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Journal Articles

Amlexanox As a Possible Breakthrough Drug for MLL/AF4 -Positive Acute Lymphoblastic Leukemia

Hayato Tamai, MD PhD, Hiroki Yamaguchi, MD PhD, Koichi Miyake, MD PhD, Miyuki Takatori, Tomoaki Kitano, Syunsuke Yui, MD, Keiko Fukunaga, MD, Kazutaka Nakayama, MD PhD, Koiti Inokuchi, PhD MD

Blood (2016) 128 (22): 1590.

https://doi.org/10.1182/blood.V128.22.1590.1590

Published: 2016

Journal Articles

The D816V C-Kit Mutation Confers Higher Proliferation Activity By JAK-STAT and Src Family Kinase Pathways Compared to N822K C-Kit Mutation in Core-Binding Factor Acute Myeloid Leukemia

Ikuko Omori, MD, Hiroki Yamaguchi, MD PhD, Tomoaki Kitano, Noriko Miyake, PhD, Koichi Miyake, MD PhD, Koiti Inokuchi, PhD MD

Blood (2014) 124 (21): 2224.

https://doi.org/10.1182/blood.V124.21.2224.2224

Published: 2014

Journal Articles

Bone Marrow Cell Based Enzyme Replacement Prolongs Survival and Improves Disease Phenotypes In a Mouse Model Of Lethal Hypophosphatasia

Osamu Iijima, PhD, Koichi Miyake, MD, PhD, Aki Nakamura, DDS, Tsutomu Igarashi, MD, PhD, Chizu Kanokoda, Atsushi Watanabe, MD, PhD, Takashi Shimada, MD, PhD

Blood (2013) 122 (21): 2897.

https://doi.org/10.1182/blood.V122.21.2897.2897

Published: 2013

Journal Articles

Rescue of Lethal Hypophosphatasia Mice by Neonatal Ex Vivo Gene Therapy Using Lentivirally Transduced Bone Marrow Cells.

Osamu Iijima, PhD, Koichi Miyake, MD, PhD, Hanako Sugano-Tajima, MD, PhD, Tsutomu Igarashi, MD, PhD, Chizu Kanokoda, Atsushi Watanabe, MD, PhD, Takashi Shimada, MD, PhD

Blood (2012) 120 (21): 3154.

https://doi.org/10.1182/blood.V120.21.3154.3154

Published: 2012

Journal Articles

AAV8 vector expressing IL24 efficiently suppresses tumor growth mediated by specific mechanisms in MLL/AF4 -positive ALL model mice

Hayato Tamai, Koichi Miyake, Hiroki Yamaguchi, Miyuki Takatori, Kazuo Dan, Koiti Inokuchi, Takashi Shimada

Blood (2012) 119 (1): 64–71.

https://doi.org/10.1182/blood-2011-05-354050

Published: 2012

Includes: Supplemental data

Journal Articles

MLL/AF4 Positive Acute Lymphoblastic Leukemia Has Resistance to Tumor Necrosis Factor-Alpha Caused by up-Regration of S100A6

Hayato Tamai, MD, Koichi Miyake, MD, PhD, Hiroki Yamaguchi, MD, PhD, Masahiro Okabe, MD, Kazuo Dan, MD, PhD, Koiti Inokuchi, PhD, MD, Takashi Shimada, MD, PHD

Blood (2010) 116 (21): 2477.

https://doi.org/10.1182/blood.V116.21.2477.2477

Published: 2010

Journal Articles

A Single Intramuscular Injection of AAV-8 Vector Expressing MDA7/IL-24 Efficiently Suppresses Tumor Growth Mediated by Multiple Anti-Cancer Mechanisms In Lymphoma Model Mice.

Nanya Wang, MD, Bai Fan, MD, Noriko Miyake, PhD, Koichi Miyake, MD, PhD, Takashi Shimada, MD, PhD

Blood (2010) 116 (21): 1474.

https://doi.org/10.1182/blood.V116.21.1474.1474

Published: 2010

Journal Articles

The Activated K-RAS Protein Accelerates Human Derived-MLL/AF4 Induced Leukemo-Lymphomogenicity In Transgenic Mice Model

Hayato Tamai, MD, Koichi Miyake, MD, PhD, Miyuki Takatori, Noriko Miyake, Hiroki Yamaguchi, MD, PhD, Kazuo Dan, MD, PhD, Takashi Shimada, MD, PHD, Koiti Inokuchi, PhD, MD

Blood (2010) 116 (21): 61.

https://doi.org/10.1182/blood.V116.21.61.61

Published: 2010

Journal Articles

Establishment and Characterization of A New Leukemia Mouse Model Induced by MLL/AF4 Fusion Protein.

Hayato Tamai, Koichi Miyake, Noriko Miyake, Hiroki Yamaguchi, Kazuo Dan, Takashi Shimada, Koiti Inokuchi

Blood (2009) 114 (22): 3573.

https://doi.org/10.1182/blood.V114.22.3573.3573

Published: 2009

Journal Articles

Human RPS19 , the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits

Johan Flygare, Anna Aspesi, Joshua C. Bailey, Koichi Miyake, Jacqueline M. Caffrey, Stefan Karlsson, Steven R. Ellis

Blood (2006) 109 (3): 980–986.

https://doi.org/10.1182/blood-2006-07-038232

Published: 2006

Journal Articles

Deficient Ribosomal Protein S19 in Diamond-Blackfan Anemia Causes a Reduction in bcl-2 and Bad and Leads to Apoptosis in Erythroid Progenitor Cells.

Koichi Miyake, MD, PhD, Taiju Utsugisawa, MD, PhD, Johan Flygare, Thomas Kiefer, MD, Isao Hamaguchi, MD, PhD, Johan Richter, MD, PhD, Stefan Karlsson, MD, PhD

Blood (2005) 106 (11): 131.

https://doi.org/10.1182/blood.V106.11.131.131

Published: 2005

Journal Articles

Deficiency of ribosomal protein S19 in CD34 + cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia

Johan Flygare, Thomas Kiefer, Koichi Miyake, Taiju Utsugisawa, Isao Hamaguchi, Lydie Da Costa, Johan Richter, Edward J. Davey, Hans Matsson, Niklas Dahl, Maciej Wiznerowicz, Didier Trono, Stefan Karlsson

Blood (2005) 105 (12): 4627–4634.

https://doi.org/10.1182/blood-2004-08-3115

Published: 2005

Journal Articles

Apoptotic Change Is a Major Reason for Defect in Early Erythroid Development in Cell Line Models for Ribosomal Protein (RP) S19 Deficient Diamond-Blackfan Anemia.

Koichi Miyake, MD, PhD, Taiju Utsugisawa, MD, PhD, Johan Flygare, Thomas Kiefer, MD, Johan Richter, MD, PhD, Maciej Wiznerowicz, MD, PhD, Didier Trono, MD, PhD, Stefan Karlsson, MD, PhD

Blood (2004) 104 (11): 2840.

https://doi.org/10.1182/blood.V104.11.2840.2840

Published: 2004

Journal Articles

Hematopoietic Mechanism in Diamond-Blackfan Anemia: Late Erythroid Development Is Not Affected by Ribosomal Protein S19 Deficiency.

Blood (2004) 104 (11): 719.

https://doi.org/10.1182/blood.V104.11.719.719

Published: 2004

Journal Articles

Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl: longer disease latency, thrombocytosis, and mild leukocytosis

Koiti Inokuchi, Kazuo Dan, Miyuki Takatori, Hidemasa Takahuji, Naoya Uchida, Mitsuharu Inami, Koichi Miyake, Hiroaki Honda, Hisamaru Hirai, Takashi Shimada

Blood (2003) 102 (1): 320–323.

https://doi.org/10.1182/blood-2002-10-3182

Published: 2003

NARROW

Amlexanox As a Possible Breakthrough Drug for MLL/AF4 -Positive Acute Lymphoblastic Leukemia

The D816V C-Kit Mutation Confers Higher Proliferation Activity By JAK-STAT and Src Family Kinase Pathways Compared to N822K C-Kit Mutation in Core-Binding Factor Acute Myeloid Leukemia

Bone Marrow Cell Based Enzyme Replacement Prolongs Survival and Improves Disease Phenotypes In a Mouse Model Of Lethal Hypophosphatasia

Rescue of Lethal Hypophosphatasia Mice by Neonatal Ex Vivo Gene Therapy Using Lentivirally Transduced Bone Marrow Cells.

AAV8 vector expressing IL24 efficiently suppresses tumor growth mediated by specific mechanisms in MLL/AF4 -positive ALL model mice

MLL/AF4 Positive Acute Lymphoblastic Leukemia Has Resistance to Tumor Necrosis Factor-Alpha Caused by up-Regration of S100A6

A Single Intramuscular Injection of AAV-8 Vector Expressing MDA7/IL-24 Efficiently Suppresses Tumor Growth Mediated by Multiple Anti-Cancer Mechanisms In Lymphoma Model Mice.

The Activated K-RAS Protein Accelerates Human Derived-MLL/AF4 Induced Leukemo-Lymphomogenicity In Transgenic Mice Model

Establishment and Characterization of A New Leukemia Mouse Model Induced by MLL/AF4 Fusion Protein.

Human RPS19 , the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits

Deficient Ribosomal Protein S19 in Diamond-Blackfan Anemia Causes a Reduction in bcl-2 and Bad and Leads to Apoptosis in Erythroid Progenitor Cells.

Deficiency of ribosomal protein S19 in CD34 + cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia

Apoptotic Change Is a Major Reason for Defect in Early Erythroid Development in Cell Line Models for Ribosomal Protein (RP) S19 Deficient Diamond-Blackfan Anemia.

Hematopoietic Mechanism in Diamond-Blackfan Anemia: Late Erythroid Development Is Not Affected by Ribosomal Protein S19 Deficiency.

Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl: longer disease latency, thrombocytosis, and mild leukocytosis

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American Society of Hematology

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American Society of Hematology

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