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Issue Archive

Volume 121, Issue 1
January 3 2013
Issue Cover

Table of Contents

Editorial

Changing of the guard
Bob Löwenberg,Nancy Berliner
View Articletitled, Changing of the guard

Inside Blood

HEMATOPOIESIS & STEM CELLS
Multifunctionality of the FA pathway
Laura E. Hays
View Articletitled, Multifunctionality of the FA pathway
IMMUNOBIOLOGY
γc cytokine signaling: graduate school in thymic education
Megan A. Luckey,Jung-Hyun Park
View Articletitled, γc cytokine signaling: graduate school in thymic education
TRANSPLANTATION
GVL for ATL?
Nirali N. Shah,Thomas A. Waldmann
View Articletitled, GVL for ATL?

Blood Work

Iron alters red blood cell morphology
Etheresia Pretorius,Boguslaw Lipinski
View Articletitled, Iron alters red blood cell morphology

Plenary Paper

Hematopoiesis and Stem Cells
Convergent differentiation: myeloid and lymphoid pathways to murine plasmacytoid dendritic cells
Priyanka Sathe,David Vremec,Li Wu,Lynn Corcoran,Ken Shortman
View Articletitled, Convergent differentiation: myeloid and lymphoid pathways to murine plasmacytoid dendritic cells

Perspectives

The triumph of good over evil: protection by the sickle gene against malaria
H. Franklin Bunn
View Articletitled, The triumph of good over evil: protection by the sickle gene against malaria

Blood Spotlight

Sense and nonsense of high-dose cytarabine for acute myeloid leukemia
Clinical Trials & Observations
Bob Löwenberg
View Articletitled, Sense and nonsense of high-dose cytarabine for acute myeloid leukemia

Review Article

The split personality of regulatory T cells in HIV infection
Mathieu F. Chevalier,Laurence Weiss
View Articletitled, The split personality of regulatory T cells in HIV infection

How I Treat

How I treat thrombocytopenia in pregnancy
Clinical Trials & Observations
Terry Gernsheimer,Andra H. James,Roberto Stasi
View Articletitled, How I treat thrombocytopenia in pregnancy

Clinical Trials and Observations

CHOP and DHAP plus rituximab followed by autologous stem cell transplantation in mantle cell lymphoma: a phase 2 study from the Groupe d'Etude des Lymphomes de l'Adulte
Clinical Trials & Observations
Richard Delarue,Corinne Haioun,Vincent Ribrag,Pauline Brice,Alain Delmer,Herve Tilly,Gilles Salles,Achiel Van Hoof,Olivier Casasnovas,Nicole Brousse,Francois Lefrere,Olivier Hermine,for the Groupe d'Etude des Lymphomes de l'Adulte (GELA)
View Articletitled, CHOP and DHAP plus rituximab followed by autologous stem cell transplantation in mantle cell lymphoma: a phase 2 study from the Groupe d'Etude des Lymphomes de l'Adulte
Supplemental data

Hematopoiesis and Stem Cells

Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4
Yonghwan Kim,Gabriella S. Spitz,Uma Veturi,Francis P. Lach,Arleen D. Auerbach,Agata Smogorzewska
View Articletitled, Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4
Supplemental data
Early T-cell progenitors are the major granulocyte precursors in the adult mouse thymus
Maria Elena De Obaldia,J. Jeremiah Bell,Avinash Bhandoola
View Articletitled, Early T-cell progenitors are the major granulocyte precursors in the adult mouse thymus
Supplemental data

Immunobiology

Disease-associated missense mutations in the EVH1 domain disrupt intrinsic WASp function causing dysregulated actin dynamics and impaired dendritic cell migration
Austen J. J. Worth,Joao Metelo,Gerben Bouma,Dale Moulding,Marco Fritzsche,Bertrand Vernay,Guillaume Charras,Giles O. C. Cory,Adrian J. Thrasher,Siobhan O. Burns
View Articletitled, Disease-associated missense mutations in the EVH1 domain disrupt intrinsic WASp function causing dysregulated actin dynamics and impaired dendritic cell migration
Supplemental data
TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell–independent isotype switch in mice
Maria Pihlgren,Alberto B. Silva,Rime Madani,Valérie Giriens,Ying Waeckerle-Men,Antonia Fettelschoss,David T. Hickman,María Pilar López-Deber,Dorin Mlaki Ndao,Marija Vukicevic,Anna Lucia Buccarello,Valérie Gafner,Nathalie Chuard,Pedro Reis,Kasia Piorkowska,Andrea Pfeifer,Thomas M. Kündig,Andreas Muhs,Pål Johansen
View Articletitled, TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell–independent isotype switch in mice
CLEC5A is critical for dengue virus–induced inflammasome activation in human macrophages
Ming-Fang Wu,Szu-Ting Chen,An-Hang Yang,Wan-Wan Lin,Yi-Ling Lin,Nien-Jung Chen,I-Shuen Tsai,Lei Li,Shie-Liang Hsieh
View Articletitled, CLEC5A is critical for dengue virus–induced inflammasome activation in human macrophages
Supplemental data
Differential effects of γc cytokines on postselection differentiation of CD8 thymocytes
Moutih Rafei,Alexandre Rouette,Sylvie Brochu,Juan Ruiz Vanegas,Claude Perreault
View Articletitled, Differential effects of γc cytokines on postselection differentiation of CD8 thymocytes
Supplemental data
CCX-CKR deficiency alters thymic stroma impairing thymocyte development and promoting autoimmunity
Mark D. Bunting,Iain Comerford,Natalie Seach,Maree V. Hammett,Darren L. Asquith,Heinrich Körner,Richard L. Boyd,Robert J. B. Nibbs,Shaun R. McColl
View Articletitled, CCX-CKR deficiency alters thymic stroma impairing thymocyte development and promoting autoimmunity
Supplemental data
CD59 deficiency is associated with chronic hemolysis and childhood relapsing immune-mediated polyneuropathy
Yoram Nevo,Bruria Ben-Zeev,Adi Tabib,Rachel Straussberg,Yair Anikster,Zamir Shorer,Aviva Fattal-Valevski,Asaf Ta-Shma,Sharon Aharoni,Malcolm Rabie,Shamir Zenvirt,Hanoch Goldshmidt,Yakov Fellig,Avraham Shaag,Dror Mevorach,Orly Elpeleg
View Articletitled, CD59 deficiency is associated with chronic hemolysis and childhood relapsing immune-mediated polyneuropathy

Lymphoid Neoplasia

Targeted nanoparticle delivery overcomes off-target immunostimulatory effects of oligonucleotides and improves therapeutic efficacy in chronic lymphocytic leukemia
Bo Yu,Yicheng Mao,Li-Yuan Bai,Sarah E. M. Herman,Xinmei Wang,Asha Ramanunni,Yan Jin,Xiaokui Mo,Carolyn Cheney,Kenneth K. Chan,David Jarjoura,Guido Marcucci,Robert J. Lee,John C. Byrd,L. James Lee,Natarajan Muthusamy
View Articletitled, Targeted nanoparticle delivery overcomes off-target immunostimulatory effects of oligonucleotides and improves therapeutic efficacy in chronic lymphocytic leukemia
Supplemental data
SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia
Parham Ramezani-Rad,Huimin Geng,Christian Hurtz,Lai N. Chan,Zhengshan Chen,Hassan Jumaa,Ari Melnick,Elisabeth Paietta,William L. Carroll,Cheryl L. Willman,Véronique Lefebvre,Markus Müschen
View Articletitled, SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia
Supplemental data
Incremental value in outcome prediction with gene expression–based signatures in diffuse large B-cell lymphoma
Brief Report
Fangxin Hong,Brad S. Kahl,Robert Gray
View Articletitled, Incremental value in outcome prediction with gene expression–based signatures in diffuse large B-cell lymphoma

Myeloid Neoplasia

Lenalidomide-mediated enhanced translation of C/EBPα-p30 protein up-regulates expression of the antileukemic microRNA-181a in acute myeloid leukemia
Christopher J. Hickey,Sebastian Schwind,Hanna S. Radomska,Adrienne M. Dorrance,Ramasamy Santhanam,Anjali Mishra,Yue-Zhong Wu,Houda Alachkar,Kati Maharry,Deedra Nicolet,Krzysztof Mrózek,Alison Walker,Anna M. Eiring,Susan P. Whitman,Heiko Becker,Danilo Perrotti,Lai-Chu Wu,Xi Zhao,Todd A. Fehniger,Ravi Vij,John C. Byrd,William Blum,L. James Lee,Michael A. Caligiuri,Clara D. Bloomfield,Ramiro Garzon,Guido Marcucci
View Articletitled, Lenalidomide-mediated enhanced translation of C/EBPα-p30 protein up-regulates expression of the antileukemic <em>microRNA-181a</em> in acute myeloid leukemia
Supplemental data
Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG)
Peter Paschka,Juan Du,Richard F. Schlenk,Verena I. Gaidzik,Lars Bullinger,Andrea Corbacioglu,Daniela Späth,Sabine Kayser,Brigitte Schlegelberger,Jürgen Krauter,Arnold Ganser,Claus-Henning Köhne,Gerhard Held,Marie von Lilienfeld-Toal,Heinz Kirchen,Mathias Rummel,Katharina Götze,Heinz-August Horst,Mark Ringhoffer,Michael Lübbert,Mohammed Wattad,Helmut R. Salih,Andrea Kündgen,Hartmut Döhner,Konstanze Döhner
View Articletitled, Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG)
Supplemental data
DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding
Till Schoofs,Christian Rohde,Katja Hebestreit,Hans-Ulrich Klein,Stefanie Göllner,Isabell Schulze,Mads Lerdrup,Nikolaj Dietrich,Shuchi Agrawal-Singh,Anika Witten,Monika Stoll,Eva Lengfelder,Wolf-Karsten Hofmann,Peter Schlenke,Thomas Büchner,Klaus Hansen,Wolfgang E. Berdel,Frank Rosenbauer,Martin Dugas,Carsten Müller-Tidow
View Articletitled, DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding
Supplemental data

Platelets and Thrombopoiesis

Canonical Wnt signaling in megakaryocytes regulates proplatelet formation
Iain C. Macaulay,Jonathan N. Thon,Marloes R. Tijssen,Brian M. Steele,Bryan T. MacDonald,Gerardene Meade,Philippa Burns,Augusto Rendon,Vishal Salunkhe,Ronan P. Murphy,Cavan Bennett,Nicholas A. Watkins,Xi He,Desmond J. Fitzgerald,Joseph E. Italiano, Jr,Patricia B. Maguire
View Articletitled, Canonical Wnt signaling in megakaryocytes regulates proplatelet formation
Supplemental data

Transplantation

Acute toxicities of unrelated bone marrow versus peripheral blood stem cell donation: results of a prospective trial from the National Marrow Donor Program
Michael A. Pulsipher,Pintip Chitphakdithai,Brent R. Logan,Bronwen E. Shaw,John R. Wingard,Hillard M. Lazarus,Edmund K. Waller,Matthew Seftel,David F. Stroncek,Angela M. Lopez,Dipnarine Maharaj,Peiman Hematti,Paul V. O'Donnell,Alison W. Loren,Susan F. Leitman,Paolo Anderlini,Steven C. Goldstein,John E. Levine,Willis H. Navarro,John P. Miller,Dennis L. Confer
View Articletitled, Acute toxicities of unrelated bone marrow versus peripheral blood stem cell donation: results of a prospective trial from the National Marrow Donor Program
Supplemental data
Immunotherapeutic strategies to prevent and treat human herpesvirus 6 reactivation after allogeneic stem cell transplantation
Ulrike Gerdemann,Laura Keukens,Jacqueline M. Keirnan,Usha L. Katari,Chinh T. Q. Nguyen,Anne P. de Pagter,Carlos A. Ramos,Alana Kennedy-Nasser,Stephen M. Gottschalk,Helen E. Heslop,Malcolm K. Brenner,Cliona M. Rooney,Ann M. Leen
View Articletitled, Immunotherapeutic strategies to prevent and treat human herpesvirus 6 reactivation after allogeneic stem cell transplantation
Supplemental data
Treatment of relapsed adult T-cell leukemia/lymphoma after allogeneic hematopoietic stem cell transplantation: the Nagasaki Transplant Group experience
Clinical Trials & Observations
Hidehiro Itonaga,Hideki Tsushima,Jun Taguchi,Takuya Fukushima,Hiroaki Taniguchi,Shinya Sato,Koji Ando,Yasushi Sawayama,Emi Matsuo,Reishi Yamasaki,Yasuyuki Onimaru,Daisuke Imanishi,Yoshitaka Imaizumi,Shinichiro Yoshida,Tomoko Hata,Yukiyoshi Moriuchi,Naokuni Uike,Yasushi Miyazaki
View Articletitled, Treatment of relapsed adult T-cell leukemia/lymphoma after allogeneic hematopoietic stem cell transplantation: the Nagasaki Transplant Group experience

Vascular Biology

AngiomiR-126 expression and secretion from circulating CD34+ and CD14+ PBMCs: role for proangiogenic effects and alterations in type 2 diabetics
Pavani Mocharla,Sylvie Briand,Giovanna Giannotti,Carola Dörries,Philipp Jakob,Francesco Paneni,Thomas Lüscher,Ulf Landmesser
View Articletitled, AngiomiR-126 expression and secretion from circulating CD34<sup>+</sup> and CD14<sup>+</sup> PBMCs: role for proangiogenic effects and alterations in type 2 diabetics
Supplemental data

Correspondence

Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia
Scott J. Hebbring,Susan L. Slager,Narendranath Epperla,Joseph J. Mazza,Zhan Ye,Zhiyi Zhou,Sara J. Achenbach,Daniel A. Vasco,Timothy G. Call,Kari G. Rabe,Neil E. Kay,Neil E. Caporaso,Mark C. Lanasa,Nicola J. Camp,Sara S. Strom,Lynn R. Goldin,James R. Cerhan,Murray H. Brilliant,Steven J. Schrodi
View Articletitled, Genetic evidence of <em>PTPN22</em> effects on chronic lymphocytic leukemia
Response: increased expression or activity of PTPN22 may compromise negative selection of autoreactive CLL cells
Dimitar G. Efremov
View Articletitled, Response: increased expression or activity of PTPN22 may compromise negative selection of autoreactive CLL cells
CLL B-cell receptors can recognize themselves: alternative epitopes and structural clues for autostimulatory mechanisms in CLL
Mascha Binder,Fabian Müller,Mareike Frick,Claudia Wehr,Frédéric Simon,Bernd Leistler,Hendrik Veelken,Roland Mertelsmann,Martin Trepel
View Articletitled, CLL B-cell receptors can recognize themselves: alternative epitopes and structural clues for autostimulatory mechanisms in CLL
Antibodies against neutrophil LY6G do not inhibit leukocyte recruitment in mice in vivo
Bryan G. Yipp,Paul Kubes
View Articletitled, Antibodies against neutrophil LY6G do not inhibit leukocyte recruitment in mice in vivo
Supplemental data
Response: Ly6G: a work in progress
Peter A. Nigrovic
View Articletitled, Response: Ly6G: a work in progress
Lactate dehydrogenase and hemolysis in sickle cell disease
Samir K. Ballas
View Articletitled, Lactate dehydrogenase and hemolysis in sickle cell disease
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