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Issue Archive

Volume 129, Issue 13
March 30 2017
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Predicting APL lethal bleeding in the ATRA era
Clinical Trials & Observations
Anna Falanga
View Articletitled, Predicting APL lethal bleeding in the ATRA era
INSIDE BLOOD COMMENTARY
Toward autophagy-targeted therapy in lymphoma
Lapo Alinari
View Articletitled, Toward autophagy-targeted therapy in lymphoma
INSIDE BLOOD COMMENTARY
Risking thromboembolism: podoplanin and glioma
Jeffrey I. Zwicker
View Articletitled, Risking thromboembolism: podoplanin and glioma
INSIDE BLOOD COMMENTARY
APL: Oh! What a tangled web we weave
Vikram Mathews
View Articletitled, APL: Oh! What a tangled web we weave
INSIDE BLOOD COMMENTARY
The classical nature of distinctive CMML monocytes
Peter L. Greenberg
View Articletitled, The classical nature of distinctive CMML monocytes

PERSPECTIVE

Tissue tolerance: a distinct concept to control acute GVHD severity
Shin-Rong Wu,Pavan Reddy
View Articletitled, Tissue tolerance: a distinct concept to control acute GVHD severity

REVIEW ARTICLE

Allogeneic hematopoietic stem cell transplantation for MDS and CMML: recommendations from an international expert panel
Clinical Trials & Observations
Theo de Witte,David Bowen,Marie Robin,Luca Malcovati,Dietger Niederwieser,Ibrahim Yakoub-Agha,Ghulam J. Mufti,Pierre Fenaux,Guillermo Sanz,Rodrigo Martino,Emilio Paolo Alessandrino,Francesco Onida,Argiris Symeonidis,Jakob Passweg,Guido Kobbe,Arnold Ganser,Uwe Platzbecker,Jürgen Finke,Michel van Gelder,Arjan A. van de Loosdrecht,Per Ljungman,Reinhard Stauder,Liisa Volin,H. Joachim Deeg,Corey Cutler,Wael Saber,Richard Champlin,Sergio Giralt,Claudio Anasetti,Nicolaus Kröger
View Articletitled, Allogeneic hematopoietic stem cell transplantation for MDS and CMML: recommendations from an international expert panel
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Determinants of fatal bleeding during induction therapy for acute promyelocytic leukemia in the ATRA era
Clinical Trials & Observations
Simon Mantha,Debra A. Goldman,Sean M. Devlin,Ju-Whei Lee,Diana Zannino,Marnie Collins,Dan Douer,Harry J. Iland,Mark R. Litzow,Eytan M. Stein,Frederick R. Appelbaum,Richard A. Larson,Richard Stone,Bayard L. Powell,Susan Geyer,Kristina Laumann,Jacob M. Rowe,Harry Erba,Steven Coutre,Megan Othus,Jae H. Park,Peter H. Wiernik,Martin S. Tallman
View Articletitled, Determinants of fatal bleeding during induction therapy for acute promyelocytic leukemia in the ATRA era

LYMPHOID NEOPLASIA

Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma
Sophia Gayle,Sean Landrette,Neil Beeharry,Chris Conrad,Marylens Hernandez,Paul Beckett,Shawn M. Ferguson,Talya Mandelkern,Meiling Zheng,Tian Xu,Jonathan Rothberg,Henri Lichenstein
View Articletitled, Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma
Supplemental data

MYELOID NEOPLASIA

Aid is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells
Hiroyoshi Kunimoto,Anna Sophia McKenney,Cem Meydan,Kaitlyn Shank,Abbas Nazir,Franck Rapaport,Benjamin Durham,Francine E. Garrett-Bakelman,Elodie Pronier,Alan H. Shih,Ari Melnick,Jayanta Chaudhuri,Ross L. Levine
View Articletitled, <em>Aid</em> is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells
Supplemental data
MUC1-mediated induction of myeloid-derived suppressor cells in patients with acute myeloid leukemia
Athalia Rachel Pyzer,Dina Stroopinsky,Hasan Rajabi,Abigail Washington,Ashujit Tagde,Maxwell Coll,Jacqueline Fung,Mary Paty Bryant,Leandra Cole,Kristen Palmer,Poorvi Somaiya,Rebecca Karp Leaf,Myrna Nahas,Arie Apel,Salvia Jain,Malgorzata McMasters,Lourdes Mendez,James Levine,Robin Joyce,Jon Arnason,Pier Paolo Pandolfi,Donald Kufe,Jacalyn Rosenblatt,David Avigan
View Articletitled, MUC1-mediated induction of myeloid-derived suppressor cells in patients with acute myeloid leukemia
Supplemental data
Activation of PPARγ by endogenous prostaglandin J2 mediates the antileukemic effect of selenium in murine leukemia
Emily R. Finch,Diwakar B. Tukaramrao,Laura L. Goodfield,Michael D. Quickel,Robert F. Paulson,K. Sandeep Prabhu
View Articletitled, Activation of PPARγ by endogenous prostaglandin J<sub>2</sub> mediates the antileukemic effect of selenium in murine leukemia
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Endothelial CD99 supports arrest of mouse neutrophils in venules and binds to neutrophil PILRs
Debashree Goswami,Sigrid März,Yu-Tung Li,Annette Artz,Kerstin Schäfer,Ruth Seelige,Mariana Pacheco-Blanco,Ding Jing,Maria Gabriele Bixel,Masatake Araki,Kimi Araki,Ken-Ichi Yamamura,Dietmar Vestweber
View Articletitled, Endothelial CD99 supports arrest of mouse neutrophils in venules and binds to neutrophil PILRs
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents
Malte Asshoff,Verena Petzer,Matthew R. Warr,David Haschka,Piotr Tymoszuk,Egon Demetz,Markus Seifert,Wilfried Posch,Manfred Nairz,Pat Maciejewski,Peter Fowles,Christopher J. Burns,Gregg Smith,Kay-Uwe Wagner,Guenter Weiss,J. Andrew Whitney,Igor Theurl
View Articletitled, Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents
Supplemental data

THROMBOSIS AND HEMOSTASIS

Podoplanin expression in primary brain tumors induces platelet aggregation and increases risk of venous thromboembolism
Clinical Trials & Observations
Julia Riedl,Matthias Preusser,Pegah Mir Seyed Nazari,Florian Posch,Simon Panzer,Christine Marosi,Peter Birner,Johannes Thaler,Christine Brostjan,Daniela Lötsch,Walter Berger,Johannes A. Hainfellner,Ingrid Pabinger,Cihan Ay
View Articletitled, Podoplanin expression in primary brain tumors induces platelet aggregation and increases risk of venous thromboembolism
Supplemental data
The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy
Guangheng Zhu,Qing Zhang,Emily C. Reddy,Naadiya Carrim,Yunfeng Chen,Xiaohong Ruby Xu,Miao Xu,Yiming Wang,Yan Hou,Li Ma,Yan Li,Min Rui,Tania N. Petruzziello-Pellegrini,Christopher Lavalle,Tyler W. Stratton,Xi Lei,Reheman Adili,Pingguo Chen,Cheng Zhu,John A. Wilkins,Richard O. Hynes,John Freedman,Heyu Ni
View Articletitled, The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy
Supplemental data
Promyelocytic extracellular chromatin exacerbates coagulation and fibrinolysis in acute promyelocytic leukemia
Muhua Cao,Tao Li,Zhangxiu He,Lixiu Wang,Xiaoyan Yang,Yan Kou,Lili Zou,Xue Dong,Valerie A. Novakovic,Yayan Bi,Junjie Kou,Bo Yu,Shaohong Fang,Jinghua Wang,Jin Zhou,Jialan Shi
View Articletitled, Promyelocytic extracellular chromatin exacerbates coagulation and fibrinolysis in acute promyelocytic leukemia
Supplemental data

TRANSPLANTATION

Lymphangiogenesis is a feature of acute GVHD, and VEGFR-3 inhibition protects against experimental GVHD
Sarah Mertlitz,Yu Shi,Martina Kalupa,Carsten Grötzinger,Jörg Mengwasser,Katarina Riesner,Steffen Cordes,Sefer Elezkurtaj,Olaf Penack
View Articletitled, Lymphangiogenesis is a feature of acute GVHD, and VEGFR-3 inhibition protects against experimental GVHD
Supplemental data

LETTERS TO BLOOD

Efficacy and safety of dinaciclib vs ofatumumab in patients with relapsed/refractory chronic lymphocytic leukemia
Clinical Trials & Observations
Paolo Ghia,Lydia Scarfò,Susan Perez,Kumudu Pathiraja,Martha Derosier,Karen Small,Christine McCrary Sisk,Nigel Patton
View Articletitled, Efficacy and safety of dinaciclib vs ofatumumab in patients with relapsed/refractory chronic lymphocytic leukemia
Supplemental data
Overall survival among older US adults with ALL remains low despite modest improvement since 1980: SEER analysis
Clinical Trials & Observations
Mark B. Geyer,Meier Hsu,Sean M. Devlin,Martin S. Tallman,Dan Douer,Jae H. Park
View Articletitled, Overall survival among older US adults with ALL remains low despite modest improvement since 1980: SEER analysis
Supplemental data
Monocyte subset analysis accurately distinguishes CMML from MDS and is associated with a favorable MDS prognosis
Chetasi Talati,Ling Zhang,Ghada Shaheen,Andrew Kuykendall,Markus Ball,Qing Zhang,Jeffrey E. Lancet,Kenneth S. Zuckerman,Alan F. List,Rami Komrokji,Lynn Moscinski,Eric Padron
View Articletitled, Monocyte subset analysis accurately distinguishes CMML from MDS and is associated with a favorable MDS prognosis

BLOOD WORK

Clusters of paracortical plasmacytoid dendritic cells in lupus lymphadenitis
Gabriel Villada,Francisco Vega
View Articletitled, Clusters of paracortical plasmacytoid dendritic cells in lupus lymphadenitis
Peripheral T-cell lymphoma with EBV-infected “anaplastic” B-cell proliferation confined to sinuses
Keisuke Kawasaki,Kennosuke Karube
View Articletitled, Peripheral T-cell lymphoma with EBV-infected “anaplastic” B-cell proliferation confined to sinuses
  • Cover Image

    Cover Image

    issue cover

    Costaining extracellular chromatin-treated endothelial cells with lactadherin and fluorescein isothiocyanate (FITC)–annexin V reveals progressive phosphatidylserine exposure on filopodia with low (red, lactadherin) and high (green, FITC–annexin V; yellow, both lactadherin and FITC–annexin V) levels, suggesting low-level staining by lactadherin prior to bright generalized staining with both proteins. See the article by Cao et al on page 1855.

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