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Volume 93, Issue 12

June 15 1999

In this Issue

INTRODUCTION: FOCUS ON HEMATOLOGY
FOCUS ON HEMATOLOGY
REVIEW ARTICLES
RAPID COMMUNICATIONS
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
CORRESPONDENCE

INTRODUCTION: FOCUS ON HEMATOLOGY

Inflammatory Reactivation and Angiogenicity of Kaposi’s Sarcoma-Associated Herpesvirus/HHV8: A Missing Link in the Pathogenesis of Acquired Immunodeficiency Syndrome-Associated Kaposi’s Sarcoma

Enrique A. Mesri

View Articletitled, Inflammatory Reactivation and Angiogenicity of Kaposi’s Sarcoma-Associated Herpesvirus/HHV8: A Missing Link in the Pathogenesis of Acquired Immunodeficiency Syndrome-Associated Kaposi’s Sarcoma

FOCUS ON HEMATOLOGY

Angiogenesis and Hematopoiesis Induced by Kaposi’s Sarcoma-Associated Herpesvirus-Encoded Interleukin-6: Presented in part at the 40th Annual American Society of Hematology Meeting, December 7, 1998 (Miami Beach, FL).

Yoshiyasu Aoki,Elaine S. Jaffe,Yuan Chang,Karen Jones,Julie Teruya-Feldstein,Patrick S. Moore,Giovanna Tosato

View Articletitled, Angiogenesis and Hematopoiesis Induced by Kaposi’s Sarcoma-Associated Herpesvirus-Encoded Interleukin-6: Presented in part at the 40th Annual American Society of Hematology Meeting, December 7, 1998 (Miami Beach, FL).

Reactivation and Persistence of Human Herpesvirus-8 Infection in B Cells and Monocytes by Th-1 Cytokines Increased in Kaposi’s Sarcoma

Paolo Monini,Sandra Colombini,Michael Stürzl,Delia Goletti,Aurelio Cafaro,Cecilia Sgadari,Stefano Buttò,Marina Franco,Patrizia Leone,Stefano Fais,Pasqualina Leone,Gianna Melucci-Vigo,Chiara Chiozzini,Francesca Carlini,Gudrun Ascherl,Emmanuelle Cornali,Christian Zietz,Eric Ramazzotti,Fabrizio Ensoli,Massimo Andreoni,Patrizio Pezzotti,Giovanni Rezza,Robert Yarchoan,Robert C. Gallo,Barbara Ensoli

View Articletitled, Reactivation and Persistence of Human Herpesvirus-8 Infection in B Cells and Monocytes by Th-1 Cytokines Increased in Kaposi’s Sarcoma

REVIEW ARTICLES

DNA Methylation

Rakesh Singal,Gordon D. Ginder

View Articletitled, DNA Methylation

RAPID COMMUNICATIONS

Granulocyte Colony-Stimulating Factor–Mobilized Allogeneic Stem Cell Transplantation Maintains Graft-Versus-Leukemia Effects Through a Perforin-Dependent Pathway While Preventing Graft-Versus-Host Disease

Luying Pan,Takanori Teshima,Geoffrey R. Hill,David Bungard,Yani S. Brinson,Vijay S. Reddy,Kenneth R. Cooke,James L.M. Ferrara

View Articletitled, Granulocyte Colony-Stimulating Factor–Mobilized Allogeneic Stem Cell Transplantation Maintains Graft-Versus-Leukemia Effects Through a Perforin-Dependent Pathway While Preventing Graft-Versus-Host Disease

Ig Heavy Chain Gene Rearrangements in T-Cell Acute Lymphoblastic Leukemia Exhibit Predominant Dh6-19 and Dh7-27 Gene Usage, Can Result in Complete V-D-J Rearrangements, and Are Rare in T-Cell Receptor β Lineage

Tomasz Szczepański,Marja J. Pongers-Willemse,Anton W. Langerak,Wietske A. Harts,Annemarie J.M. Wijkhuijs,Elisabeth R. van Wering,Jacques J.M. van Dongen

View Articletitled, Ig Heavy Chain Gene Rearrangements in T-Cell Acute Lymphoblastic Leukemia Exhibit Predominant Dh6-19 and Dh7-27 Gene Usage, Can Result in Complete V-D-J Rearrangements, and Are Rare in T-Cell Receptor β Lineage

Altered Multidrug Resistance Phenotype Caused by Anthracycline Analogues and Cytosine Arabinoside in Myeloid Leukemia

Xiu F. Hu,Alison Slater,Phillip Kantharidis,Danny Rischin,Surender Juneja,Ralph Rossi,Grace Lee,John D. Parkin,John R. Zalcberg

View Articletitled, Altered Multidrug Resistance Phenotype Caused by Anthracycline Analogues and Cytosine Arabinoside in Myeloid Leukemia

Purified Photoproducts of Merocyanine 540 Trigger Cytochrome C Release and Caspase 8-Dependent Apoptosis in Human Leukemia and Melanoma Cells

Shazib Pervaiz,Mohamed A. Seyed,Jayshreekumari L. Hirpara,Marie-Véronique Clément,Kok W. Loh

View Articletitled, Purified Photoproducts of Merocyanine 540 Trigger Cytochrome C Release and Caspase 8-Dependent Apoptosis in Human Leukemia and Melanoma Cells

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Final Height of Patients Who Underwent Bone Marrow Transplantation for Hematological Disorders During Childhood: A Study by the Working Party for Late Effects-EBMT

Amnon Cohen,Attilio Rovelli,Boudewijn Bakker,Cornelio Uderzo,Maria-Teresa van Lint,Helene Esperou,Alberto Gaiero,Alison D. Leiper,Roland Dopfer,Jean Yves Cahn,Franco Merlo,Hans J. Kolb,Gerard Socié,on behalf of the EBMT Late-Effects Working Party

View Articletitled, Final Height of Patients Who Underwent Bone Marrow Transplantation for Hematological Disorders During Childhood: A Study by the Working Party for Late Effects-EBMT

Double Induction Strategy for Acute Myeloid Leukemia: The Effect of High-Dose Cytarabine With Mitoxantrone Instead of Standard-Dose Cytarabine With Daunorubicin and 6-Thioguanine: A Randomized Trial by the German AML Cooperative Group

Thomas Büchner,Wolfgang Hiddemann,Bernhard Wörmann,Helmut Löffler,Winfried Gassmann,Torsten Haferlach,Christa Fonatsch,Detlef Haase,Claudia Schoch,Dieter Hossfeld,Eva Lengfelder,Carlo Aul,Axel Heyll,Georg Maschmeyer,Wolf-Dieter Ludwig,Maria-Cristina Sauerland,Achim Heinecke

View Articletitled, Double Induction Strategy for Acute Myeloid Leukemia: The Effect of High-Dose Cytarabine With Mitoxantrone Instead of Standard-Dose Cytarabine With Daunorubicin and 6-Thioguanine: A Randomized Trial by the German AML Cooperative Group

Cladribine Activity in Adult Langerhans-Cell Histiocytosis

Alan Saven,Carol Burian

View Articletitled, Cladribine Activity in Adult Langerhans-Cell Histiocytosis

Presenting White Blood Cell Count and Kinetics of Molecular Remission Predict Prognosis in Acute Promyelocytic Leukemia Treated With All-Trans Retinoic Acid: Result of the Randomized MRC Trial

Alan K. Burnett,David Grimwade,Ellen Solomon,Keith Wheatley,Anthony H. Goldstone,on behalf of the MRC Adult Leukaemia Working Party

View Articletitled, Presenting White Blood Cell Count and Kinetics of Molecular Remission Predict Prognosis in Acute Promyelocytic Leukemia Treated With All-Trans Retinoic Acid: Result of the Randomized MRC Trial

Serum Hyaluronan in Patients With Multiple Myeloma: Correlation With Survival and Ig Concentration

Inger Marie S. Dahl,Ingemar Turesson,Erik Holmberg,Karin Lilja,for the Nordic Myeloma Study Group

View Articletitled, Serum Hyaluronan in Patients With Multiple Myeloma: Correlation With Survival and Ig Concentration

Sequential Homoharringtonine and Interferon- in the Treatment of Early Chronic Phase Chronic Myelogenous Leukemia

Susan O’Brien,Hagop Kantarjian,Charles Koller,Eric Feldman,Miloslav Beran,Michael Andreeff,Sergio Giralt,Bruce Cheson,Michael Keating,Emil Freireich,Mary Beth Rios,Moshe Talpaz

View Articletitled, Sequential Homoharringtonine and Interferon- in the Treatment of Early Chronic Phase Chronic Myelogenous Leukemia

HEMATOPOIESIS

Dominant Negative Mutants Implicate STAT5 in Myeloid Cell Proliferation and Neutrophil Differentiation

Robert L. Ilaria, Jr,Robert G. Hawley,Richard A. Van Etten

View Articletitled, Dominant Negative Mutants Implicate STAT5 in Myeloid Cell Proliferation and Neutrophil Differentiation

Expression of p21^{Cip1/Waf1/Sdi1} and p27^Kip1Cyclin-Dependent Kinase Inhibitors During Human Hematopoiesis

Toshiyasu Taniguchi,Hisako Endo,Norio Chikatsu,Kaoru Uchimaru,Shigetaka Asano,Toshiro Fujita,Tatsutoshi Nakahata,Toru Motokura

View Articletitled, Expression of p21Cip1/Waf1/Sdi1 and p27Kip1Cyclin-Dependent Kinase Inhibitors During Human Hematopoiesis

Different Effect of Various Mutant MITF Encoded by mi,Mi^or, or Mi^wh Allele on Phenotype of Murine Mast Cells

Dae-Ki Kim,Eiichi Morii,Hideki Ogihara,Young-Mi Lee,Tomoko Jippo,Shiro Adachi,Kazutaka Maeyama,Hyung-Min Kim,Yukihiko Kitamura

View Articletitled, Different Effect of Various Mutant MITF Encoded by mi,Mior, or Miwh Allele on Phenotype of Murine Mast Cells

Differentiation in Culture of Murine Primitive Lymphohematopoietic Progenitors Toward T-Cell Lineage

Fumiya Hirayama,Yuichi Aiba,Kenji Ikebuchi,Sadayoshi Sekiguchi,Makio Ogawa

View Articletitled, Differentiation in Culture of Murine Primitive Lymphohematopoietic Progenitors Toward T-Cell Lineage

The Mouse GATA-2 Gene is Expressed in the Para-Aortic Splanchnopleura and Aorta-Gonads and Mesonephros Region

Naoko Minegishi,Jun Ohta,Hironori Yamagiwa,Norio Suzuki,Shimako Kawauchi,Yinghui Zhou,Satoru Takahashi,Norio Hayashi,James Douglas Engel,Masayuki Yamamoto

View Articletitled, The Mouse GATA-2 Gene is Expressed in the Para-Aortic Splanchnopleura and Aorta-Gonads and Mesonephros Region

Mpl Ligand Enhances the Transcription of the Cyclin D3 Gene: A Potential Role for Sp1 Transcription Factor

Zhengyu Wang,Ying Zhang,Jun Lu,Shinnshin Sun,Katya Ravid

View Articletitled, Mpl Ligand Enhances the Transcription of the Cyclin D3 Gene: A Potential Role for Sp1 Transcription Factor

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Role of Caspase in a Subset of Human Platelet Activation Responses

Anna Shcherbina,Eileen Remold-O’Donnell

View Articletitled, Role of Caspase in a Subset of Human Platelet Activation Responses

Infection With Human Immunodeficiency Virus-1 Increases Expression of Vascular Endothelial Cell Growth Factor in T Cells: Implications for Acquired Immunodeficiency Syndrome-Associated Vasculopathy

G. Ascherl,C. Hohenadl,O. Schatz,E. Shumay,J. Bogner,L. Eckhart,E. Tschachler,P. Monini,B. Ensoli,M. Stürzl

View Articletitled, Infection With Human Immunodeficiency Virus-1 Increases Expression of Vascular Endothelial Cell Growth Factor in T Cells: Implications for Acquired Immunodeficiency Syndrome-Associated Vasculopathy

Familial Overexpression of β Antithrombin Caused by an Asn135Thr Substitution

T.A. Bayston,A. Tripodi,P.M. Mannucci,E. Thompson,H. Ireland,A.C. Fitches,L. Hananeia,R.J. Olds,D.A. Lane

View Articletitled, Familial Overexpression of β Antithrombin Caused by an Asn135Thr Substitution

Some Anticardiolipin Antibodies Recognize a Combination of Phospholipids With Thrombin-Modified Antithrombin, Complement C4b-Binding Protein, and Lipopolysaccharide Binding Protein

Josiane Arvieux,Gilles Pernod,Véronique Regnault,Luc Darnige,Jérôme Garin

View Articletitled, Some Anticardiolipin Antibodies Recognize a Combination of Phospholipids With Thrombin-Modified Antithrombin, Complement C4b-Binding Protein, and Lipopolysaccharide Binding Protein

The Glycoprotein Ib/IX Complex Regulates Cell Proliferation

Shuju Feng,Nicolaos Christodoulides,Michael H. Kroll

View Articletitled, The Glycoprotein Ib/IX Complex Regulates Cell Proliferation

Physical Interaction Between Retinoic Acid Receptor and Sp1: Mechanism for Induction of Urokinase by Retinoic Acid

Yasuhiro Suzuki,Jun Shimada,Koichi Shudo,Masatoshi Matsumura,Massimo P. Crippa,Soichi Kojima

View Articletitled, Physical Interaction Between Retinoic Acid Receptor and Sp1: Mechanism for Induction of Urokinase by Retinoic Acid

Variation at the von Willebrand Factor (vWF) Gene Locus Is Associated With Plasma vWF:Ag Levels: Identification of Three Novel Single Nucleotide Polymorphisms in the vWF Gene Promoter

Angela M. Keightley,Y. Miu Lam,Jolene N. Brady,Cherie L. Cameron,David Lillicrap

View Articletitled, Variation at the von Willebrand Factor (vWF) Gene Locus Is Associated With Plasma vWF:Ag Levels: Identification of Three Novel Single Nucleotide Polymorphisms in the vWF Gene Promoter

Identification of Vascular Endothelial Growth Factor (VEGF) Receptor-2 (Flk-1) Promoter/Enhancer Sequences Sufficient for Angioblast and Endothelial Cell-Specific Transcription in Transgenic Mice

Andreas Kappel,Volker Rönicke,Annette Damert,Ingo Flamme,Werner Risau,Georg Breier

View Articletitled, Identification of Vascular Endothelial Growth Factor (VEGF) Receptor-2 (Flk-1) Promoter/Enhancer Sequences Sufficient for Angioblast and Endothelial Cell-Specific Transcription in Transgenic Mice

Induction and Suppression of Endothelial Cell Apoptosis by Sphingolipids: A Possible In Vitro Model for Cell-Cell Interactions Between Platelets and Endothelial Cells

Nobuo Hisano,Yutaka Yatomi,Kaneo Satoh,Shigeo Akimoto,Masako Mitsumata,Masayuki A. Fujino,Yukio Ozaki

View Articletitled, Induction and Suppression of Endothelial Cell Apoptosis by Sphingolipids: A Possible In Vitro Model for Cell-Cell Interactions Between Platelets and Endothelial Cells

Factor XII Tenri, a Novel Cross-Reacting Material Negative Factor XII Deficiency, Occurs Through a Proteasome-Mediated Degradation

Shinichi Kondo,Fuminori Tokunaga,Seiji Kawano,Yoichi Oono,Shunichi Kumagai,Takehiko Koide

View Articletitled, Factor XII Tenri, a Novel Cross-Reacting Material Negative Factor XII Deficiency, Occurs Through a Proteasome-Mediated Degradation

IMMUNOBIOLOGY

Identification of HLA-A2–Restricted T-Cell Epitopes Derived From the MUC1 Tumor Antigen for Broadly Applicable Vaccine Therapies

Peter Brossart,Kathrin S. Heinrich,Gernot Stuhler,Lars Behnke,Volker L. Reichardt,Stefan Stevanovic,Alexandra Muhm,Hans-Georg Rammensee,Lothar Kanz,Wolfram Brugger

View Articletitled, Identification of HLA-A2–Restricted T-Cell Epitopes Derived From the MUC1 Tumor Antigen for Broadly Applicable Vaccine Therapies

Interleukin-9 Regulates NF-κB Activity Through BCL3 Gene Induction

Mélisande Richard,Jamila Louahed,Jean-Baptiste Demoulin,Jean-Christophe Renauld

View Articletitled, Interleukin-9 Regulates NF-κB Activity Through BCL3 Gene Induction

Activated Dendritic Cells From Bone Marrow Cells of Mice Receiving Cytokine-Expressing Tumor Cells Are Associated With the Enhanced Survival of Mice Bearing Syngeneic Tumors

Shin-ichiro Fujii,Hirofumi Hamada,Koji Fujimoto,Taizo Shimomura,Makoto Kawakita

View Articletitled, Activated Dendritic Cells From Bone Marrow Cells of Mice Receiving Cytokine-Expressing Tumor Cells Are Associated With the Enhanced Survival of Mice Bearing Syngeneic Tumors

The Human (ΨL⁺μ⁻) proB Complex: Cell Surface Expression and Biochemical Structure of a Putative Transducing Receptor

Bénédicte Lemmers,Laurent Gauthier,Valérie Guelpa-Fonlupt,Michel Fougereau,Claudine Schiff

View Articletitled, The Human (ΨL+μ−) proB Complex: Cell Surface Expression and Biochemical Structure of a Putative Transducing Receptor

NEOPLASIA

Hypermethylation of the DAP-Kinase CpG Island Is a Common Alteration in B-Cell Malignancies

Rachel A. Katzenellenbogen,Stephen B. Baylin,James G. Herman

View Articletitled, Hypermethylation of the DAP-Kinase CpG Island Is a Common Alteration in B-Cell Malignancies

Fusion of the ets Transcription Factor TEL to Jak2 Results in Constitutive Jak-Stat Signaling

Jen M.-Y. Ho,Bryan K. Beattie,Jeremy A. Squire,David A. Frank,Dwayne L. Barber

View Articletitled, Fusion of the ets Transcription Factor TEL to Jak2 Results in Constitutive Jak-Stat Signaling

Increased Number of Chromosomal Imbalances and High-Level DNA Amplifications in Mantle Cell Lymphoma Are Associated With Blastoid Variants

Sı́lvia Beà,Maria Ribas,Jesús M. Hernández,Francesc Bosch,Magda Pinyol,Luis Hernández,Juan Luis Garcı́a,Teresa Flores,Marcos González,Armando López-Guillermo,Miguel A. Piris,Antonio Cardesa,Emilio Montserrat,Rosa Miró,Elı́as Campo

View Articletitled, Increased Number of Chromosomal Imbalances and High-Level DNA Amplifications in Mantle Cell Lymphoma Are Associated With Blastoid Variants

Sialoadhesin-Positive Host Macrophages Play an Essential Role in Graft-Versus-Leukemia Reactivity in Mice

Susanne Müerköster,Marian Rocha,Paul R. Crocker,Volker Schirrmacher,Victor Umansky

View Articletitled, Sialoadhesin-Positive Host Macrophages Play an Essential Role in Graft-Versus-Leukemia Reactivity in Mice

PHAGOCYTES

Human Immunoglobulin A Receptor (FcRI, CD89) Function in Transgenic Mice Requires Both FcR γ Chain and CR3 (CD11b/CD18)

Marjolein van Egmond,A.J. Hanneke van Vuuren,H. Craig Morton,Annemiek B. van Spriel,Li Shen,Frans M.A. Hofhuis,Takashi Saito,Tanya N. Mayadas,J. Sjef Verbeek,Jan G.J. van de Winkel

View Articletitled, Human Immunoglobulin A Receptor (FcRI, CD89) Function in Transgenic Mice Requires Both FcR γ Chain and CR3 (CD11b/CD18)

Lineage-Specific Modulation of Calcium Pump Expression During Myeloid Differentiation

Sophie Launay,Maurizio Giannı̀,Tünde Kovàcs,Raymonde Bredoux,Arlette Bruel,Pascal Gélébart,Fabien Zassadowski,Christine Chomienne,Jocelyne Enouf,Béla Papp

View Articletitled, Lineage-Specific Modulation of Calcium Pump Expression During Myeloid Differentiation

RED CELLS

Cellular and Subcellular Localization of the Nramp2 Iron Transporter in the Intestinal Brush Border and Regulation by Dietary Iron

F. Canonne-Hergaux,S. Gruenheid,P. Ponka,P. Gros

View Articletitled, Cellular and Subcellular Localization of the Nramp2 Iron Transporter in the Intestinal Brush Border and Regulation by Dietary Iron

TRANSFUSION MEDICINE

Normal Human Serum Contains Natural Antibodies Reactive With Autologous ABO Blood Group Antigens

Sergio H. Spalter,Srini V. Kaveri,Emmanuelle Bonnin,Jean-Claude Mani,Jean-Pierre Cartron,Michel D. Kazatchkine

View Articletitled, Normal Human Serum Contains Natural Antibodies Reactive With Autologous ABO Blood Group Antigens

The Expression of Human Blood Group Antigens During Erythropoiesis in a Cell Culture System: Presented in part as an abstract at the 39th American Society of Hematology Meeting, December 5-9, 1997 (Blood 90:175b, 1997 [abstr, suppl 1, part 2]).

Mark J.G. Southcott,Michael J.A. Tanner,David J. Anstee

View Articletitled, The Expression of Human Blood Group Antigens During Erythropoiesis in a Cell Culture System: Presented in part as an abstract at the 39th American Society of Hematology Meeting, December 5-9, 1997 (Blood 90:175b, 1997 [abstr, suppl 1, part 2]).

TRANSPLANTATION

The Impact of Obesity and Disease on Busulfan Oral Clearance in Adults

John P. Gibbs,Ted Gooley,Bruce Corneau,Georgia Murray,Patricia Stewart,Frederick R. Appelbaum,John T. Slattery

View Articletitled, The Impact of Obesity and Disease on Busulfan Oral Clearance in Adults

CORRESPONDENCE

Lack of Response to Short-Term Use of Clarithromycin (BIAXIN) in Multiple Myeloma

A.K. Stewart,S. Trudel,B.M. Al-Berouti,D.M. Sutton,J. Meharchand,C. Shustik

View Articletitled, Lack of Response to Short-Term Use of Clarithromycin (BIAXIN) in Multiple Myeloma

Jumping Translocation Breakpoint Regions Lead to Amplification of Rearranged Myc

Allen E. Coleman,Alexander L. Kovalchuk,Siegfried Janz,Alessio Palini,Thomas Ried

View Articletitled, Jumping Translocation Breakpoint Regions Lead to Amplification of Rearranged Myc

Relationship Between Levels of Leptin and Hemoglobin in Japanese Men

Masako Togo,Kazuhisa Tsukamoto,Hiroaki Satoh,Masumi Hara,Azusa Futamura,Hideo Nakarai,Kazuhiko Nakahara,Yoshiaki Hashimoto

View Articletitled, Relationship Between Levels of Leptin and Hemoglobin in Japanese Men

Engraftment of Ex Vivo-Expanded Cord Blood Cells in NOD/SCID Mice: What Is the Clinical Relevance?

Ian K. McNiece

View Articletitled, Engraftment of Ex Vivo-Expanded Cord Blood Cells in NOD/SCID Mice: What Is the Clinical Relevance?

Does Recombinant Human Granulocyte Colony-Stimulating Factor Really Prime Marrow Stem Cells in Mice and Humans?

Hans E. Johnsen

View Articletitled, Does Recombinant Human Granulocyte Colony-Stimulating Factor Really Prime Marrow Stem Cells in Mice and Humans?

The Participation of the Hemes of Flavocytochromeb₂₄₅ in the Electron Transfer Process in NADPH Oxidase

Andrew Cross

View Articletitled, The Participation of the Hemes of Flavocytochromeb245 in the Electron Transfer Process in NADPH Oxidase

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Cardiac complete response in AL amyloidosis has similar survival to matched general population

Randomized Bendamustine-Rituximab(R) + Bortezomib Induction and R + Lenalidomide Maintenance for Mantle Cell Lymphoma

Heme induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice

Interleukin-1 mediated hyperinflammation in XIAP-deficiency is associated with defective autophagy.

NOVEL THERAPEUTIC APPROACHES IN THALASSEMIAS, SICKLE CELL DISEASE AND OTHER RED CELL DISORDERS