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Journal Articles

APcK 110, a novel Inhibitor of Kit, Extends Survival of NOD-SCID Mice in An AML Xenograft Model.

Stefan Faderl, MD, Carlos Bueso-Ramos, MD, PhD, Zhiming Liu, Ashutosh Pal, William Bornmann, PhD, David Harris, Inbal Hazan-Halevy, PhD, Hagop M. Kantarjian, MD, Zeev Estrov, MD

Blood (2009) 114 (22): 1045.

https://doi.org/10.1182/blood.V114.22.1045.1045

Published: 2009

Journal Articles

Inhibition of Cytokine Signaling through Activation of Jak2 Ubiquitination by WP1130.

Vaibhav Kapuria, Luke F Peterson, PhD, William Bornmann, Ph.D., Moshe Talpaz, MD, Nicholas J Donato

Blood (2009) 114 (22): 2907.

https://doi.org/10.1182/blood.V114.22.2907.2907

Published: 2009

Journal Articles

Activation of p53 Signaling Is Synergistically Enhanced by Bcl-2 Inhibition through Induction of Noxa and Bak/Bax Heterodimers Resulting in Apoptosis of AML Stem Cells

Marina Konopleva, MD, PhD, Twee Tsao, Xiaoyang Ling, Kensuke Kojima, M.D., Ph.D., Julie Watt, Duncan H. Mak, Monique Verhaegen, William Bornmann, Maria Soengas, Michael Andreeff, M.D., Ph.D.

Blood (2008) 112 (11): 2940.

https://doi.org/10.1182/blood.V112.11.2940.2940

Published: 2008

Journal Articles

Degrasyn (a novel tyrophostin) Impacts BCR-ABL Protein Level and Is Cytotoxic to Chronic Myeloid Leukemia Early Progenitors

Luke F Peterson, PhD, Hanshi Sun, PhD, William Bornmann, PhD, Zhenghong Peng, PhD, David Maxwell, PhD, Nicholas Donato, Moshe Talpaz

Blood (2008) 112 (11): 3212.

https://doi.org/10.1182/blood.V112.11.3212.3212

Published: 2008

Journal Articles

Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells

Ji Wu, Feng Meng, Henry Lu, Ling Kong, William Bornmann, Zhenghong Peng, Moshe Talpaz, Nicholas J. Donato

Blood (2008) 111 (7): 3821–3829.

https://doi.org/10.1182/blood-2007-08-109330

Published: 2008

Journal Articles

A Novel Small-Molecule Approach To Inhibit Jak2 Tyrosine Kinase Signaling.

Vaibhav Kapuria, MS, Geoffrey Bartholomeusz, PhD, Ling-Yuan Kong, PhD, William Bornmann, PhD, Zhenghong Peng, PhD, Ashutosh Pal, PhD, David Maxwell, PhD, Moshe Talpaz, MD, Nicholas Donato, PhD

Blood (2007) 110 (11): 1556.

https://doi.org/10.1182/blood.V110.11.1556.1556

Published: 2007

Journal Articles

Degrasyn-Induced Trafficking of BCR-ABL as a Novel Mechanism of Kinase Inactivation.

Nicholas Donato, PhD, Vaibhav Kapuria, MS, Hanshi Sun, PhD, David Maxwell, PhD, Geoffrey Bartholomeusz, PhD, William Bornmann, PhD, Zhenghong Peng, PhD, Ashutosh Pal, PhD, Moshe Talpaz, MD

Blood (2007) 110 (11): 1003.

https://doi.org/10.1182/blood.V110.11.1003.1003

Published: 2007

Journal Articles

Inhibition of JAK2/STAT Signaling by Degrasyn through a Novel Mechanism.

Vaibhav Kapuria, MS, Geoffrey Bartholomeusz, Ph.D., William Bornmann, Ph.D., Ling Y. Kong, M.D., Moshe Talpaz, M.D., Nicholas J. Donato, Ph.D.

Blood (2006) 108 (11): 3423.

https://doi.org/10.1182/blood.V108.11.3423.3423

Published: 2006

Journal Articles

APCK110, a Novel and Potent Inhibitor of c-Kit, Blocks Phosphorylation of AKT and STAT3, Induces Apoptosis, and Inhibits Proliferation of Acute Myeloid Leukemia (AML) Cells.

Stefan Faderl, MD, William Bornmann, PhD, David Maxwell, PhD, Ashutosh Pal, Zheng-Hong Peng, Aleksandr Shavrin, David Harris, Quin Van, Liu Zhiming, Srdan Verstovsek, MD, PhD, Taghi Manshouri, MS, BS, Alessandra Ferrajoli, MD, Hagop M. Kantarjian, MD, Zeev Estrov, MD

Blood (2006) 108 (11): 153.

https://doi.org/10.1182/blood.V108.11.153.153

Published: 2006

Journal Articles

Activity of ABL Kinase Inhibitors in Two Distinct Models of Imatinib Resistance.

Nicholas J. Donato, PhD, Ji Wu, M.D., William Bornmann, Ph.D., Moshe Talpaz, M.D.

Blood (2006) 108 (11): 4819.

https://doi.org/10.1182/blood.V108.11.4819.4819

Published: 2006

Journal Articles

A Novel Mechanism of Action of Methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate (CDDO-Me): Direct Permeabilization of the Inner Mitochondrial Membrane To Inhibit Electron Transport and Induce Apoptosis.

Ismael Samudio, PhD, Marina Konopleva, MD, PhD, Helene Pelicano, PhD, Peng Huang, MD, PhD, Olga Frolova, PhD, William Bornmann, PhD, Yun-ming Ying, Randall Evans, PhD, Michael Andreeff, MD, PhD

Blood (2005) 106 (11): 4462.

https://doi.org/10.1182/blood.V106.11.4462.4462

Published: 2005

Journal Articles

Targeted deletion of T-cell clones using alpha-emitting suicide MHC tetramers

Rui Rong Yuan, Phillip Wong, Michael R. McDevitt, Ekaterina Doubrovina, Ingrid Leiner, William Bornmann, Richard O'Reilly, Eric G. Pamer, David A. Scheinberg

Blood (2004) 104 (8): 2397–2402.

https://doi.org/10.1182/blood-2004-01-0324

Published: 2004

NARROW

APcK 110, a novel Inhibitor of Kit, Extends Survival of NOD-SCID Mice in An AML Xenograft Model.

Inhibition of Cytokine Signaling through Activation of Jak2 Ubiquitination by WP1130.

Activation of p53 Signaling Is Synergistically Enhanced by Bcl-2 Inhibition through Induction of Noxa and Bak/Bax Heterodimers Resulting in Apoptosis of AML Stem Cells

Degrasyn (a novel tyrophostin) Impacts BCR-ABL Protein Level and Is Cytotoxic to Chronic Myeloid Leukemia Early Progenitors

Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells

A Novel Small-Molecule Approach To Inhibit Jak2 Tyrosine Kinase Signaling.

Degrasyn-Induced Trafficking of BCR-ABL as a Novel Mechanism of Kinase Inactivation.

Inhibition of JAK2/STAT Signaling by Degrasyn through a Novel Mechanism.

APCK110, a Novel and Potent Inhibitor of c-Kit, Blocks Phosphorylation of AKT and STAT3, Induces Apoptosis, and Inhibits Proliferation of Acute Myeloid Leukemia (AML) Cells.

Activity of ABL Kinase Inhibitors in Two Distinct Models of Imatinib Resistance.

A Novel Mechanism of Action of Methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate (CDDO-Me): Direct Permeabilization of the Inner Mitochondrial Membrane To Inhibit Electron Transport and Induce Apoptosis.

Targeted deletion of T-cell clones using alpha-emitting suicide MHC tetramers

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American Society of Hematology

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American Society of Hematology

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