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William Bornmann
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Journal Articles

Inhibition of Cytokine Signaling through Activation of Jak2 Ubiquitination by WP1130.

Vaibhav Kapuria, Luke F Peterson, PhD, William Bornmann, Ph.D., Moshe Talpaz, MD, Nicholas J Donato
Journal: Blood
Blood (2009) 114 (22): 2907.
https://doi.org/10.1182/blood.V114.22.2907.2907
Published: 2009
Journal Articles

APcK 110, a novel Inhibitor of Kit, Extends Survival of NOD-SCID Mice in An AML Xenograft Model.

Stefan Faderl, MD, Carlos Bueso-Ramos, MD, PhD, Zhiming Liu, Ashutosh Pal, William Bornmann, PhD, David Harris, Inbal Hazan-Halevy, PhD, Hagop M. Kantarjian, MD, Zeev Estrov, MD
Journal: Blood
Blood (2009) 114 (22): 1045.
https://doi.org/10.1182/blood.V114.22.1045.1045
Published: 2009
Journal Articles

Activation of p53 Signaling Is Synergistically Enhanced by Bcl-2 Inhibition through Induction of Noxa and Bak/Bax Heterodimers Resulting in Apoptosis of AML Stem Cells

Marina Konopleva, MD, PhD, Twee Tsao, Xiaoyang Ling, Kensuke Kojima, M.D., Ph.D., Julie Watt, Duncan H. Mak, Monique Verhaegen, William Bornmann, Maria Soengas, Michael Andreeff, M.D., Ph.D.
Journal: Blood
Blood (2008) 112 (11): 2940.
https://doi.org/10.1182/blood.V112.11.2940.2940
Published: 2008
Journal Articles

Degrasyn (a novel tyrophostin) Impacts BCR-ABL Protein Level and Is Cytotoxic to Chronic Myeloid Leukemia Early Progenitors

Luke F Peterson, PhD, Hanshi Sun, PhD, William Bornmann, PhD, Zhenghong Peng, PhD, David Maxwell, PhD, Nicholas Donato, Moshe Talpaz
Journal: Blood
Blood (2008) 112 (11): 3212.
https://doi.org/10.1182/blood.V112.11.3212.3212
Published: 2008
Journal Articles

Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells

Ji Wu, Feng Meng, Henry Lu, Ling Kong, William Bornmann, Zhenghong Peng, Moshe Talpaz, Nicholas J. Donato
Journal: Blood
Blood (2008) 111 (7): 3821–3829.
https://doi.org/10.1182/blood-2007-08-109330
Published: 2008
Journal Articles

Degrasyn-Induced Trafficking of BCR-ABL as a Novel Mechanism of Kinase Inactivation.

Nicholas Donato, PhD, Vaibhav Kapuria, MS, Hanshi Sun, PhD, David Maxwell, PhD, Geoffrey Bartholomeusz, PhD, William Bornmann, PhD, Zhenghong Peng, PhD, Ashutosh Pal, PhD, Moshe Talpaz, MD
Journal: Blood
Blood (2007) 110 (11): 1003.
https://doi.org/10.1182/blood.V110.11.1003.1003
Published: 2007
Journal Articles

A Novel Small-Molecule Approach To Inhibit Jak2 Tyrosine Kinase Signaling.

Vaibhav Kapuria, MS, Geoffrey Bartholomeusz, PhD, Ling-Yuan Kong, PhD, William Bornmann, PhD, Zhenghong Peng, PhD, Ashutosh Pal, PhD, David Maxwell, PhD, Moshe Talpaz, MD, Nicholas Donato, PhD
Journal: Blood
Blood (2007) 110 (11): 1556.
https://doi.org/10.1182/blood.V110.11.1556.1556
Published: 2007
Journal Articles

Inhibition of JAK2/STAT Signaling by Degrasyn through a Novel Mechanism.

Vaibhav Kapuria, MS, Geoffrey Bartholomeusz, Ph.D., William Bornmann, Ph.D., Ling Y. Kong, M.D., Moshe Talpaz, M.D., Nicholas J. Donato, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 3423.
https://doi.org/10.1182/blood.V108.11.3423.3423
Published: 2006
Journal Articles

APCK110, a Novel and Potent Inhibitor of c-Kit, Blocks Phosphorylation of AKT and STAT3, Induces Apoptosis, and Inhibits Proliferation of Acute Myeloid Leukemia (AML) Cells.

Stefan Faderl, MD, William Bornmann, PhD, David Maxwell, PhD, Ashutosh Pal, Zheng-Hong Peng, Aleksandr Shavrin, David Harris, Quin Van, Liu Zhiming, Srdan Verstovsek, MD, PhD, Taghi Manshouri, MS, BS, Alessandra Ferrajoli, MD, Hagop M. Kantarjian, MD, Zeev Estrov, MD
Journal: Blood
Blood (2006) 108 (11): 153.
https://doi.org/10.1182/blood.V108.11.153.153
Published: 2006
Journal Articles

Activity of ABL Kinase Inhibitors in Two Distinct Models of Imatinib Resistance.

Nicholas J. Donato, PhD, Ji Wu, M.D., William Bornmann, Ph.D., Moshe Talpaz, M.D.
Journal: Blood
Blood (2006) 108 (11): 4819.
https://doi.org/10.1182/blood.V108.11.4819.4819
Published: 2006
Journal Articles

A Novel Mechanism of Action of Methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate (CDDO-Me): Direct Permeabilization of the Inner Mitochondrial Membrane To Inhibit Electron Transport and Induce Apoptosis.

Ismael Samudio, PhD, Marina Konopleva, MD, PhD, Helene Pelicano, PhD, Peng Huang, MD, PhD, Olga Frolova, PhD, William Bornmann, PhD, Yun-ming Ying, Randall Evans, PhD, Michael Andreeff, MD, PhD
Journal: Blood
Blood (2005) 106 (11): 4462.
https://doi.org/10.1182/blood.V106.11.4462.4462
Published: 2005
Journal Articles

Targeted deletion of T-cell clones using alpha-emitting suicide MHC tetramers

Rui Rong Yuan, Phillip Wong, Michael R. McDevitt, Ekaterina Doubrovina, Ingrid Leiner, William Bornmann, Richard O'Reilly, Eric G. Pamer, David A. Scheinberg
Journal: Blood
Blood (2004) 104 (8): 2397–2402.
https://doi.org/10.1182/blood-2004-01-0324
Published: 2004