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Journal Articles

SIRT3 Is a Novel Metabolic Driver of and Therapeutic Target for Chemotherapy Resistant Dlbcls

Meng Li, PhD, Ying-Ling Chiang, PhD, Costas Lyssiotis, PhD, Matthew Teater, PhD, Hao Shen, MD, Ling Wang, MS, Jun Young Hong, BS, Hui Jin, PhD, Cihangir Duy, PhD, Sucharita Mistry, PhD, Leandro Cerchietti, MD, Justin Cross, PhD, Lewis Cantley, MD, Hening Lin, PhD, Ari Melnick, MD

Blood (2017) 130 (Supplement 1): 643.

https://doi.org/10.1182/blood.V130.Suppl_1.643.643

Published: 2017

Journal Articles

Cooperative Gene Repression By DNA Methylation and LSD1-Mediated Enhancer Inactivation in Acute Myeloid Leukemia

Cihangir Duy, PhD, Matt Teater, M.S., Francine E. Garrett-Bakelman, MD PhD, Tak C Lee, M.S., Cem Meydan, PhD, Jacob Lowell Glass, MD PhD, Meng Li, PhD, Helai Mohammad, PhD, Kimberly Smitheman, Alan H. Shih, MD PhD, Omar Abdel-Wahab, MD, Elisabeth Paietta, PhD, Martin S. Tallman, MD, Monica L. Guzman, PhD, Ryan G. Kruger, PhD, Caretha L. Creasy, PhD, Ross L. Levine, MD, Martin Carroll, MD, Ari Melnick, MD

Blood (2016) 128 (22): 1048.

https://doi.org/10.1182/blood.V128.22.1048.1048

Published: 2016

Journal Articles

Acute Myeloid Leukemia Cells Resist Chemotherapy through a Reversible Senescence-like State Maintaining Repopulation Potential

Cihangir Duy, PhD, Matt Teater, M.S., Francine E. Garrett-Bakelman, MD PhD, Martin Carroll, MD, Ari Melnick, MD

Blood (2016) 128 (22): 582.

https://doi.org/10.1182/blood.V128.22.582.582

Published: 2016

Journal Articles

Pre-B Cell Receptor-Mediated Activation of BCL6 Induces Pre-B Cell Quiescence Through Transcriptional Repression of MYC

Rahul Nahar, Parham Ramezani-Rad, Maximilian Mossner, Cihangir Duy, Leandro Cerchietti, MD, Huimin Geng, PhD, Hassan Jumaa, PhD, B. Hilda Ye, PhD, Ari Melnick, MD, Markus Muschen

Blood (2011) 118 (21): 1406.

https://doi.org/10.1182/blood.V118.21.1406.1406

Published: 2011

Journal Articles

Pre-B cell receptor–mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC

Rahul Nahar, Parham Ramezani-Rad, Maximilian Mossner, Cihangir Duy, Leandro Cerchietti, Huimin Geng, Sinisa Dovat, Hassan Jumaa, B. Hilda Ye, Ari Melnick, Markus Müschen

Blood (2011) 118 (15): 4174–4178.

https://doi.org/10.1182/blood-2011-01-331181

Published: 2011

Includes: Supplemental data

Journal Articles

Mechanisms of Pre-B Cell Receptor-Inactivation In Acute Lymphoblastic Leukemia

Cihangir Duy, Daniel Nowak, MD, Lars Klemm, Rahul Nahar, Carina Ng, Emily Elliott, Wolf-Karsten Hofmann, Nora Heisterkamp, Clifford A. Lowell, Phillip Koeffler, Markus Muschen

Blood (2010) 116 (21): 147.

https://doi.org/10.1182/blood.V116.21.147.147

Published: 2010

Journal Articles

Targeting Survivin In Recalcitrant Acute Lymphoblastic Leukemia

Eugene Park, Enzi Jiang, MD, PhD, Yao-Te Hsieh, Lars Klemm, Cihangir Duy, Edward M. Conway, MD, PhD, FRCPC, MBA, Louis M. Pelus, PhD, John Crispino, PhD, Mignon L. Loh, M.D., Eun-Suk Kang, MD, PhD, Hong-Hoe Koo, MD, PhD, Allen Yang, MD, PhD, Nora Heisterkamp, PhD, Michael Kahn, PhD, Markus Muschen, MD, Yong-Mi Kim, MD, MPH

Blood (2010) 116 (21): 3263.

https://doi.org/10.1182/blood.V116.21.3263.3263

Published: 2010

Journal Articles

IKAROS and BCL6 Limit Pre-B Cell Expansion and Prevent Leukemogenesis Downstream of the Pre-B Cell Receptor

Rahul Nahar, Parham Ramezani-Rad, Cihangir Duy, Sinisa Dovat, B. Hilda Ye, PhD, Ari M. Melnick, Markus Muschen

Blood (2010) 116 (21): 146.

https://doi.org/10.1182/blood.V116.21.146.146

Published: 2010

Journal Articles

BCL6 Is Required for the Maintenance of Leukemia-Initiating Cells In Chronic Myeloid Leukemia

Christian Hurtz, Cihangir Duy, Leandro Cerchietti, MD, Katerina Chatzi, Eugene Park, Lars Klemm, Yong-mi Kim, Michael Kahn, Melanie Braig, PhD, Martin C. Muller, Andreas Hochhaus, B. Hilda Ye, PhD, Ari M. Melnick, Markus Muschen

Blood (2010) 116 (21): 202.

https://doi.org/10.1182/blood.V116.21.202.202

Published: 2010

Journal Articles

Pre-B Cell Receptor Signaling Distinguishes E2A-PBX1 From Other Subtypes of Acute Lymphoblastic Leukemia

Rahul Nahar, Daniel Trageser, Lars Klemm, Cihangir Duy, Wolf-Karsten Hofmann, Eugene Park, Yong-mi Kim, Nora Heisterkamp, Hassan Jumaa, Markus Muschen

Blood (2010) 116 (21): 274.

https://doi.org/10.1182/blood.V116.21.274.274

Published: 2010

Journal Articles

The B Cell Mutator AID Promotes B Lymphoid Blast Crisis and Drug-Resistance in Chronic Myeloid Leukemia.

Lars Klemm, Cihangir Duy, Ilaria Iacobucci, PhD, Gregor von Levetzow, Niklas Feldhahn, Yong-mi Kim, Wolf-Karsten Hofmann, Hassan Jumaa, John Groffen, Nora Heisterkamp, Giovanni Martinelli, MD, Michael R Lieber, Rafael Casellas, Markus Müschen

Blood (2009) 114 (22): 3274.

https://doi.org/10.1182/blood.V114.22.3274.3274

Published: 2009

Journal Articles

BCL6 Is Critical for the Development of a Diverse Primary B Cell Repertoire.

Cihangir Duy, J. Jessica Yu, Srividya Swaminathan, Rahul R. Nahar, Soo-mi Kweon, Jose M. Polo, PhD, Ester Valls, Lars Klemm, Leandro Cerchietti, Gregor von Levetzow, Sebastian Herzog, Hassan Jumaa, Ignacio Moreno de Alborán, Ari Melnick, B. Hilda Ye, PhD, Markus Müschen

Blood (2009) 114 (22): 91.

https://doi.org/10.1182/blood.V114.22.91.91

Published: 2009

Journal Articles

Inactivation of Pre-B Cell Receptor-Mediated Tumor Suppression by Aberrant Splicing in Ph + Acute Lymphoblastic Leukemia.

Cihangir Duy, Mieke Sprangers, Lars Klemm, Rahul R. Nahar, Daniel Nowak, MD, Giovanni Martinelli, MD, Wolf-Karsten Hofmann, Phillip H Koeffler, MD, Hassan Jumaa, Markus Müschen

Blood (2009) 114 (22): 579.

https://doi.org/10.1182/blood.V114.22.579.579

Published: 2009

Journal Articles

Role of Survivin in Drug Resistant B-Cell Acute Lymphoblastic Leukemia.

Eugene Park, Enzi Jiang, MD, PhD, Gregor von Levetzow, Cihangir Duy, Lars Klemm, Yao-Te Hsieh, Asha Kadavallore, Hong Ma, PhD, Yi Zhao, MD, Cu Nguyen, John Groffen, PhD, Nora Heisterkamp, PhD, Markus Muschen, MD, Michael Kahn, PhD, Yong-Mi Kim, MD

Blood (2009) 114 (22): 10.

https://doi.org/10.1182/blood.V114.22.10.10

Published: 2009

Journal Articles

BCL6 Is Required for Leukemia-Initiation and Self-Renewal Signaling in Chronic Myeloid Leukemia.

Christian Hurtz, Cihangir Duy, Leandro Cerchietti, Eugene Park, Weimin Ci, PhD, Srividya Swaminathan, Soo-mi Kweon, Lars Klemm, Yong-mi Kim, Giovanni Martinelli, Wolf-Karsten Hofmann, B. Hilda Ye, PhD, Ari Melnick, Markus Müschen

Blood (2009) 114 (22): 2167.

https://doi.org/10.1182/blood.V114.22.2167.2167

Published: 2009

Journal Articles

BCL6-Dependent Negative Regulation of Cell Cycle Checkpoint Regulators Enables Drug-Resistance in Ph + Acute Lymphoblastic Leukemia.

Cihangir Duy, Leandro Cerchietti, J. Jessica Yu, Weimin Ci, PhD, Srividya Swaminathan, Rahul R. Nahar, Soo-mi Kweon, Lars Klemm, B. Hilda Ye, PhD, Ari Melnick, Markus Müschen

Blood (2009) 114 (22): 765.

https://doi.org/10.1182/blood.V114.22.765.765

Published: 2009

Journal Articles

Aberrant Splicing of the SLP65 SH2 Domain Enables Pre-B Cell Transformation and Compromises the Leukemia-Suppressive Function of the Pre-B Cell Receptor

Cihangir Duy, Lars Klemm, Rahul Nahar, Peter van Essen, Mieke Sprangers, Yong-mi Kim, Eugene Park, Giovanni Martinelli, Nora Heisterkamp, Wolf-Karsten Hofmann, MD, Hassan Jumaa, Markus Muschen

Blood (2008) 112 (11): 294.

https://doi.org/10.1182/blood.V112.11.294.294

Published: 2008

Journal Articles

BCL6-Mediated Survival Signaling Promotes Drug-Resistance in BCRABL1- Driven Acute Lymphoblastic Leukemia

Cihangir Duy, J. Jessica Yu, Leandro Cerchietti, Lars Klemm, Rahul Nahar, Yong-mi Kim, Nora Heisterkamp, Giovanni Martinelli, Wolf-Karsten Hofmann, MD, Hassan Jumaa, Ari Melnick, B. Hilda Ye, PhD, Markus Muschen

Blood (2008) 112 (11): 295.

https://doi.org/10.1182/blood.V112.11.295.295

Published: 2008

Journal Articles

The Pre-B Cell Receptor Suppresses Leukemogenesis by Censoring MYC Expression.

Rahul Nahar, Daniel Trageser, Lars Klemm, Cihangir Duy, Peter van Essen, Yong-mi Kim, Nora Heisterkamp, Giovanni Martinelli, Wolf-Karsten Hofmann, MD, Hans-Martin Jack, Hassan Jumaa, Markus Muschen

Blood (2008) 112 (11): 1918.

https://doi.org/10.1182/blood.V112.11.1918.1918

Published: 2008

Journal Articles

Lymphoid Blast Crisis Transformation and Development of Drug- Resistance in Chronic Myeloid Leukemia Are Driven by Aberrant Somatic Hypermutation

Lars Klemm, Cihangir Duy, Niklas Feldhahn, John Groffen, Yong-mi Kim, Wolf-Karsten Hofmann, MD, Hassan Jumaa, Michael R Lieber, Rafael Casellas, Markus Muschen

Blood (2008) 112 (11): 571.

https://doi.org/10.1182/blood.V112.11.571.571

Published: 2008

NARROW

SIRT3 Is a Novel Metabolic Driver of and Therapeutic Target for Chemotherapy Resistant Dlbcls

Cooperative Gene Repression By DNA Methylation and LSD1-Mediated Enhancer Inactivation in Acute Myeloid Leukemia

Acute Myeloid Leukemia Cells Resist Chemotherapy through a Reversible Senescence-like State Maintaining Repopulation Potential

Pre-B Cell Receptor-Mediated Activation of BCL6 Induces Pre-B Cell Quiescence Through Transcriptional Repression of MYC

Pre-B cell receptor–mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC

Mechanisms of Pre-B Cell Receptor-Inactivation In Acute Lymphoblastic Leukemia

Targeting Survivin In Recalcitrant Acute Lymphoblastic Leukemia

IKAROS and BCL6 Limit Pre-B Cell Expansion and Prevent Leukemogenesis Downstream of the Pre-B Cell Receptor

BCL6 Is Required for the Maintenance of Leukemia-Initiating Cells In Chronic Myeloid Leukemia

Pre-B Cell Receptor Signaling Distinguishes E2A-PBX1 From Other Subtypes of Acute Lymphoblastic Leukemia

The B Cell Mutator AID Promotes B Lymphoid Blast Crisis and Drug-Resistance in Chronic Myeloid Leukemia.

BCL6 Is Critical for the Development of a Diverse Primary B Cell Repertoire.

Inactivation of Pre-B Cell Receptor-Mediated Tumor Suppression by Aberrant Splicing in Ph + Acute Lymphoblastic Leukemia.

Role of Survivin in Drug Resistant B-Cell Acute Lymphoblastic Leukemia.

BCL6 Is Required for Leukemia-Initiation and Self-Renewal Signaling in Chronic Myeloid Leukemia.

BCL6-Dependent Negative Regulation of Cell Cycle Checkpoint Regulators Enables Drug-Resistance in Ph + Acute Lymphoblastic Leukemia.

Aberrant Splicing of the SLP65 SH2 Domain Enables Pre-B Cell Transformation and Compromises the Leukemia-Suppressive Function of the Pre-B Cell Receptor

BCL6-Mediated Survival Signaling Promotes Drug-Resistance in BCRABL1- Driven Acute Lymphoblastic Leukemia

The Pre-B Cell Receptor Suppresses Leukemogenesis by Censoring MYC Expression.

Lymphoid Blast Crisis Transformation and Development of Drug- Resistance in Chronic Myeloid Leukemia Are Driven by Aberrant Somatic Hypermutation

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American Society of Hematology

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American Society of Hematology

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