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Journal Articles

DNA Methyltransferase Inhibitors Promote Homologous Recombination Deficiency through Induction of Immune Signaling, Sensitizing Acute Myeloid Leukemia Cells to PARP Inhibitors

Aksinija A Kogan, BS, MS, Lena J Mclaughlin, BS, Maria R. Baer, MD, Stephen Baylin, MD, Michael Topper, BS, Feyruz V. Rassool, BSc, PhD

Blood (2019) 134 (Supplement_1): 3763.

https://doi.org/10.1182/blood-2019-129535

Published: 2019

Journal Articles

The Combination of PARP Inhibitors and DNMT Inhibitors Modulates Immune Activity and Suggests a Role for Immune Therapy in AML

Aksinija A Kogan, BS, MS, Michael Topper, BS, Susannah C Shissler, BS, Michael S Lee, BS, Dominique R Bollino, BS, Eun Yong Choi, Rena G Lapidus, PhD, Li Li, MD PhD, Donald Small, MD PhD, Maria R. Baer, MD, Tonya J Webb, PhD, Stephen Baylin, MD, Feyruz V. Rassool, BSc, PhD

Blood (2018) 132 (Supplement 1): 3886.

https://doi.org/10.1182/blood-2018-99-117294

Published: 2018

Journal Articles

DNA Demethylating Agents Generate a Brcaness Effect in Multiple Sporadic Tumor Types: Prediction for Sensitivity to PARP Inhibitors in AML

Aksinija A Kogan, BS, MS, Lena J Mclaughlin, BS, Michael Topper, BS, Nidal Muvarak, PhD, Lora Stojanovic, BS, T Michael Creed, BS, MS, Soren Bentzen, PhD DMSc, Curt I. Civin, MD, Maria R. Baer, MD, Tami J Kingsbury, PhD, Stephen Baylin, MD, Feyruz V. Rassool, BSc, PhD

Blood (2017) 130 (Supplement 1): 3347.

https://doi.org/10.1182/blood.V130.Suppl_1.3347.3347

Published: 2017

Journal Articles

Concurrent Treatment with Pim Kinase Inhibitor Downregulates Alternative Non-Homologous End-Joining Repair and Decreases Genomic Instability in FLT3-ITD Cells Treated with Topoisomerase 2 Inhibitor Chemotherapy Drugs

Kshama A. Doshi, PhD, Shivani Kapoor, MS, Ying Zou, MD PhD, Xiang Li, PhD, Mario Scarpa, MS, Nidal Muvarak, PhD, Pratik Nagaria, PhD, Olga Goloubeva, PhD MSc, Adriana E. Tron, PhD, Charles J. Bieberich, PhD, Feyruz V. Rassool, BSc, PhD, Maria R. Baer, MD

Blood (2017) 130 (Supplement 1): 1243.

https://doi.org/10.1182/blood.V130.Suppl_1.1243.1243

Published: 2017

Journal Articles

The Pim Kinase Inhibitor AZD1208 Enhances Topoisomerase-2 Inhibitor Induction of Apoptosis of Acute Myeloid Leukemia Cells with FLT3-ITD through Increased Oxidative Stress

Kshama A. Doshi, M.S., Karthika Natarajan, PhD, Feyruz V. Rassool, PhD, Dennis Huszar, PhD, Maria R. Baer, MD

Blood (2015) 126 (23): 1268.

https://doi.org/10.1182/blood.V126.23.1268.1268

Published: 2015

Journal Articles

Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile

Kimberly Cramer-Morales, Margaret Nieborowska-Skorska, Kara Scheibner, Michelle Padget, David A. Irvine, Tomasz Sliwinski, Kimberly Haas, Jaewoong Lee, Huimin Geng, Darshan Roy, Artur Slupianek, Feyruz V. Rassool, Mariusz A. Wasik, Wayne Childers, Mhairi Copland, Markus Müschen, Curt I. Civin, Tomasz Skorski

Blood (2013) 122 (7): 1293–1304.

https://doi.org/10.1182/blood-2013-05-501072

Published: 2013

Includes: Multimedia, Supplemental data

Journal Articles

Defective nonhomologous end joining blocks B-cell development in FLT3/ITD mice

Li Li, Li Zhang, Jinshui Fan, Kathleen Greenberg, Stephen Desiderio, Feyruz V. Rassool, Donald Small

Blood (2011) 117 (11): 3131–3139.

https://doi.org/10.1182/blood-2010-05-286070

Published: 2011

Includes: Supplemental data

Journal Articles

B-Lymphocyte Development Is Impaired by FLT3/ITD Signaling in Knock-in Mice Because of Defective Non-Homologous End-Joining.

Li Li, MD, PhD, Li Zhang, PhD, Jinshui Fan, PhD, Kathleen E Greenberg, BS, Stephen Desiderio, MD, PhD, Feyruz V. Rassool, PhD, Donald Small, MD, PhD

Blood (2009) 114 (22): 184.

https://doi.org/10.1182/blood.V114.22.184.184

Published: 2009

Journal Articles

DNA Ligase III Alpha and (Poly-ADP) Ribose Polymerase (PARP1) Are Therapeutic Targets in Imatinib-Resistant (IR) Chronic Myeloid Leukemia (CML).

Lisa A. Tobin, Aaron P. Rapoport, MD, Ivana Gojo, MD, Maria R. Baer, Alan E. Tomkinson, Feyruz V. Rassool

Blood (2009) 114 (22): 853.

https://doi.org/10.1182/blood.V114.22.853.853

Published: 2009

Journal Articles

Cell Lines and “Knock-in” Mice Bearing FLT3/ITD Mutations Exhibit Elevated Repair Errors Generated through Alternative DNA Double Strand Break Repair Pathways: Implications for Genomic Instability.

Jinshui Fan, PhD, Li Li, MD, PhD, Donald Small, MD, PhD, Feyruz V. Rassool

Blood (2009) 114 (22): 3237.

https://doi.org/10.1182/blood.V114.22.3237.3237

Published: 2009

Journal Articles

Histone Deacetylase Inhibitors Promote Abnormal Binding of DNA Repair Proteins to DNA Double Strand Breaks: Consequences for DNA Repair and Genomic Instability?.

Carine Robert, PhD, Ivana Gojo, MD, Feyruz V. Rassool, PhD

Blood (2009) 114 (22): 186.

https://doi.org/10.1182/blood.V114.22.186.186

Published: 2009

Journal Articles

Inhibiting Alternative Non Homologus Endjoining (NHEJ) Pathways: Therapeutic Targets in Chronic Myeloid Leukemia (CML).

Annahita Sallmyr, PhD, Lisa Tobin, Alan E. Tomkinson, Feyruz V. Rassool

Blood (2008) 112 (11): 1088.

https://doi.org/10.1182/blood.V112.11.1088.1088

Published: 2008

Journal Articles

Up-regulation of WRN and DNA ligase IIIα in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks

Annahita Sallmyr, Alan E. Tomkinson, Feyruz V. Rassool

Blood (2008) 112 (4): 1413–1423.

https://doi.org/10.1182/blood-2007-07-104257

Published: 2008

Includes: Supplemental data

Journal Articles

Internal Tandem Duplications of FLT3 Induces Increased ROS Production, DNA Damage and Misrepair: Implications for Genomic Instability and Disease Resistance in Myeloid Malignancies.

Jinshui Fan, PhD, Annahita Sallmyr, PhD, Kyu-Te Kim, PhD, Kamal Datta, MD, Paul Shapiro, PhD, Donald Small, MD, Feyruz V. Rassool, PhD

Blood (2007) 110 (11): 17.

https://doi.org/10.1182/blood.V110.11.17.17

Published: 2007

Journal Articles

Up-Regulated WRN and DNA Ligase IIIα Are Involved in Alternative NHEJ Repair Pathway of DNA Double Strand Breaks (DSB) in Chronic Myeloid Leukemia (CML).

Annahita Sallmyr, PhD, Feyruz V. Rassool, Ph.D.

Blood (2007) 110 (11): 1016.

https://doi.org/10.1182/blood.V110.11.1016.1016

Published: 2007

Journal Articles

Genetic rearrangements beget genomic instability

Feyruz V. Rassool

Blood (2004) 104 (12): 3424–3425.

https://doi.org/10.1182/blood-2004-09-3404

Published: 2004

Journal Articles

Increased DNA Damage and Error-Prone Repair in MPD/MDS Mice with Disease Progression: Key Indicators for Increased Genomic Instability.

Feyruz V. Rassool, PhD, Terry J. Gaymes, PhD, Nicola Brady, PhD, Nicholas Lea, PhD, Marika Pla, PhD, Thi Hai Phan, PhD, Scott Kogan, MD, Christine Chomienne, MDPhD, Nicholas S. Thomas, PhD, Ghulam J. Mafti, MD, Rose Ann Padua, PhD

Blood (2004) 104 (11): 200.

https://doi.org/10.1182/blood.V104.11.200.200

Published: 2004

NARROW

DNA Methyltransferase Inhibitors Promote Homologous Recombination Deficiency through Induction of Immune Signaling, Sensitizing Acute Myeloid Leukemia Cells to PARP Inhibitors

The Combination of PARP Inhibitors and DNMT Inhibitors Modulates Immune Activity and Suggests a Role for Immune Therapy in AML

DNA Demethylating Agents Generate a Brcaness Effect in Multiple Sporadic Tumor Types: Prediction for Sensitivity to PARP Inhibitors in AML

Concurrent Treatment with Pim Kinase Inhibitor Downregulates Alternative Non-Homologous End-Joining Repair and Decreases Genomic Instability in FLT3-ITD Cells Treated with Topoisomerase 2 Inhibitor Chemotherapy Drugs

The Pim Kinase Inhibitor AZD1208 Enhances Topoisomerase-2 Inhibitor Induction of Apoptosis of Acute Myeloid Leukemia Cells with FLT3-ITD through Increased Oxidative Stress

Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile

Defective nonhomologous end joining blocks B-cell development in FLT3/ITD mice

B-Lymphocyte Development Is Impaired by FLT3/ITD Signaling in Knock-in Mice Because of Defective Non-Homologous End-Joining.

DNA Ligase III Alpha and (Poly-ADP) Ribose Polymerase (PARP1) Are Therapeutic Targets in Imatinib-Resistant (IR) Chronic Myeloid Leukemia (CML).

Cell Lines and “Knock-in” Mice Bearing FLT3/ITD Mutations Exhibit Elevated Repair Errors Generated through Alternative DNA Double Strand Break Repair Pathways: Implications for Genomic Instability.

Histone Deacetylase Inhibitors Promote Abnormal Binding of DNA Repair Proteins to DNA Double Strand Breaks: Consequences for DNA Repair and Genomic Instability?.

Inhibiting Alternative Non Homologus Endjoining (NHEJ) Pathways: Therapeutic Targets in Chronic Myeloid Leukemia (CML).

Up-regulation of WRN and DNA ligase IIIα in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks

Internal Tandem Duplications of FLT3 Induces Increased ROS Production, DNA Damage and Misrepair: Implications for Genomic Instability and Disease Resistance in Myeloid Malignancies.

Up-Regulated WRN and DNA Ligase IIIα Are Involved in Alternative NHEJ Repair Pathway of DNA Double Strand Breaks (DSB) in Chronic Myeloid Leukemia (CML).

Genetic rearrangements beget genomic instability

Increased DNA Damage and Error-Prone Repair in MPD/MDS Mice with Disease Progression: Key Indicators for Increased Genomic Instability.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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