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Journal Articles

Duodenal macrophages control dietary iron absorption via local degradation of transferrin

Blood (2023) 141 (23): 2878–2890.

https://doi.org/10.1182/blood.2022016632

Published: 2023

Includes: Supplemental data

Journal Articles

A fully human anti-BMP6 antibody reduces the need for erythropoietin in rodent models of the anemia of chronic disease

Blood (2020) 136 (9): 1080–1090.

https://doi.org/10.1182/blood.2019004653

Published: 2020

Includes: Supplemental data

Journal Articles

A FULLY Human Bispecific Antibody Functionally Rescues Factor VIII Deficiency EX VIVO

Wei Wang, PhD, John Blackwood, PhD, Roberto Magliozzi, PhD, Leonardo Moraes, PhD, Jeffrey Hollins, PhD, Alessandro Sinopoli, PhD, Bertie Chi, PhD, Laura Mitchell, PhD, Chris Sellick, PhD, Claire Pearce, PhD, Igor Theurl, MD PhD, Volker Germaschewski, Jacob Galson, PhD, Luca Badiali, PhD, Karen Dickson, PhD, Allan Bradley, PhD, E-Chiang Lee, PhD

Blood (2019) 134 (Supplement_1): 2410.

https://doi.org/10.1182/blood-2019-123359

Published: 2019

Journal Articles

Generation and Characterisation of KY1066, a Fully Human Antibody Targeting the Enzymatic Activity of Matriptase-2 for the Treatment of Iron Overload in Beta Thalassemia

Matthew Wake, PhD, Jonathan Papworth, BSc, Luke Bayliss, BSc, Benjamin Grimshaw, PhD, Natalie Rynkiewicz, PhD, Jemima Paterson, BSc, Alicia Poindron, MSc, Erin Spearing, Emily Carter, Robyne Hudson, BSc, Verena Petzer, MD, Amelie Largounez, BSc, Audrey Belot, BSc, Anais Palin, BSc, Igor Theurl, MD PhD, Volker Germaschewski, Delphine Meynard, PhD

Blood (2019) 134 (Supplement_1): 3532.

https://doi.org/10.1182/blood-2019-124075

Published: 2019

Journal Articles

Disbalanced Erythroid Ferroportin Expression Contributes to Ineffective Erythroid Output in Anemia of Chronic Disease

Verena Petzer, MD, Piotr Tymoszuk, PhD, Markus Seifert, Natascha Brigo, MSc, Philipp Grubwieser, Sylvia Berger, Richard Hilbe, Egon Demetz, PhD, Lara Valente de Souza, MD, Günter Weiss, Univ. Prof. Dr., Dominik Wolf, Univ. Prof. Dr., Igor Theurl, MD PhD

Blood (2019) 134 (Supplement_1): 3533.

https://doi.org/10.1182/blood-2019-131202

Published: 2019

Journal Articles

On Demand Recruitment of Macrophages Is Required for Erythroid Niche Formation during Stress Erythropoiesis in the Bone Marrow

Verena Petzer, MD, Piotr Tymoszuk, PhD, Felix Böhm, Markus Seifert, Sieghart Sopper, PhD, Christa Pfeifhofer-Obermair, PhD, Natascha Brigo, MSc, Dominik Wolf, MD, Günter Weiss, MD, Igor Theurl, MD PhD

Blood (2018) 132 (Supplement 1): 848.

https://doi.org/10.1182/blood-2018-99-116244

Published: 2018

Journal Articles

A Fully Human Anti-BMP6 Antibody Reduces the Need for Erythropoietin Stimulating Agent in Two Rodent Anemia of Chronic Disease Models

Verena Petzer, MD, Piotr Tymoszuk, PhD, Matthew Wake, PhD, Luke Bayliss, BSc, Jonathan Papworth, BSc, Joana Carvalho, PhD, Cecilia Deantonio, PhD, Malte Ferdinand Asshoff, MD, Markus Seifert, Sylvia Berger, Dominik Wolf, MD, Günter Weiss, MD, Volker Germaschewski, PhD, Igor Theurl, MD PhD

Blood (2018) 132 (Supplement 1): 1045.

https://doi.org/10.1182/blood-2018-99-115747

Published: 2018

Journal Articles

Anemia at older age: etiologies, clinical implications, and management

Reinhard Stauder, Peter Valent, Igor Theurl

Blood (2018) 131 (5): 505–514.

https://doi.org/10.1182/blood-2017-07-746446

Published: 2018

Journal Articles

Non-Transferrin-Bound Iron Serves As Iron Source for Aspergillus Fumigatus Growth

Verena Petzer, MD, Piotr Tymoszuk, PhD, Markus Seifert, Dorothea Orth-Höller, MD, Martin Wermke, MD, Uwe Platzbecker, MD, Günter Weiss, MD, Hubertus Haas, PhD, Igor Theurl, MD PhD

Blood (2017) 130 (Supplement 1): 2214.

https://doi.org/10.1182/blood.V130.Suppl_1.2214.2214

Published: 2017

Journal Articles

Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents

Malte Asshoff, Verena Petzer, Matthew R. Warr, David Haschka, Piotr Tymoszuk, Egon Demetz, Markus Seifert, Wilfried Posch, Manfred Nairz, Pat Maciejewski, Peter Fowles, Christopher J. Burns, Gregg Smith, Kay-Uwe Wagner, Guenter Weiss, J. Andrew Whitney, Igor Theurl

Blood (2017) 129 (13): 1823–1830.

https://doi.org/10.1182/blood-2016-09-740092

Published: 2017

Includes: Supplemental data

Journal Articles

Preclinical Modeling of ACVR1-Dependent Hepcidin Production and Anemia By Momelotinib

Matthew Warr, Malte Asshoff, Jim Zheng, Shringi Sharma, Pat Maciejewski, Guenter Weiss, Igor Theurl, J. Andrew Whitney

Blood (2016) 128 (22): 1967.

https://doi.org/10.1182/blood.V128.22.1967.1967

Published: 2016

Journal Articles

The Extent of Labile Plasma Iron (LPI) Predicts for Non-Relapse-Mortality (NRM) in AML and MDS Patients with Systemic Iron Overload Undergoing Allogenic Stem Cell Transplantation Results of the Prospective, German-Austrian Allive Trial

Martin Wermke, MD, Julia Eckoldt, Katharina Goetze, MD, Stefan A. Klein, Gesine Bug, MD, Friedrich Stölzel, MD, Malte von Bonin, MD, Johannes Schetelig, MD M. Sc,, Michael Laniado, MD, Verena Plodeck, MD, Wolf-Karsten Hofmann, MD, Gerhard Ehninger, MD, Martin Bornhäuser, MD, Dominik Wolf, MD, Igor Theurl, MDPhD, Uwe Platzbecker, MD

Blood (2015) 126 (23): 386.

https://doi.org/10.1182/blood.V126.23.386.386

Published: 2015

Journal Articles

The Jak1/Jak2 Inhibitor Momelotinib Inhibits Alk2, Decreases Hepcidin Production and Ameliorates Anemia of Chronic Disease (ACD) in Rodents

Malte Asshoff, MD, Matthew Warr, PhD, David Haschka, MD, Piotr Tymoszuk, PhD, Verena Petzer, Egon Demetz, PhD, Pat Maciejewski, PhD, Markus Seifert, Manfred Nairz, MDPhD, Wilfried Posch, PhD, Peter Fowles, Guenter Weiss, MD, Andy Whitney, Igor Theurl, MDPhD

Blood (2015) 126 (23): 538.

https://doi.org/10.1182/blood.V126.23.538.538

Published: 2015

Journal Articles

Stress Erythropoiesis Is Associated with Changes in the Transcriptome of Central Macrophages

Ritama Gupta, Bart Crielaard, Piali Mukherjee, Igor Theurl, Carla Casu, Stefano Rivella, PhD

Blood (2014) 124 (21): 1404.

https://doi.org/10.1182/blood.V124.21.1404.1404

Published: 2014

Journal Articles

Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats

Igor Theurl, Andrea Schroll, Thomas Sonnweber, Manfred Nairz, Milan Theurl, Wolfgang Willenbacher, Kathrin Eller, Dominik Wolf, Markus Seifert, Chia Chi Sun, Jodie L. Babitt, Charles C. Hong, Tracey Menhall, Patrick Gearing, Herbert Y. Lin, Guenter Weiss

Blood (2011) 118 (18): 4977–4984.

https://doi.org/10.1182/blood-2011-03-345066

Published: 2011

Includes: Supplemental data

Journal Articles

Absence of functional Hfe protects mice from invasive Salmonella enterica Serovar Typhimurium infection via induction of lipocalin-2

Manfred Nairz, Igor Theurl, Andrea Schroll, Milan Theurl, Gernot Fritsche, Ewald Lindner, Markus Seifert, Marie-Laure V. Crouch, Klaus Hantke, Shizuo Akira, Ferric C. Fang, Günter Weiss

Blood (2009) 114 (17): 3642–3651.

https://doi.org/10.1182/blood-2009-05-223354

Published: 2009

Includes: Supplemental data

Journal Articles

Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications

Igor Theurl, Elmar Aigner, Milan Theurl, Manfred Nairz, Markus Seifert, Andrea Schroll, Thomas Sonnweber, Lukas Eberwein, Derrick R. Witcher, Anthony T. Murphy, Victor J. Wroblewski, Eva Wurz, Christian Datz, Guenter Weiss

Blood (2009) 113 (21): 5277–5286.

https://doi.org/10.1182/blood-2008-12-195651

Published: 2009

Includes: Supplemental data

Journal Articles

Response: Monocyte hepcidin and the anemia of chronic disease

Guenter Weiss, Igor Theurl

Blood (2008) 111 (7): 3902–3903.

https://doi.org/10.1182/blood-2008-01-134163

Published: 2008

Journal Articles

Autocrine formation of hepcidin induces iron retention in human monocytes

Igor Theurl, Milan Theurl, Markus Seifert, Sabine Mair, Manfred Nairz, Holger Rumpold, Heinz Zoller, Rosa Bellmann-Weiler, Harald Niederegger, Heribert Talasz, Günter Weiss

Blood (2008) 111 (4): 2392–2399.

https://doi.org/10.1182/blood-2007-05-090019

Published: 2008

Journal Articles

Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease

Igor Theurl, Verena Mattle, Markus Seifert, Mariagabriella Mariani, Christian Marth, Günter Weiss

Blood (2006) 107 (10): 4142–4148.

https://doi.org/10.1182/blood-2005-08-3364

Published: 2006

NARROW

Duodenal macrophages control dietary iron absorption via local degradation of transferrin

A fully human anti-BMP6 antibody reduces the need for erythropoietin in rodent models of the anemia of chronic disease

A FULLY Human Bispecific Antibody Functionally Rescues Factor VIII Deficiency EX VIVO

Generation and Characterisation of KY1066, a Fully Human Antibody Targeting the Enzymatic Activity of Matriptase-2 for the Treatment of Iron Overload in Beta Thalassemia

Disbalanced Erythroid Ferroportin Expression Contributes to Ineffective Erythroid Output in Anemia of Chronic Disease

On Demand Recruitment of Macrophages Is Required for Erythroid Niche Formation during Stress Erythropoiesis in the Bone Marrow

A Fully Human Anti-BMP6 Antibody Reduces the Need for Erythropoietin Stimulating Agent in Two Rodent Anemia of Chronic Disease Models

Anemia at older age: etiologies, clinical implications, and management

Non-Transferrin-Bound Iron Serves As Iron Source for Aspergillus Fumigatus Growth

Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents

Preclinical Modeling of ACVR1-Dependent Hepcidin Production and Anemia By Momelotinib

The Extent of Labile Plasma Iron (LPI) Predicts for Non-Relapse-Mortality (NRM) in AML and MDS Patients with Systemic Iron Overload Undergoing Allogenic Stem Cell Transplantation Results of the Prospective, German-Austrian Allive Trial

The Jak1/Jak2 Inhibitor Momelotinib Inhibits Alk2, Decreases Hepcidin Production and Ameliorates Anemia of Chronic Disease (ACD) in Rodents

Stress Erythropoiesis Is Associated with Changes in the Transcriptome of Central Macrophages

Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats

Absence of functional Hfe protects mice from invasive Salmonella enterica Serovar Typhimurium infection via induction of lipocalin-2

Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications

Response: Monocyte hepcidin and the anemia of chronic disease

Autocrine formation of hepcidin induces iron retention in human monocytes

Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease

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American Society of Hematology

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American Society of Hematology

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