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Journal Articles

Acute Promyelocytic Leukemia: Long-Term Outcomes from the HARMONY Project

Maria Teresa Voso, Luca Guarnera, Sören Lehmann, Konstanze Döhner, Hartmut Döhner, Uwe Platzbecker, Nigel H. Russell, Richard James Dillon, Ian Thomas, Gert J Ossenkoppele, Torsten Haferlach, Marco Vignetti, Edoardo La Sala, Alfonso Piciocchi, Paola Fazi, Ángela Villaverde Ramiro, Laura Tur Giménez, Carmelo Gurnari, Lars Bullinger, Jesus M. Hernandez
Journal: Blood
Blood blood.2024026186.
https://doi.org/10.1182/blood.2024026186
Published: 2024
Includes: Supplemental data
Journal Articles

Intraindividual Comparison of Recognition of Symptom Burden in MPN between Patient- and Physician-Reported Assessment and Its Impact on Survival - an Analysis By the German Study Group for MPN (GSG-MPN)

Kirsi Manz, Florian H. Heidel, Steffen Koschmieder, Rudolf Schlag, Joerg Lipke, Frank Stegelmann, Martin Griesshammer, Martine Klausmann, Carl Crodel, Andreas Hochhaus, Holger Schulz, Joachim R. Goethert, Haifa Kathrin Al-Ali, Heiko Becker, Andreas Reiter, Gernot Beutel, Kim Kricheldorf, Tim H. H. Brummendorf, Wolfgang Hoffmann, Konstanze Döhner, Susanne Isfort
Journal: Blood
Blood (2024) 144 (Supplement 1): 406.
https://doi.org/10.1182/blood-2024-206143
Published: 2024
Journal Articles

Genetic Diversity Drives Differing Morphological and Clinical Presentation and Survival in Myelodysplastic-Type CMML with a Low Absolute Monocyte Count

Curtis A Lachowiez, Georgios Asimomitis, Elsa Bernard, Yanis Tazi, Maria Creignou, Ulrich Germing, Norbert Gattermann, Amanda Gilkes, Ian Thomas, Lars Bullinger, Konstanze Döhner, Luca Malcovati, Nigel H. Russell, Mario Cazzola, Hartmut Döhner, Brian J P Huntly, Robert P Hasserjian, Eva Hellstrom Lindberg, Sanam Loghavi, Elli Papaemmanuil
Journal: Blood
Blood (2024) 144 (Supplement 1): 1830.
https://doi.org/10.1182/blood-2024-209450
Published: 2024
Journal Articles

The Prognostic Impact of Myelodysplasia-Related Gene Mutations in Acute Myeloid Leukemia with FLT3 -ITD Mutations

Rabea Mecklenbrauck, Angela Villaverde Ramiro, Eric Sträng, Razif Gabdoulline, Javier Martínez Elicegui, Marta Sobas, Lisa Pleyer, Maria Teresa Voso, Axel Benner, Alberto Hernández Sánchez, Jesse M. Tettero, Laura Tur, Klaus H Metzeler, Guadalupe Onate, Soren Lehmann, Brian J P Huntly, Ian Thomas, Felicitas R Thol, Florian Heidel, Peter J. M. Valk, Konstanze Döhner, Torsten Haferlach, Ken I Mills, Hartmut Döhner, Gastone Castellani, Gert Ossenkoppele, Jesus Maria Hernandez Rivas, Lars Bullinger, Michael Heuser
Journal: Blood
Blood (2024) 144 (Supplement 1): 844.
https://doi.org/10.1182/blood-2024-202362
Published: 2024
Journal Articles

ROP-ET: A Prospective Phase III Trial Investigating the Efficacy and Safety of Ropeginterferon Alfa-2b in Essential Thrombocythemia Patients with Limited Treatment Options

Jean-Jacques Kiladjian, Francisca Ferrer Marin, Haifa Kathrin Al-Ali, Alberto Alvarez-Larran, Eloise Beggiato, Maria Bieniaszewska, Massimo Breccia, Veronika Buxhofer-Ausch, Olga Cerna, Ana Manuela Crisan, Catalin Danaila, Valerio De Stefano, Konstanze Döhner, Victoria Empson, Joanna Gora Tybor, Martin Griesshammer, Sebastian Grosicki, Paola Guglielmelli, Valentín García Gutiérrez, Sr., Florian Heidel, Arpad Illes, Chloe James, Steffen Koschmieder, Krauth Maria-Theresa, Kurt Krejcy, Mihaela Cornelia Lazaroiu, Jiri Mayer, Zsolt Nagy, Francesca Palandri, Vasiliki Pappa, Andreas Reiter, Tomasz Sacha, Stefanie Schlager, Stefan Ulrich Schmidt, Evangelos Terpos, Ciprian Tomuleasa, Jose Miguel Torregrosa Diaz, Martin Unger, Albert Woelfler, Blanca Xicoy, Christoph Klade
Journal: Blood
Blood (2024) 144 (Supplement 1): 6635.
https://doi.org/10.1182/blood-2024-199028
Published: 2024
Journal Articles

10 Year Follow-up of CALGB 10603/Ratify: Midostaurin Versus Placebo Plus Intensive Chemotherapy in Newly Diagnosed FLT3 Mutant Acute Myeloid Leukemia Patients Aged 18-60 Years

Richard M Stone, Jun Yin, Sumithra J Mandrekar, Axel Benner, Maral Saadati, Ilene A. Galinsky, Ben L. Sanford, Rebecca Teske, Susan M. Geyer, Thomas Prior, Sergio Amadori, Frederick R. Appelbaum, Joseph Brandwein, Konstanze Döhner, Gerhard Ehninger, Arnold Ganser, Rebecca B. Klisovic, Jürgen Krauter, Guido Marcucci, Bruno Medeiros, Dietger W. Niederwieser, Miguel A. Sanz, Richard F. Schlenk, Hubert Serve, Jorge Sierra, Martin S. Tallman, Andrew H Wei, Theo J.M. de Witte, Christian Thiede, Hartmut Döhner, Richard A. Larson
Journal: Blood
Blood (2024) 144 (Supplement 1): 218.
https://doi.org/10.1182/blood-2024-201058
Published: 2024
Journal Articles

The Differential Impact of Secondary-Type Mutations in a Multinational Cohort of 5311 Intensively Treated Acute Myeloid Leukemia Patients

Jan-Niklas Eckardt, Marius Bill, Konstanze Döhner, Christian Rausch, Klaus H Metzeler, Karsten Spiekermann, Sebastian Stasik, Tim Sauer, Sebastian Scholl, Andreas Hochhaus, Martina Crysandt, Tim H. H. Brummendorf, Utz Krug, Bernhard Wörmann, Hermann Einsele, Wolfgang Hiddemann, Dennis Görlich, Maria Cristina Sauerland, Björn Steffen, Andreas Neubauer, Andreas Burchert, Kerstin Schaefer-Eckart, Wolfgang E. Berdel, Christoph Schliemann, Stefan W. Krause, Mathias Hänel, Maher Hanoun, Martin Kaufmann, Lars Fransecky, Jan Braess, Johannes Schetelig, Jan Moritz Middeke, Lars Bullinger, Michael Heuser, Felicitas R Thol, Hubert Serve, Claudia D Baldus, Uwe Platzbecker, Carsten Mueller-Tidow, Barbora Weinbergerova, Jiri Mayer, Pierre-Yves Dumas, Sarah Bertoli, Eric Delabesse, Christian Récher, Arnaud Pigneux, Tobias Herold, Arnold Ganser, Hartmut Döhner, Martin Bornhäuser, Christian Thiede, Christoph Röllig
Journal: Blood
Blood (2024) 144 (Supplement 1): 2934.
https://doi.org/10.1182/blood-2024-201945
Published: 2024
Journal Articles

CSF3R T618I Is Stabilized By Calnexin and Induces Unfolded Protein Response (UPR) and ER-Phagy: A Pro-Survival Pathway for Oncogenic Misfolded CSF3R Proteins in Chronic Neutrophilic Leukemia (CNL)

Alessandra Hartke, Julia Klotz, Axel Künstner, Anke Fähnrich, Hauke Busch, Timo Gemoll, Jasmin Osius, Steffen Koschmieder, Tim H. H. Brummendorf, Heike L. Pahl, Florian H. Heidel, Konstanze Döhner, Martin Griesshammer, Andreas Reiter, Justus Duyster, Nikolas C. C. von Bubnoff, Sivahari P. Gorantla
Journal: Blood
Blood (2024) 144 (Supplement 1): 1348.
https://doi.org/10.1182/blood-2024-202513
Published: 2024
Journal Articles

Proposals for revised International Working Group–European LeukemiaNet criteria for anemia response in myelofibrosis

Brief Report
Ayalew Tefferi, Giovanni Barosi, Francesco Passamonti, Juan-Carlos Hernandez-Boluda, Prithviraj Bose, Konstanze Döhner, Martin Ellis, Naseema Gangat, Jacqueline S. Garcia, Heinz Gisslinger, Jason Gotlib, Paola Guglielmelli, Vikas Gupta, Claire Harrison, Elizabeth O. Hexner, Gabriela S. Hobbs, Jean-Jacques Kiladjian, Steffen Koschmieder, Nicolaus Kroger, Andrew T. Kuykendall, Giuseppe G. Loscocco, John Mascarenhas, Lucia Masarova, Ruben Mesa, Barbara Mora, Olatoyosi Odenike, Stephen T. Oh, Animesh Pardanani, Anand Patel, Naveen Pemmaraju, Alessandro Rambaldi, Raajit Rampal, Shireen Sirhan, Natasha Szuber, Moshe Talpaz, Pankit J. Vachhani, Alessandro M. Vannucchi, Tiziano Barbui
Journal: Blood
Blood (2024) 144 (17): 1813–1820.
https://doi.org/10.1182/blood.2024025802
Published: 2024
Journal Articles

Decider-2: Prospective Randomized Multicenter Phase III Trial of Decitabine and Venetoclax Administered in Combination with All- Trans Retinoic Acid (ATRA) or Placebo in Patients with Acute Myeloid Leukemia Who Are Ineligible for Induction Chemotherapy

Michael Lübbert, Claudia Schmoor, Olga Grishina, Christoph Rummelt, Johanna Thomas, Michael Heuser, Konstanze Döhner, Hartmut Döhner, Heiko Becker, Ralph Wäsch
Journal: Blood
Blood (2023) 142 (Supplement 1): 1495.
https://doi.org/10.1182/blood-2023-181871
Published: 2023
Journal Articles

Genomic Characterization of Acute Myeloid Leukemia with Aberrations of Chromosome 7: A Multinational Cohort of 523 Patients

Adriane Halik, Marlon Tilgner, Patricia Silva, Natalia Estrada-Barreras, Robert Altwasser, Ekaterina Jahn, Michael Heuser, Hsin-An Hou, Marta Pratcorona, Robert Kerrin Hills, Klaus H Metzeler, Laurène Fenwarth, Anna Dolnik, Christine Terré, Klara Kopp, Martin Szyska, Jan Krönke, Loïc Vasseur, Bob Lowenberg, Jordi Esteve, Peter J. M. Valk, Matthieu Duchmann, Wen-Chien Chou, David C. Linch, Hartmut Döhner, Rosemary E. Gale, Konstanze Döhner, Lars Bullinger, Kenichi Yoshida, Frederik Damm
Journal: Blood
Blood (2023) 142 (Supplement 1): 63.
https://doi.org/10.1182/blood-2023-185627
Published: 2023
Journal Articles

Machine Learning Provides Individualized Prediction of Outcomes after First Complete Remission in Adult AML Patients - Results from the Harmony Platform

Alberto Hernández Sánchez, Javier Martínez Elicegui, Marta Sobas, Eric Sträng, Axel Benner, María Abáigar, Gastone Castellani, Laura Tur, Peter J. M. Valk, Angela Villaverde Ramiro, Klaus H Metzeler, Raúl Azibeiro Melchor, Jurjen Versluis, Daniele Dall'Olio, Teresa González, Jesse M. Tettero, Joaquin Martinez-Lopez, Helena Fidalgo, Jorge Sierra, Frederik Damm, Ken I Mills, Soren Lehmann, Ian Thomas, Jiří Mayer, Christian Thiede, Maria Teresa Voso, Guillermo Sanz, Konstanze Döhner, Michael Heuser, Torsten Haferlach, Amin T. Turki, Dirk Reinhardt, Michel van Speybroeck, Renate Schulze-Rath, Martje Barbus, John E Butler, Jesús María Hernández-Rivas, Brian Huntly, Gert Ossenkoppele, Hartmut Döhner, Lars Bullinger
Journal: Blood
Blood (2023) 142 (Supplement 1): 62.
https://doi.org/10.1182/blood-2023-183029
Published: 2023
Journal Articles

Influence of Bone Marrow Blast Enumeration and Co-Occurring Myelodysplasia Related Gene Mutations in NPM1 -Mutated Myeloid Malignancies

Curtis A Lachowiez, Georgios Asimomitis, Elsa Bernard, Ivory Tang, Yanis Tazi, Amanda Gilkes, Ian Thomas, Lars Bullinger, Konstanze Döhner, Hartmut Dohner, Brian Huntly, Nigel H. Russell, Sanam Loghavi, Elli Papaemmanuil
Journal: Blood
Blood (2023) 142 (Supplement 1): 818.
https://doi.org/10.1182/blood-2023-179598
Published: 2023
Journal Articles

The Genomic Landscape and Its Clinical Implication in NPM1 -Mutated AML Patients: A Study within the AMLSG 09-09 Clinical Trial

Sibylle Cocciardi, Nina Weiß, Maral Saadati, Sabrina Skambraks, Daniela Weber, Isabelle Schneider, Annika Meid, Sophia Aicher, Kathrin Bengesser-Kuhn, Andrea Corbacioglu, Verena I. Gaidzik, Frauke Theis, Walter Fiedler, Michael Kühn, Ulrich Germing, Karin T. Mayer, Michael Lübbert, Felicitas Thol, Michael Heuser, Arnold Ganser, Lars Bullinger, Axel Benner, Hartmut Döhner, Konstanze Döhner
Journal: Blood
Blood (2023) 142 (Supplement 1): 4311.
https://doi.org/10.1182/blood-2023-185566
Published: 2023
Journal Articles

Long-Term Outcome of 1296 Patients with Newly Diagnosed with APL: A Harmony Alliance Study

Luca Guarnera, Soren Lehmann, Konstanze Döhner, Hartmut Döhner, Uwe Platzbecker, Nigel H. Russell, Richard Dillon, Ian Thomas, Gert Ossenkoppele, Marco Vignetti, Edoardo la Sala, Alfonso Piciocchi, Angela Villaverde Ramiro, Laura Tur, Carmelo Gurnari, Lars Bullinger, Jesús María Hernández-Rivas, Maria Teresa Voso
Journal: Blood
Blood (2023) 142 (Supplement 1): 727.
https://doi.org/10.1182/blood-2023-185121
Published: 2023
Journal Articles

Prognostic Impact of Clonality of Myelodysplasia-Related Gene Mutations in AML

Rabea Mecklenbrauck, Nora Borchert, Piroska Klement, Carolin Funke, Maximilian Brandes, Louisa-Kristin Dallmann, Walter Fiedler, Jürgen Krauter, Arne Trummer, Bernd Hertenstein, Verena I. Gaidzik, Konstanze Döhner, Hartmut Döhner, Arnold Ganser, Felicitas Thol, Michael Heuser
Journal: Blood
Blood (2023) 142 (Supplement 1): 817.
https://doi.org/10.1182/blood-2023-179412
Published: 2023
Journal Articles

Firstline Treatment with Ruxolitinib Versus Best Available Therapy in Patients with Polycythemia Vera: Pre-Specified Interim Analysis of the Randomized Phase 2b Ruxobeat Clinical Trial of the German Study Group for Myeloproliferative Neoplasms (GSG-MPN)

Steffen Koschmieder, Susanne Isfort, Lino L. Teichmann, Philippe Schafhausen, Florian Heidel, Andreas Hochhaus, Martin Griesshammer, Katja Sockel, Philipp Jost, Denise Wolleschak, Konstanze Döhner, Joachim R. Goethert, Markus P. Radsak, Marinela Augustin, Heiko Becker, Aristoteles Giagounidis, Markus Schaich, Martine Klausmann, Nikolas Von Bubnoff, Frank Stegelmann, Maike Kortmann, Julia Frank, Martin Hellmich, Tim H. Brümmendorf
Journal: Blood
Blood (2023) 142 (Supplement 1): 619.
https://doi.org/10.1182/blood-2023-173225
Published: 2023
Journal Articles

Gemtuzumab Ozogamicin Plus Intensive Chemotherapy for Patients with NPM1 -Mutated Acute Myeloid Leukemia

Hartmut Döhner, Daniela Weber, Julia Krzykalla, Walter Fiedler, Michael W.M. Kühn, Thomas Schroeder, Karin Mayer, Michael Lübbert, Mohammad Wattad, Katharina Götze, Lars Fransecky, Elisabeth Koller, Gerald Wulf, Jan Schleicher, Mark Ringhoffer, Richard Greil, Bernd Hertenstein, Jürgen Krauter, Uwe M. Martens, David Nachbaur, Maisun Abu Samra, Sigrid Machherndl-Spandl, Nadezda Basara, Claudia Leis, Anika Schrade, Silke Kapp-Schwoerer, Lars Bullinger, Felicitas R. Thol, Michael Heuser, Peter Paschka, Verena I. Gaidzik, Maral Saadati, Axel Benner, Richard F. Schlenk, Konstanze Döhner, Arnold Ganser
Journal: Blood
Blood (2022) 140 (Supplement 1): 2010–2013.
https://doi.org/10.1182/blood-2022-166084
Published: 2022
Journal Articles

Rearrangements Involving 11q23/ KMT2A : Mutational Landscape and Prognostic Implications - Results of the Harmony Alliance AML Database

Alberto Hernández Sánchez, Teresa González, Marta Anna Sobas, Eric Sträng, Castellani Gastone, María Abáigar, Peter JM Valk, Angela Villaverde Ramiro, Axel Benner, Klaus H. Metzeler, Jesse M. Tettero, Joaquín Martínez-López, Marta Pratcorona, Javier Martinez Elicegui, Ken I Mills, Christian Thiede, Guillermo Sanz, Konstanze Döhner, Michael Heuser, Torsten Haferlach, Amin T. Turki, Dirk Reinhardt, Renate Schulze-Rath, Martje Barbus, Jesús María Hernández-Rivas, Brian James Patrick Huntly, Gert Ossenkoppele, Hartmut Döhner, Lars Bullinger
Journal: Blood
Blood (2022) 140 (Supplement 1): 551–554.
https://doi.org/10.1182/blood-2022-167480
Published: 2022
Journal Articles

Analysis of Patient-Level Data from 3 Cooperative Group Trials Confirms a Survival Advantage for NPM1 m Patients Achieving MRD-Negative CR after Intensive Induction

Konstanze Döhner, Hartmut Döhner, Daniela Weber, Silke Kapp-Schwoerer, Amanda Gilkes, Ian Thomas, Sean Johnson, Nicola Potter, Yana Bevan, Jad Othman, Nigel H. Russell, Christoph Röllig, Christian Thiede, Martin Bornhaeuser, Thomas Oellerich, Jenna Elder, Luis A. Carvajal, Zung To, Jorge DiMartino, Richard Dillon
Journal: Blood
Blood (2022) 140 (Supplement 1): 6293–6294.
https://doi.org/10.1182/blood-2022-159212
Published: 2022