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Issue Archive

Volume 119, Issue 1
January 5 2012
Issue Cover

Table of Contents

Inside Blood

CLINICAL TRIALS
M(yeloma)IXing up T maintenance
Simon J. Harrison,Amit Khot
View Articletitled, M(yeloma)IXing up T maintenance
CLINICAL TRIALS
Two genes, tipifarnib, and AML
Rosa Ruchlemer
View Articletitled, Two genes, tipifarnib, and AML
TRANSPLANTATION
The Serenity Prayer for acute GVHD
Georgia B. Vogelsang
View Articletitled, The Serenity Prayer for acute GVHD

Blood Work

Accelerated phase of Chediak-Higashi syndrome
Sheeja T. Pullarkat
View Articletitled, Accelerated phase of Chediak-Higashi syndrome

Plenary Paper

PLENARY PAPER
The role of maintenance thalidomide therapy in multiple myeloma: MRC Myeloma IX results and meta-analysis
Clinical Trials & Observations
Gareth J. Morgan,Walter M. Gregory,Faith E. Davies,Sue E. Bell,Alexander J. Szubert,Julia M. Brown,Nuria N. Coy,Gordon Cook,Nigel H. Russell,Claudius Rudin,Huw Roddie,Mark T. Drayson,Roger G. Owen,Fiona M. Ross,Graham H. Jackson,J. Anthony Child,on behalf of the National Cancer Research Institute Haematological Oncology Clinical Studies Group
View Articletitled, The role of maintenance thalidomide therapy in multiple myeloma: MRC Myeloma IX results and meta-analysis
Supplemental data

Review Articles

Novel treatment concepts for graft-versus-host disease
Dominik Wolf,Marie von Lilienfeld-Toal,Anna Maria Wolf,Michael Schleuning,Michael von Bergwelt-Baildon,Stefanie A. E. Held,Peter Brossart
View Articletitled, Novel treatment concepts for graft-versus-host disease
Reconstruction of integrin activation
Feng Ye,Chungho Kim,Mark H. Ginsberg
View Articletitled, Reconstruction of integrin activation

Clinical Trials and Observations

Immunoglobulin D amyloidosis: a distinct entity
Clinical Trials & Observations
Morie A. Gertz,Francis K. Buadi,Suzanne R. Hayman,David Dingli,Angela Dispenzieri,Philip R. Greipp,Shaji K. Kumar,Martha Q. Lacy,John A. Lust,Nelson Leung,S. Vincent Rajkumar,Stephen J. Russell,Steven R. Zeldenrust,Joseph R. Mikhael,Vivek Roy,Robert A. Kyle
View Articletitled, Immunoglobulin D amyloidosis: a distinct entity

Gene Therapy

AAV8 vector expressing IL24 efficiently suppresses tumor growth mediated by specific mechanisms in MLL/AF4-positive ALL model mice
Hayato Tamai,Koichi Miyake,Hiroki Yamaguchi,Miyuki Takatori,Kazuo Dan,Koiti Inokuchi,Takashi Shimada
View Articletitled, AAV8 vector expressing IL24 efficiently suppresses tumor growth mediated by specific mechanisms in <em>MLL/AF4</em>-positive ALL model mice
Supplemental data
Generation of CD19-chimeric antigen receptor modified CD8+ T cells derived from virus-specific central memory T cells
Seitaro Terakura,Tori N. Yamamoto,Rebecca A. Gardner,Cameron J. Turtle,Michael C. Jensen,Stanley R. Riddell
View Articletitled, Generation of CD19-chimeric antigen receptor modified CD8<sup>+</sup> T cells derived from virus-specific central memory T cells
Supplemental data

Hematopoiesis and Stem Cells

Integrin-αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells
Terumasa Umemoto,Masayuki Yamato,Jun Ishihara,Yoshiko Shiratsuchi,Mika Utsumi,Yohei Morita,Hiroko Tsukui,Masao Terasawa,Takehiko Shibata,Kohji Nishida,Yoshiro Kobayashi,Brian G. Petrich,Hiromitsu Nakauchi,Koji Eto,Teruo Okano
View Articletitled, Integrin-αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells
Supplemental data

Immunobiology

Antigen stored in dendritic cells after macropinocytosis is released unprocessed from late endosomes to target B cells
Delphine Le Roux,Agnès Le Bon,Audrey Dumas,Kahina Taleb,Martin Sachse,Romain Sikora,Marion Julithe,Alexandre Benmerah,Georges Bismuth,Florence Niedergang
View Articletitled, Antigen stored in dendritic cells after macropinocytosis is released unprocessed from late endosomes to target B cells
Supplemental data
Maturation and function of human dendritic cells are regulated by B lymphocytes
Ahsen Morva,Sébastien Lemoine,Achouak Achour,Jacques-Olivier Pers,Pierre Youinou,Christophe Jamin
View Articletitled, Maturation and function of human dendritic cells are regulated by B lymphocytes
Supplemental data
Inhibition of PPARγ in myeloid-lineage cells induces systemic inflammation, immunosuppression, and tumorigenesis
Lingyan Wu,Cong Yan,Magdalena Czader,Oded Foreman,Janice S. Blum,Reuben Kapur,Hong Du
View Articletitled, Inhibition of PPARγ in myeloid-lineage cells induces systemic inflammation, immunosuppression, and tumorigenesis
Supplemental data
Critical role for perforin and Fas-dependent killing of dendritic cells in the control of inflammation
Min Chen,Kumar Felix,Jin Wang
View Articletitled, Critical role for perforin and Fas-dependent killing of dendritic cells in the control of inflammation
Supplemental data
Increased serum soluble IL-15Rα levels in T-cell large granular lymphocyte leukemia
Jing Chen,Mike Petrus,Richard Bamford,Joanna H. Shih,John C. Morris,John E. Janik,Thomas A. Waldmann
View Articletitled, Increased serum soluble IL-15Rα levels in T-cell large granular lymphocyte leukemia
Supplemental data
Active vaccination with Dickkopf-1 induces protective and therapeutic antitumor immunity in murine multiple myeloma
Jianfei Qian,Yuhuan Zheng,Chengyun Zheng,Lijuan Wang,Hong Qin,Sungyoul Hong,Haiyan Li,Yong Lu,Jin He,Jing Yang,Sattva Neelapu,Larry W. Kwak,Jian Hou,Qing Yi
View Articletitled, Active vaccination with Dickkopf-1 induces protective and therapeutic antitumor immunity in murine multiple myeloma
Supplemental data

Lymphoid Neoplasia

The repertoire of λ light chains causing predominant amyloid heart involvement and identification of a preferentially involved germline gene, IGLV1-44
Vittorio Perfetti,Giovanni Palladini,Simona Casarini,Valentina Navazza,Paola Rognoni,Laura Obici,Rosangela Invernizzi,Stefano Perlini,Catherine Klersy,Giampaolo Merlini
View Articletitled, The repertoire of λ light chains causing predominant amyloid heart involvement and identification of a preferentially involved germline gene, <em>IGLV1-44</em>
Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program
Mathieu Boxus,Jean-Claude Twizere,Sébastien Legros,Richard Kettmann,Luc Willems
View Articletitled, Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program
Supplemental data
Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells
Sergey Krysov,Samantha Dias,Alex Paterson,C. Ian Mockridge,Kathleen N. Potter,Kelly-Ann Smith,Margaret Ashton-Key,Freda K. Stevenson,Graham Packham
View Articletitled, Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells
Supplemental data
Tcl1 interacts with Atm and enhances NF-κB activation in hematologic malignancies
Eugenio Gaudio,Riccardo Spizzo,Francesco Paduano,Zhenghua Luo,Alexey Efanov,Alexey Palamarchuk,Amanda S. Leber,Mohamed Kaou,Nicola Zanesi,Arianna Bottoni,Stefan Costinean,Laura Z. Rassenti,Tatsuya Nakamura,Thomas J. Kipps,Rami I. Aqeilan,Yuri Pekarsky,Francesco Trapasso,Carlo M. Croce
View Articletitled, Tcl1 interacts with Atm and enhances NF-κB activation in hematologic malignancies
Supplemental data
The BRAF V600E mutation in hairy cell leukemia and other mature B-cell neoplasms
Brief Report
Luca Arcaini,Silvia Zibellini,Emanuela Boveri,Roberta Riboni,Sara Rattotti,Marzia Varettoni,Maria Luisa Guerrera,Marco Lucioni,Annamaria Tenore,Michele Merli,Silvia Rizzi,Lucia Morello,Chiara Cavalloni,Matteo C. Da Vià,Marco Paulli,Mario Cazzola
View Articletitled, The <em>BRAF</em> V600E mutation in hairy cell leukemia and other mature B-cell neoplasms
Supplemental data
Simple genetic diagnosis of hairy cell leukemia by sensitive detection of the BRAF-V600E mutation
Brief Report
Enrico Tiacci,Gianluca Schiavoni,Francesco Forconi,Alessia Santi,Livio Trentin,Achille Ambrosetti,Debora Cecchini,Elisa Sozzi,Paola Francia di Celle,Cristiana Di Bello,Alessandro Pulsoni,Robin Foà,Giorgio Inghirami,Brunangelo Falini
View Articletitled, Simple genetic diagnosis of hairy cell leukemia by sensitive detection of the <em>BRAF</em>-V600E mutation

Myeloid Neoplasia

Acute leukemia incidence and patient survival among children and adults in the United States, 2001-2007
Clinical Trials & Observations
Graça M. Dores,Susan S. Devesa,Rochelle E. Curtis,Martha S. Linet,Lindsay M. Morton
View Articletitled, Acute leukemia incidence and patient survival among children and adults in the United States, 2001-2007
Supplemental data
Increased BMI correlates with higher risk of disease relapse and differentiation syndrome in patients with acute promyelocytic leukemia treated with the AIDA protocols
Clinical Trials & Observations
Massimo Breccia,Luca Mazzarella,Vincenzo Bagnardi,Davide Disalvatore,Giuseppina Loglisci,Giuseppe Cimino,Anna Maria Testi,Giuseppe Avvisati,Maria Concetta Petti,Clara Minotti,Roberto Latagliata,Robin Foà,Pier Giuseppe Pelicci,Francesco Lo-Coco
View Articletitled, Increased BMI correlates with higher risk of disease relapse and differentiation syndrome in patients with acute promyelocytic leukemia treated with the AIDA protocols
Multi-institutional phase 2 clinical and pharmacogenomic trial of tipifarnib plus etoposide for elderly adults with newly diagnosed acute myelogenous leukemia
Clinical Trials & Observations
Judith E. Karp,Tatiana I. Vener,Mitch Raponi,Ellen K. Ritchie,B. Douglas Smith,Steven D. Gore,Lawrence E. Morris,Eric J. Feldman,Jacqueline M. Greer,Sami Malek,Hetty E. Carraway,Valerie Ironside,Steven Galkin,Mark J. Levis,Michael A. McDevitt,Gail R. Roboz,Christopher D. Gocke,Carlo Derecho,John Palma,Yixin Wang,Scott H. Kaufmann,John J. Wright,Elizabeth Garret-Mayer
View Articletitled, Multi-institutional phase 2 clinical and pharmacogenomic trial of tipifarnib plus etoposide for elderly adults with newly diagnosed acute myelogenous leukemia
Supplemental data
A functional variant in the core promoter of the CD95 cell death receptor gene predicts prognosis in acute promyelocytic leukemia
Nicola J. Sunter,Kathryn Scott,Robert Hills,David Grimwade,Sheila Taylor,Lisa J. Worrillow,Sarah E. Fordham,Victoria J. Forster,Graham Jackson,Simon Bomken,Gail Jones,James M. Allan
View Articletitled, A functional variant in the core promoter of the <em>CD95</em> cell death receptor gene predicts prognosis in acute promyelocytic leukemia
Supplemental data
Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML
Marianne Bach Treppendahl,Xiangning Qiu,Alexandra Søgaard,Xiaojing Yang,Cecilie Nandrup-Bus,Christoffer Hother,Mette Klarskov Andersen,Lars Kjeldsen,Lars Möllgaard,Eva Hellström-Lindberg,Johan Jendholm,Bo T. Porse,Peter A. Jones,Gangning Liang,Kirsten Grønbæk
View Articletitled, Allelic methylation levels of the noncoding <em>VTRNA2-1</em> located on chromosome 5q31.1 predict outcome in AML
Supplemental data
Purinergic signaling inhibits human acute myeloblastic leukemia cell proliferation, migration, and engraftment in immunodeficient mice
Valentina Salvestrini,Roberta Zini,Lara Rossi,Sara Gulinelli,Rossella Manfredini,Elisa Bianchi,Wanda Piacibello,Luisa Caione,Giorgia Migliardi,Maria Rosaria Ricciardi,Agostino Tafuri,Marco Romano,Simona Salati,Francesco Di Virgilio,Sergio Ferrari,Michele Baccarani,Davide Ferrari,Roberto M. Lemoli
View Articletitled, Purinergic signaling inhibits human acute myeloblastic leukemia cell proliferation, migration, and engraftment in immunodeficient mice
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Protumoral role of monocytes in human B-cell precursor acute lymphoblastic leukemia: involvement of the chemokine CXCL10
Yunqin Lee,Manesh Chittezhath,Valentina André,Helen Zhao,Michael Poidinger,Andrea Biondi,Giovanna D'Amico,Subhra K. Biswas
View Articletitled, Protumoral role of monocytes in human B-cell precursor acute lymphoblastic leukemia: involvement of the chemokine CXCL10
Supplemental data

Platelets and Thrombopoiesis

Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A
Yingfan Zhang,Mary Anne Conti,Daniela Malide,Fan Dong,Aibing Wang,Yelena A. Shmist,Chengyu Liu,Patricia Zerfas,Mathew P. Daniels,Chi-Chao Chan,Elliot Kozin,Bechara Kachar,Michael J. Kelley,Jeffrey B. Kopp,Robert S. Adelstein
View Articletitled, Mouse models of <em>MYH9</em>-related disease: mutations in nonmuscle myosin II-A
Supplemental data
The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes
Oliver Borst,Eva-Maria Schmidt,Patrick Münzer,Tanja Schönberger,Syeda T. Towhid,Margitta Elvers,Christina Leibrock,Evi Schmid,Anja Eylenstein,Dietmar Kuhl,Andreas E. May,Meinrad Gawaz,Florian Lang
View Articletitled, The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes
Supplemental data

Red Cells, Iron, and Erythropoiesis

Ribosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts
Rastislav Horos,Hanna IJspeert,Dagmar Pospisilova,Regine Sendtner,Charlotte Andrieu-Soler,Erdogan Taskesen,Andrzej Nieradka,Radek Cmejla,Michael Sendtner,Ivo P. Touw,Marieke von Lindern
View Articletitled, Ribosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts
Supplemental data

Transplantation

Distinct graft-versus-leukemic stem cell effects of early or delayed donor leukocyte infusions in a mouse chronic myeloid leukemia model
Yi-Fen Lu,L. Cristina Gavrilescu,Monica Betancur,Katherine Lazarides,Hans Klingemann,Richard A. Van Etten
View Articletitled, Distinct graft-versus-leukemic stem cell effects of early or delayed donor leukocyte infusions in a mouse chronic myeloid leukemia model
Supplemental data
Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17
Hisakazu Nishimori,Yoshinobu Maeda,Takanori Teshima,Haruko Sugiyama,Koichiro Kobayashi,Yoshiko Yamasuji,Sachiyo Kadohisa,Hidetaka Uryu,Kengo Takeuchi,Takehiro Tanaka,Tadashi Yoshino,Yoichiro Iwakura,Mitsune Tanimoto
View Articletitled, Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17
Supplemental data
Risk factors for acute GVHD and survival after hematopoietic cell transplantation
Clinical Trials & Observations
Madan Jagasia,Mukta Arora,Mary E. D. Flowers,Nelson J. Chao,Philip L. McCarthy,Corey S. Cutler,Alvaro Urbano-Ispizua,Steven Z. Pavletic,Michael D. Haagenson,Mei-Jie Zhang,Joseph H. Antin,Brian J. Bolwell,Christopher Bredeson,Jean-Yves Cahn,Mitchell Cairo,Robert Peter Gale,Vikas Gupta,Stephanie J. Lee,Mark Litzow,Daniel J. Weisdorf,Mary M. Horowitz,Theresa Hahn
View Articletitled, Risk factors for acute GVHD and survival after hematopoietic cell transplantation

Vascular Biology

Cyclic AMP response element-binding protein prevents endothelial permeability increase through transcriptional controlling p190RhoGAP expression
Koteswara Rao Chava,Mohammad Tauseef,Tiffany Sharma,Dolly Mehta
View Articletitled, Cyclic AMP response element-binding protein prevents endothelial permeability increase through transcriptional controlling p190RhoGAP expression
Supplemental data
  • Cover Image

    Cover Image

    issue cover

    Three-dimensional reconstruction of merged confocal microscopy images of fixed bone marrow tissue from MYH9 mutant mouse, AgfpR702C/A+, stained with CD41-APC (red) that identifies the abnormal proplatelets that are shorter and thicker, with fewer branches and buds compared with those of control mice. Aggregates of nonmuscle myosin IIA (green) are seen in the many neutrophils that populate the bone marrow tissue. Green: GFP-tagged nonmuscle myosin IIA with R702C mutation. See the article by Zhang et al on page 238 that describes 3 mouse models of the human MYH9-related disease.

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