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Journal Articles

Effects of Eculizumab Treatment on the Quality of Life in Patients with Paroxysmal Nocturnal Hemoglobinuria Treated in Japan

Yasutaka Ueda, MD PhD, Naoshi Obara, MD PhD, Yuji Yonemura, MD PhD, Hideyoshi Noji, MD PhD, Takahisa Matsuda, Hirozumi Akiyama, Takayuki Ikezoe, MD, PhD, Shigeru Chiba, MD PhD, Yoshinobu Kanda, MD PhD, Tatsuya Kawaguchi, MD PhD, Tsutomu Shichishima, MD PhD, Hideki Nakakuma, MD PhD, Shinichiro Okamoto, MD PhD, Jun-Ichi Nishimura, MD PhD, Yuzuru Kanakura, MD PhD, Haruhiko Ninomiya, MD PhD

Blood (2017) 130 (Supplement 1): 4749.

https://doi.org/10.1182/blood.V130.Suppl_1.4749.4749

Published: 2017

Journal Articles

Analysis of 3 Year Post Marketing Surveillance of Eculizumab in Japan

Blood (2014) 124 (21): 4870.

https://doi.org/10.1182/blood.V124.21.4870.4870

Published: 2014

Journal Articles

Persistently high quality of life conferred by coexisting congenital deficiency of terminal complement C9 in a paroxysmal nocturnal hemoglobinuria patient

Nobuyoshi Hanaoka, Yoshiko Murakami, Masahide Nagata, Shoichi Nagakura, Yuji Yonemura, Takashi Sonoki, Taroh Kinoshita, Hideki Nakakuma

Blood (2012) 119 (16): 3866–3868.

https://doi.org/10.1182/blood-2012-02-408161

Published: 2012

Journal Articles

Pretreatment of Low-Dose Decitabine to Leukemia Cells Markedly Enhances the Cytotoxicity of Gemtuzumab Ozogamicin

Miwa Kurimoto, MD, Hiroshi Matsuoka, MD, PhD, Nobuyoshi Hanaoka, MD, PhD, Shima Uneda, MD, PhD, Takashi Sonoki, MD, PhD, Hideki Nakakuma, MD, PhD

Blood (2011) 118 (21): 5000.

https://doi.org/10.1182/blood.V118.21.5000.5000

Published: 2011

Journal Articles

Chronic Renal Insufficiency in Japanese Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH): Improvement with Eculizumab Treatment in the Long-Term Follow-up of the AEGIS Study.

Yuzuru Kanakura, MD, PhD, Kazuma Ohyashiki, MD, PhD, Tsutomu Shichishima, MD, PhD, Shinichiro Okamoto, MD, PhD, Kiyoshi Ando, MD, PhD, Haruhiko Ninomiya, MD, PhD, Tatsuya Kawaguchi, MD, PhD, Shinji Nakao, MD, PhD, Hideki Nakakuma, MD, PhD, Jun-ichi Nishimura, MD, PhD, Taroh Kinoshita, PhD, Camille Bedrosian, MD, Marye Ellen Valentine, MS, Keiya Ozawa, MD, PhD, Mitsuhiro Omine, MD

Blood (2009) 114 (22): 1980.

https://doi.org/10.1182/blood.V114.22.1980.1980

Published: 2009

Journal Articles

Selective FLT3 Inhibitor FI-700 Neutralizes Mcl-1 and Enhances p53-Mediated Apoptosis in Acute Myeloid Leukemia (AML) Cells with Activating Mutations of FLT3 Via Mcl-1/Noxa Axis.

Kensuke Kojima, MD, PhD, Marina Konopleva, MD, PhD, Twee Tsao, Michael Andreeff, MD, PhD, Hiroshi Ishida, Yukimasa Shiotsu, PhD, Linhua Jin, PhD, Yoko Tabe, MD, PhD, Hideki Nakakuma, MD, PhD

Blood (2009) 114 (22): 2597.

https://doi.org/10.1182/blood.V114.22.2597.2597

Published: 2009

Journal Articles

Safety and Efficacy of the Terminal Complement Inhibitor Eculizumab in Japanese Patients with Paroxysmal Nocturnal Hemoglobinuria: AEGIS Phase II Clinical Study Results.

Yuzuru Kanakura, MD, PhD, Kazuma Ohyashiki, MD, Tsutomu Shichishima, MD, PhD, Shinichiro Okamoto, MD, PhD, Kiyoshi Ando, MD, Haruhiko Ninomiya, MD, PhD, Tatsuya Kawaguchi, MD, PhD, Shinji Nakao, MD, Hideki Nakakuma, MD, PhD, Jun-Ichi Nishimura, MD, PhD, Taroh Kinoshita, PhD, Camille Bedrosian, MD, Marye Ellen Valentine, MS, Keiya Ozawa, MD, PhD, Mitsuhiro Omine, MD

Blood (2008) 112 (11): 3438.

https://doi.org/10.1182/blood.V112.11.3438.3438

Published: 2008

Journal Articles

Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia

Kensuke Kojima, Marina Konopleva, Twee Tsao, Hideki Nakakuma, Michael Andreeff

Blood (2008) 112 (7): 2886–2895.

https://doi.org/10.1182/blood-2008-01-128611

Published: 2008

Journal Articles

NKG2D-Mediated Marrow Injury in Paroxysmal Nocturnal Hemoglobinuria and Its Related Disorders.

Nobuyoshi Hanaoka, MD, PhD, Tatsuya Kawaguchi, MD, PhD, Kentaro Horikawa, MD, PhD, Shoichi Nagakura, MD, PhD, Sonoko Ishihara, MD, PhD, Yasuchika Tsuzuki, MD, Yuji Yonemura, MD, PhD, Hideki Nakakuma, MD, PhD

Blood (2007) 110 (11): 3674.

https://doi.org/10.1182/blood.V110.11.3674.3674

Published: 2007

Journal Articles

ULBP and MICA/B as Novel Indicators for Both Diagnosis of Immune-Mediated Marrow Injury and Favorable Response to Immunosuppressive Therapy in Bone Marrow Failure Syndromes.

Nobuyoshi Hanaoka, MD, PhD, Tatsuya Kawaguchi, MD, PhD, Kentaro Horikawa, MD, PhD, Shoichi Nagakura, MD, PhD, Yasuchika Tsuzuki, MD, Yuji Yonemura, MD, PhD, Hideki Nakakuma, MD, PhD

Blood (2006) 108 (11): 990.

https://doi.org/10.1182/blood.V108.11.990.990

Published: 2006

Journal Articles

Immunoselection by natural killer cells of PIGA mutant cells missing stress-inducible ULBP

Nobuyoshi Hanaoka, Tatsuya Kawaguchi, Kentaro Horikawa, Shoichi Nagakura, Hiroaki Mitsuya, Hideki Nakakuma

Blood (2006) 107 (3): 1184–1191.

https://doi.org/10.1182/blood-2005-03-1337

Published: 2006

Journal Articles

Appearance of Stress-Inducible Membrane Proteins ULBP on Blood Cells of Patients with PNH, Aplastic Anemia, and MDS: Possible Implication of ULBP in Immune-Mediated Marrow Injury.

Nobuyoshi Hanaoka, MD, Kentaro Horikawa, MD, PhD, Yasuchika Tsuzuki, MD, Shoichi Nagakura, MD, PhD, Sonoko Ishihara, MD, PhD, Hiroaki Mitsuya, MD, PhD, Hideki Nakakuma, MD, PhD, Tatsuya Kawaguchi, MD, PhD

Blood (2005) 106 (11): 1041.

https://doi.org/10.1182/blood.V106.11.1041.1041

Published: 2005

Journal Articles

Decrease in Sensitivity of PIG-A -Mutant Cells to Natural Killer Cells Conferred by Missing of Stress-Inducible Membrane Proteins ULBPs.

Nobuyoshi Hanaoka, MD, Tatsuya Kawaguchi, MD, PhD, Kentaro Horikawa, MD, PhD, Shoichi Nagakura, MD, PhD, Sonoko Ishihara, MD, PhD, Hiroaki Mitsuya, MD, PhD, Hideki Nakakuma, MD, PhD

Blood (2004) 104 (11): 2829.

https://doi.org/10.1182/blood.V104.11.2829.2829

Published: 2004

Journal Articles

Blocking Complement-Mediated Hemolysis of PNH Erythrocytes by RNA Aptamers to C8 and C9.

Jun-ichi Nishimura, MD, PhD, Shahid Nimjee, Haixiang Jiang, MD, PhD, Tatsuya Kawaguchi, MD, PhD, Hideki Nakakuma, MD, PhD, Mitsuhiro Omine, MD, Michael M. Frank, MD, Russell E. Ware, MD, PhD, Bruce A. Sullenger, PhD

Blood (2004) 104 (11): 2824.

https://doi.org/10.1182/blood.V104.11.2824.2824

Published: 2004

Journal Articles

Decreased susceptibility of leukemic cells with PIG-A mutation to natural killer cells in vitro

Shoichi Nagakura, Sonoko Ishihara, Daniel E. Dunn, Jun-ichi Nishimura, Tatsuya Kawaguchi, Kentaro Horikawa, Michihiro Hidaka, Tadashi Kagimoto, Nozomu Eto, Hiroaki Mitsuya, Taroh Kinoshita, Neal S. Young, Hideki Nakakuma

Blood (2002) 100 (3): 1031–1037.

https://doi.org/10.1182/blood.V100.3.1031

Published: 2002

Journal Articles

Frequent detection of T cells with mutations of the hypoxanthine-guanine phosphoribosyl transferase gene in patients with paroxysmal nocturnal hemoglobinuria

Kentaro Horikawa, Tatsuya Kawaguchi, Sonoko Ishihara, Shoichi Nagakura, Michihiro Hidaka, Tadashi Kagimoto, Hiroaki Mitsuya, Hideki Nakakuma

Blood (2002) 99 (1): 24–29.

https://doi.org/10.1182/blood.V99.1.24

Published: 2002

Journal Articles

Apoptosis Resistance of Blood Cells From Patients With Paroxysmal Nocturnal Hemoglobinuria, Aplastic Anemia, and Myelodysplastic Syndrome

Kentaro Horikawa, Hideki Nakakuma, Tatsuya Kawaguchi, Norihiro Iwamoto, Shoichi Nagakura, Tadashi Kagimoto, Kiyoshi Takatsuki

Blood (1997) 90 (7): 2716–2722.

https://doi.org/10.1182/blood.V90.7.2716

Published: 1997

NARROW

Effects of Eculizumab Treatment on the Quality of Life in Patients with Paroxysmal Nocturnal Hemoglobinuria Treated in Japan

Analysis of 3 Year Post Marketing Surveillance of Eculizumab in Japan

Persistently high quality of life conferred by coexisting congenital deficiency of terminal complement C9 in a paroxysmal nocturnal hemoglobinuria patient

Pretreatment of Low-Dose Decitabine to Leukemia Cells Markedly Enhances the Cytotoxicity of Gemtuzumab Ozogamicin

Chronic Renal Insufficiency in Japanese Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH): Improvement with Eculizumab Treatment in the Long-Term Follow-up of the AEGIS Study.

Selective FLT3 Inhibitor FI-700 Neutralizes Mcl-1 and Enhances p53-Mediated Apoptosis in Acute Myeloid Leukemia (AML) Cells with Activating Mutations of FLT3 Via Mcl-1/Noxa Axis.

Safety and Efficacy of the Terminal Complement Inhibitor Eculizumab in Japanese Patients with Paroxysmal Nocturnal Hemoglobinuria: AEGIS Phase II Clinical Study Results.

Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia

NKG2D-Mediated Marrow Injury in Paroxysmal Nocturnal Hemoglobinuria and Its Related Disorders.

ULBP and MICA/B as Novel Indicators for Both Diagnosis of Immune-Mediated Marrow Injury and Favorable Response to Immunosuppressive Therapy in Bone Marrow Failure Syndromes.

Immunoselection by natural killer cells of PIGA mutant cells missing stress-inducible ULBP

Appearance of Stress-Inducible Membrane Proteins ULBP on Blood Cells of Patients with PNH, Aplastic Anemia, and MDS: Possible Implication of ULBP in Immune-Mediated Marrow Injury.

Decrease in Sensitivity of PIG-A -Mutant Cells to Natural Killer Cells Conferred by Missing of Stress-Inducible Membrane Proteins ULBPs.

Blocking Complement-Mediated Hemolysis of PNH Erythrocytes by RNA Aptamers to C8 and C9.

Decreased susceptibility of leukemic cells with PIG-A mutation to natural killer cells in vitro

Frequent detection of T cells with mutations of the hypoxanthine-guanine phosphoribosyl transferase gene in patients with paroxysmal nocturnal hemoglobinuria

Apoptosis Resistance of Blood Cells From Patients With Paroxysmal Nocturnal Hemoglobinuria, Aplastic Anemia, and Myelodysplastic Syndrome

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American Society of Hematology

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American Society of Hematology

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