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Debora Soncini
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Journal Articles

Higher CD56 Expression on Multiple Myeloma Cells Increases CD38 Expression, Reduces Intracellular NAD+ Levels, and Enhances the Efficacy of Daratumumab-Based Treatment Strategies

Giulia Giorgetti, Pamela Becherini, Elena Maroto-Martin, Daniela Fenoglio, Debora Soncini, Claudia Martinuzzi, Santina Bruzzone, Andrea Benzi, Aimable Nahimana, Chiara Rosa Maria Uras, Anaïs Schavgoulidze, Jessica Ng Fong, Roberto M. Lemoli, Nikhil C Munshi, Mariateresa Fulciniti, Michele Cea
Journal: Blood
Blood (2023) 142 (Supplement 1): 1951.
https://doi.org/10.1182/blood-2023-189439
Published: 2023
Journal Articles

Deciphering the Immune Microenvironment in Waldenstrom's Macroglobulinemia

Antonio Sacco, Vanessa Desantis, Jon Celay, Viviana Giustini, Fabio Rigali, Francesco Savino, Michele Cea, Debora Soncini, Antonia Cagnetta, Antonio Giovanni Solimando, Deborah D'Aliberti, Silvia Spinelli, Daniele Ramazzotti, Camillo Almici, Katia Todoerti, Antonino Neri, Antonella Anastasia, Alessandra Tucci, Marina Motta, Marco Chiarini, Yawara Kawano, Jose A Martinez-Climent, Rocco Piazza, Aldo Roccaro
Journal: Blood
Blood (2023) 142 (Supplement 1): 4690.
https://doi.org/10.1182/blood-2023-188408
Published: 2023
Journal Articles

The NAD + Metabolic Dependency Restriction Overcomes Drug-Resistance Phenotype of Multiple Myeloma CELLS

Debora Soncini, Pamela Becherini, Silvia Ravera, Claudia Martinuzzi, Alessio Nencioni, Santina Bruzzone, Francesco Piacente, Giulia Giorgetti, Francesco Ladisa, Michel A. Duchosal, Aimable Nahimana, Roberto M. Lemoli, Michele Cea
Journal: Blood
Blood (2023) 142 (Supplement 1): 6609.
https://doi.org/10.1182/blood-2023-189720
Published: 2023
Journal Articles

Targeting the immune microenvironment in Waldenström macroglobulinemia via halting the CD40/CD40-ligand axis

Antonio Sacco, Vanessa Desantis, Jon Celay, Viviana Giustini, Fabio Rigali, Francesco D. Savino, Michele Cea, Debora Soncini, Antonia Cagnetta, Antonio G. Solimando, Deborah D’Aliberti, Silvia Spinelli, Daniele Ramazzotti, Camillo Almici, Katia Todoerti, Antonino Neri, Antonella Anastasia, Alessandra Tucci, Marina Motta, Marco Chiarini, Yawara Kawano, Jose A. Martinez-Climent, Rocco Piazza, Aldo M. Roccaro
Journal: Blood
Blood (2023) 141 (21): 2615–2628.
https://doi.org/10.1182/blood.2022019240
Published: 2023
Includes: Supplemental data
Journal Articles

Clonal Hematopoiesis: Exploiting Molecular Landscape of Multiple Myeloma Patients for Choosing the Most Appropriate Therapeutic Strategy

Elisa Gelli, Antonella Laudisi, Claudia Martinuzzi, Debora Soncini, Pamela Becherini, Fabio Guolo, Concetta Conticello, Daniele Derudas, Francesco Di Raimondo, Antonia Cagnetta, Domenico Coviello, Roberto Massimo Lemoli, Michele Cea
Journal: Blood
Blood (2022) 140 (Supplement 1): 7064–7065.
https://doi.org/10.1182/blood-2022-169263
Published: 2022
Journal Articles

The Multi-Kinases Inhibitor ARQ531 Enhanches Anti-MM Activity of Imids By Dual Deregulation of MAP- and Cyclin-Dependent Kinases Activities

Debora Soncini, Pamela Becherini, Elisa Gelli, Claudia Martinuzzi, Fabio Guolo, Antonino Neri, Antonia Cagnetta, Roberto Massimo Lemoli, Michele Cea
Journal: Blood
Blood (2022) 140 (Supplement 1): 9929.
https://doi.org/10.1182/blood-2022-169453
Published: 2022
Journal Articles

Erwinia Chrysantemi-Derived L-Asparaginase Strongly Enhances Proteasome Inhibitors Activity By Deregulating Cell Metabolic Programs

Paola Minetto, MD, Debora Soncini, PhD, Fabio Guolo, MD, Samantha Ruberti, BSc, PhD, Veronica Retali, Paola Contini, Nadia Bisso, MD, Nikki Di Felice, MD, Giulia Rivoli, MD, Antonia Cagnetta, MD, Marco Gobbi, MD, Roberto Massimo Lemoli, MD, Michele Cea, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3221.
https://doi.org/10.1182/blood-2018-99-119622
Published: 2018
Journal Articles

Glutamine-Dependence Targeting By Asparaginase Significantly Increases Anti-Myeloma Activity of Proteasome Inhibitors

Paola Minetto, MD, Debora Soncini, PhD, Antonia Cagnetta, MD, Fabio Guolo, MD, Veronica Retali, Giulia Rivoli, MD, Nadia Bisso, MD, Nikki Di Felice, MD, Maurizio Miglino, PhD, Letizia Canepa, MD, Roberto Massimo Lemoli, MD, Marco Gobbi, MD, Michele Cea
Journal: Blood
Blood (2017) 130 (Supplement 1): 1796.
https://doi.org/10.1182/blood.V130.Suppl_1.1796.1796
Published: 2017
Journal Articles

CD38 Deregulation As Strategy to Make Multiple Myeloma Cells More Sensitive to NAD+ Depleting Agents

Michele Cea, MD, Antonia Cagnetta, MD, Debora Soncini, PhD, Paola Minetto, MD, Micaela Bergamaschi, MD, Giulia Rivoli, MD, Letizia Canepa, MD, Marco Gobbi, MD, Roberto M Lemoli, MD
Journal: Blood
Blood (2016) 128 (22): 5671.
https://doi.org/10.1182/blood.V128.22.5671.5671
Published: 2016
Journal Articles

SIRT6 Inhibition As a Novel Approach for Treating Acute Myeloid Leukemia

Michele Cea, MD, Antonia Cagnetta, MD, Debora Soncini, PhD, Paola Minetto, MD, Davide Lovera, MD, Fabio Guolo, MD, Nicoletta Colombo, PhD, Filippo Ballerini, MD, Marino Clavio, MD, Maurizio Miglino, PhD, Marco Gobbi, MD, Roberto M Lemoli, MD
Journal: Blood
Blood (2016) 128 (22): 5222.
https://doi.org/10.1182/blood.V128.22.5222.5222
Published: 2016
Journal Articles

Catastrophic NAD + Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE.

Santina Bruzzone, Ph.D., Floriana Fruscione, Sara Morando, Alessandro Poggi, Anna Garuti, Martina Selmo, Tiziana Ferrando, Federica Benvenuto, Michele Cea, MD, Debora Soncini, Eva Moran, Ph.D., Ilaria Rocco, Gabriella Cirmena, Gabriele Zoppoli, MD, Alberto Ballestrero, MD, Ph.D., Bernard Sordat, Franco Patrone, Antonio Uccelli, Alessio Nencioni, MD, Ph.D.
Journal: Blood
Blood (2009) 114 (22): 4732.
https://doi.org/10.1182/blood.V114.22.4732.4732
Published: 2009
Journal Articles

Potent Synergistic Activity of the NAD+ Synthesis Inhibitor APO866 and of the Apoptosis Inducer TRAIL in in Vitro and Ex Vivo Cellular Models of Non Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia.

Gabriele Zoppoli, MD, Michele Cea, MD, Floriana Fruscione, Santina Bruzzone, Ph.D., Debora Soncini, Davide Bedognetti, MD, Eva Moran, Ph.D., Enrico Balleari, MD, Andrea Bruzzone, MD, Anna Garuti, Gabriella Cirmena, Ilaria Rocco, Marco Gobbi, MD, Ph.D., Riccardo Ghio, MD, Ph.D., Yves Pommier, MD, Ph.D., Angelo Michele Carella, MD, Ph.D., Alberto Ballestrero, MD, Ph.D., Silvio Parodi, MD, Ph.D., Franco Patrone, MD, Ph.D., Alessio Nencioni, MD, Ph.D.
Journal: Blood
Blood (2009) 114 (22): 2733.
https://doi.org/10.1182/blood.V114.22.2733.2733
Published: 2009