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Issue Archive

Volume 121, Issue 7
February 14 2013
Issue Cover

Table of Contents

Inside Blood

INSIDE BLOOD
CAReful epitope selection matters
Rupert Handgretinger
View Articletitled, CAReful epitope selection matters
GENE THERAPY
Gene therapy targets XLP
A. H. Filipovich
View Articletitled, Gene therapy targets XLP
INSIDE BLOOD
UGT2B17 as a disease accelerator in CLL
Yiming Zhong,John C. Byrd
View Articletitled, UGT2B17 as a disease accelerator in CLL
RED CELLS, IRON, & ERYTHROPOIESIS
Inhibiting the hepcidin inhibitor for treatment of iron overload
Laura Silvestri
View Articletitled, Inhibiting the hepcidin inhibitor for treatment of iron overload
TRANSPLANTATION
Location, location, location: advancing veto cell therapies
James C. Zimring
View Articletitled, Location, location, location: advancing veto cell therapies

Blood Work

Systemic mastocytosis
Sylvie Bouvier,Anne Arnaud
View Articletitled, Systemic mastocytosis

Plenary Paper

GENE THERAPY
SAP gene transfer restores cellular and humoral immune function in a murine model of X-linked lymphoproliferative disease
Brief Report
Christine Rivat,Claire Booth,Maria Alonso-Ferrero,Michael Blundell,Neil J. Sebire,Adrian J. Thrasher,H. Bobby Gaspar
View Articletitled, SAP gene transfer restores cellular and humoral immune function in a murine model of X-linked lymphoproliferative disease
Supplemental data

Perspectives

The myth of the second remission of acute leukemia in the adult
Clinical Trials & Observations
Stephen J. Forman,Jacob M. Rowe
View Articletitled, The myth of the second remission of acute leukemia in the adult

Clinical Trials and Observations

FACS analysis of Stat3/5 signaling reveals sensitivity to G-CSF and IL-6 as a significant prognostic factor in pediatric AML: a Children's Oncology Group report
Clinical Trials & Observations
Michele S. Redell,Marcos J. Ruiz,Robert B. Gerbing,Todd A. Alonzo,Beverly J. Lange,David J. Tweardy,Soheil Meshinchi
View Articletitled, FACS analysis of Stat3/5 signaling reveals sensitivity to G-CSF and IL-6 as a significant prognostic factor in pediatric AML: a Children's Oncology Group report
Supplemental data

Hematopoiesis and Stem Cells

Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation
Elenoe C. Smith,Alexandra M. Teixeira,Rachel C. Chen,Lin Wang,Yuan Gao,Katherine L. Hahn,Diane S. Krause
View Articletitled, Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation
Supplemental data

Immunobiology

Control of regulatory T cells is necessary for vaccine-like effects of antiviral immunotherapy by monoclonal antibodies
Roudaina Nasser,Mireia Pelegrin,Marc Plays,Laurent Gros,Marc Piechaczyk
View Articletitled, Control of regulatory T cells is necessary for vaccine-like effects of antiviral immunotherapy by monoclonal antibodies
Peptide length determines the outcome of TCR/peptide-MHCI engagement
Julia Ekeruche-Makinde,John J. Miles,Hugo A. van den Berg,Ania Skowera,David K. Cole,Garry Dolton,Andrea J. A. Schauenburg,Mai Ping Tan,Johanne M. Pentier,Sian Llewellyn-Lacey,Kim M. Miles,Anna M. Bulek,Mathew Clement,Tamsin Williams,Andrew Trimby,Mick Bailey,Pierre Rizkallah,Jamie Rossjohn,Mark Peakman,David A. Price,Scott R. Burrows,Andrew K. Sewell,Linda Wooldridge
View Articletitled, Peptide length determines the outcome of TCR/peptide-MHCI engagement
Supplemental data
Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection
Edwin Leeansyah,Anupama Ganesh,Máire F. Quigley,Anders Sönnerborg,Jan Andersson,Peter W. Hunt,Ma Somsouk,Steven G. Deeks,Jeffrey N. Martin,Markus Moll,Barbara L. Shacklett,Johan K. Sandberg
View Articletitled, Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection
Supplemental data
Distinct gene-expression profiles associated with the susceptibility of pathogen-specific CD4 T cells to HIV-1 infection
Haitao Hu,Martin Nau,Phil Ehrenberg,Agnes-Laurence Chenine,Camila Macedo,Yu Zhou,Z. John Daye,Zhi Wei,Maryanne Vahey,Nelson L. Michael,Jerome H. Kim,Mary Marovich,Silvia Ratto-Kim
View Articletitled, Distinct gene-expression profiles associated with the susceptibility of pathogen-specific CD4 T cells to HIV-1 infection
Supplemental data
A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation
Sharvan Sehrawat,Paul-Albert Koenig,Oktay Kirak,Christian Schlieker,Manuel Fankhauser,Hidde L. Ploegh
View Articletitled, A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation
Supplemental data
Inhibitory KIR/HLA incompatibility between sexual partners confers protection against HIV-1 transmission
Wim Jennes,Sonja Verheyden,Julie W. Mertens,Makhtar Camara,Moussa Seydi,Tandakha N. Dieye,Souleymane Mboup,Christian Demanet,Luc Kestens
View Articletitled, Inhibitory <em>KIR/HLA</em> incompatibility between sexual partners confers protection against HIV-1 transmission
Gene-expression signatures differ between different clinical forms of familial hemophagocytic lymphohistiocytosis
e-blood
Janos Sumegi,Shawnagay V. Nestheide,Michael G. Barnes,Joyce Villanueva,Kejian Zhang,Alexei A. Grom,Alexandra H. Filipovich
View Articletitled, Gene-expression signatures differ between different clinical forms of familial hemophagocytic lymphohistiocytosis
Supplemental data

Lymphoid Neoplasia

Anti-CD22–chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
Waleed Haso,Daniel W. Lee,Nirali N. Shah,Maryalice Stetler-Stevenson,Constance M. Yuan,Ira H. Pastan,Dimiter S. Dimitrov,Richard A. Morgan,David J. FitzGerald,David M. Barrett,Alan S. Wayne,Crystal L. Mackall,Rimas J. Orentas
View Articletitled, Anti-CD22–chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
Supplemental data
Overexpression of uridine diphospho glucuronosyltransferase 2B17 in high-risk chronic lymphocytic leukemia
Clinical Trials & Observations
Michaela Gruber,Judith Bellemare,Gregor Hoermann,Andreas Gleiss,Edit Porpaczy,Martin Bilban,Trang Le,Sonja Zehetmayer,Christine Mannhalter,Alexander Gaiger,Medhat Shehata,Karin Fleiss,Cathrin Skrabs,Éric Lévesque,Katrina Vanura,Chantal Guillemette,Ulrich Jaeger
View Articletitled, Overexpression of uridine diphospho glucuronosyltransferase 2B17 in high-risk chronic lymphocytic leukemia
Supplemental data
Telomere length in mantle cell lymphoma
Brief Report
Billy Michael Chelliah Jebaraj,Dirk Kienle,André Lechel,Daniel Mertens,Maria Heuberger,German Ott,Andreas Rosenwald,Thomas F. E. Barth,Peter Möller,Thorsten Zenz,Hartmut Döhner,Stephan Stilgenbauer
View Articletitled, Telomere length in mantle cell lymphoma
Supplemental data
Application of a new wall-less plate technology to complex multistep cell-based investigations using suspension cells
e-blood
Gabriel A. Quiñones,Travis I. Moore,Katrina Nicholes,Hyunjae Lee,Sudong Kim,Laura Sun,Noo Li Jeon,Jean-Philippe Stephan
View Articletitled, Application of a new wall-less plate technology to complex multistep cell-based investigations using suspension cells
Supplemental data

Myeloid Neoplasia

Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2-V617F polycythemia vera mouse model
Lucia Kubovcakova,Pontus Lundberg,Jean Grisouard,Hui Hao-Shen,Vincent Romanet,Rita Andraos,Masato Murakami,Stephan Dirnhofer,Kay-Uwe Wagner,Thomas Radimerski,Radek C. Skoda
View Articletitled, Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a <em>JAK2</em>-V617F polycythemia vera mouse model
Supplemental data
Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia
e-blood
Emmet McCormack,Maja Mujić,Tereza Osdal,Øystein Bruserud,Bjørn Tore Gjertsen
View Articletitled, Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia
Supplemental data

Red Cells, Iron, and Erythropoiesis

An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe−/− mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia
Paul J. Schmidt,Iva Toudjarska,Anoop K. Sendamarai,Tim Racie,Stuart Milstein,Brian R. Bettencourt,Julia Hettinger,David Bumcrot,Mark D. Fleming
View Articletitled, An RNAi therapeutic targeting Tmprss6 decreases iron overload in <em>Hfe</em><sup>−/−</sup> mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia
Supplemental data

Thrombosis and Hemostasis

Dysfunction of the PI3 kinase/Rap1/integrin αIIbβ3 pathway underlies ex vivo platelet hypoactivity in essential thrombocythemia
Samantha F. Moore,Roger W. Hunter,Matthew T. Harper,Joshua S. Savage,Samreen Siddiq,Sarah K. Westbury,Alastair W. Poole,Andrew D. Mumford,Ingeborg Hers
View Articletitled, Dysfunction of the PI3 kinase/Rap1/integrin α<sub>IIb</sub>β<sub>3</sub> pathway underlies ex vivo platelet hypoactivity in essential thrombocythemia

Transplantation

Murine anti–third-party central-memory CD8+ T cells promote hematopoietic chimerism under mild conditioning: lymph-node sequestration and deletion of anti-donor T cells
Eran Ophir,Noga Or-Geva,Irina Gurevich,Orna Tal,Yaki Eidelstein,Elias Shezen,Raanan Margalit,Assaf Lask,Guy Shakhar,David Hagin,Esther Bachar-Lustig,Shlomit Reich-Zeliger,Andreas Beilhack,Robert Negrin,Yair Reisner
View Articletitled, Murine anti–third-party central-memory CD8<sup>+</sup> T cells promote hematopoietic chimerism under mild conditioning: lymph-node sequestration and deletion of anti-donor T cells
Supplemental data

Vascular Biology

Evidence for the interaction of fibroblast growth factor-2 with the lymphatic endothelial cell marker LYVE-1
Natalia Platonova,Geraldine Miquel,Birgit Regenfuss,Said Taouji,Claus Cursiefen,Eric Chevet,Andreas Bikfalvi
View Articletitled, Evidence for the interaction of fibroblast growth factor-2 with the lymphatic endothelial cell marker LYVE-1
Supplemental data

Correspondence

BCR-ABL1 is a secondary event after JAK2V617F in patients with polycythemia vera who develop chronic myeloid leukemia
Xiaoli Wang,Joseph Tripodi,Marina Kremyanskaya,Amanda Blouin,Paul Roda,Ronald Hoffman,Vesna Najfeld
View Articletitled, <em>BCR-ABL1</em> is a secondary event after <em>JAK2V617F</em> in patients with polycythemia vera who develop chronic myeloid leukemia
Hemichorea in a patient with JAK2V617F blood cells
Jane Lew,Steven J. Frucht,Marina Kremyanskaya,Ronald Hoffman,John Mascarenhas
View Articletitled, Hemichorea in a patient with <em>JAK2V617F</em> blood cells
Supplemental data
No cross-resistance after sequential use of romiplostim and eltrombopag in chronic immune thrombocytopenic purpura
Giovanni D'Arena,Roberto Guariglia,Giovanna Mansueto,Maria Carmen Martorelli,Giuseppe Pietrantuono,Oreste Villani,Rosa Lerose,Pellegrino Musto
View Articletitled, No cross-resistance after sequential use of romiplostim and eltrombopag in chronic immune thrombocytopenic purpura
C1-esterase inhibitor concentrate rescues erythrocytes from complement-mediated destruction in autoimmune hemolytic anemia
Diana Wouters,Femke Stephan,Paul Strengers,Masja de Haas,Conny Brouwer,Anton Hagenbeek,Marinus H. J. van Oers,Sacha Zeerleder
View Articletitled, C1-esterase inhibitor concentrate rescues erythrocytes from complement-mediated destruction in autoimmune hemolytic anemia
All Issues

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Asciminib is a novel inhibitor of ABL1 and ABL2 gene fusions in ALL but requires the ABL SH3 domain for efficacy
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