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Issue Archive

Volume 119, Issue 16
April 19 2012
Issue Cover

Table of Contents

Inside Blood

INSIDE BLOOD
Unique approach for B lymphoma therapy
Alan L. Epstein
View Articletitled, Unique approach for B lymphoma therapy
CLINICAL TRIALS
Avoiding intuxication
James B. Bussel,Douglas B. Cines
View Articletitled, Avoiding intuxication
PLATELETS & THROMBOPOIESIS
Inside platelet-leukocyte cross-talk
Paola Patrignani,Melania Dovizio
View Articletitled, Inside platelet-leukocyte cross-talk
PLATELETS & THROMBOPOIESIS
Applying the brakes to platelet activation
Lawrence F. Brass,Peisong Ma
View Articletitled, Applying the brakes to platelet activation
THROMBOSIS & HEMOSTASIS
ADAMTS13 meets MR, then what?
X. Long Zheng
View Articletitled, ADAMTS13 meets MR, then what?
THROMBOSIS & HEMOSTASIS
Improving on nature: redesigning ADAMTS13
Johanna A. Kremer Hovinga,Jan Voorberg
View Articletitled, Improving on nature: redesigning ADAMTS13
TRANSPLANTATION
MataHari reveals secrets of GVHD
Alan M. Hanash
View Articletitled, MataHari reveals secrets of GVHD

Blood Work

Naegleria fowleri meningoencephalitis
Neslihan Cetin,Douglas Blackall
View Articletitled, <em>Naegleria fowleri</em> meningoencephalitis

Perspectives

Follicular lymphoma and the immune system: from pathogenesis to antibody therapy
Freda K. Stevenson,George T. Stevenson
View Articletitled, Follicular lymphoma and the immune system: from pathogenesis to antibody therapy
Supplemental data

Review Article

Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies
Zijun Y. Xu-Monette,L. Jeffrey Medeiros,Yong Li,Robert Z. Orlowski,Michael Andreeff,Carlos E. Bueso-Ramos,Timothy C. Greiner,Timothy J. McDonnell,Ken H. Young
View Articletitled, Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies
Supplemental data

Clinical Trials and Observations

Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure
Clinical Trials & Observations
Michael R. DeBaun,Sharada A. Sarnaik,Mark J. Rodeghier,Caterina P. Minniti,Thomas H. Howard,Rathi V. Iyer,Baba Inusa,Paul T. Telfer,Melanie Kirby-Allen,Charles T. Quinn,Françoise Bernaudin,Gladstone Airewele,Gerald M. Woods,Julie Ann Panepinto,Beng Fuh,Janet K. Kwiatkowski,Allison A. King,Melissa M. Rhodes,Alexis A. Thompson,Mark E. Heiny,Rupa C. Redding-Lallinger,Fenella J. Kirkham,Hernan Sabio,Corina E. Gonzalez,Suzanne L. Saccente,Karen A. Kalinyak,John J. Strouse,Jason M. Fixler,Mae O. Gordon,J. Phillip Miller,Michael J. Noetzel,Rebecca N. Ichord,James F. Casella
View Articletitled, Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure
Low-dose rituximab in adult patients with idiopathic autoimmune hemolytic anemia: clinical efficacy and biologic studies
Clinical Trials & Observations
Wilma Barcellini,Francesco Zaja,Anna Zaninoni,Francesca Guia Imperiali,Marta Lisa Battista,Eros Di Bona,Bruno Fattizzo,Dario Consonni,Agostino Cortelezzi,Renato Fanin,Alberto Zanella
View Articletitled, Low-dose rituximab in adult patients with idiopathic autoimmune hemolytic anemia: clinical efficacy and biologic studies

Hematopoiesis and Stem Cells

Angiotensin-converting enzyme (CD143) specifies emerging lympho-hematopoietic progenitors in the human embryo
Lidia Sinka,Katia Biasch,Ibrahim Khazaal,Bruno Péault,Manuela Tavian
View Articletitled, Angiotensin-converting enzyme (CD143) specifies emerging lympho-hematopoietic progenitors in the human embryo
Supplemental data
Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis
Louis C. Doré,Timothy M. Chlon,Christopher D. Brown,Kevin P. White,John D. Crispino
View Articletitled, Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis
Supplemental data

Immunobiology

Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity
Lishomwa C. Ndhlovu,Sandra Lopez-Vergès,Jason D. Barbour,R. Brad Jones,Aashish R. Jha,Brian R. Long,Eric C. Schoeffler,Tsuyoshi Fujita,Douglas F. Nixon,Lewis L. Lanier
View Articletitled, Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity
Supplemental data
Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice
Laurens P. Kil,Marjolein J. W. de Bruijn,Menno van Nimwegen,Odilia B. J. Corneth,Jan Piet van Hamburg,Gemma M. Dingjan,Friedrich Thaiss,Guus F. Rimmelzwaan,Dirk Elewaut,Dianne Delsing,Pieter Fokko van Loo,Rudi W. Hendriks
View Articletitled, Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice
Supplemental data

Lymphoid Neoplasia

Ofatumumab monotherapy in rituximab-refractory follicular lymphoma: results from a multicenter study
Clinical Trials & Observations
Myron S. Czuczman,Luis Fayad,Vincent Delwail,Guillaume Cartron,Eric Jacobsen,Kazimierz Kuliczkowski,Brian K. Link,Lauren Pinter-Brown,John Radford,Andrzej Hellmann,Eve Gallop-Evans,Christine G. DiRienzo,Nancy Goldstein,Ira Gupta,Roxanne C. Jewell,Thomas S. Lin,Steen Lisby,Martin Schultz,Charlotte A. Russell,Anton Hagenbeek,on behalf of the 405 Study Investigators
View Articletitled, Ofatumumab monotherapy in rituximab-refractory follicular lymphoma: results from a multicenter study
Supplemental data
Molecular distinctions between pediatric and adult mature B-cell non-Hodgkin lymphomas identified through genomic profiling
Karen E. Deffenbacher,Javeed Iqbal,Warren Sanger,Yulei Shen,Cynthia Lachel,Zhongfeng Liu,Yanyan Liu,Megan S. Lim,Sherrie L. Perkins,Kai Fu,Lynette Smith,James Lynch,Louis M. Staudt,Lisa M. Rimsza,Elaine Jaffe,Andreas Rosenwald,German K. Ott,Jan Delabie,Elias Campo,Randy D. Gascoyne,Mitchell S. Cairo,Dennis D. Weisenburger,Timothy C. Greiner,Thomas G. Gross,Wing C. Chan
View Articletitled, Molecular distinctions between pediatric and adult mature B-cell non-Hodgkin lymphomas identified through genomic profiling
Supplemental data
Dual-targeting immunotherapy of lymphoma: potent cytotoxicity of anti-CD20/CD74 bispecific antibodies in mantle cell and other lymphomas
Pankaj Gupta,David M. Goldenberg,Edmund A. Rossi,Thomas M. Cardillo,John C. Byrd,Natarajan Muthusamy,Richard R. Furman,Chien-Hsing Chang
View Articletitled, Dual-targeting immunotherapy of lymphoma: potent cytotoxicity of anti-CD20/CD74 bispecific antibodies in mantle cell and other lymphomas
Supplemental data

Myeloid Neoplasia

Correlation of CD33 expression level with disease characteristics and response to gemtuzumab ozogamicin containing chemotherapy in childhood AML
Clinical Trials & Observations
Jessica A. Pollard,Todd A. Alonzo,Michael Loken,Robert B. Gerbing,Phoenix A. Ho,Irwin D. Bernstein,Susana C. Raimondi,Betsy Hirsch,Janet Franklin,Roland B. Walter,Alan Gamis,Soheil Meshinchi
View Articletitled, Correlation of CD33 expression level with disease characteristics and response to gemtuzumab ozogamicin containing chemotherapy in childhood AML
Efficacy of vorinostat in a murine model of polycythemia vera
Hajime Akada,Saeko Akada,Ajeet Gajra,Alicia Bair,Stephen Graziano,Robert E. Hutchison,Golam Mohi
View Articletitled, Efficacy of vorinostat in a murine model of polycythemia vera
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Cysteinyl leukotriene overproduction in aspirin-exacerbated respiratory disease is driven by platelet-adherent leukocytes
Tanya M. Laidlaw,Molly S. Kidder,Neil Bhattacharyya,Wei Xing,Shiliang Shen,Ginger L. Milne,Mariana C. Castells,Heng Chhay,Joshua A. Boyce
View Articletitled, Cysteinyl leukotriene overproduction in aspirin-exacerbated respiratory disease is driven by platelet-adherent leukocytes
Supplemental data

Platelets and Thrombopoiesis

Regulator of G-protein signaling 18 integrates activating and inhibitory signaling in platelets
Kristina Gegenbauer,Giuliano Elia,Alfonso Blanco-Fernandez,Albert Smolenski
View Articletitled, Regulator of G-protein signaling 18 integrates activating and inhibitory signaling in platelets

Red Cells, Iron, and Erythropoiesis

Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait
Lauren Gong,Catherine Maiteki-Sebuguzi,Philip J. Rosenthal,Alan E. Hubbard,Chris J. Drakeley,Grant Dorsey,Bryan Greenhouse
View Articletitled, Evidence for both innate and acquired mechanisms of protection from <em>Plasmodium falciparum</em> in children with sickle cell trait
Incidence of neoplasia in Diamond Blackfan anemia: a report from the Diamond Blackfan Anemia Registry
Clinical Trials & Observations
Adrianna Vlachos,Philip S. Rosenberg,Eva Atsidaftos,Blanche P. Alter,Jeffrey M. Lipton
View Articletitled, Incidence of neoplasia in Diamond Blackfan anemia: a report from the Diamond Blackfan Anemia Registry
The hypersensitive sites of the murine β-globin locus control region act independently to affect nuclear localization and transcriptional elongation
M. A. Bender,Tobias Ragoczy,Jongjoo Lee,Rachel Byron,Agnes Telling,Ann Dean,Mark Groudine
View Articletitled, The hypersensitive sites of the murine β-globin locus control region act independently to affect nuclear localization and transcriptional elongation
Supplemental data

Thrombosis and Hemostasis

The macrophage mannose receptor promotes uptake of ADAMTS13 by dendritic cells
Nicoletta Sorvillo,Wouter Pos,Linda M. van den Berg,Rob Fijnheer,Luisa Martinez-Pomares,Teunis B. Geijtenbeek,Eszter Herczenik,Jan Voorberg
View Articletitled, The macrophage mannose receptor promotes uptake of ADAMTS13 by dendritic cells
Supplemental data
Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura
Cui Jian,Juan Xiao,Lingjie Gong,Christopher G. Skipwith,Sheng-Yu Jin,Hau C. Kwaan,X. Long Zheng
View Articletitled, Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura
Supplemental data

Transplantation

Induction of acute GVHD by sex-mismatched H-Y antigens in the absence of functional radiosensitive host hematopoietic–derived antigen-presenting cells
Tomomi Toubai,Isao Tawara,Yaping Sun,Chen Liu,Evelyn Nieves,Rebecca Evers,Thea Friedman,Robert Korngold,Pavan Reddy
View Articletitled, Induction of acute GVHD by sex-mismatched H-Y antigens in the absence of functional radiosensitive host hematopoietic–derived antigen-presenting cells
Supplemental data
Acute graft-versus-host disease biomarkers measured during therapy can predict treatment outcomes: a Blood and Marrow Transplant Clinical Trials Network study
John E. Levine,Brent R. Logan,Juan Wu,Amin M. Alousi,Javier Bolaños-Meade,James L. M. Ferrara,Vincent T. Ho,Daniel J. Weisdorf,Sophie Paczesny
View Articletitled, Acute graft-versus-host disease biomarkers measured during therapy can predict treatment outcomes: a Blood and Marrow Transplant Clinical Trials Network study
Supplemental data

Correspondence

Risk of second cancers in chronic myeloproliferative neoplasms
Maria Chiara Susini,Giovanna Masala,Elisabetta Antonioli,Lisa Pieri,Paola Guglielmelli,Domenico Palli,Alberto Bosi,Alessandro M. Vannucchi
View Articletitled, Risk of second cancers in chronic myeloproliferative neoplasms
Response: cancer risk in chronic myeloproliferative neoplasms
Henrik Frederiksen,Dóra Körmendiné Farkas,Christian Fynbo Christiansen,Hans Carl Hasselbalch,Henrik Toft Sørensen
View Articletitled, Response: cancer risk in chronic myeloproliferative neoplasms
Regulation of human dendritic cells by B cells depends on the signals they receive
Mohan S. Maddur,Srini V. Kaveri,Jagadeesh Bayry
View Articletitled, Regulation of human dendritic cells by B cells depends on the signals they receive
Rearrangement of NOTCH1 or BCL3 can independently trigger progression of CLL
Kim De Keersmaecker,Lucienne Michaux,André Bosly,Carlos Graux,Julio Finalet Ferreiro,Peter Vandenberghe,Jan Cools,Iwona Wlodarska
View Articletitled, Rearrangement of <em>NOTCH1</em> or <em>BCL3</em> can independently trigger progression of CLL
Persistently high quality of life conferred by coexisting congenital deficiency of terminal complement C9 in a paroxysmal nocturnal hemoglobinuria patient
Nobuyoshi Hanaoka,Yoshiko Murakami,Masahide Nagata,Shoichi Nagakura,Yuji Yonemura,Takashi Sonoki,Taroh Kinoshita,Hideki Nakakuma
View Articletitled, Persistently high quality of life conferred by coexisting congenital deficiency of terminal complement C9 in a paroxysmal nocturnal hemoglobinuria patient
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Data mining for second malignancies after CAR-T
Silva A, Almeida ARM, Cachucho A, et al. Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma. Blood. 2021;138(12):1040-1052.
MRD and EFS in pediatric T-lymphoblastic lymphoma
Outcomes of younger patients with mantle-cell lymphoma experiencing late relapse (>24 months): the LATE-POD study
Mutational profile of previously treated chronic lymphocytic leukemia patients progressing on acalabrutinib or ibrutinib

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