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Journal Articles

STAT5 and NF-κB Induced Oncogenic Mir-155 Directly Targets PU.1 in FLT3-ITD Associated AML

Dennis Gerloff, Rebekka Grundler, Daniela Braeuer-Hartmann, Christiane Katzerke, Jens-Uwe Hartmann, Carsten Mueller-Tidow, MD, Justus Duyster, MD, Daniel G. Tenen, MD, Dietger Niederwieser, Gerhard Behre, MD

Blood (2012) 120 (21): 3515.

https://doi.org/10.1182/blood.V120.21.3515.3515

Published: 2012

Journal Articles

SRC is a signaling mediator in FLT3-ITD– but not in FLT3-TKD–positive AML

Hannes Leischner, Corinna Albers, Rebekka Grundler, Elena Razumovskaya, Karsten Spiekermann, Stefan Bohlander, Lars Rönnstrand, Katharina Götze, Christian Peschel, Justus Duyster

Blood (2012) 119 (17): 4026–4033.

https://doi.org/10.1182/blood-2011-07-365726

Published: 2012

Includes: Supplemental data

Journal Articles

Oncogenic JAK2V617F requires an intact SH2-like domain for constitutive activation and induction of a myeloproliferative disease in mice

Sivahari P. Gorantla, Tobias N. Dechow, Rebekka Grundler, Anna Lena Illert, Christian Meyer zum Büschenfelde, Marcus Kremer, Christian Peschel, Justus Duyster

Blood (2010) 116 (22): 4600–4611.

https://doi.org/10.1182/blood-2009-07-236133

Published: 2010

Includes: Supplemental data

Journal Articles

Combination of c-SRC and FLT3 Inhibitors Has An Additive Inhibitory Effect on FLT3 ITD but Not on FLT3 TKD Positive Cells

Hannes Leischner, Rebekka Grundler, Corinna Albers, Anna Lena Illert, MD, Katharina Götze, MD, Christian Peschel, MD, Justus Duyster, MD

Blood (2010) 116 (21): 2892.

https://doi.org/10.1182/blood.V116.21.2892.2892

Published: 2010

Journal Articles

Unraveling STAT Signaling in NPM/ALK-Induced Lymphoma: STAT3 but Not STAT5 Is Required for Lymphomagenesis in a Bone Marrow Transplantation Model Using Conditional Knockout Mice.

Tobias Dechow, Elisa Amon, Cornelius Miething, Rebekka Grundler, Nicole Schatz, Marcus Kremer, Wolfgang Reindl, Ingo Ringshausen, Christian Peschel, Justus Duyster

Blood (2009) 114 (22): 1969.

https://doi.org/10.1182/blood.V114.22.1969.1969

Published: 2009

Journal Articles

SRC Is a Critical Signaling Mediator in FLT3-ITD Positive AML.

Hannes Leischner, Rebekka Grundler, Ph.D, Corinna Albers, Anna Lena Illert, Karsten Spiekermann, MD, Christian Peschel, MD, Justus Duyster, MD

Blood (2009) 114 (22): 477.

https://doi.org/10.1182/blood.V114.22.477.477

Published: 2009

Journal Articles

Kinase Activity of RTKs Is Dispensable for Factor Independent Growth and Transformation of a Myeloid Cell Line 32D in the Presence of Cbl Mutants.

Bülent Sargin on behalf of the Study Alliance Leukemias (SAL), Srinivasa Rao Bandi, Marion Rensinghoff, Rebekka Grundler, Lara Tickenbrock, Justus Duyster, Wolfgang E Berdel, Christian Brandts, MD, Hubert Serve, Carsten Müller-Tidow

Blood (2009) 114 (22): 3970.

https://doi.org/10.1182/blood.V114.22.3970.3970

Published: 2009

Journal Articles

Myeloproliferative Disease or Myeloid Leukemia Caused by Cbl Mutants in a Mouse Transplantation Model.

Bülent Sargin on behalf of the Study Alliance Leukemias (SAL), Srinivasa Rao Bandi, Marion Rensinghoff, Rebekka Grundler, Lara Tickenbrock, Gabriele Köhler, Justus Duyster, Wolfgang E Berdel, Hubert Serve, Christian Brandts, MD, Carsten Müller-Tidow

Blood (2009) 114 (22): 3973.

https://doi.org/10.1182/blood.V114.22.3973.3973

Published: 2009

Journal Articles

E3 ligase–defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease

Srinivasa Rao Bandi, Christian Brandts, Marion Rensinghoff, Rebekka Grundler, Lara Tickenbrock, Gabriele Köhler, Justus Duyster, Wolfgang E. Berdel, Carsten Müller-Tidow, Hubert Serve, on behalf of the Study Alliance Leukemias, Bülent Sargin

Blood (2009) 114 (19): 4197–4208.

https://doi.org/10.1182/blood-2008-12-190934

Published: 2009

Includes: Supplemental data

Journal Articles

Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor

Frank Breitenbuecher, Susanne Schnittger, Rebekka Grundler, Boyka Markova, Birgit Carius, Alexandra Brecht, Justus Duyster, Torsten Haferlach, Christoph Huber, Thomas Fischer

Blood (2009) 113 (17): 4074–4077.

https://doi.org/10.1182/blood-2007-11-125476

Published: 2009

Journal Articles

Dissecting Proto-Oncogenic PIM Serine/Threonine Kinases in FLT3-ITDInduced Leukemogenesis: PIM1 Regulates CXCL12/CXCR4-Mediated Homing and Migration

Christelle Gasser, Rebekka Grundler, Laurent Brault, Alec Bullock, Tobias Dechow, Martjin Nawijn, Sabine Woetzel, Sabine Ehret, Georgina Berridge, Anke Spoo, Christine Dierks, Andrea Biondi, Stefan Knapp, Justus Duyster, Juerg Schwaller

Blood (2008) 112 (11): 3796.

https://doi.org/10.1182/blood.V112.11.3796.3796

Published: 2008

Journal Articles

Molecular Mechanisms of JAK2V617F Oncogenic Activation: The JAK2- V617F Mutant Utilizes the SH2 Domain for Constitutive Kinase Activity in the Presence of Unstimulated Heterodimeric Cytokine Receptor.

Sivahari P Gorantla, M.Sc., Tobias Dechow, M.D., Rebekka Grundler, Ph.D, Christian Peschel, MD, Justus Duyster

Blood (2008) 112 (11): 175.

https://doi.org/10.1182/blood.V112.11.175.175

Published: 2008

Journal Articles

NPM-ALK Induces Tumour Development in a Murine Model of Anaplastic Large Cell Lymphoma (ALCL) Independently of Bcl-3 Expression.

Charlotte Gruber, MD, Rebekka Grundler, PhD, Georg Haecker, MD, Falco Fend, MD, Christian Peschel, MD, Justus Duyster, MD

Blood (2007) 110 (11): 460.

https://doi.org/10.1182/blood.V110.11.460.460

Published: 2007

Journal Articles

Flt3-dependent transformation by inactivating c-Cbl mutations in AML

Bülent Sargin, Chunaram Choudhary, Nicola Crosetto, Mirko H. H. Schmidt, Rebekka Grundler, Marion Rensinghoff, Christine Thiessen, Lara Tickenbrock, Joachim Schwäble, Christian Brandts, Benjamin August, Steffen Koschmieder, Srinivasa Rao Bandi, Justus Duyster, Wolfgang E. Berdel, Carsten Müller-Tidow, Ivan Dikic, Hubert Serve

Blood (2007) 110 (3): 1004–1012.

https://doi.org/10.1182/blood-2007-01-066076

Published: 2007

Journal Articles

The Oncogenic Fusionprotein NPM-ALK Cooperates with Bcl2 To Induce T-Cell Lymphomas in Mice.

Cornelius Miething, MD, Rebekka Grundler, PhD, Claudia Mugler, Anette Bauer, Georg Häcker, MD, Christian Peschel, MD, Justus Duyster, MD

Blood (2006) 108 (11): 2058.

https://doi.org/10.1182/blood.V108.11.2058.2058

Published: 2006

Journal Articles

Interferon Regulatory Factor 4 Is Not Required for Induction of Chronic Myeloid Leukaemia-Like Myeloproliferative Disease by Bcr/Abl in Mice.

Anna Lena Illert, MD, Cornelius Miething, MD, Rebekka Grundler, PhD, Manuel Schmidt, PhD, Andreas Burchert, MD, Andreas Neubauer, MD, Claudia Mugler, Christian Peschel, MD, Justus Duyster, MD

Blood (2005) 106 (11): 2866.

https://doi.org/10.1182/blood.V106.11.2866.2866

Published: 2005

Journal Articles

The Transcription Factors RUNX1/AML1 and RUNX3/AML2 Protect Bcr-Abl-Transformed B-Cells from Imatinib Induced Apoptosis.

Cornelius Miething, MD, Rebekka Grundler, PhD, Claudia Mugler, Heike Pfeifer, MD, Oliver Ottmann, MD, Simone Barwisch, Michael Speicher, PhD, Christian Peschel, MD, Justus Duyster, MD

Blood (2005) 106 (11): 540.

https://doi.org/10.1182/blood.V106.11.540.540

Published: 2005

Journal Articles

FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model

Rebekka Grundler, Cornelius Miething, Christian Thiede, Christian Peschel, Justus Duyster

Blood (2005) 105 (12): 4792–4799.

https://doi.org/10.1182/blood-2004-11-4430

Published: 2005

Journal Articles

A New Method of Retroviral Lineage Specific Expression Utilizing the Cre/lox System Induces a T-Lymphoid Malignancy in a Mouse Model of ALCL.

Cornelius Miething, MD, Rebekka Grundler, Claudia Mugler, Christian Peschel, MD, Justus Duyster, MD

Blood (2004) 104 (11): 348.

https://doi.org/10.1182/blood.V104.11.348.348

Published: 2004

Journal Articles

FLT3 ITD and FLT3 Tyrosine Kinase Domain Mutants Induce Different Phenotypes in a Murine Bone Marrow Transplant Model.

Rebekka Grundler, Cornelius Miething, MD, Christian Thiede, MD, Christian Peschel, MD, Justus Duyster, MD

Blood (2004) 104 (11): 3371.

https://doi.org/10.1182/blood.V104.11.3371.3371

Published: 2004

NARROW

STAT5 and NF-κB Induced Oncogenic Mir-155 Directly Targets PU.1 in FLT3-ITD Associated AML

SRC is a signaling mediator in FLT3-ITD– but not in FLT3-TKD–positive AML

Oncogenic JAK2V617F requires an intact SH2-like domain for constitutive activation and induction of a myeloproliferative disease in mice

Combination of c-SRC and FLT3 Inhibitors Has An Additive Inhibitory Effect on FLT3 ITD but Not on FLT3 TKD Positive Cells

Unraveling STAT Signaling in NPM/ALK-Induced Lymphoma: STAT3 but Not STAT5 Is Required for Lymphomagenesis in a Bone Marrow Transplantation Model Using Conditional Knockout Mice.

SRC Is a Critical Signaling Mediator in FLT3-ITD Positive AML.

Kinase Activity of RTKs Is Dispensable for Factor Independent Growth and Transformation of a Myeloid Cell Line 32D in the Presence of Cbl Mutants.

Myeloproliferative Disease or Myeloid Leukemia Caused by Cbl Mutants in a Mouse Transplantation Model.

E3 ligase–defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease

Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor

Dissecting Proto-Oncogenic PIM Serine/Threonine Kinases in FLT3-ITDInduced Leukemogenesis: PIM1 Regulates CXCL12/CXCR4-Mediated Homing and Migration

Molecular Mechanisms of JAK2V617F Oncogenic Activation: The JAK2- V617F Mutant Utilizes the SH2 Domain for Constitutive Kinase Activity in the Presence of Unstimulated Heterodimeric Cytokine Receptor.

NPM-ALK Induces Tumour Development in a Murine Model of Anaplastic Large Cell Lymphoma (ALCL) Independently of Bcl-3 Expression.

Flt3-dependent transformation by inactivating c-Cbl mutations in AML

The Oncogenic Fusionprotein NPM-ALK Cooperates with Bcl2 To Induce T-Cell Lymphomas in Mice.

Interferon Regulatory Factor 4 Is Not Required for Induction of Chronic Myeloid Leukaemia-Like Myeloproliferative Disease by Bcr/Abl in Mice.

The Transcription Factors RUNX1/AML1 and RUNX3/AML2 Protect Bcr-Abl-Transformed B-Cells from Imatinib Induced Apoptosis.

FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model

A New Method of Retroviral Lineage Specific Expression Utilizing the Cre/lox System Induces a T-Lymphoid Malignancy in a Mouse Model of ALCL.

FLT3 ITD and FLT3 Tyrosine Kinase Domain Mutants Induce Different Phenotypes in a Murine Bone Marrow Transplant Model.

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American Society of Hematology

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American Society of Hematology

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