra, Remie Houston, Emily Guzzardi, Anthony R. Martinez Benitez, Aaron D Viny, Richard Koche, Dan A. Landau, Ross L. Levine
Journal: Blood
Blood (2022) 140 (Supplement 1): 803–804.
https://doi.org/10.1182/blood-2022-164827
Published: 2022
Journal Articles

BMP2/SMAD pathway activation in JAK2/p53-mutant megakaryocyte/erythroid progenitors promotes leukemic transformation

Bing Li, Wenbin An, Hua Wang, Timour Baslan, Shoron Mowla, Aishwarya Krishnan, Wenbin Xiao, Richard P. Koche, Ying Liu, Sheng F. Cai, Zhijian Xiao, Andriy Derkach, Ilaria Iacobucci, Charles G. Mullighan, Kristian Helin, Scott W. Lowe, Ross L. Levine, Raajit K. Rampal
Journal: Blood
Blood (2022) 139 (25): 3630–3646.
https://doi.org/10.1182/blood.2021014465
Published: 2022
Includes: Supplemental data
Journal Articles

Plasmacytoid dendritic cell expansion defines a distinct subset of RUNX1 -mutated acute myeloid leukemia

Wenbin Xiao, Alexander Chan, Michael R. Waarts, Tanmay Mishra, Ying Liu, Sheng F. Cai, Jinjuan Yao, Qi Gao, Robert L. Bowman, Richard P. Koche, Isabelle S. Csete, Nicole L. DelGaudio, Andriy Derkach, Jeeyeon Baik, Sophia Yanis, Christopher A. Famulare, Minal Patel, Maria E. Arcila, Maximilian Stahl, Raajit K. Rampal, Martin S. Tallman, Yanming Zhang, Ahmet Dogan, Aaron D. Goldberg, Mikhail Roshal, Ross L. Levine
Journal: Blood
Blood (2021) 137 (10): 1377–1391.
https://doi.org/10.1182/blood.2020007897
Published: 2021
Includes: Supplemental data
Journal Articles

Clinical Outcomes of Acute Myeloid Leukemia Patients Bridged to Allogeneic Stem Cell Transplant By Venetoclax Combination Therapy

Maximilian Stahl, MD, Kamal Menghrajani, MD, Andriy Derkach, PhD, Susan DeWolf, MD, Josel D Ruiz, MPH, Doris M Ponce, MD, Brian C. Shaffer, MD, Roni Tamari, MD, James W. Young, MD, Juliet Barker, MBBS, Ann A. Jakubowski, MDPhD, Boglarka Gyurkocza, MD, Alexander Chan, Wenbin Xiao, MD PhD, Jacob L Glass, MDPhD, Amber C. King, PharmD, BCOP, Sheng F Cai, MDPhD, Anthony Daniyan, MD, Christopher Famulare, MS, Bernadette M. Cuello, BSN, MSN, NP, RN, Troy Z. Horvat, PharmD, BCOP, Eytan M. Stein, MD, Mikhail Roshal, MD PhD, Sergio Giralt, MD, Miguel-Angel Perales, MD, Christina Cho, MD, Martin S. Tallman, MD, Aaron D Goldberg, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 16–17.
https://doi.org/10.1182/blood-2020-137749
Published: 2020
Journal Articles

Molecular Predictors and Effectiveness of Measurable Residual Disease (MRD) Eradication with Chemotherapy and Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia

Maximilian Stahl, MD, Andriy Derkach, PhD, Christopher Famulare, MS, Christina Cho, MD, Sean Devlin, PhD, Noushin Farnoud, PhD, Kamal Menghrajani, MD, Minal A Patel, MPH, Sheng F Cai, MDPhD, Mark B. Geyer, MD, Andrew Dunbar, MD, Zachary D. Epstein-Peterson, MD, Erin McGovern, BA, Jessica Schulman, BSc, Jacob L Glass, MDPhD, Justin Taylor, MD, Aaron D Viny, MDMS, Eytan M. Stein, MD, Bartlomiej Getta, FRCPA, FRACP, MBBS, Maria E. Arcila, MD, Ross L. Levine, MD, Juliet Barker, MBBS, Brian C. Shaffer, MD, Esperanza B. Papadopoulos, MD, Boglarka Gyurkocza, MD, Miguel-Angel Perales, MD, Omar Abdel-Wahab, MD, Elli Papaemmanuil, PhD, Sergio A. Giralt, MD, Yanming Zhang, MD, Mikhail Roshal, MD PhD, Martin S. Tallman, MD, Aaron D Goldberg, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18–20.
https://doi.org/10.1182/blood-2020-137552
Published: 2020
Journal Articles

Leukemia Cell of Origin Influences p53 Activity and Therapeutic Sensitivity Via an Evi1-Dependent Mechanism

Sheng F Cai, MD PhD, S Haihua Chu, PhD, Aaron D Goldberg, MD PhD, Salma Parvin, PhD, Richard Koche, PhD, Jacob L Glass, MD PhD, Eytan M. Stein, MD, Martin S. Tallman, MD, Filiz Sen, MD, Christopher Famulare, MS, Monica Cusan, MD, Chun-Hao Huang, PhD, Chun-Wei David Chen, PhD, Lihua Zou, PhD, Keith B Cordner, BS, Vidushi Durani, MS, Mitali Kini, BS, Madison Rex, Johannes Zuber, Timour Baslan, PhD, Scott W. Lowe, PhD, Hugh Young Rienhoff, Jr., MD, Ross L. Levine, MD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 109.
https://doi.org/10.1182/blood-2019-122483
Published: 2019
Journal Articles

A Phase Ib/II Study of the Histone Methyltransferase Inhibitor Pinometostat in Combination with Azacitidine in Patients with 11q23-Rearranged Acute Myeloid Leukemia

Kamal Menghrajani, MD, Sheng F Cai, MD PhD, Sean M. Devlin, PhD, Scott A. Armstrong, MD PhD, Richard Piekarz, MD PhD MS, BA, Michelle Rudek, PharmD, PhD, Martin S. Tallman, MD, Eytan M. Stein, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2655.
https://doi.org/10.1182/blood-2019-121926
Published: 2019
Journal Articles

RAS Mutations Are Independently Associated with Decreased Overall Survival and Event-Free Survival in Patients with AML Receiving Induction Chemotherapy

Brian J Ball, Meier Hsu, MS, Sean M. Devlin, PhD, Christopher Famulare, MS, Sheng F Cai, MDPhD, Andrew Dunbar, MD, Zachary D. Epstein-Peterson, MD, Kamal Menghrajani, MD, Jacob L Glass, MDPhD, Justin Taylor, MD, Aaron D Viny, MDMS, Aaron D Goldberg, MDPhD, Martin S. Tallman, MD, Eytan M. Stein, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 18.
https://doi.org/10.1182/blood-2019-125319
Published: 2019
Journal Articles

LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML

Monica Cusan, Sheng F. Cai, Helai P. Mohammad, Andrei Krivtsov, Alan Chramiec, Evangelia Loizou, Matthew D. Witkin, Kimberly N. Smitheman, Daniel G. Tenen, Min Ye, Britta Will, Ulrich Steidl, Ryan G. Kruger, Ross L. Levine, Hugh Y. Rienhoff, Jr, Richard P. Koche, Scott A. Armstrong
Journal: Blood
Blood (2018) 131 (15): 1730–1742.
https://doi.org/10.1182/blood-2017-09-807024
Published: 2018
Includes: Supplemental data
Journal Articles

Granzyme B is not required for regulatory T cell–mediated suppression of graft-versus-host disease

Sheng F. Cai, Xuefang Cao, Anjum Hassan, Todd A. Fehniger, Timothy J. Ley
Journal: Blood
Blood (2010) 115 (9): 1669–1677.
https://doi.org/10.1182/blood-2009-07-233676
Published: 2010
Includes: Supplemental data
Journal Articles

IL-12 Stimulates Interferon-Gamma Mediated Inhibition of Tumor-Induced Regulatory T Cell Proliferation and Enhances Tumor Clearance

Xuefang Cao, PhD, Lynne I. Collins, Sheng F. Cai, Joshua C. Mayer, Michael J. Walter, MD, David Piwnica-Worms, MD, PhD, Robert D. Schreiber, PhD, Timothy J. Ley, MD
Journal: Blood
Blood (2008) 112 (11): 2558.
https://doi.org/10.1182/blood.V112.11.2558.2558
Published: 2008
Journal Articles

Differential Regulation of Granzyme B and C Expression in Murine Cytotoxic T and NK Cells.

Sheng F. Cai, BS, Todd A. Fehniger, MD/PhD, Xuezhi Dai, PhD, Xuefang Cao, PhD, Timothy J. Ley, MD
Journal: Blood
Blood (2007) 110 (11): 2291.
https://doi.org/10.1182/blood.V110.11.2291.2291
Published: 2007
Journal Articles

Granzyme B Is Important for Treg-Mediated Suppression of NK-Dependent Tumor Clearance In Vivo .

Xuefang Cao, PhD, Sheng F. Cai, BS, Todd A. Fehniger, MD/PhD, Jiling Song, BS, David Piwnica-Worms, MD/PhD, Timothy James Ley, MD
Journal: Blood
Blood (2006) 108 (11): 133.
https://doi.org/10.1182/blood.V108.11.133.133
Published: 2006
Journal Articles

Murine NK Cells Require Activation-Dependent Expression of Granzyme B and Perforin To Become Potent Cytotoxic Effectors.

Todd A. Fehniger, MD, PhD, Sheng F. Cai, BS, Xuefang Cao, PhD, Andrew J. Bredemeyer, BS, Rachel M. Presti, MD/PhD, Anthony R. French, MD/PhD, Timothy James Ley, MD
Journal: Blood
Blood (2006) 108 (11): 920.
https://doi.org/10.1182/blood.V108.11.920.920
Published: 2006