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Journal Articles

AML Genotype-Specific and Non-Specific Regulation of Mesenchymal Stromal Cell Transcriptome in the Bone Marrow Microenvironment

Rodrigo Jacamo, PhD, Xiaoyang Ling, PhD, Zhiqiang Wang, Wencai Ma, PhD, Min Zhang, PhD, Peter P. Ruvolo, PhD, Vivian R Ruvolo, MA, Scott W. Lowe, PhD, Johannes Zuber, MD, Marina Konopleva, MD PhD, R Eric Davis, MD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1586.
https://doi.org/10.1182/blood.V124.21.1586.1586
Published: 2014
Journal Articles

Unique Effects of p53 −/− Leukemic Cells On Mesenchymal Stromal Cell Gene Expression Profile in Vitro

Xiaoyang Ling, PhD, Ye Chen, PhD, Peter P. Ruvolo, PhD, Vivian Ruvolo, Zhiqiang Wang, Ph.D., Min Zhang, Ph.D., Yuexi Shi, Marina Konopleva, MD, PhD, Richard E Davis, MD, Michael Andreeff, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3468.
https://doi.org/10.1182/blood.V120.21.3468.3468
Published: 2012
Journal Articles

MRx102, a Novel Triptolide Analogue, Has Low Nanomolar Activity Against AML Stem/Progenitor Cells in Vitro and in a Murine Model of AML

Bing Z Carter, Ph.D., Duncan H Mak, M.S., Yuxie Shi, John M. Fidler, Ph.D., Rong Chen, PhD, Xiaoyang Ling, PhD, William Plunkett, PhD, Michael Andreeff, M.D., Ph.D.
Journal: Blood
Blood (2011) 118 (21): 1547.
https://doi.org/10.1182/blood.V118.21.1547.1547
Published: 2011
Journal Articles

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML

Zhihong Zeng, Yue Xi Shi, Ismael J. Samudio, Rui-Yu Wang, Xiaoyang Ling, Olga Frolova, Mark Levis, Joshua B. Rubin, Robert R. Negrin, Elihu H. Estey, Sergej Konoplev, Michael Andreeff, Marina Konopleva
Journal: Blood
Blood (2009) 113 (24): 6215–6224.
https://doi.org/10.1182/blood-2008-05-158311
Published: 2009
Includes: Supplemental data
Journal Articles

Activation of p53 Signaling Is Synergistically Enhanced by Bcl-2 Inhibition through Induction of Noxa and Bak/Bax Heterodimers Resulting in Apoptosis of AML Stem Cells

Marina Konopleva, MD, PhD, Twee Tsao, Xiaoyang Ling, Kensuke Kojima, M.D., Ph.D., Julie Watt, Duncan H. Mak, Monique Verhaegen, William Bornmann, Maria Soengas, Michael Andreeff, M.D., Ph.D.
Journal: Blood
Blood (2008) 112 (11): 2940.
https://doi.org/10.1182/blood.V112.11.2940.2940
Published: 2008
Journal Articles

Vaccination with Leukemia Cell Expression Membrane Bound GM-CSF Overcomes the Host Immunosuppression Induced by Leukemia

Di Ling, Ralph B. Arlinghaus, PhD, Xiaoyang Ling, PhD
Journal: Blood
Blood (2008) 112 (11): 5435.
https://doi.org/10.1182/blood.V112.11.5435.5435
Published: 2008
Journal Articles

Combination of Sorafenib and Arsenic Trioxide Exerts Synergistic Anti-Leukemia Effects in Sorafenib-Resistant FLT3-ITD-Harboring AML Cells

Weiguo Zhang, MD, PhD, Marina Konopleva, MD, PhD, Yuexi Shi, Xiaoyang Ling, PhD, Michael Andreeff, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 2656.
https://doi.org/10.1182/blood.V112.11.2656.2656
Published: 2008
Journal Articles

Sorafenib (BAY 43-9006) Directly Targets FLT3-ITD in Acute Myelogenous Leukemia.

Weiguo Zhang, MD, PhD, Marina Konopleva, M.D., Ph.D., Yue-Xi Shi, David Harris, Donald Small, M.D., Ph.D., Xiaoyang Ling, Ph.D., Zeev Estrov, M.D., Jorge Cortes, M.D., Michael Andreeff, M.D., Ph.D.
Journal: Blood
Blood (2006) 108 (11): 255.
https://doi.org/10.1182/blood.V108.11.255.255
Published: 2006
Journal Articles

Mesenchymal Stem Cells Selectively Engraft into Tumor Stroma and Produce Potent Antitumor Proteins In Situ.

Michael Andreeff, MD, PhD, Jennifer Dembinski, Brett M. Hall, Ph.D., Matus Studeny, M.D., Xiaoyang Ling, Ph.D., Maria Cabreira-Hansen, Ph.D., A. Kate Sasser, Teresa McQueen, Frederick Lang, M.D., Frank C. Marini, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 352.
https://doi.org/10.1182/blood.V108.11.352.352
Published: 2006
Journal Articles

The Cyclin-Dependent Kinase Inhibitor p57KIP2 Functions as a Tumor Suppressor Gene in Human Leukemia.

Shao-Qing Kuang, MD, PhD, Xiaoyang Ling, PhD, Blanca Sanchez-Gonzalez, MD, Hui Yang, MD, PhD, Guillermo Garcia-Manero, MD
Journal: Blood
Blood (2005) 106 (11): 1604.
https://doi.org/10.1182/blood.V106.11.1604.1604
Published: 2005
Journal Articles

Mechanisms of Apoptosis Induction by BH3 Inhibitor ABT-737 in AML.

Michael Andreeff, MD, PhD, Rooha Contractor, Peter P. Ruvolo, PhD, Xingming Deng, MD, PhD, Ismael Samudio, PhD, Yue-Xi Shi, Teresa McQueen, BS, Rui-Yu Wang, MD, PhD, Wendy Schober, Xiaoyang Ling, PhD, Frank C. Marini, PhD, David Harris, Zeev Estrov, MD, James McCubrey, PhD, W. Stratford May, MD, PhD, Marina Konopleva, MD, PhD
Journal: Blood
Blood (2005) 106 (11): 244.
https://doi.org/10.1182/blood.V106.11.244.244
Published: 2005
Journal Articles

Vaccination with Leukemia Cells Expressing Cell-Surface-Associated GM-CSF Blocks Leukemia Induction in Immunocompetent Mice.

Xiaoyang Ling, Ph.D, Yan Wang, M.D., Ralph B. Arlinghaus, Ph.D.
Journal: Blood
Blood (2004) 104 (11): 2531.
https://doi.org/10.1182/blood.V104.11.2531.2531
Published: 2004