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Sivahari P. Gorantla
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Journal Articles

Ruxolitinib Mediated Paradox JAK2 Hyperphosphorylation Is Due To The Protection Of Activation Loop Phosphotyrosines From Phosphatases

Sivahari P. Gorantla, Ph.D, Kolluri Suresh Babu, M.sc, Anna Lena Illert, M.D, Nikolas von Bubnoff, Christian Peschel, Justus Duyster
Journal: Blood
Blood (2013) 122 (21): 2847.
https://doi.org/10.1182/blood.V122.21.2847.2847
Published: 2013
Journal Articles

FLT3-ITD Interacts with and Phosphorylates IL-3β, and JAK1/2 Dependent IL-3β Activation Bypasses FLT3-ITD in FLT3 Kinase Independent Inhibitor Resistance in Vitro: Evidence for the Significance of IL-3β for FLT3-ITD Dependent Oncogeneic Signaling in AML.

Christoph Rummelt, Sivahari P. Gorantla, Michael Sigl, Jana Saenger, Katharina Götze, Christian Peschel, MD, Justus Duyster, Nikolas von Bubnoff
Journal: Blood
Blood (2012) 120 (21): 2423.
https://doi.org/10.1182/blood.V120.21.2423.2423
Published: 2012
Journal Articles

Oncogenic JAK2V617F requires an intact SH2-like domain for constitutive activation and induction of a myeloproliferative disease in mice

Sivahari P. Gorantla, Tobias N. Dechow, Rebekka Grundler, Anna Lena Illert, Christian Meyer zum Büschenfelde, Marcus Kremer, Christian Peschel, Justus Duyster
Journal: Blood
Blood (2010) 116 (22): 4600–4611.
https://doi.org/10.1182/blood-2009-07-236133
Published: 2010
Includes: Supplemental data
Journal Articles

Sorafenib and Nilotinib Are Candidates to Overcome Imatinib Resistance in Myeloproliferation with FIP1L1-PDGFRA.

Nikolas von Bubnoff, MD, Sivahari P Gorantla, MSc, Richard A. Engh, PhD, Taiana de Oliveira, PhD, Silvia Thoene, MSc, Espen Åberg, PhD, Christian Peschel, MD, Justus Duyster, MD
Journal: Blood
Blood (2009) 114 (22): 2912.
https://doi.org/10.1182/blood.V114.22.2912.2912
Published: 2009
Journal Articles

Identification of a Novel Mode of Kinase Inhibitor Resistance: An F604S Exchange in FIP1L1-PDGFRA Modulates FIP1L1-PDGFRA Protein Stability in a SRC-Dependent Manner

Sivahari P. Gorantla, Nikolas von Bubnoff, MD, Christian Peschel, MD, Justus Duyster, MD
Journal: Blood
Blood (2008) 112 (11): 2792.
https://doi.org/10.1182/blood.V112.11.2792.2792
Published: 2008
Journal Articles

Molecular Mechanisms of JAK2V617F Oncogenic Activation: The JAK2- V617F Mutant Utilizes the SH2 Domain for Constitutive Kinase Activity in the Presence of Unstimulated Heterodimeric Cytokine Receptor.

Sivahari P Gorantla, M.Sc., Tobias Dechow, M.D., Rebekka Grundler, Ph.D, Christian Peschel, MD, Justus Duyster
Journal: Blood
Blood (2008) 112 (11): 175.
https://doi.org/10.1182/blood.V112.11.175.175
Published: 2008
Journal Articles

Generation of Specific Resistance Profiles in FLT3-ITD and FIP1L1-PDGFRalpha towards Specifically Acting Tyrosine Kinase Inhibitors.

Nikolas von Bubnoff, MD, Silvia Thoene, Sivahari P. Gorantla, Jana Saenger, Christian Peschel, MD, Justus Duyster, MD
Journal: Blood
Blood (2006) 108 (11): 1376.
https://doi.org/10.1182/blood.V108.11.1376.1376
Published: 2006
Journal Articles

Role of SH2 Domain in JAK2-V617F Mediated Transformation.

Sivahari P. Gorantla, MSc, Tobias Dechow, M.D, Christian Peschel, M.D, Justus Duyster, M.D
Journal: Blood
Blood (2006) 108 (11): 3608.
https://doi.org/10.1182/blood.V108.11.3608.3608
Published: 2006