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Journal Articles

Loss of p53 Impairs Death Receptor Expression and Confers Resistance to CD19-Directed CAR T-Cell Therapy in B-Cell Precursor Acute Lymphoblastic Leukemia

Willem P. J. Cox, Noel M. M. Dautzenberg, Linde Dekker, Tesa Klenovšek, Marliek van Hoesel, Gawin R. Stoll, Roland P. Kuiper, Laurens T. van der Meer, Friso G. J. Calkoen, Stefan Nierkens, Frank N. van Leeuwen

Blood (2023) 142 (Supplement 1): 598.

https://doi.org/10.1182/blood-2023-177911

Published: 2023

Journal Articles

TP53 Aberrant B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Are Uniquely Sensitive to a Combination of Pyrimidine De Novo Synthesis Blockade and Replication Checkpoint Inhibition

Gawin R. Stoll, Dorette Van Ingen Schenau, Willem P. J. Cox, Ziqin Tang, Emmely M. Wagener, Laurens T. van der Meer, Frank N. van Leeuwen

Blood (2023) 142 (Supplement 1): 4189.

https://doi.org/10.1182/blood-2023-179159

Published: 2023

Journal Articles

IKZF1 Deletions Induce Resistance to AraC in BCP-ALL Reversible By CDK8/19 Inhibition

Britt M T Vervoort, Miriam Butler, Dorette van Ingen Schenau, Vincent H.J. van der Velden, Beat Bornhauser, Jean-Pierre Bourquin, Laurens T van der Meer, Frank N van Leeuwen

Blood (2022) 140 (Supplement 1): 3465–3466.

https://doi.org/10.1182/blood-2022-162246

Published: 2022

Journal Articles

Histone Deacetylase Inhibition Restores Therapy Response in TP53 mutated Acute Lymphoblastic Leukemia to Chemotherapy

Willem Cox, Miriam Butler, Dorette S van Ingen Schenau, Nadia Anderson, Lieke de Groot, Laurens T van der Meer, Frank N van Leeuwen

Blood (2022) 140 (Supplement 1): 3132–3133.

https://doi.org/10.1182/blood-2022-157118

Published: 2022

Journal Articles

MLL ( KMT2A)- rearranged Acute Lymphoblastic Leukemias Are Addicted to S-Adenosyl Methionine (SAM): Implications for Therapy

Trisha Tee, Titine Ruiter, Danique Wajon, Shuiyan Wu, Ahmed Dahaoui, Dorette S van Ingen Schenau, Laurens T van der Meer, Frank N van Leeuwen

Blood (2022) 140 (Supplement 1): 6343–6344.

https://doi.org/10.1182/blood-2022-159450

Published: 2022

Journal Articles

BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway

Miriam Butler, Dorette S. van Ingen Schenau, Jiangyan Yu, Silvia Jenni, Maria P. Dobay, Rico Hagelaar, Britt M. T. Vervoort, Trisha M. Tee, Fieke W. Hoff, Jules P. Meijerink, Steven M. Kornblau, Beat Bornhauser, Jean-Pierre Bourquin, Roland P. Kuiper, Laurens T. van der Meer, Frank N. van Leeuwen

Blood (2021) 138 (23): 2383–2395.

https://doi.org/10.1182/blood.2021011787

Published: 2021

Includes: Supplemental data

Journal Articles

Crispr/Cas9 Based Kinome Screen Identifies Novel Targets That Determine Sensitivity for Asparaginase Therapy in Acute Lymphoblastic Leukemia

Laurens T Van Der Meer, PhD, Jiangyan Yu, MSc, Miriam Butler, MSc, Jolien M R van der Meer, MSc, Roland P Kuiper, PhD, Frank N van Leeuwen, PhD

Blood (2015) 126 (23): 2629.

https://doi.org/10.1182/blood.V126.23.2629.2629

Published: 2015

Journal Articles

Cathepsin B Mediated Lysosomal Degradation in Macrophages Controls the Pharmacokinetics of the Therapeutic Protein Asparaginase

Laurens T Van Der Meer, PhD, Samantha YA Terry, PhD, Dorette van Ingen Schenau, MSc, Kiki Andree, MSc, Gerben M Franssen, BSc, Debbie Roeleveld, MSc, Bart Metselaar, PhD, Thomas Reinheckel, PhD, Peter M Hoogerbrugge, MD PhD, Otto C Boerman, PhD, Frank N van Leeuwen, PhD

Blood (2015) 126 (23): 3768.

https://doi.org/10.1182/blood.V126.23.3768.3768

Published: 2015

Journal Articles

Tumor Suppressors BTG1 and IKZF1 Cooperate during Mouse Leukemia Development and Impact Relapse Rate in Childhood Acute Lymphoblastic Leukemia

Blanca Scheijen, PhD, Esther Tijchon, Dorette van Ingen Schenau, Rene Marke, Liesbeth van Emst, Laurens T Van Der Meer, PhD, Roland P Kuiper, PhD, Judith M. Boer, PhD, Rob Pieters, MD PhD, Peter M Hoogerbrugge, MD PhD, Monique L. Den Boer, PhD, Frank N van Leeuwen, PhD

Blood (2015) 126 (23): 905.

https://doi.org/10.1182/blood.V126.23.905.905

Published: 2015

Journal Articles

The Leukemia-Associated Protein BTG1 Is Required for ATF4-Mediated Cellular Stress Responses

Laurensia Yuniati, MSc, Laurens T van der Meer, PhD, Geert JV Poelmans, MD PhD, Sander AL Palit, BSc, Caroline Rodenbach, Dorette S van IngenSchenau, MSc, Peter M Hoogerbrugge, MD PhD, Blanca Scheijen, PhD, Frank N van Leeuwen, PhD

Blood (2014) 124 (21): 3587.

https://doi.org/10.1182/blood.V124.21.3587.3587

Published: 2014

Journal Articles

The Therapeutic Protein Asparaginase Is Efficiently Cleared By Bone Barrow and Spleen Resident Macrophages

Laurens T van der Meer, PhD, Samantha YA Terry, PhD, Dorette S van IngenSchenau, MSc, Kiki C Andree, MSc, Peter M Hoogerbrugge, MD PhD, Otto C Boerman, PhD, Frank N van Leeuwen, PhD

Blood (2014) 124 (21): 3630.

https://doi.org/10.1182/blood.V124.21.3630.3630

Published: 2014

Journal Articles

Btg1-Deficiency Promotes ETV6-RUNX1-Mediated Leukemic Transformation By Upregulation of BCL6

Esther Tijchon, MSc, Liesbeth van Emst, Bsc, Dorette van Ingen Schenau, MSc, Laurens T van der Meer, PhD, Simone de Rijk, BSc, Owen Williams, PhD, Peter M Hoogerbrugge, MD PhD, Blanca Scheijen, PhD, Frank N. van Leeuwen, PhD

Blood (2014) 124 (21): 5193.

https://doi.org/10.1182/blood.V124.21.5193.5193

Published: 2014

Journal Articles

A germ line mutation in cathepsin B points toward a role in asparaginase pharmacokinetics

Laurens T. van der Meer, Esmé Waanders, Marloes Levers, Hanka Venselaar, Debbie Roeleveld, Joachim Boos, Claudia Lanvers, Roger J. Brüggemann, Roland P. Kuiper, Peter M. Hoogerbrugge, Frank N. van Leeuwen, D. Maroeska te Loo

Blood (2014) 124 (19): 3027–3029.

https://doi.org/10.1182/blood-2014-06-582627

Published: 2014

Includes: Supplemental data

Journal Articles

Loss Of BTG1 Function Promotes ETV6-RUNX1 -Mediated Leukemic Transformation

Esther J.H. Tijchon, MSc, Liesbeth van Emst, BSc, Dorette van Ingen Schenau, Msc, Laurens T. van der Meer, PhD, Owen Williams, PhD, Peter M. Hoogerbrugge, Blanca Scheijen, PhD, Frank N. van Leeuwen, PhD

Blood (2013) 122 (21): 2545.

https://doi.org/10.1182/blood.V122.21.2545.2545

Published: 2013

Journal Articles

Loss Of Tumor Suppressor BTG1 Enhances ATF4 Function and Promotes Cell Survival

Laurens T. van der Meer, PhD, Laurensia Yuniati, MSc, Esther J.H. Tijchon, MSc, Liesbeth van Emst, BSc, Manon Alkema, Caroline Rodenbach, Blanca Scheijen, PhD, Peter M. Hoogerbrugge, Frank N. van Leeuwen, PhD

Blood (2013) 122 (21): 3796.

https://doi.org/10.1182/blood.V122.21.3796.3796

Published: 2013

Journal Articles

A Germline Mutation in Cathepsin B in a Child with ALL Points towards a Key Role for This Enzyme in L-Asparaginase Pharmacokinetics.

Laurens T. van der Meer, PhD, Esmé Waanders, PhD, Marloes Levers, BSc, Hanka Venselaar, MSc, Debbie Roeleveld, BSc, Joachim Boos, MD, PhD, Claudia Lanvers-Kaminsky, PhD, Roland P. Kuiper, PhD, Peter M. Hoogerbrugge, MD, PhD, Frank N. van Leeuwen, PhD, D. Maroeska W.M. te Loo, MD, PhD

Blood (2012) 120 (21): 2458.

https://doi.org/10.1182/blood.V120.21.2458.2458

Published: 2012

Journal Articles

Focal BTG1 Deletions Occur in Specific Precursor B-Cell Acute Lymphoblastic Leukemia Subtypes At Defined Hotspots Due to Aberrant V(D)J Recombination

Blanca Scheijen, PhD, Esmé Waanders, PhD, Simon V. van Reijmersdal, BSc, Laurens T. van der Meer, PhD, Liesbeth van Emst, BSc, Eugene Verwiel, MSc, Yvet Kroeze, MSc, Edwin Sonneveld, PhD, Peter M. Hoogerbrugge, MD, PhD, Ad Geurts van Kessel, PhD, Frank N. van Leeuwen, PhD, Roland P. Kuiper, PhD

Blood (2011) 118 (21): 399.

https://doi.org/10.1182/blood.V118.21.399.399

Published: 2011

Journal Articles

Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1

Jurgen A. F. Marteijn, Laurens T. van der Meer, Liesbeth van Emst, Simon van Reijmersdal, Willemijn Wissink, Theo de Witte, Joop H. Jansen, Bert A. Van der Reijden

Blood (2007) 110 (9): 3128–3135.

https://doi.org/10.1182/blood-2006-11-058602

Published: 2007

Includes: Supplemental data

Journal Articles

Gfi1 Protein Turnover Is Regulated by the Ubiquitin Ligase Triad1.

Laurens T. van der Meer, Jurgen A.F. Marteijn, Theo M. de Witte, Joop H. Jansen, Bert A. van der Reijden

Blood (2006) 108 (11): 1173.

https://doi.org/10.1182/blood.V108.11.1173.1173

Published: 2006

Journal Articles

Diminished proteasomal degradation results in accumulation of Gfi1 protein in monocytes

Jurgen A. F. Marteijn, Laurens T. van der Meer, Liesbeth Van Emst, Theo de Witte, Joop H. Jansen, Bert A. van der Reijden

Blood (2006) 109 (1): 100–108.

https://doi.org/10.1182/blood-2006-02-003590

Published: 2006

NARROW

Loss of p53 Impairs Death Receptor Expression and Confers Resistance to CD19-Directed CAR T-Cell Therapy in B-Cell Precursor Acute Lymphoblastic Leukemia

TP53 Aberrant B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Are Uniquely Sensitive to a Combination of Pyrimidine De Novo Synthesis Blockade and Replication Checkpoint Inhibition

IKZF1 Deletions Induce Resistance to AraC in BCP-ALL Reversible By CDK8/19 Inhibition

Histone Deacetylase Inhibition Restores Therapy Response in TP53 mutated Acute Lymphoblastic Leukemia to Chemotherapy

MLL ( KMT2A)- rearranged Acute Lymphoblastic Leukemias Are Addicted to S-Adenosyl Methionine (SAM): Implications for Therapy

BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway

Crispr/Cas9 Based Kinome Screen Identifies Novel Targets That Determine Sensitivity for Asparaginase Therapy in Acute Lymphoblastic Leukemia

Cathepsin B Mediated Lysosomal Degradation in Macrophages Controls the Pharmacokinetics of the Therapeutic Protein Asparaginase

Tumor Suppressors BTG1 and IKZF1 Cooperate during Mouse Leukemia Development and Impact Relapse Rate in Childhood Acute Lymphoblastic Leukemia

The Leukemia-Associated Protein BTG1 Is Required for ATF4-Mediated Cellular Stress Responses

The Therapeutic Protein Asparaginase Is Efficiently Cleared By Bone Barrow and Spleen Resident Macrophages

Btg1-Deficiency Promotes ETV6-RUNX1-Mediated Leukemic Transformation By Upregulation of BCL6

A germ line mutation in cathepsin B points toward a role in asparaginase pharmacokinetics

Loss Of BTG1 Function Promotes ETV6-RUNX1 -Mediated Leukemic Transformation

Loss Of Tumor Suppressor BTG1 Enhances ATF4 Function and Promotes Cell Survival

A Germline Mutation in Cathepsin B in a Child with ALL Points towards a Key Role for This Enzyme in L-Asparaginase Pharmacokinetics.

Focal BTG1 Deletions Occur in Specific Precursor B-Cell Acute Lymphoblastic Leukemia Subtypes At Defined Hotspots Due to Aberrant V(D)J Recombination

Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1

Gfi1 Protein Turnover Is Regulated by the Ubiquitin Ligase Triad1.

Diminished proteasomal degradation results in accumulation of Gfi1 protein in monocytes

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American Society of Hematology

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American Society of Hematology

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