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Journal Articles

Mapping Microenvironment-Mediated Signaling Dependency of Targeted Inhibitors: A Mechanism-Based Approach of Selecting Effective Therapy Targeting Drug Resistant AML

Zhihong Zeng, MD, Wenbin Liu, PhD, Twee Tsao, MS, Yihua Qiu, MD, Ismael Samudio, PhD, Keith Baggerly, PhD, Steven M. Kornblau, MD, Hagop M Kantarjian, MD, Michael Andreeff, MD PhD, Marina Konopleva, MD PhD

Blood (2015) 126 (23): 1398.

https://doi.org/10.1182/blood.V126.23.1398.1398

Published: 2015

Journal Articles

Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment

Zhihong Zeng, Yue Xi Shi, Twee Tsao, YiHua Qiu, Steven M. Kornblau, Keith A. Baggerly, Wenbin Liu, Katti Jessen, Yi Liu, Hagop Kantarjian, Christian Rommel, David A. Fruman, Michael Andreeff, Marina Konopleva

Blood (2012) 120 (13): 2679–2689.

https://doi.org/10.1182/blood-2011-11-393934

Published: 2012

Includes: Supplemental data

Journal Articles

The Synergistic Effect of DNA Methylation Inhibitor 5-Azacytidine and Bcl-2 Signaling Blockade ABT-737 Combination Treatment Induce Apoptosis In AML

Yuexi Shi, Twee Tsao, Hongbo Lu, MMSC, Sergej Konoplev, MD, PhD, Wendy D. Schober, Michael Andreeff, MD, PhD, Marina Konopleva, MD, PhD

Blood (2010) 116 (21): 3311.

https://doi.org/10.1182/blood.V116.21.3311.3311

Published: 2010

Journal Articles

Targeting mTORC1/2 by a mTOR Kinase Inhibitor (PP242) induces Apoptosis In AML Cells Under Conditions Mimicking Bone Marrow Microenvironment

Zhihong Zeng, Yuexi Shi, Twee Tsao, Yihua Qiu, Steven M. Kornblau, MD, Keith Baggerly, Wenbin Liu, Yi Liu, PhD, Christian Rommel, PhD, David A. Fruman, Michael Andreeff, MD, PhD, Marina Konopleva, MD, PhD

Blood (2010) 116 (21): 778.

https://doi.org/10.1182/blood.V116.21.778.778

Published: 2010

Journal Articles

MicroRNA 29b functions in acute myeloid leukemia

Ramiro Garzon, Catherine E. A. Heaphy, Violaine Havelange, Muller Fabbri, Stefano Volinia, Twee Tsao, Nicola Zanesi, Steven M. Kornblau, Guido Marcucci, George A. Calin, Michael Andreeff, Carlo M. Croce

Blood (2009) 114 (26): 5331–5341.

https://doi.org/10.1182/blood-2009-03-211938

Published: 2009

Includes: Supplemental data

Journal Articles

Selective FLT3 Inhibitor FI-700 Neutralizes Mcl-1 and Enhances p53-Mediated Apoptosis in Acute Myeloid Leukemia (AML) Cells with Activating Mutations of FLT3 Via Mcl-1/Noxa Axis.

Kensuke Kojima, MD, PhD, Marina Konopleva, MD, PhD, Twee Tsao, Michael Andreeff, MD, PhD, Hiroshi Ishida, Yukimasa Shiotsu, PhD, Linhua Jin, PhD, Yoko Tabe, MD, PhD, Hideki Nakakuma, MD, PhD

Blood (2009) 114 (22): 2597.

https://doi.org/10.1182/blood.V114.22.2597.2597

Published: 2009

Journal Articles

Simultaneous Targeting of Bcl-2/Bcl-Xl and MEK/ERK Results in Highly Synergistic Induction of Apoptosis in Human AML, Both in Vitro and In Vivo.

Marina Konopleva, MD, PhD, Michele Milella, MD, Julie C Watts, PhD, Maria Rosaria Ricciardi, PhD, Borys Korchin, PhD, Twee Tsao, PhD, Paola Bergamo, MS, Duncan H. Mak, PhD, Samantha Decandia, PhD, James McCubrey, PhD, Agostino Tafuri, MD, Michael Andreeff, MD, PhD

Blood (2009) 114 (22): 2757.

https://doi.org/10.1182/blood.V114.22.2757.2757

Published: 2009

Journal Articles

Parallel Signaling through PI3K/AKT/mTOR Mediates Resistance to MEK Inhibition in Preclinical Models of Acute Myeloid Leukemia (AML): Synergistic Effects of Combined MEK and mTOR Inhibition.

Maria Rosaria Ricciardi, PhD, Twee Tsao, PhD, Stephen Lee Abrams, PhD, Paola Bergamo, MS, Linda S Steelman, BS., MS, Samantha Decandia, PhD, Lara Felicioni, PhD, Ludovica Ciuffreda, PhD, Cristina Di Sanza, PhD, Antonio Marchetti, MD, PhD, Francesco Cognetti, MD, James McCubrey, PhD, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD, Agostino Tafuri, MD, Michele Milella, MD

Blood (2009) 114 (22): 594.

https://doi.org/10.1182/blood.V114.22.594.594

Published: 2009

Journal Articles

Activation of p53 Signaling Is Synergistically Enhanced by Bcl-2 Inhibition through Induction of Noxa and Bak/Bax Heterodimers Resulting in Apoptosis of AML Stem Cells

Marina Konopleva, MD, PhD, Twee Tsao, Xiaoyang Ling, Kensuke Kojima, M.D., Ph.D., Julie Watt, Duncan H. Mak, Monique Verhaegen, William Bornmann, Maria Soengas, Michael Andreeff, M.D., Ph.D.

Blood (2008) 112 (11): 2940.

https://doi.org/10.1182/blood.V112.11.2940.2940

Published: 2008

Journal Articles

Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia

Kensuke Kojima, Marina Konopleva, Twee Tsao, Hideki Nakakuma, Michael Andreeff

Blood (2008) 112 (7): 2886–2895.

https://doi.org/10.1182/blood-2008-01-128611

Published: 2008

Journal Articles

The Role of Apoptotic Inducing Factor (AIF) in Acute Myeloid Leukemia (AML).

Rui-Yu Wang, MD, PhD, Bing Z. Carter, PhD, Twee Tsao, Wendy Schober, Teresa McQueen, BS, Marina Konopleva, MD, PhD, Michael Andreeff, MD, PhD

Blood (2005) 106 (11): 2369.

https://doi.org/10.1182/blood.V106.11.2369.2369

Published: 2005

Journal Articles

Mechanisms and Activity of PPARγ-Active Triterpenoids CDDO and CDDO-Me in Leukemias.

Marina Konopleva, MD, PhD, Ismael Samudio, PhD, Twee Tsao, Steven M. Kornblau, MD, Yue-Xi Shi, Teresa McQueen, BS, Rooha Contractor, Michael B. Sporn, MD, Colin J. Meyer, MD, Warren Huff, Stephen H. Safe, PhD, Hagop Kantarjian, MD, Michael Andreeff, MD, PhD

Blood (2005) 106 (11): 2460.

https://doi.org/10.1182/blood.V106.11.2460.2460

Published: 2005

Journal Articles

MDM2 Inhibitor Nutlin-3a Induces p53-Dependent Apoptosis Via Transcription-Dependent and -Independent Pathways and Overcomes Fludarabine-Resistance in CLL.

Kensuke Kojima, MD, PhD, Marina Konopleva, MD, PhD, Ismael J. Samudio, PhD, Teresa McQueen, BS, Twee Tsao, Zhihong Zeng, MD, William K. Plunkett, PhD, Michael Andreeff, MD, PhD

Blood (2005) 106 (11): 445.

https://doi.org/10.1182/blood.V106.11.445.445

Published: 2005

Journal Articles

MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

Kensuke Kojima, Marina Konopleva, Ismael J. Samudio, Masato Shikami, Maria Cabreira-Hansen, Teresa McQueen, Vivian Ruvolo, Twee Tsao, Zhihong Zeng, Lyubomir T. Vassilev, Michael Andreeff

Blood (2005) 106 (9): 3150–3159.

https://doi.org/10.1182/blood-2005-02-0553

Published: 2005

Journal Articles

ARTS, a Pro-Apoptotic Mitochondrial Septin-Like Protein That Binds to XIAP, Is Silenced in Acute Lymphoblastic and Primitive Acute Myeloblastic Leukemia Cells.

Masato Shikami, M.D., Ph.D., Marina Konopleva, M.D., Ph.D., Ismael Samudio, Ph.D., Koyu Hoshino, M.D., Ph.D., Guillermo Garcia-Manero, M.D., Kensuke Kojima, M.D., Ph.D., Twee Tsao, Teresa McQueen, Michael Andreeff, M.D., Ph.D.

Blood (2004) 104 (11): 3378.

https://doi.org/10.1182/blood.V104.11.3378.3378

Published: 2004

Journal Articles

PML-RARα is associated with leptin-receptor induction: the role of mesenchymal stem cell–derived adipocytes in APL cell survival

Yoko Tabe, Marina Konopleva, Mark F. Munsell, Frank C. Marini, Claudia Zompetta, Teresa McQueen, Twee Tsao, Shourong Zhao, Sherry Pierce, Jun Igari, Elihu H. Estey, Michael Andreeff

Blood (2004) 103 (5): 1815–1822.

https://doi.org/10.1182/blood-2003-03-0802

Published: 2004

Journal Articles

Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis

Bing Z. Carter, Steven M. Kornblau, Twee Tsao, Rui-Yu Wang, Wendy D. Schober, Michele Milella, Hsi-Guang Sung, John C. Reed, Michael Andreeff

Blood (2003) 102 (12): 4179–4186.

https://doi.org/10.1182/blood-2003-03-0960

Published: 2003

Journal Articles

Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia

Marina Konopleva, Twee Tsao, Peter Ruvolo, Irina Stiouf, Zeev Estrov, Clinton E. Leysath, Shourong Zhao, David Harris, Shirong Chang, C. Ellen Jackson, Mark Munsell, Nanjoo Suh, Gordon Gribble, Tadashi Honda, W. Stratford May, Michael B. Sporn, Michael Andreeff

Blood (2002) 99 (1): 326–335.

https://doi.org/10.1182/blood.V99.1.326

Published: 2002

NARROW

Mapping Microenvironment-Mediated Signaling Dependency of Targeted Inhibitors: A Mechanism-Based Approach of Selecting Effective Therapy Targeting Drug Resistant AML

Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment

The Synergistic Effect of DNA Methylation Inhibitor 5-Azacytidine and Bcl-2 Signaling Blockade ABT-737 Combination Treatment Induce Apoptosis In AML

Targeting mTORC1/2 by a mTOR Kinase Inhibitor (PP242) induces Apoptosis In AML Cells Under Conditions Mimicking Bone Marrow Microenvironment

MicroRNA 29b functions in acute myeloid leukemia

Selective FLT3 Inhibitor FI-700 Neutralizes Mcl-1 and Enhances p53-Mediated Apoptosis in Acute Myeloid Leukemia (AML) Cells with Activating Mutations of FLT3 Via Mcl-1/Noxa Axis.

Simultaneous Targeting of Bcl-2/Bcl-Xl and MEK/ERK Results in Highly Synergistic Induction of Apoptosis in Human AML, Both in Vitro and In Vivo.

Parallel Signaling through PI3K/AKT/mTOR Mediates Resistance to MEK Inhibition in Preclinical Models of Acute Myeloid Leukemia (AML): Synergistic Effects of Combined MEK and mTOR Inhibition.

Activation of p53 Signaling Is Synergistically Enhanced by Bcl-2 Inhibition through Induction of Noxa and Bak/Bax Heterodimers Resulting in Apoptosis of AML Stem Cells

Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia

The Role of Apoptotic Inducing Factor (AIF) in Acute Myeloid Leukemia (AML).

Mechanisms and Activity of PPARγ-Active Triterpenoids CDDO and CDDO-Me in Leukemias.

MDM2 Inhibitor Nutlin-3a Induces p53-Dependent Apoptosis Via Transcription-Dependent and -Independent Pathways and Overcomes Fludarabine-Resistance in CLL.

MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

ARTS, a Pro-Apoptotic Mitochondrial Septin-Like Protein That Binds to XIAP, Is Silenced in Acute Lymphoblastic and Primitive Acute Myeloblastic Leukemia Cells.

PML-RARα is associated with leptin-receptor induction: the role of mesenchymal stem cell–derived adipocytes in APL cell survival

Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis

Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia

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American Society of Hematology

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American Society of Hematology

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