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Issue Archive

Volume 118, Issue 15
October 13 2011
Issue Cover

Table of Contents

Inside Blood

INSIDE BLOOD
CD37: the comeback kid
Ian W. Flinn
View Articletitled, CD37: the comeback kid
CLINICAL TRIALS
“Sowing dragon's teeth?” Myeloma and AML
Philip L. McCarthy,Kouros Owzar,Kenneth Anderson
View Articletitled, “Sowing dragon's teeth?” Myeloma and AML
MYELOID NEOPLASIA
Imatinib is receptive to a collaboration
Nicholas J. Donato
View Articletitled, Imatinib is receptive to a collaboration
TRANSPLANTATION
Cracking the cement overcoat
Georgia B. Vogelsang
View Articletitled, Cracking the cement overcoat
VASCULAR BIOLOGY
CD63 positions CD62P for rolling
Klaus Ley
View Articletitled, CD63 positions CD62P for rolling

Plenary Paper

THROMBOSIS AND HEMOSTASIS
Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome
Bojing Shao,Mark G. Wahrenbrock,Longbiao Yao,Tovo David,Shaun R. Coughlin,Lijun Xia,Ajit Varki,Rodger P. McEver
View Articletitled, Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome

Review Article

EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma
Werner Kempf,Katrin Pfaltz,Maarten H. Vermeer,Antonio Cozzio,Pablo L. Ortiz-Romero,Martine Bagot,Elise Olsen,Youn H. Kim,Reinhard Dummer,Nicola Pimpinelli,Sean Whittaker,Emmilia Hodak,Lorenzo Cerroni,Emilio Berti,Steve Horwitz,H. Miles Prince,Joan Guitart,Teresa Estrach,José A. Sanches,Madeleine Duvic,Annamari Ranki,Brigitte Dreno,Sonja Ostheeren-Michaelis,Robert Knobler,Gary Wood,Rein Willemze
View Articletitled, EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma

Evidence-Based Focused Review

Evidence-based focused review of the treatment of idiopathic warm immune hemolytic anemia in adults
Mark Crowther,Y. L. Tracey Chan,Ian K. Garbett,Wendy Lim,Mark A. Vickers,Mark A. Crowther
View Articletitled, Evidence-based focused review of the treatment of idiopathic warm immune hemolytic anemia in adults
Supplemental data

How I treat

How I treat hemophagocytic lymphohistiocytosis
Clinical Trials & Observations
Michael B. Jordan,Carl E. Allen,Sheila Weitzman,Alexandra H. Filipovich,Kenneth L. McClain
View Articletitled, How I treat hemophagocytic lymphohistiocytosis

Clinical Trials and Observations

Epratuzumab with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy in patients with previously untreated diffuse large B-cell lymphoma
Clinical Trials & Observations
Ivana N. M. Micallef,Matthew J. Maurer,Gregory A. Wiseman,Daniel A. Nikcevich,Paul J. Kurtin,Michael W. Cannon,Domingo G. Perez,Gamini S. Soori,Brian K. Link,Thomas M. Habermann,Thomas E. Witzig
View Articletitled, Epratuzumab with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy in patients with previously untreated diffuse large B-cell lymphoma
SET oncoprotein overexpression in B-cell chronic lymphocytic leukemia and non-Hodgkin lymphoma: a predictor of aggressive disease and a new treatment target
Clinical Trials & Observations
Dale J. Christensen,Youwei Chen,Jessica Oddo,Karen M. Matta,Jessica Neil,Evan D. Davis,Alicia D. Volkheimer,Mark C. Lanasa,Daphne R. Friedman,Barbara K. Goodman,Jon P. Gockerman,Louis F. Diehl,Carlos M. de Castro,Joseph O. Moore,Michael P. Vitek,J. Brice Weinberg
View Articletitled, SET oncoprotein overexpression in B-cell chronic lymphocytic leukemia and non-Hodgkin lymphoma: a predictor of aggressive disease and a new treatment target
Supplemental data

Hematopoiesis and Stem Cells

cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis
Yiyue Zhang,Hao Jin,Li Li,F. Xiao-Feng Qin,Zilong Wen
View Articletitled, cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis
Supplemental data
A blood flow–dependent klf2a-NO signaling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos
Lu Wang,Panpan Zhang,Yonglong Wei,Ya Gao,Roger Patient,Feng Liu
View Articletitled, A blood flow–dependent <em>klf2a</em>-NO signaling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos
Supplemental data

Immunobiology

Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation
Paul J. Tacken,Wiebke Ginter,Luciana Berod,Luis J. Cruz,Ben Joosten,Tim Sparwasser,Carl G. Figdor,Alessandra Cambi
View Articletitled, Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation
Supplemental data
Regulation of memory B-cell survival by the BH3-only protein Puma
Cyril Clybouw,Silke Fischer,Marie Thérèse Auffredou,Patricia Hugues,Catherine Alexia,Philippe Bouillet,Martine Raphael,Gérald Leca,Andreas Strasser,David M. Tarlinton,Aimé Vazquez
View Articletitled, Regulation of memory B-cell survival by the BH3-only protein Puma

Lymphoid Neoplasia

An open-label, pilot study of fludarabine, cyclophosphamide, and alemtuzumab in relapsed/refractory patients with B-cell chronic lymphocytic leukemia
Clinical Trials & Observations
Marco Montillo,Alessandra Tedeschi,Valeria Belsito Petrizzi,Francesca Ricci,Monica Crugnola,Mauro Spriano,Pierangelo Spedini,Fiorella Ilariucci,Lilj Uziel,Immacolata Attolico,Eleonora Vismara,Angelo De Blasio,Alfonso Zaccaria,Enrica Morra
View Articletitled, An open-label, pilot study of fludarabine, cyclophosphamide, and alemtuzumab in relapsed/refractory patients with B-cell chronic lymphocytic leukemia
HDM-2 inhibition suppresses expression of ribonucleotide reductase subunit M2, and synergistically enhances gemcitabine-induced cytotoxicity in mantle cell lymphoma
Richard J. Jones,Veerabhadran Baladandayuthapani,Sattva Neelapu,Luis E. Fayad,Jorge E. Romaguera,Michael Wang,Rakesh Sharma,Dajun Yang,Robert Z. Orlowski
View Articletitled, HDM-2 inhibition suppresses expression of ribonucleotide reductase subunit M2, and synergistically enhances gemcitabine-induced cytotoxicity in mantle cell lymphoma
Supplemental data
A novel Fc-engineered monoclonal antibody to CD37 with enhanced ADCC and high proapoptotic activity for treatment of B-cell malignancies
Karl-Heinz Heider,Kerstin Kiefer,Thorsten Zenz,Matthias Volden,Stephan Stilgenbauer,Elinborg Ostermann,Anke Baum,Herbert Lamche,Zaruhi Küpcü,Alexander Jacobi,Steffen Müller,Ulrich Hirt,Günther R. Adolf,Eric Borges
View Articletitled, A novel Fc-engineered monoclonal antibody to CD37 with enhanced ADCC and high proapoptotic activity for treatment of B-cell malignancies
Supplemental data
The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia
Brief Report
Alejandro Gutierrez,Alex Kentsis,Takaomi Sanda,Linda Holmfeldt,Shann-Ching Chen,Jianhua Zhang,Alexei Protopopov,Lynda Chin,Suzanne E. Dahlberg,Donna S. Neuberg,Lewis B. Silverman,Stuart S. Winter,Stephen P. Hunger,Stephen E. Sallan,Shan Zha,Frederick W. Alt,James R. Downing,Charles G. Mullighan,A. Thomas Look
View Articletitled, The <em>BCL11B</em> tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia
Supplemental data
Pre-B cell receptor–mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC
Brief Report
Rahul Nahar,Parham Ramezani-Rad,Maximilian Mossner,Cihangir Duy,Leandro Cerchietti,Huimin Geng,Sinisa Dovat,Hassan Jumaa,B. Hilda Ye,Ari Melnick,Markus Müschen
View Articletitled, Pre-B cell receptor–mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of <em>MYC</em>
Supplemental data
Noninvasive bioluminescent imaging of primary patient acute lymphoblastic leukemia: a strategy for preclinical modeling
e-blood
David M. Barrett,Alix E. Seif,Carmine Carpenito,David T. Teachey,Jonathan D. Fish,Carl H. June,Stephan A. Grupp,Gregor S. D. Reid
View Articletitled, Noninvasive bioluminescent imaging of primary patient acute lymphoblastic leukemia: a strategy for preclinical modeling
Supplemental data

Myeloid Neoplasia

Risk of thyroid cancer, brain cancer, and non-Hodgkin lymphoma after adult leukemia: a nationwide study
Clinical Trials & Observations
Sune F. Nielsen,Stig E. Bojesen,Henrik S. Birgens,Børge G. Nordestgaard
View Articletitled, Risk of thyroid cancer, brain cancer, and non-Hodgkin lymphoma after adult leukemia: a nationwide study
Supplemental data
Risk of acute myeloid leukemia and myelodysplastic syndromes after multiple myeloma and its precursor disease (MGUS)
Clinical Trials & Observations
Sham Mailankody,Ruth M. Pfeiffer,Sigurdur Y. Kristinsson,Neha Korde,Magnus Bjorkholm,Lynn R. Goldin,Ingemar Turesson,Ola Landgren
View Articletitled, Risk of acute myeloid leukemia and myelodysplastic syndromes after multiple myeloma and its precursor disease (MGUS)
Supplemental data
Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFNα via accelerating the degradation of its receptor
Sabyasachi Bhattacharya,Hui Zheng,Christos Tzimas,Martin Carroll,Darren P. Baker,Serge Y. Fuchs
View Articletitled, Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFNα via accelerating the degradation of its receptor
Supplemental data
Low expression of MN1 associates with better treatment response in older patients with de novo cytogenetically normal acute myeloid leukemia
Clinical Trials & Observations
Sebastian Schwind,Guido Marcucci,Jessica Kohlschmidt,Michael D. Radmacher,Krzysztof Mrózek,Kati Maharry,Heiko Becker,Klaus H. Metzeler,Susan P. Whitman,Yue-Zhong Wu,Bayard L. Powell,Maria R. Baer,Jonathan E. Kolitz,Andrew J. Carroll,Richard A. Larson,Michael A. Caligiuri,Clara D. Bloomfield
View Articletitled, Low expression of <em>MN1</em> associates with better treatment response in older patients with de novo cytogenetically normal acute myeloid leukemia
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Alternative activation of macrophages by IL-4 enhances the proteolytic capacity of their phagosomes through synergistic mechanisms
Dale R. Balce,Baoquan Li,Euan R. O. Allan,Joanna M. Rybicka,Regina M. Krohn,Robin M. Yates
View Articletitled, Alternative activation of macrophages by IL-4 enhances the proteolytic capacity of their phagosomes through synergistic mechanisms
Supplemental data
Leukocyte integrin activation mediates transient neutropenia after G-CSF administration
Robert E. Donahue,Laura Tuschong,Thomas R. Bauer, Jr,Yu Ying Yau,Susan F. Leitman,Dennis D. Hickstein
View Articletitled, Leukocyte integrin activation mediates transient neutropenia after G-CSF administration

Platelets and Thrombopoiesis

An important role for Akt3 in platelet activation and thrombosis
Kelly A. O'Brien,Aleksandra Stojanovic-Terpo,Nissim Hay,Xiaoping Du
View Articletitled, An important role for Akt3 in platelet activation and thrombosis
Supplemental data

Red Cells, Iron, and Erythropoiesis

Hepcidin regulation by innate immune and infectious stimuli
Andrew E. Armitage,Lucy A. Eddowes,Uzi Gileadi,Suzanne Cole,Natasha Spottiswoode,Tharini Ashtalakshmi Selvakumar,Ling-Pei Ho,Alain R. M. Townsend,Hal Drakesmith
View Articletitled, Hepcidin regulation by innate immune and infectious stimuli
Supplemental data
Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice
Andrea U. Steinbicker,Thomas B. Bartnikas,Lisa K. Lohmeyer,Patricio Leyton,Claire Mayeur,Sonya M. Kao,Alexandra E. Pappas,Randall T. Peterson,Donald B. Bloch,Paul B. Yu,Mark D. Fleming,Kenneth D. Bloch
View Articletitled, Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice
Supplemental data

Thrombosis and Hemostasis

In vivo distribution of β2 glycoprotein I under various pathophysiologic conditions
Chiara Agostinis,Stefania Biffi,Chiara Garrovo,Paolo Durigutto,Andrea Lorenzon,Alpan Bek,Roberta Bulla,Claudia Grossi,Maria O. Borghi,PierLuigi Meroni,Francesco Tedesco
View Articletitled, In vivo distribution of β2 glycoprotein I under various pathophysiologic conditions
Supplemental data
Increased risk of venous thrombosis in persons with clinically diagnosed superficial vein thrombosis: results from the MEGA study
Brief Report
Kirsten van Langevelde,Willem M. Lijfering,Frits R. Rosendaal,Suzanne C. Cannegieter
View Articletitled, Increased risk of venous thrombosis in persons with clinically diagnosed superficial vein thrombosis: results from the MEGA study

Transplantation

A phase 1 study of imatinib for corticosteroid-dependent/refractory chronic graft-versus-host disease: response does not correlate with anti-PDGFRA antibodies
Clinical Trials & Observations
George L. Chen,Sally Arai,Mary E. D. Flowers,Joanne M. Otani,Jingxin Qiu,Ethan C. Cheng,Alex McMillan,Laura J. Johnston,Judith A. Shizuru,David B. Miklos
View Articletitled, A phase 1 study of imatinib for corticosteroid-dependent/refractory chronic graft-versus-host disease: response does not correlate with anti-PDGFRA antibodies
Supplemental data
Global and organ-specific chronic graft-versus-host disease severity according to the 2005 NIH Consensus Criteria
Clinical Trials & Observations
Sally Arai,Madan Jagasia,Barry Storer,Xiaoyu Chai,Joseph Pidala,Corey Cutler,Mukta Arora,Daniel J. Weisdorf,Mary E. D. Flowers,Paul J. Martin,Jeanne Palmer,David Jacobsohn,Steven Z. Pavletic,Georgia B. Vogelsang,Stephanie J. Lee
View Articletitled, Global and organ-specific chronic graft-versus-host disease severity according to the 2005 NIH Consensus Criteria
Sclerotic-type chronic GVHD of the skin: clinical risk factors, laboratory markers, and burden of disease
Clinical Trials & Observations
Kathryn J. Martires,Kristin Baird,Seth M. Steinberg,Lana Grkovic,Galen O. Joe,Kirsten M. Williams,Sandra A. Mitchell,Manuel Datiles,Fran T. Hakim,Steven Z. Pavletic,Edward W. Cowen
View Articletitled, Sclerotic-type chronic GVHD of the skin: clinical risk factors, laboratory markers, and burden of disease
Supplemental data
Clofarabine and busulfan conditioning facilitates engraftment and provides significant antitumor activity in nonremission hematologic malignancies
Clinical Trials & Observations
John Magenau,Hiromi Tobai,Attaphol Pawarode,Thomas Braun,Edward Peres,Pavan Reddy,Carrie Kitko,Sung Choi,Gregory Yanik,David Frame,Andrew Harris,Harry Erba,Lisa Kujawski,Kojo Elenitoba-Johnson,Jennifer Sanks,Dawn Jones,Sophie Paczesny,James Ferrara,John Levine,Shin Mineishi
View Articletitled, Clofarabine and busulfan conditioning facilitates engraftment and provides significant antitumor activity in nonremission hematologic malignancies
Supplemental data

Vascular Biology

CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin
Emily L. Doyle,Victoria Ridger,Francesco Ferraro,Mark Turmaine,Paul Saftig,Daniel F. Cutler
View Articletitled, CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin
Supplemental data
Tetraspanin CD151 maintains vascular stability by balancing the forces of cell adhesion and cytoskeletal tension
Feng Zhang,Jarett E. Michaelson,Simon Moshiach,Norman Sachs,Wenyuan Zhao,Yao Sun,Arnoud Sonnenberg,Jill M. Lahti,Hayden Huang,Xin A. Zhang
View Articletitled, Tetraspanin CD151 maintains vascular stability by balancing the forces of cell adhesion and cytoskeletal tension
Supplemental data
Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling
Boaz Kigel,Noa Rabinowicz,Asya Varshavsky,Ofra Kessler,Gera Neufeld
View Articletitled, Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling
Supplemental data
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Cardiac complete response in AL amyloidosis has similar survival to matched general population
Randomized Bendamustine-Rituximab(R) + Bortezomib Induction and R + Lenalidomide Maintenance for Mantle Cell Lymphoma
Heme induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice
Interleukin-1 mediated hyperinflammation in XIAP-deficiency is associated with defective autophagy.
NOVEL THERAPEUTIC APPROACHES IN THALASSEMIAS, SICKLE CELL DISEASE AND OTHER RED CELL DISORDERS

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