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Maël Heiblig
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Journal Articles

Clinical outcome of patients with TP53 AML treated with non-intensive vidaza-venetoclax chemotherapy : Venaura retrospective regional multicenter study.

Free
Chloe Cote, Mael Heiblig, Urbain Tauveron-Jalenques, Martin Carre, Amine Belhabri, Gaspar Aspas Requena, Sylvain Lamure, Ugo Thévenet, Clemence Santana, Adrien Contejean, Jerome Cornillon, Elisabeth Daguenet, Pascale Flandrin-Gresta, Emmanuelle Tavernier
Journal: Blood
Blood (2025) 146 (Supplement 1): 3442.
https://doi.org/10.1182/blood-2025-3442
Published: 2025
Journal Articles

Oral azacitidine maintenance improved survival for t-AML or AML-MR patients in first remission after CPX-351 and not eligible to HSCT

Free
Caroline Fileni, David Swoboda, Alexander Coltoff, Najla Al Ali, Rami Komrokji, Onyee Chan, Geoffrey Uy, Sarah Bertoli, Alessandro Isidori, Lenaig Le Clech, Mael Heiblig, Ludovic Gabellier, Patrick Lawrence, Lydia Kretschmer, Christoph Röllig, Jeffrey Lancet, Andrew Wei, David Sallman, Thomas Cluzeau
Journal: Blood
Blood (2025) 146 (Supplement 1): 3441.
https://doi.org/10.1182/blood-2025-3441
Published: 2025
Journal Articles

Odyssey: A first-in-human study of the aldehyde dehydrogenase (ALDH) inhibitor abd-3001 in patients with refractory/relapsed acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS)

Free
Mael Heiblig, Lina Benajiba, Julien Colle, Sandrine Loron, Juliette Soret, Rafael Daltro De Oliveira, Geoffroy Venton, Marie-Virginie Larcher, Laure Farnault, Mühübe Yazir, Mileidys Perez, Ismail Ceylan, Guillaume Martin, Annick Pelletier, Jean-Jacques Kiladjian, Régis Costello
Journal: Blood
Blood (2025) 146 (Supplement 1): 3421.
https://doi.org/10.1182/blood-2025-3421
Published: 2025
Journal Articles

Revumenib for patients with relapsed or refractory (R/R) Nucleophosmin 1–Mutated (NPM1m) Acute Myeloid Leukemia (AML): Outcomes by prior treatment in the phase 2 AUGMENT-101 study

Free
Martha Arellano, Michael Thirman, John DiPersio, Mael Heiblig, Eytan Stein, Andre Schuh, Andrius Zucenka, Stephane De Botton, Carolyn Grove, Gabriel Mannis, Cristina Papayannidis, Alexander Perl, Ghayas Issa, Ibrahim Aldoss, Ashish Bajel, David Dickens, Michael Kühn, Ioannis Mantzaris, Emmanuel Raffoux, Elie Traer, Irina Amitai, Hartmut Döhner, Corinna Greco, Tibor Kovacsovics, Christine McMahon, Pau Montesinos, Arnaud Pigneux, Paul Shami, Richard Stone, Ofir Wolach, John Harpel, Yakov Chudnovsky, Li Yu, Rebecca Bagley, Angela R. Smith, James Blachly
Journal: Blood
Blood (2025) 146 (Supplement 1): 3418.
https://doi.org/10.1182/blood-2025-3418
Published: 2025
Journal Articles

Impact of 7-day versus standard venetoclax exposure in combination with azacitidine in frontline AML settings: A real-world analysis from the venaura retrospective multicenter study

Free
Gaspar Aspas Requena, Pedro Chorao, Samy Chraibi, Urbain Tauveron-Jalenques, Amine Belhabri, Emmanuelle Tavernier, Martin Carre, Jerome Cornillon, Adrien Contejean, Clémence Santana, Clément Rocher, Sylvain Lamure, Natacha Mauz, Ugo Thévenet, Boullanger Nadine, Gian-Matteo Pica, Dony Arthur, Mauricette Michallet, Stefan Wickenhauser, Mael Heiblig
Journal: Blood
Blood (2025) 146 (Supplement 1): 3398.
https://doi.org/10.1182/blood-2025-3398
Published: 2025
Journal Articles

Characteristics and prognostic significance of myelodysplastic syndrome (MDS)-related features in vexas syndrome

Free
Lin-Pierre Zhao, Olivier Kosmider, Mael Heiblig, Thomas Moulinet, Thibault Comont, Hervé Lobbes, Jean-Denis Karam, Louis Terriou, Samuel Ardois, Guillaume Le Guenno, Vincent Jachiet, Louis Wolff, Jerome Hadjadj, Jean-David Bouaziz, Olivier Fain, Benjamin Terrier, Sophie Georgin-Lavialle, Lise Larcher, Emmanuelle Clappier, Marie Sebert, Lionel Ades, Arsene Mekinian, Pierre Fenaux
Journal: Blood
Blood (2025) 146 (Supplement 1): 3165.
https://doi.org/10.1182/blood-2025-3165
Published: 2025
Journal Articles

Azacitidine (AZA) and venetoclax (VEN) combination for the treatment of immune mediate inflammatory diseases (IMID) associated with myeloid neoplasms (MN)

Free
Armelle Otiniano, Vincent Jachiet, Jerome Hadjadj, Mael Heiblig, Pierre LOZAC H, Mathieu Wemeau, Maxime Battistella, Mirabelle Ruyer Thompson, Eve Zakine, Urbain Tauveron-Jalenques, Marc Ruivard, Benoit De Renzis, Pierre Fenaux, Olivier Fain, Lin-Pierre Zhao, Arsene Mekinian
Journal: Blood
Blood (2025) 146 (Supplement 1): 5630.
https://doi.org/10.1182/blood-2025-5630
Published: 2025
Journal Articles

Monotherapy update from Phase 1 portion in Phase1/2 trial of the menin-MLL inhibitor enzomenib (DSP-5336) in patients with relapsed or refractory acute leukemia

Free
Naval Daver, Joshua Zeidner, Justin Watts, Junichiro Yuda, Mark Levis, Pau Montesinos, Cristina Papayannidis, Kentaro Fukushima, Takahiro Shima, Emmanuel Raffoux, Uma Borate, Neil Palmisiano, Joseph Brandwein, Mael Heiblig, Yasushi Miyazaki, Takayuki Ikezoe, Melissa Ooi, Shang-Ju Wu, Eunice Wang, Susana Vives, Stephen Strickland, Dimitri Breems, Naoko Hosono, Yoshiaki Ogawa, Koichi Onodera, Andrew Brunner, Gina Keiffer, Timothy Pardee, Paul Shami, Alireza Eghtedar, Hongliang Cai, Bo Xu, Priya Robson, Akinobu Watanabe, Matthew Hitron, Jatin Shah, Hagop Kantarjian, Harry Erba
Journal: Blood
Blood (2025) 146 (Supplement 1): 763.
https://doi.org/10.1182/blood-2025-763
Published: 2025
Journal Articles

Comprehensive mutational profiling and clinical outcome of adults AML with NUP98 rearrangement

Free
Ducourneau Benoit, Arnaud Pages, Stéphanie Struski, Matthieu Decamp, Emmanuel Raffoux, Céline Berthon, Laurene Fenwarth, Vincent Marmouset, Cecile Pautas, Thomas Cluzeau, Delphine Lebon, Madalina Uzunov, Patricio Pereyra, Mael Heiblig, Jean-Valère Malfuson, Laure Farnault, Pierre-Yves Dumas, Julia HIEULLE, Sarah Bertoli, Sylvain Chantepie, Nathalie Auger, Audrey Bidet, Marie Joelle Mozziconacci, Augustin Boudry, Isabelle Luquet, Laureen Chat, Romain Loyaux, Lina EL-MURR, Emmanuelle Clappier, Claude Gardin, Mathilde Hunault, Stephane De Botton, Arnaud Pigneux, Dominique Penther, Eric Delabesse, Raphael Itzykson, Claude Preudhomme, Herve Dombret, Christian Recher, Nicolas Duployez, Jean-Baptiste Micol
Journal: Blood
Blood (2025) 146 (Supplement 1): 7002.
https://doi.org/10.1182/blood-2025-7002
Published: 2025
Journal Articles

Ivosidenib in refractory or relapsed IDH1-mutated Acute Myeloid Leukemia patients in real life settings: The ivoobs observational study from the french AML intergroup ALFA/filo

Free
Mael Heiblig, Pierre Peterlin, Stéphane Morisset, Pierre-Yves Dumas, Marie Sebert, Sarah Bertoli, Paolo Musiu, Aurélie Ravinet, Sylvain Garciaz, Delphine Lebon, Pascal Turlure, Yohan Desbrosses, Juliette Lambert, Quentin Cabrera, Sarah Bonnet, Célestine Simand, Kamel Laribi, Anne Banos, Ambroise Marçais, Benjamin Carpentier, Adrien Daniel, Corentin Orvain, Thomas Cluzeau, Marlene Ochmann, Adrien Contejean, Cecile Pautas, Rudy Birsen, Benjamin Papoular, Celia Salanoubat, Jamilé Frayfer, Gianmatteo Pica, Julia HIEULLE, Nicolas Vallet, Ariane Mineur, Stephane De Botton, Christian Recher, Arnaud Pigneux
Journal: Blood
Blood (2025) 146 (Supplement 1): 3455.
https://doi.org/10.1182/blood-2025-3455
Published: 2025
Journal Articles

Thrombocytosis drives alteration of primary hemostasis and acquired von willebrand syndrome occurrence in myeloproliferative neoplasms

Free
Gabriel Antherieu, Hamdi Rezigue, Marie-Odile Geay-Baillat, Sandrine Loron, Marie Balsat, Hélène Labussière-Wallet, Marie-Virginie Larcher, Vincent Alcazer, Sophie Ducastelle-Lepretre, Gaëlle Fossard, Zofia Gross, Fiorenza Barraco, Lila Gilis, Anne-Marie Daull, Herve Ghesquieres, Christophe Nougier, Yesim Dargaud, Mael Heiblig
Journal: Blood
Blood (2025) 146 (Supplement 1): 5570.
https://doi.org/10.1182/blood-2025-5570
Published: 2025
Journal Articles

A baseline transcriptomic signature predictive of clinical response to menin inhibitors in AML : The PRE-men retrosprospective Study

Free
Vincent Alcazer, Sandrine Hayette, Pauline Bertin-Mourot, Juliette Helluin, Marie-Virginie Larcher, Hélène Labussière-Wallet, Sandrine Loron, Gaëlle Fossard, Sophie Ducastelle-Lepretre, Marie Balsat, Anne-Marie Daull, Fiorenza Barraco, Lila Gilis, Zofia Gross, Kaddour Chabane, Pierre Sujobert, Mael Heiblig
Journal: Blood
Blood (2025) 146 (Supplement 1): 3482.
https://doi.org/10.1182/blood-2025-3482
Published: 2025
Journal Articles

Frequency and impact of FLT3-ITD microclones in younger AML patients

Free
Nicolas Duployez, Romane Joudinaud, Augustin Boudry, Mathilde Hunault, Emmanuelle Tavernier, Cecile Pautas, Sarah Bertoli, Suzanne Tavitian, Emmanuel Raffoux, Marie-Anne Hospital, Raja Prince-Eladnani, Mael Heiblig, Sylvain Chantepie, Martin Carre, Pierre Peterlin, Maria Pilar Gallego Hernanz, Romain Guieze, Célestine Simand, Pascal Turlure, Anne Huynh, Emilie Lemasle, Ludovic Gabellier, Juliette Lambert, Felipe Suarez, Samy Chraibi, Laurence Sanhes, Karine Celli-Lebras, Ariane Mineur, Claude Gardin, Norbert Ifrah, Norbert Vey, Regis Peffault De Latour, Isabelle Luquet, Dominique Penther, Raphael Itzykson, Eric Delabesse, Jean-François Hamel, Stephane De Botton, Arnaud Pigneux, Herve Dombret, Christian Recher, Claude Preudhomme, Pierre-Yves Dumas
Journal: Blood
Blood (2025) 146 (Supplement 1): 456.
https://doi.org/10.1182/blood-2025-456
Published: 2025
Journal Articles

Prognostic risk integration for survival modeling (PRISM) in newly diagnosed acute myeloid leukemia treated with venetoclax:  a multinational retrospective cohort study

Free
Curtis Lachowiez, Andy Kaempf, Jad Othman, Seongseok Yun, Mael Heiblig, Michael Heuser, Rabia Shahswar, Anand Patel, Rafael Madero-Marroquin, Joseph Cannova, Irene Zacheo, Federica Monaco, Dimitrios Drekolias, Fatima Tuz Zahra, Amine Belhabri, Urbain Tauveron-Jalenques, Emmanuelle Tavernier, Martin Carre, Gaspar Aspas Requena, Nicola Long, Rachel Cook, Elie Traer, Ronan Swords, Jennifer Saultz, Jenny O'Nions, Faisal Basheer, John Laurie, Shivani Handa, Eytan Stein, Maria Baer, Wendy Stock, Rebecca Olin, William Blum, Gary Schiller, Tara Lin, Emily Curran, Ying Huang, Rina Welkie, Ashley Yocum, Giovanni Marconi, Ellen Madarang, Justin Watts, Yazan Madanat, Richard Dillon, Sanam Loghavi, Joshua Zeidner, Daniel Pollyea, Elsa Bernard
Journal: Blood
Blood (2025) 146 (Supplement 1): 453.
https://doi.org/10.1182/blood-2025-453
Published: 2025
Journal Articles

Outcomes following lower-intensity therapy with venetoclax in patients with NPM1-mutated Acute Myeloid Leukemia are highly dependent upon co-occurring mutations

Free
Curtis Lachowiez, Seongseok Yun, Mael Heiblig, Michael Heuser, Rabia Shahswar, Anand Patel, Rafael Madero-Marroquin, Joseph Cannova, Dimitrios Drekolias, Fatima Tuz Zahra, Amine Belhabri, Urbain Tauveron-Jalenques, Emmanuelle Tavernier, Martin Carre, Gaspar Aspas Requena, Jenny O'Nions, Faisal Basheer, John Laurie, Ellen Madarang, Richard Dillon, Sanam Loghavi, Joshua Zeidner, Dan Pollyea, Justin Watts, Jad Othman
Journal: Blood
Blood (2025) 146 (Supplement 1): 5278.
https://doi.org/10.1182/blood-2025-5278
Published: 2025
Journal Articles

Impact of midostaurin in younger AML patients intensively treated with high-dose anthracycline

Free
Pierre-Yves Dumas, Mathieu Leclerc, Mathilde Hunault, Emmanuelle Tavernier, Cecile Pautas, Sarah Bertoli, Thibaut Leguay, Suzanne Tavitian, Emmanuel Raffoux, Marie-Anne Hospital, Sylvain Chantepie, Mael Heiblig, Martin Carre, Pierre Peterlin, Maria Pilar Gallego Hernanz, Romain Guieze, Célestine Simand, Pascal Turlure, Anne Huynh, Emilie Lemasle, Ludovic Gabellier, Juliette Lambert, Delphine Lebon, Madalina Uzunov, Jean-Valère Malfuson, Thomas Cluzeau, Samy Chraibi, Laurence Sanhes, Karine Celli-Lebras, Ariane Mineur, Claude Gardin, Norbert Ifrah, Norbert Vey, Regis Peffault De Latour, Isabelle Luquet, Dominique Penther, Eric Delabesse, Jean-François Hamel, Raphael Itzykson, Claude Preudhomme, Stephane De Botton, Nicolas Duployez, Arnaud Pigneux, Herve Dombret, Christian Recher
Journal: Blood
Blood (2025) 146 (Supplement 1): 1682.
https://doi.org/10.1182/blood-2025-1682
Published: 2025
Journal Articles

Real life study of ivosidenib in either monotherapy or combined with azacytidine for first line mutant IDH1 AML: A study from the french AML intergroup ALFA/filo

Free
Pierre Peterlin, Mael Heiblig, Stéphane Morisset, Sarah Bertoli, Marie Sebert, Thomas Cluzeau, Corentin Orvain, Pierre-Yves Dumas, Paolo Musiu, Sylvain Garciaz, Yohan Desbrosses, Gaspar Aspas Requena, Rudy Birsen, Pascal Turlure, Celestine Simand, Adrien Contejean, Celia Salanoubat, Benjamin Carpentier, Ambroise Marçais, Juliette Lambert, Delphine Lebon, Quentin Cabrera, Sarah Bonnet, Kamel Laribi, Anne Banos, Adrien Daniel, Marlene Ochmann, Cecile Pautas, Benjamin Papoular, Jamile Frayfer, Gian Matteo Pica, Julia HIEULLE, Nicolas Vallet, Ariane Mineur, Arnaud Pigneux, Christian Recher, Stephane De Botton
Journal: Blood
Blood (2025) 146 (Supplement 1): 1658.
https://doi.org/10.1182/blood-2025-1658
Published: 2025
Journal Articles

Revumenib for patients with relapsed or refractory (R/R) KMT2Ar acute leukemia: Outcomes by leukemia type in the phase 2 AUGMENT-101 study

Free
Ibrahim Aldoss, Ghayas Issa, James Blachly, Michael Thirman, Gabriel Mannis, Martha Arellano, John DiPersio, Elie Traer, C. Zwaan, Neerav Shukla, Branko Cuglievan, Carolyn Grove, Matthew Greenwood, Christine McMahon, Alexander Perl, Richard Stone, Cristina Papayannidis, David Dickens, Mael Heiblig, Andrius Zucenka, Pau Montesinos, Ioannis Mantzaris, Tibor Kovacsovics, Paul Shami, Li Yu, Rebecca Bagley, Angela R. Smith, Eytan Stein
Journal: Blood
Blood (2025) 146 (Supplement 1): 1001.
https://doi.org/10.1182/blood-2025-1001
Published: 2025
Journal Articles

Secondary-type acute myeloid leukemia is associated with a higher risk of invasive fungal infection during intensive induction therapy. a correlative study on the ALFA 0702 trial.

Free
Jean-Eudes Fahrner, Mauricette Michallet, Laurene Fenwarth, Mohamad Sobh, Stéphane Morisset, Alexandre Deloire, Emmanuel Raffoux, Stephane De Botton, Sylvain Chantepie, Stephane Girault, Céline Berthon, Sarah Bertoli, Stephane Lepretre, Pierre Yves Dumas, Juliette Lambert, Delphine Lebon, Cecile Pautas, Jean Valère Malfuson, Norbert Vey, Thorsten Braun, Felipe Suarez, Aline Schmidt, Remy Gressin, Caroline Bonmati, Karine Celli-Lebras, Mael Heiblig, Mohamed El-Hamri, Claude Preudhomme, Hervé Dombret, Anne Bergeron, Nicolas Duployez, Raphael Itzykson
Journal: Blood
Blood (2025) 146 (Supplement 1): 994.
https://doi.org/10.1182/blood-2025-994
Published: 2025
Journal Articles

Induction chemotherapy with a single anthracycline-containing cycle in younger adults with newly diagnosed AML – the french backbone intergroup (BIG)-1 study on behalf of the filo, ALFA, and SFGM-TC study groups

Free
Christian Recher, Cecile Pautas, Sarah Bertoli, Pierre-Yves Dumas, Emmanuel Raffoux, Marie-Anne Hospital, Raja Prince-Eladnani, Mael Heiblig, Martin Carre, Sylvain Chantepie, Pierre Peterlin, Maria Pilar Gallego Hernanz, Juliette Lambert, Corentin Orvain, Romain Guieze, Pascal Turlure, Celestine Simand, Emilie Lemasle, Chantal Himberlin, Caroline Bonmati, Jean Valère Malfuson, Delphine Lebon, Thomas Cluzeau, Emmanuelle Tavernier, Jean-Baptiste Micol, Karine Celli-Lebras, Ariane Mineur, Claude Gardin, Norbert Ifrah, Norbert Vey, Regis Peffault De Latour, Anne Huynh, Thibaut Leguay, Isabelle Luquet, Dominique Penther, Nicolas Duployez, Eric Delabesse, Claude Preudhomme, Herve Dombret, Jean-François Hamel, Arnaud Pigneux, Hunault-Berger Mathilde
Journal: Blood
Blood (2025) 146 (Supplement 1): 43.
https://doi.org/10.1182/blood-2025-43
Published: 2025