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Journal Articles

The NAD + Metabolic Dependency Restriction Overcomes Drug-Resistance Phenotype of Multiple Myeloma CELLS

Debora Soncini, Pamela Becherini, Silvia Ravera, Claudia Martinuzzi, Alessio Nencioni, Santina Bruzzone, Francesco Piacente, Giulia Giorgetti, Francesco Ladisa, Michel A. Duchosal, Aimable Nahimana, Roberto M. Lemoli, Michele Cea

Blood (2023) 142 (Supplement 1): 6609.

https://doi.org/10.1182/blood-2023-189720

Published: 2023

Journal Articles

Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells

Blood (2016) 127 (9): 1138–1150.

https://doi.org/10.1182/blood-2015-06-649970

Published: 2016

Includes: Supplemental data

Journal Articles

A Novel Synthetic Lethal Approach Targeting SIRT6 in Acute Myeloid Leukemia

Michele Cea, MD, Antonia Cagnetta, MD, Davide Lovera, MD, Raffaella Grasso, PhD, Nicoletta Colombo, PhD, Micaela Bergamaschi, MD, Sara Aquino, MD, Fabio Guolo, MD, Paola Minetto, MD, Filippo Ballerini, MD, Letizia Canepa, MD, Sophia Adamia, PhD, Alessio Nencioni, Ivana Pierri, MD, Marino Clavio, Maurizio Miglino, PhD, Marco Gobbi, MD, Roberto Massimo Lemoli, MD

Blood (2015) 126 (23): 1375.

https://doi.org/10.1182/blood.V126.23.1375.1375

Published: 2015

Journal Articles

Intracellular NAD + depletion enhances bortezomib-induced anti-myeloma activity

Antonia Cagnetta, Michele Cea, Teresa Calimeri, Chirag Acharya, Mariateresa Fulciniti, Yu-Tzu Tai, Teru Hideshima, Dharminder Chauhan, Mike Y. Zhong, Franco Patrone, Alessio Nencioni, Marco Gobbi, Paul Richardson, Nikhil Munshi, Kenneth C. Anderson

Blood (2013) 122 (7): 1243–1255.

https://doi.org/10.1182/blood-2013-02-483511

Published: 2013

Includes: Supplemental data

Journal Articles

Targeting NAD + salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition

Michele Cea, Antonia Cagnetta, Mariateresa Fulciniti, Yu-Tzu Tai, Teru Hideshima, Dharminder Chauhan, Aldo Roccaro, Antonio Sacco, Teresa Calimeri, Francesca Cottini, Jana Jakubikova, Sun-Young Kong, Franco Patrone, Alessio Nencioni, Marco Gobbi, Paul Richardson, Nikhil Munshi, Kenneth C. Anderson

Blood (2012) 120 (17): 3519–3529.

https://doi.org/10.1182/blood-2012-03-416776

Published: 2012

Includes: Supplemental data

Journal Articles

Targeting NAD + Salvage Pathway Induces Autophagy in Multiple Myeloma Cells

Michele Cea, MD, Antonia Cagnetta, MD, Yu-Tzu Tai, PhD, Mariateresa Fulciniti, PhD, Teru Hideshima, MD, PhD, Dharminder Chauhan, PhD, Sun-Young Kong, MD, PhD, Teresa Calimeri, M.D., Francesca Cottini, MD, Jana Jakubikova, PhD, Alessio Nencioni, Marco Gobbi, MD, Franco Patrone, Kenneth C. Anderson, MD

Blood (2011) 118 (21): 2920.

https://doi.org/10.1182/blood.V118.21.2920.2920

Published: 2011

Journal Articles

Hedgehog Signaling Is Useful as a Novel Molecular Marker for Predicting Relapse and Resistance During Chronic Myeloid Leukemia Treatment.

Michele Cea, Antonia Cagnetta, Gabriella Cirmena, Anna Garuti, Ilaria Rocco, Claudia Palermo, Ivana Pierri, Marco Gobbi, MD, Alberto Ballestrero, Alessio Nencioni, Franco Patrone, Angelo Michele Carella

Blood (2010) 116 (21): 1215.

https://doi.org/10.1182/blood.V116.21.1215.1215

Published: 2010

Journal Articles

Potent Synergistic Activity of the NAD+ Synthesis Inhibitor APO866 and of the Apoptosis Inducer TRAIL in in Vitro and Ex Vivo Cellular Models of Non Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia.

Blood (2009) 114 (22): 2733.

https://doi.org/10.1182/blood.V114.22.2733.2733

Published: 2009

Journal Articles

Deacetylase Inhibitor Cocktails Provide Striking Synergistic Interactions in Human Leukemia Cells.

Michele Cea, MD, Antonia Cagnetta, Floriana Fruscione, Santina Bruzzone, Ph.D., Gabriele Zoppoli, MD, Anna Garuti, Eva Moran, Ph.D., Valentina Grillo, Fabio Ferrando, Salvatore Casciaro, Ivana Pierri, Marco Gobbi, MD, Alberto Ballestrero, MD, Ph.D., Franco Patrone, MD, Ph.D., Alessio Nencioni, MD, Ph.D.

Blood (2009) 114 (22): 4404.

https://doi.org/10.1182/blood.V114.22.4404.4404

Published: 2009

Journal Articles

Patients Treated with Rituximab-Containing Immunochemotherapy Have a Significant and Prolonged Lack of Humoral Response to Influenza Vaccine Associated with a Persistent Depletion of B Memory Cells.

Blood (2009) 114 (22): 936.

https://doi.org/10.1182/blood.V114.22.936.936

Published: 2009

Journal Articles

Catastrophic NAD + Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE.

Santina Bruzzone, Ph.D., Floriana Fruscione, Sara Morando, Alessandro Poggi, Anna Garuti, Martina Selmo, Tiziana Ferrando, Federica Benvenuto, Michele Cea, MD, Debora Soncini, Eva Moran, Ph.D., Ilaria Rocco, Gabriella Cirmena, Gabriele Zoppoli, MD, Alberto Ballestrero, MD, Ph.D., Bernard Sordat, Franco Patrone, Antonio Uccelli, Alessio Nencioni, MD, Ph.D.

Blood (2009) 114 (22): 4732.

https://doi.org/10.1182/blood.V114.22.4732.4732

Published: 2009

Journal Articles

APO866 activity in hematologic malignancies: a preclinical in vitro study

Michele Cea, Gabriele Zoppoli, Santina Bruzzone, Floriana Fruscione, Eva Moran, Anna Garuti, Ilaria Rocco, Gabriella Cirmena, Salvatore Casciaro, Francesca Olcese, Ivana Pierri, Antonia Cagnetta, Fabio Ferrando, Riccardo Ghio, Marco Gobbi, Alberto Ballestrero, Franco Patrone, Alessio Nencioni

Blood (2009) 113 (23): 6035–6037.

https://doi.org/10.1182/blood-2009-03-209213

Published: 2009

Journal Articles

Crosspresentation: a matter of pH

Alessio Nencioni, Peter Brossart

Blood (2008) 112 (12): 4368–4369.

https://doi.org/10.1182/blood-2008-08-175703

Published: 2008

Journal Articles

Regulation of Dendritic Cell Function by Histone Deacetylase Inhibitors.

Julia Beck, Alessio Nencioni, MD, Frank Grünebach, PhD, Anita Bringmann, Lothar Kanz, MD, Franco Patrone, MD, Alberto Ballestrero, MD, Peter Brossart, MD

Blood (2006) 108 (11): 930.

https://doi.org/10.1182/blood.V108.11.930.930

Published: 2006

Journal Articles

Proteasome inhibitor bortezomib modulates TLR4-induced dendritic cell activation

Alessio Nencioni, Karin Schwarzenberg, Katharina M. Brauer, Susanne M. Schmidt, Alberto Ballestrero, Frank Grünebach, Peter Brossart

Blood (2006) 108 (2): 551–558.

https://doi.org/10.1182/blood-2005-08-3494

Published: 2006

Journal Articles

Proteasome Inhibitors Affect the Function of Human Dendritic Cells and Induce Caspase-Mediated Apoptosis.

Karin von Schwarzenberg, Alessio Nencioni, MD, Anita Bringmann, Lothar Kanz, MD, Franco Patrone, MD, Alberto Ballestrero, MD, Peter Brossart, MD

Blood (2005) 106 (11): 2229.

https://doi.org/10.1182/blood.V106.11.2229.2229

Published: 2005

Journal Articles

Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis

Alessio Nencioni, Fei Hua, Christopher P. Dillon, Rayka Yokoo, Christoph Scheiermann, Mike H. Cardone, Eleonora Barbieri, Ilaria Rocco, Anna Garuti, Sebastian Wesselborg, Claus Belka, Peter Brossart, Franco Patrone, Alberto Ballestrero

Blood (2005) 105 (8): 3255–3262.

https://doi.org/10.1182/blood-2004-10-3984

Published: 2005

NARROW

The NAD + Metabolic Dependency Restriction Overcomes Drug-Resistance Phenotype of Multiple Myeloma CELLS

Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells

A Novel Synthetic Lethal Approach Targeting SIRT6 in Acute Myeloid Leukemia

Intracellular NAD + depletion enhances bortezomib-induced anti-myeloma activity

Targeting NAD + salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition

Targeting NAD + Salvage Pathway Induces Autophagy in Multiple Myeloma Cells

Hedgehog Signaling Is Useful as a Novel Molecular Marker for Predicting Relapse and Resistance During Chronic Myeloid Leukemia Treatment.

Potent Synergistic Activity of the NAD+ Synthesis Inhibitor APO866 and of the Apoptosis Inducer TRAIL in in Vitro and Ex Vivo Cellular Models of Non Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia.

Deacetylase Inhibitor Cocktails Provide Striking Synergistic Interactions in Human Leukemia Cells.

Patients Treated with Rituximab-Containing Immunochemotherapy Have a Significant and Prolonged Lack of Humoral Response to Influenza Vaccine Associated with a Persistent Depletion of B Memory Cells.

Catastrophic NAD + Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE.

APO866 activity in hematologic malignancies: a preclinical in vitro study

Crosspresentation: a matter of pH

Regulation of Dendritic Cell Function by Histone Deacetylase Inhibitors.

Proteasome inhibitor bortezomib modulates TLR4-induced dendritic cell activation

Proteasome Inhibitors Affect the Function of Human Dendritic Cells and Induce Caspase-Mediated Apoptosis.

Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis

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American Society of Hematology

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American Society of Hematology

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