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Journal Articles

Discovery of the Unique GMP-Grade iPSC Clones That Give Rise to Functional, High Purity, Matured CD8 Alpha Beta T or Gamma Delta T with Exponential Expansion Capacity

Ying-Tsen Tung, Chih-Lung Chen, Annie Yi-Ting Lai, Chien-Yu Hsu, Chien-Hsi Chen, Po-Fan Chu, Lin-Yu Liao, Tzu-Chien Kuo, Chieh-Teng Cheng, Chun-Yu Lin, Wan-Chen Tsai, Wei-Ting Chen, Darien Zhing Herr Chan, Hsin-Hua Cho, Cheng-Kai Wang, Yo-Chuen Lin, Jin-Yi Lu, Lee-Yieng Lim, Jhang-Sian Yu, Ming-Chin Ko, Chia-Hung Lin, Yi-Han Dai, I-Ting Chen, Fang-Pei Chang, Shao-Ju Weng, Ting-Yi Wu, Yuan-Yu Hsia, Fu-Fei Hsu, Lillian Yi-Ting Lai, Shiou-Ling Jian, Shih-Wen Huang, Yu-Chih Peng, Ke-Hsun Hsu, Liang-Yi Chen, Ji-Kuan Wang, Yao-Yu Chen, Chih-Kai Yin, Yi-Hung Ou, Min-Ren Chiang, Wen-Hao Wang, Tsung-Hao Yeh, Xiaming Peng, Yang Shi, Pei Zhang, Ya-Chu Yu, Yun Gao, Yen-Hsien Lee, Pei-Chun Wu, Ta-Hsun Liao, De-Kuan Chang, Lien-Szu Wu, Jen-Chih Chi, Ching-Ying Huang, Alex Shih-Min Huang
Journal: Blood
Blood (2024) 144 (Supplement 1): 7195.
https://doi.org/10.1182/blood-2024-203106
Published: 2024
Journal Articles

LP-168 (Rocbrutinib), a Novel Covalent and Non-Covalent Next-Generation Inhibitor of Bruton's Tyrosine Kinase: Updates on the Phase 1 Trial and Initial Results of the CLL Gatekeeper Mutation Cohort

Jennifer A. Woyach, Danielle M. Brander, Boyu Hu, Kerry A. Rogers, Zulfa Omer, Deborah M. Stephens, Andrea Sitlinger, Fenlai Tan, Yi Chen, Stephen P. Anthony, Yu Chen, Kewei Shang, John C. Byrd
Journal: Blood
Blood (2024) 144 (Supplement 1): 4622.
https://doi.org/10.1182/blood-2024-205775
Published: 2024
Journal Articles

Genome-Wide CRISPR/Cas9 Knockout Screen Reveals Novel LP-168 (Rocbrutinib) Combinations Targeting BCL-2 Protein Members for Chronic Lymphocytic Leukemia

Britten K. Gordon, Ethan C. Whipp, Lianbo Yu, Samon Benrashid, Andrew D. Mitchell, Alexander He, Jazmin Urrutia, Shrilekha Misra, Alexander R. Marr, Tzung-Huei Lai, Naina Karnati, Shanmugapriya Thangavadivel, Kerry A. Rogers, Seema A. Bhat, Nicole R. Grieselhuber, Yi Chen, Fenlai Tan, Stephen P. Anthony, Yu Chen, Deepa Sampath, Rosa Lapalombella, Jennifer A. Woyach
Journal: Blood
Blood (2024) 144 (Supplement 1): 3587.
https://doi.org/10.1182/blood-2024-203522
Published: 2024
Journal Articles

Using Gene Therapy to Solve Challenges with CAR-T Cell Immunotherapy: Lead Selection and Preclinical Development of an Adeno-Associated Virus with Reduced Immunogenicity Exhibiting Efficient and Long-Term Expression of an Anti-CD19 T-Cell Engager

Mark A Currier, Allen Reha, Brian Hutzen, Pin-Yi Wang, Chun-yu Chen, Andrea Glaspell, Siddhi Nath Paudel, Akila S Venkataramany, Debashree Das, Danielle Hanlon, Allan A. Kaspar, Samit Varma, Brian K. Kaspar, Jacob G. Scott, Pablo Morales, Peter Ralph, Tonny Johnson, Tania L. Weiss, Timothy P Cripe
Journal: Blood
Blood (2024) 144 (Supplement 1): 1056.
https://doi.org/10.1182/blood-2024-198463
Published: 2024
Journal Articles

A Phase 1, Multicenter, Open-Label, Dose-Escalation Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Clinical Activity of Orally Administered LP-108 (Lacutoclax) As Monotherapy and in Combination with Azacitidine in Subjects with Relapsed or Refractory Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML), or Acute Myeloid Leukemia (AML)

Juan Miguel Bergua Burgues, Kristin Koenig, Pau Montesinos, Dale L. Bixby, Patrick W. Burke, Naval Daver, Stephen P. Anthony, Fenlai Tan, Yi Chen, Yu Chen, Ignacio Casas Aviles, Emily K Curran
Journal: Blood
Blood (2024) 144 (Supplement 1): 6009.
https://doi.org/10.1182/blood-2024-208792
Published: 2024
Journal Articles

iPSC-Derived CAR-Gamma Delta T with Novel Combinatorial KO Demonstrated Extended Longevity and Profound Anti-Tumor Efficacy without Cytokine Support in Preclinical Studies

Jhang-Sian Yu, Chia-Hung Lin, Ying-Tsen Tung, Fang-Pei Chang, Edward Po-Fan Chu, Shiou-Ling Jian, Fu-Fei Hsu, Ming-Chin Ko, Yi-Han Dai, Chieh-Teng Cheng, Tzu-Chien Kuo, I-Ting Chen, Ting-Yi Wu, Jin-Yi Lu, Ke-Hsun Hsu, Wei-Ting Chen, Darien Zhing Herr Chan, Yi-Ting Lai, Shao-Ju Weng, Liang-Yi Chen, Yuan-Yu Hsia, Yi-Hung Ou, Yo-Chuen Lin, Shih-Wen Huang, Yu-Chih Peng, Chien-Hsi Chen, Chien-Yu Hsu, Yi-Ting Lai, Chih-Lung Chen, Chun-Yu Lin, Lin-Yu Liao, Wan-Chen Tsai, Hsin-Hua Cho, Cheng-Kai Wang, Lee-Yieng Lim, Ji-Kuan Wang, Yao-Yu Chen, Chih-Kai Yin, Wen-Hao Wang, Tsung-Hao Yeh, Min-Ren Chiang, Ruyue Ji, Jen-Chih Chi, Lien-Szu Wu, Jennifer Huang, De-Kuan Chang, Alex Shih-Min Huang
Journal: Blood
Blood (2024) 144 (Supplement 1): 4790.
https://doi.org/10.1182/blood-2024-205086
Published: 2024
Journal Articles

OPN-6602, an Orally Bioavailable EP300/CBP Bromodomain Inhibitor, Targets Multiple Myeloma through Suppression of IRF4 and MYC

Bernice Matusow, Sadegh Saghafinia, Pei Pei Li, Amanda Kohler, Pan-Yu Chen, Christine Nichols, Parmveer Singh, Kerry Inokuchi, Jackie M. Walling, Gideon Bollag
Journal: Blood
Blood (2024) 144 (Supplement 1): 1908.
https://doi.org/10.1182/blood-2024-208181
Published: 2024
Journal Articles

Targeting Covalent and Non-Covalent Btki-Resistant CLL Using the Dual Irreversible/Reversible 4 th Generation BTK Inhibitor LP-168

Britten Gordon, Elizabeth Muhowski, Janani Ravikrishnan, Samon Benrashid, Andrew Mitchell, Alexander He, Shrilekha Misra, Tzung-Huei Lai, Shanmugapriya Thangavadivel, Alexander Marr, Lianbo Yu, Brandi Walker, Elizabeth Perry, Kerry A Rogers, Adam S Kittai, Seema A Bhat, John C. Byrd, Deepa Sampath, Rosa Lapalombella, Weiguo Han, Neil E. Kay, Yi Chen, Fenlai Tan, Stephen P. Anthony, Yu Chen, Jennifer A. Woyach
Journal: Blood
Blood (2023) 142 (Supplement 1): 416.
https://doi.org/10.1182/blood-2023-178259
Published: 2023
Journal Articles

PD-1 Antibody (Sintilimab) Plus Histone Deacetylase Inhibitor (Chidamide) for the Treatment of Refractory or Relapsed Extranodal Natural Killer/T Cell Lymphoma, Nasal Type (r/r ENKTL): Updates of the Phase Ib/II Scent Study

Gao Yan, Liling Zhang, Wenyu Li, Xu Wei, Ru Feng, Xue-Ping Li, Yu Chen, Huijing Wu, Xiaoxiao Wang, Bing Bai, Huiqiang Huang
Journal: Blood
Blood (2023) 142 (Supplement 1): 1689.
https://doi.org/10.1182/blood-2023-186252
Published: 2023
Journal Articles

Venetoclax Combined with Azacitidine and Homoharringtonine in Adults with Secondary Acute Myeloid Leukemia

Fei Huang, Yu Chen, Zhongxun Shi, Huijun Huang, Jianyong Li, Wenyi Shen
Journal: Blood
Blood (2023) 142 (Supplement 1): 5962.
https://doi.org/10.1182/blood-2023-186713
Published: 2023
Journal Articles

Initial Results of a Phase 1 Dose Escalation Study of LP-168, a Novel Covalent and Non-Covalent Next-Generation Inhibitor of Bruton's Tyrosine Kinase

Jennifer A. Woyach, Deborah M. Stephens, Danielle M Brander, Adam S Kittai, Boyu Hu, Andrea Sitlinger, Emily K Curran, Fenlai Tan, Yi Chen, Stephen P. Anthony, Yu Chen, John C. Byrd
Journal: Blood
Blood (2023) 142 (Supplement 1): 328.
https://doi.org/10.1182/blood-2023-186432
Published: 2023
Journal Articles

Pre-Clinical Evaluation of a New-Generation Orally Bioavailable Dual Bcl-2/Bcl-Xl Inhibitor LP-118 in Mantle Cell Lymphoma

Ling-Ling Lee, Cong Zhu, Brianna Feldmeier, Yao Chen, Wenyu Li, Yu Chen, Stephen P. Anthony, Yue Shen, Fenlai Tan, Yi Chen, Bing Dai
Journal: Blood
Blood (2023) 142 (Supplement 1): 3640.
https://doi.org/10.1182/blood-2023-180190
Published: 2023
Journal Articles

Patient- and Clinician-Reported Performance Status in Patients with Multiple Myeloma Treated in the United States Using Real World Data

Vishal Bhatnagar, Bindu Kanapuru, Laura Fernandes, Ting-Yu Chen, Mallorie H. Fiero, Erica Horodniceanu, Nicole Gormley, Catherine Lerro, Fatima Rizvi, Yuan-Li Shen, Felice Yang, Anna Barcellos, Andrew J. Belli, Eric Hansen, Ching-Kun Wang, Donna Rivera, Paul Kluetz
Journal: Blood
Blood (2022) 140 (Supplement 1): 7156–7157.
https://doi.org/10.1182/blood-2022-166842
Published: 2022
Journal Articles

LP-118, a Novel BCL2 Inhibitor, Shows Potent in Vitro Anti-Myeloma Activity

Rodrigo Fonseca, Yuan Xiao Zhu, P. Leif Bergsagel, Marta Chesi, Akhilesh Pandey, Kiran Mangalaparthi, Yi Chen, Felai Tan, Stephen P. Anthony, Yu Chen, Yue Shen, Bing Dai, Esteban Braggio, Rafael Fonseca
Journal: Blood
Blood (2022) 140 (Supplement 1): 7129–7130.
https://doi.org/10.1182/blood-2022-167372
Published: 2022
Journal Articles

LP-118, a Selective Bcl-2 Inhibitor with Tuned Bcl-Xl Activity, Causes Myeloid Differentiation and Cell Death in Acute Myeloid Leukemia (AML)

Kristin L Koenig, Colin Brame, Steven Sher, Larry Beaver, Casey B. Cempre, Katie Williams, Matthew Purcell, Bonnie Harrington, Yi Chen, Felai Tan, Stephen P. Anthony, Yu Chen, Yue Shen, John C. Byrd, Rosa Lapalombella
Journal: Blood
Blood (2022) 140 (Supplement 1): 9068–9069.
https://doi.org/10.1182/blood-2022-170578
Published: 2022
Journal Articles

Targeting Apoptosis with Novel BH3 Mimetics in T-Lineage Acute Lymphoblastic Leukemia

Caner Saygin, Bartholomew Eisfelder, Giorgia Giordano, Anika Thomas-Toth, Yi Chen, Felai Tan, Stephen P. Anthony, Yu Chen, Yue Shen, James LaBelle, Wendy Stock
Journal: Blood
Blood (2022) 140 (Supplement 1): 10689–10690.
https://doi.org/10.1182/blood-2022-163673
Published: 2022
Journal Articles

Phosphorylation Stabilized TET1 Acts As an Oncoprotein and Therapeutic Target in B-Cell Acute Lymphoblastic Leukemia

Zhenhua Chen, Keren Zhou, Jianhuang Xue, Andrew Small, Gang Xiao, Le Xuan Truong Nguyen, Zheng Zhang, Emily Prince, Hengyou Weng, Huilin Huang, Zhicong Zhao, Ying Qing, Chao Shen, Li Han, Brandon Tan, Wei Li, Rui Su, Hanjun Qin, Yangchan Li, Dong Wu, Zhaohui Gu, Vu N Ngo, Xin He, Jianfei Chao, Keith Leung, Kitty Wang, Lei Dong, Xi Qin, Zhenming Cai, Yue Sheng, Yu Chen, Xiwei Wu, Bin Zhang, Yanhong Shi, Guido Marcucci, Zhijian Qian, Mingjiang Xu, Markus Müschen, Xiaolan Deng, Jianjun Chen
Journal: Blood
Blood (2022) 140 (Supplement 1): 998–1000.
https://doi.org/10.1182/blood-2022-165469
Published: 2022
Journal Articles

Degradation of Janus kinases in CRLF2 -rearranged acute lymphoblastic leukemia

Yunchao Chang, Jaeki Min, Jamie A. Jarusiewicz, Marisa Actis, Shanshan Yu-Chen Bradford, Anand Mayasundari, Lei Yang, Divyabharathi Chepyala, Lisa J. Alcock, Kathryn G. Roberts, Stanley Nithianantham, Dylan Maxwell, Lauren Rowland, Randolph Larsen, Aman Seth, Hiroaki Goto, Toshihiko Imamura, Koshi Akahane, Baranda S. Hansen, Shondra M. Pruett-Miller, Elisabeth M. Paietta, Mark R. Litzow, Chunxu Qu, Jun J. Yang, Marcus Fischer, Zoran Rankovic, Charles G. Mullighan
Journal: Blood
Blood (2021) 138 (23): 2313–2326.
https://doi.org/10.1182/blood.2020006846
Published: 2021
Includes: Supplemental data
Journal Articles

Characterization of LP-118, a Novel Small Molecule Inhibitor of Bcl-2 and Bcl-Xl in Chronic Lymphocytic Leukemia Resistant to Venetoclax

Janani Ravikrishnan, Elizabeth M. Muhowski, Tzung-Huei Lai, Shrilekha Misra, Daisy Diaz Rohena, Felai Tan, Yi Chen, Stephen P. Anthony, Yu Chen, Yue Shen, John C. Byrd, Deepa Sampath, Jennifer A. Woyach
Journal: Blood
Blood (2021) 138 (Supplement 1): 679.
https://doi.org/10.1182/blood-2021-151852
Published: 2021
Journal Articles

Modified Intensive Induction Treatment for Elderly Acute Myeloid Leukemia Patients Based on Peripheral Blast Clearance Rate: A Phase II Single-Arm Study

Ya Li, Xiaoyang Li, Hongming Zhu, Yunxiang Zhang, Yu Chen, Qiusheng Chen, Yu Zheng, Junmin Li
Journal: Blood
Blood (2021) 138 (Supplement 1): 1260.
https://doi.org/10.1182/blood-2021-152042
Published: 2021