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Volume 122, Issue 7
August 15 2013
Issue Cover

Table of Contents

INSIDE BLOOD

IMMUNOBIOLOGY
Cancer makes new friends with old tricks
Francesco Dazzi
View Articletitled, Cancer makes new friends with old tricks
CLINICAL TRIALS & OBSERVATIONS
Importance of subsegmental pulmonary embolism
Clinical Trials & Observations
Gary E. Raskob
View Articletitled, Importance of subsegmental pulmonary embolism
IMMUNOBIOLOGY
Ruxolitinib targets DCs: for better or worse?
Ayalew Tefferi
View Articletitled, Ruxolitinib targets DCs: for better or worse?
INSIDE BLOOD
The sequence of events in diffuse large B-cell lymphoma
John G. Gribben
View Articletitled, The sequence of events in diffuse large B-cell lymphoma
RED CELLS, IRON, & ERYTHROPOIESIS
PNH from mutations of another PIG gene
Lucio Luzzatto
View Articletitled, PNH from mutations of another <em>PIG</em> gene
TRANSPLANTATION
CMV: a warrior against leukemia?
Per Ljungman
View Articletitled, CMV: a warrior against leukemia?

BLOOD WORK

Hepatosplenic T-cell lymphoma appearing in the peripheral blood
Minoru Kojima,Hiromichi Matsushita
View Articletitled, Hepatosplenic T-cell lymphoma appearing in the peripheral blood
Philadelphia chromosome positive acute B-lymphoblastic leukemia with extreme leukocytosis
Vishal Bhatnagar,Ashkan Emadi
View Articletitled, Philadelphia chromosome positive acute B-lymphoblastic leukemia with extreme leukocytosis

PLENARY PAPER

Fibrocytes represent a novel MDSC subset circulating in patients with metastatic cancer
Hua Zhang,Irena Maric,Michael J. DiPrima,Javed Khan,Rimas J. Orentas,Rosandra N. Kaplan,Crystal L. Mackall
View Articletitled, Fibrocytes represent a novel MDSC subset circulating in patients with metastatic cancer
Supplemental data

REVIEW ARTICLE

Cold agglutinin disease
Paul L. Swiecicki,Livia T. Hegerova,Morie A. Gertz
View Articletitled, Cold agglutinin disease
Erythrocytosis: the HIF pathway in control
Kristin Franke,Max Gassmann,Ben Wielockx
View Articletitled, Erythrocytosis: the HIF pathway in control

CLINICAL TRIALS AND OBSERVATIONS

Intermediate-dose versus high-dose prophylaxis for severe hemophilia: comparing outcome and costs since the 1970s
Clinical Trials & Observations
Kathelijn Fischer,Katarina Steen Carlsson,Pia Petrini,Margareta Holmström,Rolf Ljung,H. Marijke van den Berg,Erik Berntorp
View Articletitled, Intermediate-dose versus high-dose prophylaxis for severe hemophilia: comparing outcome and costs since the 1970s
Supplemental data
Obinutuzumab (GA101) plus CHOP or FC in relapsed/refractory follicular lymphoma: results of the GAUDI study (BO21000)
Clinical Trials & Observations
John Radford,Andrew Davies,Guillaume Cartron,Franck Morschhauser,Gilles Salles,Robert Marcus,Michael Wenger,Guiyuan Lei,Elisabeth Wassner-Fritsch,Umberto Vitolo
View Articletitled, Obinutuzumab (GA101) plus CHOP or FC in relapsed/refractory follicular lymphoma: results of the GAUDI study (BO21000)
Risk profile and clinical outcome of symptomatic subsegmental acute pulmonary embolism
CME
Paul L. den Exter,Josien van Es,Frederikus A. Klok,Lucia J. Kroft,Marieke J. H. A. Kruip,Pieter Willem Kamphuisen,Harry R. Büller,Menno V. Huisman
View Articletitled, Risk profile and clinical outcome of symptomatic subsegmental acute pulmonary embolism

HEMATOPOIESIS AND STEM CELLS

Genetic interaction between Kit and Scl
Julie Lacombe,Gorazd Krosl,Mathieu Tremblay,Bastien Gerby,Richard Martin,Peter D. Aplan,Sebastien Lemieux,Trang Hoang
View Articletitled, Genetic interaction between <em>Kit</em> and <em>Scl</em>
Supplemental data
Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embryonic and induced pluripotent stem cells
Jung Bok Lee,Tamra E. Werbowetski-Ogilvie,Jong-Hee Lee,Brendan A. S. McIntyre,Angelique Schnerch,Seok-Ho Hong,In-Hyun Park,George Q. Daley,Irwin D. Bernstein,Mickie Bhatia
View Articletitled, Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embryonic and induced pluripotent stem cells
Supplemental data

IMMUNOBIOLOGY

Maternofetal transplacental transport of recombinant IgG antibodies lacking effector functions
Line Mathiesen,Leif K. Nielsen,Jan Terje Andersen,Algirdas Grevys,Inger Sandlie,Terje E. Michaelsen,Morten Hedegaard,Lisbeth E. Knudsen,Morten Hanefeld Dziegiel
View Articletitled, Maternofetal transplacental transport of recombinant IgG antibodies lacking effector functions
Supplemental data
Soluble GARP has potent antiinflammatory and immunomodulatory impact on human CD4+ T cells
Susanne A. Hahn,Heiko F. Stahl,Christian Becker,Anita Correll,Franz-Joseph Schneider,Andrea Tuettenberg,Helmut Jonuleit
View Articletitled, Soluble GARP has potent antiinflammatory and immunomodulatory impact on human CD4<sup>+</sup> T cells
Supplemental data
The JAK-inhibitor ruxolitinib impairs dendritic cell function in vitro and in vivo
Annkristin Heine,Stefanie Andrea Erika Held,Solveig Nora Daecke,Stephanie Wallner,Sowmya Parampalli Yajnanarayana,Christian Kurts,Dominik Wolf,Peter Brossart
View Articletitled, The JAK-inhibitor ruxolitinib impairs dendritic cell function in vitro and in vivo
Supplemental data
Src-kinase inhibitors sensitize human cells of myeloid origin to Toll-like-receptor–induced interleukin 12 synthesis
Matthias Wölfl,Stefanie Schwinn,Young-Eun Yoo,Marie L. Reß,Matthias Braun,Martin Chopra,Susanne C. Schreiber,Victor I. Ayala,Claes Ohlen,Matthias Eyrich,Andreas Beilhack,Paul G. Schlegel
View Articletitled, Src-kinase inhibitors sensitize human cells of myeloid origin to Toll-like-receptor–induced interleukin 12 synthesis
Supplemental data

LYMPHOID NEOPLASIA

Detection of MRD may predict the outcome of patients with Philadelphia chromosome–positive ALL treated with tyrosine kinase inhibitors plus chemotherapy
Farhad Ravandi,Jeffrey L. Jorgensen,Deborah A. Thomas,Susan O’Brien,Rebecca Garris,Stefan Faderl,Xuelin Huang,Sijin Wen,Jan A. Burger,Alessandra Ferrajoli,Partow Kebriaei,Richard E. Champlin,Zeev Estrov,Pramoda Challagundla,Sa A. Wang,Rajyalakshmi Luthra,Jorge E. Cortes,Hagop M. Kantarjian
View Articletitled, Detection of MRD may predict the outcome of patients with Philadelphia chromosome–positive ALL treated with tyrosine kinase inhibitors plus chemotherapy
Supplemental data
A mutation in MYD88 (L265P) supports the survival of lymphoplasmacytic cells by activation of Bruton tyrosine kinase in Waldenström macroglobulinemia
Guang Yang,Yangsheng Zhou,Xia Liu,Lian Xu,Yang Cao,Robert J. Manning,Christopher J. Patterson,Sara J. Buhrlage,Nathanael Gray,Yu-Tzu Tai,Kenneth C. Anderson,Zachary R. Hunter,Steven P. Treon
View Articletitled, A mutation in MYD88 (L265P) supports the survival of lymphoplasmacytic cells by activation of Bruton tyrosine kinase in Waldenström macroglobulinemia
CD30 targeting with brentuximab vedotin: a novel therapeutic approach to primary effusion lymphoma
Shruti Bhatt,Brittany M. Ashlock,Yasodha Natkunam,Victoria Sujoy,Jennifer Rose Chapman,Juan Carlos Ramos,Enrique A. Mesri,Izidore S. Lossos
View Articletitled, CD30 targeting with brentuximab vedotin: a novel therapeutic approach to primary effusion lymphoma
Supplemental data
Intracellular NAD+ depletion enhances bortezomib-induced anti-myeloma activity
Antonia Cagnetta,Michele Cea,Teresa Calimeri,Chirag Acharya,Mariateresa Fulciniti,Yu-Tzu Tai,Teru Hideshima,Dharminder Chauhan,Mike Y. Zhong,Franco Patrone,Alessio Nencioni,Marco Gobbi,Paul Richardson,Nikhil Munshi,Kenneth C. Anderson
View Articletitled, Intracellular NAD<sup>+</sup> depletion enhances bortezomib-induced anti-myeloma activity
Supplemental data
Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing
Ryan D. Morin,Karen Mungall,Erin Pleasance,Andrew J. Mungall,Rodrigo Goya,Ryan D. Huff,David W. Scott,Jiarui Ding,Andrew Roth,Readman Chiu,Richard D. Corbett,Fong Chun Chan,Maria Mendez-Lago,Diane L. Trinh,Madison Bolger-Munro,Greg Taylor,Alireza Hadj Khodabakhshi,Susana Ben-Neriah,Julia Pon,Barbara Meissner,Bruce Woolcock,Noushin Farnoud,Sanja Rogic,Emilia L. Lim,Nathalie A. Johnson,Sohrab Shah,Steven Jones,Christian Steidl,Robert Holt,Inanc Birol,Richard Moore,Joseph M. Connors,Randy D. Gascoyne,Marco A. Marra
View Articletitled, Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing
Supplemental data
NOTCH1, SF3B1, and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: results from the CLL2H trial of the GCLLSG
Brief Report
Andrea Schnaiter,Peter Paschka,Marianna Rossi,Thorsten Zenz,Andreas Bühler,Dirk Winkler,Mario Cazzola,Konstanze Döhner,Jennifer Edelmann,Daniel Mertens,Sabrina Kless,Silja Mack,Raymonde Busch,Michael Hallek,Hartmut Döhner,Stephan Stilgenbauer
View Articletitled, <em>NOTCH1</em>, <em>SF3B1</em>, and <em>TP53</em> mutations in fludarabine-refractory CLL patients treated with alemtuzumab: results from the CLL2H trial of the GCLLSG
Supplemental data

MYELOID NEOPLASIA

Plzf drives MLL-fusion–mediated leukemogenesis specifically in long-term hematopoietic stem cells
Ryoichi Ono,Masahiro Masuya,Hideaki Nakajima,Yutaka Enomoto,Eri Miyata,Akihide Nakamura,Satomi Ishii,Kei Suzuki,Fumi Shibata-Minoshima,Naoyuki Katayama,Toshio Kitamura,Tetsuya Nosaka
View Articletitled, Plzf drives <em>MLL</em>-fusion–mediated leukemogenesis specifically in long-term hematopoietic stem cells
Supplemental data
Tyrosine kinase inhibitor usage, treatment outcome, and prognostic scores in CML: report from the population-based Swedish CML registry
Martin Höglund,Fredrik Sandin,Karin Hellström,Mats Björeman,Magnus Björkholm,Mats Brune,Arta Dreimane,Marja Ekblom,Sören Lehmann,Per Ljungman,Claes Malm,Berit Markevärn,Kristina Myhr-Eriksson,Lotta Ohm,Ulla Olsson-Strömberg,Anders Själander,Hans Wadenvik,Bengt Simonsson,Leif Stenke,Johan Richter
View Articletitled, Tyrosine kinase inhibitor usage, treatment outcome, and prognostic scores in CML: report from the population-based Swedish CML registry
Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile
Kimberly Cramer-Morales,Margaret Nieborowska-Skorska,Kara Scheibner,Michelle Padget,David A. Irvine,Tomasz Sliwinski,Kimberly Haas,Jaewoong Lee,Huimin Geng,Darshan Roy,Artur Slupianek,Feyruz V. Rassool,Mariusz A. Wasik,Wayne Childers,Mhairi Copland,Markus Müschen,Curt I. Civin,Tomasz Skorski
View Articletitled, Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile
Supplemental data

PLATELETS AND THROMBOPOIESIS

Proplatelet generation in the mouse requires PKCε-dependent RhoA inhibition
Giuliana Gobbi,Prisco Mirandola,Cecilia Carubbi,Elena Masselli,Stephen M. Sykes,Francesca Ferraro,Antonio Nouvenne,Jonathan N. Thon,Joseph E. Italiano, Jr,Marco Vitale
View Articletitled, Proplatelet generation in the mouse requires PKCε-dependent RhoA inhibition
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

A case of paroxysmal nocturnal hemoglobinuria caused by a germline mutation and a somatic mutation in PIGT
Brief Report
Peter M. Krawitz,Britta Höchsmann,Yoshiko Murakami,Britta Teubner,Ulrike Krüger,Eva Klopocki,Heidemarie Neitzel,Alexander Hoellein,Christina Schneider,Dmitri Parkhomchuk,Jochen Hecht,Peter N. Robinson,Stefan Mundlos,Taroh Kinoshita,Hubert Schrezenmeier
View Articletitled, A case of paroxysmal nocturnal hemoglobinuria caused by a germline mutation and a somatic mutation in <em>PIGT</em>
Supplemental data

TRANSPLANTATION

CMV reactivation after allogeneic HCT and relapse risk: evidence for early protection in acute myeloid leukemia
Margaret L. Green,Wendy M. Leisenring,Hu Xie,Roland B. Walter,Marco Mielcarek,Brenda M. Sandmaier,Stanley R. Riddell,Michael Boeckh
View Articletitled, CMV reactivation after allogeneic HCT and relapse risk: evidence for early protection in acute myeloid leukemia
Supplemental data

ERRATA

Bhardwaj A, Sethi G, Vadhan-Raj S, et al. Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-κB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood. 2007;109(6):2293-2302.
View Articletitled, Bhardwaj A, Sethi G, Vadhan-Raj S, et al. Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-κB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. <em>Blood</em>. 2007;109(6):<span class="related-article">2293-2302</span>.
Sethi G, Ahn KS, Pandey MK, Aggarwal BB. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB-regulated gene products and TAK1-mediated NF-κB activation. Blood. 2007;109(7):2727-2735.
View Articletitled, Sethi G, Ahn KS, Pandey MK, Aggarwal BB. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB-regulated gene products and TAK1-mediated NF-κB activation. <em>Blood</em>. 2007;109(7):<span class="related-article">2727-2735</span>.
Kunnumakkara AB, Nair AS, Ahn KS, et al. Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-κB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. Blood. 2007;109(12):5112-5121.
View Articletitled, Kunnumakkara AB, Nair AS, Ahn KS, et al. Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-κB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. <em>Blood</em>. 2007;109(12):<span class="related-article">5112-5121</span>.
Morak M, Attarbaschi A, Fischer S, et al. Small sizes and indolent evolutionary dynamics challenge the potential role of P2RY8-CRLF2-harboring clones as main relapse-driving force in childhood ALL. Blood. 2012;120(26):5134-5142.
View Articletitled, Morak M, Attarbaschi A, Fischer S, et al. Small sizes and indolent evolutionary dynamics challenge the potential role of <em>P2RY8-CRLF2</em>-harboring clones as main relapse-driving force in childhood ALL. <em>Blood</em>. 2012;120(26):<span class="related-article">5134-5142</span>.

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

Outcome of SSPE
CME
View Articletitled, Outcome of SSPE
  • Cover Image

    Cover Image

    issue cover

    The image was obtained by fluorescent microscopy showing expression of Notch1 (green) in cells comprising an embryoid body derived from human pluripotent stem cells (hPSCs) during hematopoietic differentiation in the presence of the Notch ligand, Jagged-1. The activation of Notch signaling augmented hPSC hematopoietic differentiation via downstream effector, hairy and enhancer of split 1, at the expense of endothelial development. See the article by Lee et al on page 1162.

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