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Issue Archive

Volume 124, Issue 19
November 6 2014
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Heparan sulfate: a stem cell therapy target?
Timothy S. Olson
View Articletitled, Heparan sulfate: a stem cell therapy target?
INSIDE BLOOD COMMENTARY
Lymphotoxin-α keeps the gate open for T-cell infiltration in cHL
Uta E. Höpken
View Articletitled, Lymphotoxin-α keeps the gate open for T-cell infiltration in cHL
INSIDE BLOOD COMMENTARY
Hit the spleen, JAK!
Steven W. Lane,Ann Mullally
View Articletitled, Hit the spleen, JAK!
INSIDE BLOOD COMMENTARY
Leukemia cells make ruthless competitors
Ravi Bhatia
View Articletitled, Leukemia cells make ruthless competitors
INSIDE BLOOD COMMENTARY
Identifying mutant pathways in the histiocytoses
H. Miles Prince
View Articletitled, Identifying mutant pathways in the histiocytoses

PLENARY PAPER

TRANSPLANTATION
Dominant unit CD34+ cell dose predicts engraftment after double-unit cord blood transplantation and is influenced by bank practice
Duncan Purtill,Katherine Smith,Sean Devlin,Richard Meagher,Joann Tonon,Marissa Lubin,Doris M. Ponce,Sergio Giralt,Nancy A. Kernan,Andromachi Scaradavou,Cladd E. Stevens,Juliet N. Barker
View Articletitled, Dominant unit CD34<sup>+</sup> cell dose predicts engraftment after double-unit cord blood transplantation and is influenced by bank practice
Supplemental data

HOW I TREAT

How I treat Burkitt lymphoma in adults
Caron Jacobson,Ann LaCasce
View Articletitled, How I treat Burkitt lymphoma in adults

CLINICAL TRIALS AND OBSERVATIONS

A phase 1/2 study of an adjuvanted varicella-zoster virus subunit vaccine in autologous hematopoietic cell transplant recipients
Clinical Trials & Observations
Edward A. Stadtmauer,Keith M. Sullivan,Francisco M. Marty,Sanjeet S. Dadwal,Genovefa A. Papanicolaou,Thomas C. Shea,Sherif B. Mossad,Charalambos Andreadis,Jo-Anne H. Young,Francis K. Buadi,Mohamed El Idrissi,Thomas C. Heineman,Elchonon M. Berkowitz
View Articletitled, A phase 1/2 study of an adjuvanted varicella-zoster virus subunit vaccine in autologous hematopoietic cell transplant recipients
Supplemental data
Clinical heterogeneity and predictors of outcome in primary autoimmune hemolytic anemia: a GIMEMA study of 308 patients
Clinical Trials & Observations
Wilma Barcellini,Bruno Fattizzo,Anna Zaninoni,Tommaso Radice,Ilaria Nichele,Eros Di Bona,Monia Lunghi,Cristina Tassinari,Fiorella Alfinito,Antonella Ferrari,Anna Paola Leporace,Pasquale Niscola,Monica Carpenedo,Carla Boschetti,Nicoletta Revelli,Maria Antonietta Villa,Dario Consonni,Laura Scaramucci,Paolo De Fabritiis,Giuseppe Tagariello,Gianluca Gaidano,Francesco Rodeghiero,Agostino Cortelezzi,Alberto Zanella
View Articletitled, Clinical heterogeneity and predictors of outcome in primary autoimmune hemolytic anemia: a GIMEMA study of 308 patients
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning
Borja Saez,Francesca Ferraro,Rushdia Z. Yusuf,Colleen M. Cook,Vionnie W. C. Yu,Ana Pardo-Saganta,Stephen M. Sykes,Rahul Palchaudhuri,Amir Schajnovitz,Sutada Lotinun,Stefania Lymperi,Simon Mendez-Ferrer,Raquel del Toro,Robyn Day,Radovan Vasic,Sanket S. Acharya,Roland Baron,Charles P. Lin,Yu Yamaguchi,Amy J. Wagers,David T. Scadden
View Articletitled, Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning
Supplemental data
OVOL2 is a critical regulator of ER71/ETV2 in generating FLK1+, hematopoietic, and endothelial cells from embryonic stem cells
Brief Report
Ju Young Kim,Ra Ham Lee,Tae Min Kim,Dong-Wook Kim,Young-Joo Jeon,Sung-Ho Huh,Se-Yeong Oh,Michael Kyba,Hiroshi Kataoka,Kyunghee Choi,David M. Ornitz,Jung-Il Chae,Changwon Park
View Articletitled, OVOL2 is a critical regulator of ER71/ETV2 in generating FLK1<sup>+</sup>, hematopoietic, and endothelial cells from embryonic stem cells
Supplemental data

IMMUNOBIOLOGY

An autologous leukemia cell vaccine prevents murine acute leukemia relapse after cytarabine treatment
John D. Gibbins,Lindsay R. Ancelet,Robert Weinkove,Benjamin J. Compton,Gavin F. Painter,Troels R. Petersen,Ian F. Hermans
View Articletitled, An autologous leukemia cell vaccine prevents murine acute leukemia relapse after cytarabine treatment
Supplemental data
Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100
Cindy Eunhee Lee,David A. Fulcher,Belinda Whittle,Rochna Chand,Nicole Fewings,Matthew Field,Daniel Andrews,Christopher C. Goodnow,Matthew C. Cook
View Articletitled, Autosomal-dominant B-cell deficiency with alopecia due to a mutation in <em>NFKB2</em> that results in nonprocessable p100
Supplemental data

LYMPHOID NEOPLASIA

Reed-Sternberg cell–derived lymphotoxin-α activates endothelial cells to enhance T-cell recruitment in classical Hodgkin lymphoma
Chee Wai Fhu,Anne M. Graham,Celestial T. Yap,Suhail Al-Salam,Antonio Castella,Siew Meng Chong,Yaw-Chyn Lim
View Articletitled, Reed-Sternberg cell–derived lymphotoxin-α activates endothelial cells to enhance T-cell recruitment in classical Hodgkin lymphoma
Supplemental data
Immunohistochemistry as a valuable tool to assess CD30 expression in peripheral T-cell lymphomas: high correlation with mRNA levels
Brief Report
Céline Bossard,Maria Pamela Dobay,Marie Parrens,Laurence Lamant,Edoardo Missiaglia,Corinne Haioun,Antoine Martin,Bettina Fabiani,Richard Delarue,Olivier Tournilhac,Mauro Delorenzi,Philippe Gaulard,Laurence de Leval
View Articletitled, Immunohistochemistry as a valuable tool to assess CD30 expression in peripheral T-cell lymphomas: high correlation with mRNA levels
Supplemental data

MYELOID NEOPLASIA

JAK2 inhibitors do not affect stem cells present in the spleens of patients with myelofibrosis
Xiaoli Wang,Fei Ye,Joseph Tripodi,Cing Siang Hu,Jiajing Qiu,Vesna Najfeld,Jesse Novak,Yan Li,Raajit Rampal,Ronald Hoffman
View Articletitled, JAK2 inhibitors do not affect stem cells present in the spleens of patients with myelofibrosis
Supplemental data
JAK2V617F+ myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2
Yuki Kagoya,Akihide Yoshimi,Takako Tsuruta-Kishino,Shunya Arai,Takashi Satoh,Shizuo Akira,Mineo Kurokawa
View Articletitled, JAK2V617F<sup>+</sup> myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2
Supplemental data
Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis
Rikhia Chakraborty,Oliver A. Hampton,Xiaoyun Shen,Stephen J. Simko,Albert Shih,Harshal Abhyankar,Karen Phaik Har Lim,Kyle R. Covington,Lisa Trevino,Ninad Dewal,Donna M. Muzny,Harshavardhan Doddapaneni,Jianhong Hu,Linghua Wang,Philip J. Lupo,M. John Hicks,Diana L. Bonilla,Karen C. Dwyer,Marie-Luise Berres,Poulikos I. Poulikakos,Miriam Merad,Kenneth L. McClain,David A. Wheeler,Carl E. Allen,D. Williams Parsons
View Articletitled, Mutually exclusive recurrent somatic mutations in <em>MAP2K1</em> and <em>BRAF</em> support a central role for ERK activation in LCH pathogenesis
Supplemental data
Recurrent RAS and PIK3CA mutations in Erdheim-Chester disease
Brief Report
Jean-François Emile,Eli L. Diamond,Zofia Hélias-Rodzewicz,Fleur Cohen-Aubart,Frédéric Charlotte,David M. Hyman,Eunhee Kim,Raajit Rampal,Minal Patel,Chezi Ganzel,Shlomzion Aumann,Gladwys Faucher,Catherine Le Gall,Karen Leroy,Magali Colombat,Jean-Emmanuel Kahn,Salim Trad,Philippe Nizard,Jean Donadieu,Valérie Taly,Zahir Amoura,Omar Abdel-Wahab,Julien Haroche
View Articletitled, Recurrent <em>RAS</em> and <em>PIK3CA</em> mutations in Erdheim-Chester disease
Supplemental data

BLOOD WORK

Histiocytic clearance of neoplastic cells in acute promyelocytic leukemia
Kristian T. Schafernak,Seth J. Corey
View Articletitled, Histiocytic clearance of neoplastic cells in acute promyelocytic leukemia

CORRESPONDENCE

In contemporary patients with polycythemia vera, rates of thrombosis and risk factors delineate a new clinical epidemiology
Clinical Trials & Observations
Tiziano Barbui,Alessandra Carobbio,Elisa Rumi,Guido Finazzi,Heinz Gisslinger,Francesco Rodeghiero,Maria Luigia Randi,Alessandro Rambaldi,Bettina Gisslinger,Lisa Pieri,Irene Bertozzi,Ilaria Casetti,Animesh Pardanani,Francesco Passamonti,Alessandro M. Vannucchi,Ayalew Tefferi
View Articletitled, In contemporary patients with polycythemia vera, rates of thrombosis and risk factors delineate a new clinical epidemiology
Cryptic XPO1-MLLT10 translocation is associated with HOXA locus deregulation in T-ALL
Jonathan Bond,Aurélie Bergon,Amandine Durand,Isabelle Tigaud,Xavier Thomas,Vahid Asnafi,Salvatore Spicuglia,Elizabeth Macintyre
View Articletitled, Cryptic <em>XPO1-MLLT10</em> translocation is associated with <em>HOXA</em> locus deregulation in T-ALL
Two types of amyloid in a single heart
Shameem Mahmood,Janet A. Gilbertson,Nigel Rendell,Carol J. Whelan,Helen J. Lachmann,Ashutosh D. Wechalekar,Philip N. Hawkins,Julian D. Gillmore
View Articletitled, Two types of amyloid in a single heart
A germ line mutation in cathepsin B points toward a role in asparaginase pharmacokinetics
Clinical Trials & Observations
Laurens T. van der Meer,Esmé Waanders,Marloes Levers,Hanka Venselaar,Debbie Roeleveld,Joachim Boos,Claudia Lanvers,Roger J. Brüggemann,Roland P. Kuiper,Peter M. Hoogerbrugge,Frank N. van Leeuwen,D. Maroeska te Loo
View Articletitled, A germ line mutation in cathepsin B points toward a role in asparaginase pharmacokinetics
Supplemental data
Bendamustine, etoposide, cytarabine, melphalan, and autologous stem cell rescue produce a 72% 3-year PFS in resistant lymphoma
Clinical Trials & Observations
Giuseppe Visani,Pietro Maria Stefani,Saveria Capria,Lara Malerba,Piero Galieni,Francesco Gaudio,Giorgina Specchia,Giovanna Meloni,Filippo Gherlinzoni,Roberta Gonella,Marco Gobbi,Armando Santoro,Felicetto Ferrara,Marco Rocchi,Enrique M. Ocio,Maria Dolores Caballero,Federica Loscocco,Alessandro Isidori
View Articletitled, Bendamustine, etoposide, cytarabine, melphalan, and autologous stem cell rescue produce a 72% 3-year PFS in resistant lymphoma
Blockade of endothelial cell protein C receptor augments factor VIIa hemostatic effect in hemophilia treatment
Jagan Sundaram,Usha R. Pendurthi,Charles T. Esmon,L. Vijaya Mohan Rao
View Articletitled, Blockade of endothelial cell protein C receptor augments factor VIIa hemostatic effect in hemophilia treatment

ERRATA

Young JA, Ting KK, Li J, et al. Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin–restricted miRNA antagonists of miR-27. Blood. 2012; 122(16):2911-2919.
View Articletitled, Young JA, Ting KK, Li J, et al. Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin–restricted miRNA antagonists of miR-27. <em>Blood</em>. 2012; 122(16):2911-2919.
All Issues

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Asciminib is a novel inhibitor of ABL1 and ABL2 gene fusions in ALL but requires the ABL SH3 domain for efficacy
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How I Treat Low-risk Polycythemia Vera Patients who Require Cytoreduction
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