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Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single-agent activity in patients with relapsed multiple myeloma
Phase 2 study of carfilzomib, thalidomide, and dexamethasone as induction/consolidation therapy for newly diagnosed multiple myeloma
Issue Archive
January 15 2015
In this Issue
Table of Contents
INSIDE BLOOD COMMENTARIES
PLENARY PAPER
HOW I TREAT
CLINICAL TRIALS AND OBSERVATIONS
Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single-agent activity in patients with relapsed multiple myeloma
Clinical Trials & Observations
Shaji K. Kumar,Betsy LaPlant,Wee Joo Chng,Jeffrey Zonder,Natalie Callander,Rafael Fonseca,Briant Fruth,Vivek Roy,Charles Erlichman,A. Keith Stewart,for the Mayo Phase 2 Consortium,for the Mayo Phase 2 Consortium,for the Mayo Phase 2 Consortium,for the Mayo Phase 2 Consortium,for the Mayo Phase 2 Consortium,for the Mayo Phase 2 Consortium,for the Mayo Phase 2 Consortium,for the Mayo Phase 2 Consortium,for the Mayo Phase 2 Consortium,for the Mayo Phase 2 Consortium
Phase 2 study of carfilzomib, thalidomide, and dexamethasone as induction/consolidation therapy for newly diagnosed multiple myeloma
Clinical Trials & Observations
Pieter Sonneveld,Emilie Asselbergs,Sonja Zweegman,Bronno van der Holt,Marie Jose Kersten,Edo Vellenga,Marinus van Marwijk-Kooy,Annemiek Broyl,Okke de Weerdt,Sarah Lonergan,Antonio Palumbo,Henk Lokhorst
HEMATOPOIESIS AND STEM CELLS
IMMUNOBIOLOGY
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
Recurrent ETNK1 mutations in atypical chronic myeloid leukemia
Carlo B. Gambacorti-Passerini,Carla Donadoni,Andrea Parmiani,Alessandra Pirola,Sara Redaelli,Giovanni Signore,Vincenzo Piazza,Luca Malcovati,Diletta Fontana,Roberta Spinelli,Vera Magistroni,Giuseppe Gaipa,Marco Peronaci,Alessandro Morotti,Cristina Panuzzo,Giuseppe Saglio,Emilio Usala,Dong-Wook Kim,Delphine Rea,Konstantinos Zervakis,Nora Viniou,Argiris Symeonidis,Heiko Becker,Jacqueline Boultwood,Leonardo Campiotti,Matteo Carrabba,Elena Elli,Graham R. Bignell,Elli Papaemmanuil,Peter J. Campbell,Mario Cazzola,Rocco Piazza
Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression
Philip A. Beer,David J. H. F. Knapp,Paul H. Miller,Nagarajan Kannan,Ivan Sloma,Kathy Heel,Sonja Babovic,Elizabeth Bulaeva,Gabrielle Rabu,Jefferson Terry,Brian J. Druker,Marc M. Loriaux,Keith R. Loeb,Jerald P. Radich,Wendy N. Erber,Connie J. Eaves
Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia
Elliot Stieglitz,Camille B. Troup,Laura C. Gelston,John Haliburton,Eric D. Chow,Kristie B. Yu,Jon Akutagawa,Amaro N. Taylor-Weiner,Y. Lucy Liu,Yong-Dong Wang,Kyle Beckman,Peter D. Emanuel,Benjamin S. Braun,Adam Abate,Robert B. Gerbing,Todd A. Alonzo,Mignon L. Loh
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites
Clare M. Smith,Ante Jerkovic,Hervé Puy,Ingrid Winship,Jean-Charles Deybach,Laurent Gouya,Giel van Dooren,Christopher Dean Goodman,Angelika Sturm,Hana Manceau,Geoffrey Ian McFadden,Peter David,Odile Mercereau-Puijalon,Gaétan Burgio,Brendan J. McMorran,Simon J. Foote
THROMBOSIS AND HEMOSTASIS
TRANSPLANTATION
Therapeutic activity of multiple common γ-chain cytokine inhibition in acute and chronic GVHD
Anne-Kathrin Hechinger,Benjamin A. H. Smith,Ryan Flynn,Kathrin Hanke,Cameron McDonald-Hyman,Patricia A. Taylor,Dietmar Pfeifer,Björn Hackanson,Franziska Leonhardt,Gabriele Prinz,Heide Dierbach,Annette Schmitt-Graeff,Jiri Kovarik,Bruce R. Blazar,Robert Zeiser
CONTINUING MEDICAL EDUCATION (CME) QUESTIONS
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Cover Image
Cover Image
![issue cover]()
Intraaortic hematopoietic cell clusters (IAHCs) are observed in the aorta of most vertebrate species and contain the first hematopoietic stem cells generated during embryonic development. This scanning electron microscopy image shows an IAHC (yellow) tightly attached to the endothelial layer (pink) of the aorta of an E10 mouse embryo (magnification ×1600). The subaortic mesenchyme is also artificially colored (blue) to show the delimitation between the different structures. See the article by Boisset et al on page 465.
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