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Journal Articles

Aln-TMP: A Subcutaneously Administered RNAi Therapeutic Targeting Tmprss6 For The Treatment Of β-Thalassemia

James Butler, PhD, Shannon Fishman, BS, Tim Racie, BS, Julia Hettinger, BS, Brian R Bettencourt, PhD, Klaus Charisse, PhD, Kevin Fitzgerald, PhD
Journal: Blood
Blood (2013) 122 (21): 2260.
https://doi.org/10.1182/blood.V122.21.2260.2260
Published: 2013
Journal Articles

An RNAi-Therapeutic Targeting Tmprss6, in Conjunction With Oral Chelator Therapy, Ameliorates Anemia and Additively Diminishes Secondary Iron Overload In a Mouse Model Of β-Thalassemia Intermedia

Paul J Schmidt, PhD, Tim Racie, BS, Jim S Butler, PhD, Kevin Fitzgerald, PhD, Mark D Fleming, D.Phil., M.D.
Journal: Blood
Blood (2013) 122 (21): 1019.
https://doi.org/10.1182/blood.V122.21.1019.1019
Published: 2013
Journal Articles

An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe −/− mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia

Paul J. Schmidt, Iva Toudjarska, Anoop K. Sendamarai, Tim Racie, Stuart Milstein, Brian R. Bettencourt, Julia Hettinger, David Bumcrot, Mark D. Fleming
Journal: Blood
Blood (2013) 121 (7): 1200–1208.
https://doi.org/10.1182/blood-2012-09-453977
Published: 2013
Includes: Supplemental data
Journal Articles

RNAi-Mediated Inhibition of Tmprss6 Ameliorates Anemia and Secondary Iron Overload in a Mouse Model of β-Thalassemia Intermedia and Decreases Iron Overload in Hfe −/− Mice

Paul J Schmidt, PhD, Anoop K Sendamarai, PhD, Ivanka Toudjarska, PhD, Tim Racie, Jim S Butler, PhD, Mark D. Fleming, MD, DPhil, David Bumcrot, PhD
Journal: Blood
Blood (2012) 120 (21): 1018.
https://doi.org/10.1182/blood.V120.21.1018.1018
Published: 2012
Journal Articles

An RNAi Therapeutic Targeting Antithrombin Increases Thrombin Generation in Nonhuman Primates

Akin Akinc, PhD, Alfica Sehgal, PhD, Scott Barros, PhD, Julia Hettinger, Klaus Charisse, PhD, Josh Brodsky, June Qin, Tim Racie
Journal: Blood
Blood (2012) 120 (21): 3370.
https://doi.org/10.1182/blood.V120.21.3370.3370
Published: 2012
Journal Articles

Targeting the Hepcidin Pathway with RNAi Therapeutics for the Treatment of Anemia

Akin Akinc, PhD, Amy Chan-Daniels, PhD, Alfica Sehgal, PhD, Don Foster, Brian R Bettencourt, PhD, Julia Hettinger, Tim Racie, Justin Aubin, Satya Kuchimanchi, PhD, Hila Epstein-Barash, PhD, Tomoko Nakayama, PhD
Journal: Blood
Blood (2011) 118 (21): 688.
https://doi.org/10.1182/blood.V118.21.688.688
Published: 2011
Journal Articles

RNAi-Mediated Inhibition of Activated Protein C- A New Approach for Hemophilia Treatment

Ivanka Toudjarska, PhD, Zuhua Cai, Tim Racie, Julia Hettinger, Stuart Milstein, PhD, Brian R Bettencourt, PhD, Dinah WY Sah, PhD, David Bumcrot, PhD, John Maraganore, PhD, Akshay Vaishnaw, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 1204.
https://doi.org/10.1182/blood.V118.21.1204.1204
Published: 2011
Journal Articles

RNAi-Mediated Inhibition of Tmprss6 Elevates Hamp1 Expression and Reduces Serum Iron Levels in Mice

Ivanka Toudjarska, PhD, Zuhua Cai, Tim Racie, Stuart Milstein, PhD, Brian R Bettencourt, PhD, Julia Hettinger, Dinah WY Sah, PhD, Akshay Vaishnaw, MD, PhD, David Bumcrot, PhD
Journal: Blood
Blood (2011) 118 (21): 1045.
https://doi.org/10.1182/blood.V118.21.1045.1045
Published: 2011