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Jae-Won Shin
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Journal Articles

Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopenia

Kyle R. Spinler, Jae-Won Shin, Michele P. Lambert, Dennis E. Discher
Journal: Blood
Blood (2015) 125 (3): 525–533.
https://doi.org/10.1182/blood-2014-05-576462
Published: 2015
Includes: Supplemental data
Journal Articles

Dose-Response Titration In a Bone Marrow Niche Model Reveals AKT As a Target That Modulates Sensitivity Of Myeloid Leukemia To Extracellular Matrix Mechanics: Implications In Drug Resistance

Jae-Won Shin, Ph.D., David J. Mooney, Ph.D.
Journal: Blood
Blood (2013) 122 (21): 1292.
https://doi.org/10.1182/blood.V122.21.1292.1292
Published: 2013
Journal Articles

Platelet-Like-Particles Sheared From Myosin-II-Inhibited Megakaryocytes Highlights The Elevated Thrombocrit Of May-Hegglin Anomaly

Kyle R Spinler, B.S., Jae-Won Shin, Ph.D., Dennis E Discher, Ph.D.
Journal: Blood
Blood (2013) 122 (21): 2426.
https://doi.org/10.1182/blood.V122.21.2426.2426
Published: 2013
Journal Articles

Hierarchical Determination of Nuclear Deformability by Lamin Isoforms During Adult Hematopoiesis: Implications in Blood Cell Trafficking

Jae-Won Shin, Ph.D., Kyle R Spinler, B.S., Joe Swift, Ph.D., Dennis E Discher, Ph.D.
Journal: Blood
Blood (2012) 120 (21): 1200.
https://doi.org/10.1182/blood.V120.21.1200.1200
Published: 2012
Journal Articles

Shear-Optimized Platelet-Like-Particles From High Ploidy Mks: From Segregation to Composition and Activation

Kyle R Spinler, B.S., Jae-Won Shin, Ph.D., Dennis E Discher, Ph.D.
Journal: Blood
Blood (2012) 120 (21): 3456.
https://doi.org/10.1182/blood.V120.21.3456.3456
Published: 2012
Journal Articles

RhoA Is Essential for Maintaining Normal Megakaryocyte Ploidy Distribution and Platelet Generation

Aae Suzuki, Jae-Won Shin, Ph.D., Yuhuan Wang, PhD, Mortimer Poncz, MD, John K. Choi, MD, PhD, Dennis E Discher, Ph.D., Christopher L. Carpenter, MD, PhD, Lurong Lian, Liang Zhao, Ph.D., Yanfeng Wang, Charles S. Abrams, MD
Journal: Blood
Blood (2012) 120 (21): 385.
https://doi.org/10.1182/blood.V120.21.385.385
Published: 2012
Journal Articles

Myosin-II Is a Major Modulator of Human Hematopoietic Stem Cell Proliferation and Differentiation

Jae-Won Shin, B.S., Amnon Buxboim, Ph.D., Dennis E Discher, Ph.D.
Journal: Blood
Blood (2011) 118 (21): 2343.
https://doi.org/10.1182/blood.V118.21.2343.2343
Published: 2011
Journal Articles

Platelet Generation Under Shear Force Is Modulated by Site-Specific Phosphorylation of Myosin-II Heavy Chain,

Kyle R Spinler, B.S., Jae-Won Shin, B.S., Dennis E Discher, Ph.D.
Journal: Blood
Blood (2011) 118 (21): 3262.
https://doi.org/10.1182/blood.V118.21.3262.3262
Published: 2011
Journal Articles

Myosin-II Plays Central Roles In Cell Life and Death Decisions During Adult Hematopoiesis.

Jae-Won Shin, B.S., Kyle R Spinler, B.S., Joe Swift, Ph.D., Dennis E Discher, Ph.D.
Journal: Blood
Blood (2010) 116 (21): 1595.
https://doi.org/10.1182/blood.V116.21.1595.1595
Published: 2010